• Archives of Plastic Surgery
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• 제36권5호
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• pp.543-547
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• 2009

Purpose: Adhesion is the most common and troublesome complication after repair of flexor tendon injury. Recently, use of sodium hyaluronate derivatives for adhesion prevention is increasing. A commercial product, Guardix$^{(R)}$, sodium hyaluronate(NaHe) combined with carboxymethylcellulose(CMC) has been newly developed as a preventive material for adhesion. We have investigated its effect in rabbits. Methods: Twenty seven male New Zealand white rabbits were operated under ketamine anesthesia. After tendon repair in zone II of the hind paw, Guardix$^{(R)}$(experimental group) or normal saline(control group) was administered. Biomechanical tests were performed to estimate adhesion formation at 2, 4, 8, and 12 weeks after the operation. Maximum tensile load to flex the distal interphalangeal joint 50 degree from its resting state(MTL50) was measured, depicting the amount of adhesion formed. Subsequently, breaking strength was assessed. Results: There were no postoperative complications such as infection, wound dehiscence, or hematoma. MTL50 was significantly lower in the experimental group than in the control group at 4, 8, 12 weeks (p<0.05). Mean value of MTL50 was 6.64N in the experimental group and 28.53N in the control group at 12 weeks after surgery. There were no significant differences in breaking strength. Conclusion: Our results indicate that Guardix$^{(R)}$ is helpful in reducing adhesion formation and does not interfere with normal healing processes of the tendon.

• Journal of Ginseng Research
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• 제46권4호
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• pp.526-535
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• 2022

Background: During the pathogenesis of tendinopathy, the chronic inflammation caused by the injury and apoptosis leads to the generation of scars. Ginsenoside Rg1 (Rg1) is extracted from ginseng and has anti-inflammatory effects. Rg1 is a unique phytoestrogen that can activate the estrogen response element. This research aimed to explore whether Rg1 can function in the process of tendon repair through the estrogen receptor. Methods: In this research, the effects of Rg1 were evaluated in tenocytes and in a rat model of Achilles tendinitis (AT). Protein levels were shown by western blotting. qRT-PCR was employed for evaluating mRNA levels. Cell proliferation was evaluated through EdU assay and cell migration was evaluated by transwell assay and scratch test assay. Results: Rg1 up-regulated the expression of matrix-related factors and function of tendon in AT rat model. Rg1 reduced early inflammatory response and apoptosis in the tendon tissue of AT rat model. Rg1 promoted tenocyte migration and proliferation. The effects of Rg1 on tenocytes were inhibited by ICI182780. Rg1 activates the insulin-like growth factor-I receptor (IGF1R) and MAPK signaling pathway. Conclusion: Rg1 promotes injured tendon healing in AT rat model through IGF1R and MAPK signaling pathway activation.

• 대한정형외과스포츠의학회지
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• 제9권1호
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• pp.22-27
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• 2010

도시화, 사회 경제적 발달로 인하여 많은 사람들이 달리기 운동을 즐기고 있다. 달리기는 단순한 운동이지만 반복적인 동작을 하기 때문에 관절에 특이적인 손상이 발생될 수가 있다. 달리기 운동 손상의 원인은 급성기의 손상보다는 만성적인 과사용 증후군으로 인한 것이 대부분이다. 또한 달리기를 할 때 흔히 동반되는 손상은 전방 슬관절 통증, 장경 인대 증후군, 피로 골절, 족저 근막염, 아킬레스 건염, 후방 경골 인대 증후군 등이 있다. 달리기 운동 손상의 가장 흔한 부위는 무릎 관절이다. 이에 저자들은 문헌 고찰을 하여, 달리기 운동 손상 중에서 무릎에서 발생하는 손상의 종류, 원인, 예방, 재활적인 치료 등을 중심으로 알아보고자 한다.

• 대한족부족관절학회지
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• 제13권2호
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• pp.193-196
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• 2009

The first metatarsophalangeal joint injury is common in professional soldiers and athletes. But this was rarely reported. A professional soldier has varus instability in the first metatarsophalangeal joint due to hyperextension. In the MR Imaging, weavy appearance in lateral collateral ligament and high signal change in plantar plate was shown. So he has surgical treatment using reconstructive procedure. At first, $4^{th}$ extensor digitorum longus tendon was splitted longitudinally and harvested, second triangular shape reconstruction on lateral joint line was done using harvested tendon. One year later, fifteen degrees was limited compared with intact side. Reconstruction using $4^{th}$ extensor digitorum longus tendon in traumatic dynamic hallux varus was good method.

• 대한정형외과스포츠의학회지
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• 제5권2호
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• pp.110-116
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• 2006

견관절의 외전 및 외회전 운동시 이두 근 장 두의 내측으로 가해지는 응력은 이두 근 활차 및 견갑하건의 손상과 함께 이 두 근장 두의 내측 탈구를 유발할 수 있으며 회 전근 개 파열과 동반될 경우 증상을 더욱 악화시킬 수 있으므로 진단 및 치료에 주의를 요한다. 관절와 상완관절 상부의 병적 변화로 유발되는 상부 관절순 전후방 병변 (SLAP)은 관절경적 검사 및 치료가 보편화 됨에 따라 견관절 기능 부전의 원인으로 그 중요도가 더욱 커지고 있는 질환중의 하나이다. SLAP병변의 치료는 임상증상 및 병형의 양상에 따라 결정되며, 정상적인 변형에 대해 과 치료를 하지 않도록 유의하여야 한다.

• 대한정형외과스포츠의학회지
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• 제5권1호
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• pp.81-84
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• 2006

Rupture of the rectus femoris at the musculotendinous junction is very rarely reported in the literature, especially which is caused by chronic repetitive stimulation. A 21 year old soldier complained of progressing right thigh pain and mass for 8 weeks after military training. MRI of the right thigh showed inhomogenous mass lesion suspecting soft tissue tumor. However ultrasonographic examination showed torn retracted rectus femoris tendon at musculotendinous junction. One year after primary repair of ruptured tendon, the patient is free from symptoms and returned to full previous activities. Knowledge of this sonographic and MRI finding will help the surgeon to diagnose and treat this rare injury.

• 한국전문물리치료학회지
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• 제14권4호
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• pp.7-13
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• 2007

The purpose of this study was to investigate correlations among objective measurements of spasticity in patients with brain lesions. Thirty-two stroke and traumatic brain injury subjects participated in the study. Spasticity was quantified using the knee first flexion angle, relaxation index obtained from a pendulum drop test, and the amplitude of a knee tendon reflex test. Pearson's product correlation coefficient was used to examine relationships among these measurements of spasticity. There was a significant positive correlation between the relaxation index and knee first flexion angle in patients with brain lesions (r=.895, p<.01). There was also significant negative correlation between the amplitude of knee tendon reflex and relaxation index (r=-.612, p<.01), and between amplitude and knee first flexion angle (r=-.537, p<.01). Thus, it is possible to use the knee first flexion angle as an objective measure of spasticity, rather than relaxation index, which is more complicated to obtain. Further studies are needed to explore the effects of functional improvement and long-lasting carryover effects of spasticity using a simple objective measure such as the knee first flexion angle from a pendulum test.

• The Korean Journal of Pain
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• 제7권1호
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• pp.34-38
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• 1994

The common disorder called tennis elbow exhibits typical clinical characteristics, i.e. painful condition at the lateral aspect of elbow joint on resisted wrist extension. However an exact cause for this painful condition has not yet been established. Many observers believe that the usual lesion of tennis elbow is a partial rupture of the extensor tendon at the tenoperiosteal juction on the lateral epicondyle of humerus. However the mechanism of the tendon rupture has never been explained. Conservative treatments on the tender area have been the most common therapeutic modalities for pain relief of tennis elbow. Based on my clinical experiences and anatomical studies, I discerned that tennis elbow is a periostitis of lateral epicondyle of humerus secondary to spastic contraction of muscular belly of extensor carpi radialis after over-stretched injury. Therefore, spasmolytic treatment on the extensor carpi radialis muscle provided a favorable result for permanent relief for tennis elbow pain.

• 대한족부족관절학회지
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• 제26권3호
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• pp.123-129
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• 2022

Purpose: To evaluate the correlation between the fibrillar pattern of the Achilles tendon on ultrasonography (US) and functional outcomes in patients who underwent open tendon repair after Achilles tendon rupture. Materials and Methods: Data of 44 patients who had been subjected to US at least 6 months after repair, during the period between July 2012 and July 2019 were reviewed. Those with bilateral tendon rupture, re-rupture, open injury, and chronic or insertional rupture, were excluded from the review. We divided them into two groups, the homogenous group (HoP) and the heterogenous group (HeP) based on the fibrillar pattern on US. We also divided the HoP into linear and wavy subgroups, and the HeP into no hypoechoic lesion and hypoechoic lesion subgroups. The rupture type of the Achilles tendon, radiographic factors including US and magnetic resonance images, patient-related, surgical factors, and clinical results at the last visit after repair were assessed retrospectively. Results: The tendon thickness was 11.4±1.7 mm in the HoP, and 14.5±3.0 mm in the HeP (p<0.001). A shredded pattern was observed in 17 cases (65.4%) in the HoP, and in 17 cases (94.4%) in the HeP (p=0.031). The mean value of the number of sutures used was 8.9±3.05 in the HoP and 11.39±1.75 in the HeP (p=0.001). The mean value of the difference in calf circumference was 0.9±0.67 cm in the HoP and 1.36±0.71 cm in the HeP (p=0.037). There were no statistically significant differences in the fibrillar patterns and patient-related factors. Conclusion: The fibrillar pattern observed after repair was correlated with the functional outcome and showed a significant relationship with the rupture pattern and the number of sutures used. Therefore, we suggest a careful individualized postoperative rehabilitation protocol to maximize functional outcomes by referring to the fibrillar pattern in US, especially in shredded ruptures.

• 한국임상수의학회지
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• 제40권2호
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• pp.93-103
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• 2023

The tendon is a dense connective tissue that connects muscle to bone and plays an essential role in joint motion. The injured tendon heals slowly owing to its low cellularity and vascularity. This study aimed to evaluate and compare the effects of regenerative injection therapy (RIT), 20 % dextrose prolotherapy (DP), and platelet-rich plasma (PRP) injections that can promote tendon healing. Twenty-one New Zealand white rabbits were divided into the control, DP, and PRP treatment groups. The superficial digital flexor tendon (SDFT) of the right hindlimb of each rabbit was used. A round defect of 2 mm was induced. Approximately 0.2 mL of 20% dextrose and autologous PRP were injected into the proximal and distal ends of the SDFT mass. Radiographic and ultrasonographic examination and cross-sectional area (CSA) calculations were performed pre-operatively and at 2, 4, and 8 weeks. The SDFT of both limbs was transected for biomechanical and histomorphometric evaluations. The SDFT of the left limb was transected for intact control. Semi-quantitative analysis was performed to evaluate the histomorphometric properties. Additional analysis was performed using H&E, Masson's trichrome, and immunohistochemical staining. The biomechanical evaluation showed that the treatment groups had higher tensile strength compared to the defect control group, while the PRP group had higher tensile strength than the DP group. On histological examination, the treatment groups appeared to be relatively closer to the remodeling phase of the healing process than the defect control group; the characteristics of the PRP group were closer to the remodeling phase than those of the DP group. The ultrasonographic examination showed different tendencies. Increased values in the CSA were observed during the early period in the treatment groups. This study suggests that PRP and DP can promote the healing of tendon injury, and these effects were superior with PRP than that with DP.