• Current Optics and Photonics
• /
• 제1권2호
• /
• pp.132-137
• /
• 2017

To investigate the usefulness of optical coherence tomography (OCT) for imaging lymphedema, we directly compared it to other histological methods in a mouse model of lymphedema. We performed detailed imaging of the lymphedema lesion on a mouse tail. We imaged the mouse tail in vivo with OCT and created histopathological samples. We constructed a spectrometer-based OCT system using a fiber-optic Michelson interferometer. The light was directed to 50:50 couplers that split the light into reference and sample arms. Backscattered light from a reference mirror and the sample produced an interference fringe. An OCT image of the lymphedema model revealed an inflammatory reaction of the skin that was accompanied by edema, leading to an increase in the light attenuation in the dermal and subcutaneous layers. Similar to OCT image findings, histological biopsy showed an inflammatory response that involved edema, increased neutrophils in epidermis and subdermis, and lymphatic microvascular dilatation. Furthermore, the lymphedema model showed an increase in thickness of the dermis in both diagnostic studies. In the mouse tail model of lymphedema, OCT imaging showed very similar results to other histological examinations. OCT provides a quick and useful diagnostic imaging technique for lymphedema and is a valuable addition or complement to other noninvasive imaging tools.

• Journal of Biosystems Engineering
• /
• 제37권2호
• /
• pp.122-129
• /
• 2012

Purpose: Recent mechatronics technology is the most appropriate high technology in agricultural applications to save repetitious labor. Method: Cow's body parameters were measured by several traditional measurers. Image processing technology was used to measure automatically their parameters to reduce labor and time. The parameters were measured form a small model cow which is easily measured, instead to a real cow. The image processing system designed and built for this project was composed of a PC, grabber card, and two cameras, which are located on the side and the top of the model cow. Tests of verification had measured 10 dairy cows. Result: Nine parameters of the model cow's body were measured, and the difference between the real data and the data by image processing was less than 16.7%. Based on the results of the research, the parameters of a real cow had measured of chest depth, withers height, Pelvic arch height, body length, slope body length, chest width, hip width, thurl width, and pin bone width were compared with image processing data. Conclusions: In the Demonstration test, Result had obtained similar data of cow model experiments, and the most of errors were shown less than 5% relatively good result.

• Asian-Australasian Journal of Animal Sciences
• /
• 제31권4호
• /
• pp.499-504
• /
• 2018

Objective: Recent studies have challenged the traditional paradigm that growth hormone receptor (GHR) displays physiological functions only in the cell membrane. It has been demonstrated that GHR localizes to the cell nucleus and still exhibits important physiological roles. The phenomenon of nuclear localization of growth hormone (GH)-induced GHR has previously been described in vitro. However, until recently, whether GH could induce nuclear localization of GHR in vivo was unclear. Methods: In the present study, we used pig as an animal model, and porcine growth hormone (pGH) or saline was injected into the inferior vena cava. We subsequently observed the localization of porcine growth hormone receptor (pGHR) using multiple techniques, including, immunoprecipitation and Western-blotting, indirect immunofluorescence assay and electronmicroscopy. Results: The results showed that pGH could induce nuclear localization of pGHR. Taken together, the results of the present study provided the first demonstration that pGHR was translocated to cell nuclei under pGH stimulation in vivo. Conclusion: Nuclear localization of pGHR induced by the in vivo pGH treatment suggests new functions and/or novel roles of nuclear pGHR, which deserve further study.

• 한국수소및신에너지학회논문집
• /
• 제34권2호
• /
• pp.91-99
• /
• 2023

Participation in power trading using surplus power is considered a business model active in the domestic energy trade market, but it is limited only if the legal requirements according to the type, capacity, and use of the facilities to be applied for are satisfied. The hydrogen residential demonstration model presented in this paper includes solar power, energy storage system (ESS), fuel cell, and water electrolysis facilities in electrical facilities for private use with low-voltage power receiving system. The concept of operations strategy for this model focuses on securing the energy self-sufficiency ratio of the entire system, securing economic feasibility through the optimal operation module installed in the energy management system (EMS), and securing the stability of the internal power balancing issue during the stand-alone mode. An electric facility configuration method of a hydrogen residential complex demonstrated to achieve this operational goal has a structure in which individual energy sources are electrically connected to the main bus, and ESS is also directly connected to the main bus instead of a renewable connection type to perform charging/discharging operation for energy balancing management in the complex. If surplus power exists after scheduling, participation in power trading through reverse transmission parallel operation can be considered to solve the energy balancing problem and ensure profitability. Consequentially, this paper reviews the legal regulations on participation in electric power trading using surplus power from hydrogen residential models that can produce and consume power, gas, and thermal energy including hybrid distributed power sources, and suggests action plans.

• International Journal of Aeronautical and Space Sciences
• /
• 제4권2호
• /
• pp.61-68
• /
• 2003

The space systems are being operated in a uncertain space environment and are desired to have autonomous capability for long periods of time without frequent telecommunications with the ground station. At the same time, requirements for new set of satellite system set of projects/systems calling for "autonomous" operations for long unattended periods of time are emerging. Since, by the nature of space systems, it is desired to perform its mission flawlessly and also it is of extreme importance to have fault-tolerant sensors and actuators for the purpose of validating science measurement data for the mission success. This studies focused on the identification/demonstration of critical technology innovations that will be applied to the Validation Control System.

• 한국공작기계학회:학술대회논문집
• /
• 한국공작기계학회 2003년도 춘계학술대회 논문집
• /
• pp.73-78
• /
• 2003

Ultrasonic measurement is one of important technologies in the lift-time maintenance of nuclear poler plant. Ultrasonic inspection system is consisted of the operator, equipment and procedure. The reliability of ultrasonic inspection system is affected by its ability. The performance demonstration round robin was conducted to quantify the capability of ultrasonic inspection for in-service. The small number of teams who employed procedures that met or exceeded ASME Sec. XI Code requirements detected the piping of nuclear power plant with various cracks to evaluate the capability of detection and sizing. In this paper, the statistical reliability assessment of ultrasonic nondestructive inspection data using Monte Carlo simulation is presented. The results of the probability of detection (POD) analysis using Monte Carlo simulation are compared to these of logistic probability model. In these results, Monte Carlo simulation was found to be very useful to the reliability assessment f3r the small hit/miss data sets.

• IMMUNE NETWORK
• /
• 제2권1호
• /
• pp.1-5
• /
• 2002

Estimated number of adults and children newly infected with HIV-1 during 2001 alone is 5 million in total. An effective vaccine, in addition to education & public health approaches, has been believed to be the best option to stop the HIV-1 transmission, especially for developing countries. Among AIDS vaccine candidates, DNA vaccine is relatively safe and, in a certain extent, mimics some attributes of live attenuated vaccine, with regard to in vivo gene expression & the type of immunity induced. We recently demonstrated that DNA vaccines expressing SIVmac239 structural and regulatory genes, augmented with coadministration of IL-12 mutant induced the strongest T cell responses, resulting in low to undetectable setpoint viral loads, stable $CD4^+$ T cell counts, and no evidence of clinical diseases or mortality by day 420 after challenge. This finding is the second demonstration, following the protective result of live attenuated SIV vaccine in SIVmac-rhesus monkey model, which was known to have safety problem. So, our DNA vaccines could give a significant impact on HIV-1 epidemic by slowing or stopping the spread of HIV-1, leading to eventual eradication of HIV-1 and AIDS in the population.

• 국제학술발표논문집
• /
• The 8th International Conference on Construction Engineering and Project Management
• /
• pp.122-128
• /
• 2020

This research investigates how a Virtual Reality (VR)-based simulation could be used to train safe operation skills for forklift operators. Forklift operation is categorized as high-risk work by many occupational health and safety regulators and authorities due to high injury and fatality rates involved with forklifts. Therefore, many safety guidelines have been developed for forklift operators. Typically, forklift operation safety training is delivered based on instructional texts or videos, which have limitations in influencing people's safety behavior. Against this background, we propose a VR-based forklift simulator that can enable safe operation skills training through a feedback system. The training program consists of several modules to teach how to perform the basic tasks of forklift operation, such as driving, loading and unloading, following the safety guidelines. The system provides instantaneous instructions and feedback regarding safe operation. This training system is based on the model of "learning-by-doing". The user can repeat the training modules as many times as necessary before being able to perform the given task without violating any safety guidelines. The last training module tests the user's acquisition of all safety skills required. The user feedback from several demonstration sessions showed the potential usefulness of the proposed training system.

• 한국산업정보학회논문지
• /
• 제22권4호
• /
• pp.11-18
• /
• 2017

본 논문은 소비자에게 공급되는 수돗물의 공급시설(Water Supply Network)에 IoT 기술을 활용하여 소비자의 물 사용량을 원격으로 검침하고, 공급시설의 누수를 줄여서 원가를 절감하는 스마트 물관리(Smart Water Management) 기술의 적용효과를 검증하였다. SWM 실증모형은 수돗물 공급시설에 원격 누수감지센서, 스마트 미터링(Smart Metering), 초소형 멀티센서를 설치하고, 원격에서 운영현황을 실시간으로 감시하고 소비자에게 수돗물 사용량과 수질을 스마트폰 앱으로 제공하였다. 이때, 소비자가 수돗물 사용량 정보를 이용하여 수돗물을 아껴 쓰는지, 수돗물 수질정보를 이용하여 직접 음용하는지를 조사하였다. 특히, 본 연구에서는 SWM을 실증 적용함으로써 공급시설의 유수율 향상, 수돗물 음용률 향상, 소비자 민원 감소, 운영비용 절감, 수돗물 사용량 절감이 달성되는지를 검증하는데 목적이 있다. 또한 수돗물 공급시설의 IoT 센서, 운영자 모니터링 시스템, 이상발생시 탐사복구 솔루션이 융합된 하나의 SWM 모델을 수립하였으며, 관련 기술 개발을 통해 국내 물산업을 육성하고, SWM을 선진수준으로 확산하였다는데 의의가 있다고 하겠다.

• Nuclear Engineering and Technology
• /
• 제49권7호
• /
• pp.1379-1387
• /
• 2017

This paper presents a comparison of homogenization techniques implemented in the APOLLO3 platform for transport core calculations: standard scalar flux weighting and new flux-moment homogenization, in different combinations with (or without) leakage models. Besides the historical B1-homogeneous model, a new B-heterogeneous one has indeed been implemented recently in the two/three-dimensional-transport solver using the method of characteristics. First analyses have been performed on a very simple Sodium Fast Reactor core with a regular hexagonal lattice. They show that using the heterogeneous leakage model in association with flux-moment homogenization strongly improves the prediction of $k_{eff}$ and void reactivity effects. These good results are confirmed when the application is done to the fissile assemblies of the more complex CFV (Low Void Effect) core of the ASTRID (Advanced Sodium Technological Reactor for Industrial Demonstration) project of sodium-cooled fast breeder reactor (Generation IV).