IMMUNE NETWORK
- Volume 2 Issue 1
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- Pages.1-5
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- 2002
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
Perspectives of AIDS Vaccine Development: T Cell-based Vaccine
- Sung, Young Chul (National Research Lab., Department of Life Science, Pohang University of Science and Technology)
- Published : 2002.03.31
Abstract
Estimated number of adults and children newly infected with HIV-1 during 2001 alone is 5 million in total. An effective vaccine, in addition to education & public health approaches, has been believed to be the best option to stop the HIV-1 transmission, especially for developing countries. Among AIDS vaccine candidates, DNA vaccine is relatively safe and, in a certain extent, mimics some attributes of live attenuated vaccine, with regard to in vivo gene expression & the type of immunity induced. We recently demonstrated that DNA vaccines expressing SIVmac239 structural and regulatory genes, augmented with coadministration of IL-12 mutant induced the strongest T cell responses, resulting in low to undetectable setpoint viral loads, stable