• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.557-563
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• 2013

Intrahepatic cholangiocarcinoma (ICC) is ranked as one of the top five causes of cancer-related deaths. ICC in Thai patients is associated with infection with the liver fluke, Opisthorchis viverrini, but the molecular basis for development remains unclear. The present study employed a microarray approach to compare gene expression profiles of ICCs and normal liver tissues from the same patients residing in Northeast Thailand, a region with a high prevalence of liver fluke infection. In ICC samples, 2,821 and 1,361 genes were found to be significantly up- and down-regulated respectively (unpaired t-test, p<0.05; fold-change ${\gep}2.0$). For validation of the microarray results, 7 up-regulated genes (FXYD3, GPRC5A, CEACAM5, MUC13, EPCAM, TMC5, and EHF) and 3 down-regulated genes (CPS1, TAT, and ITIH1) were selected for confirmation using quantitative RT-PCR, resulting in 100% agreement. The metallothionine heavy metal pathway contains the highest percentage of genes with statistically significant changes in expression. This study provides exon-level expression profiles in ICC that should be fruitful in identifying novel genetic markers for classifying and possibly early diagnosis of this highly fatal type of cholangiocarcinoma.

• Nuclear Engineering and Technology
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• v.52 no.7
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• pp.1545-1556
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• 2020

Recently, the International Commission on Radiological Protection (ICRP) has developed the Mesh-type Reference Computational Phantoms (MRCPs) for adult male and female to overcome the limitations of the current Voxel-type Reference Computational Phantoms (VRCPs) described in ICRP Publication 110 due to the limited voxel resolutions and the nature of voxel geometry. In our previous study, the MRCPs were used to calculate the dose coefficients (DCs) for idealized external exposures of photons and electrons. The present study is an extension of the previous study to include three additional particles (i.e., neutrons, protons, and helium ions) into the DC library by conducting Monte Carlo radiation transport simulations with the Geant4 code. The calculated MRCP DCs were compared with the reference DCs of ICRP Publication 116 which are based on the VRCPs, to appreciate the impact of the new reference phantoms on the DC values. We found that the MRCP DCs of organ/tissue doses and effective doses were generally similar to the ICRP-116 DCs for neutrons, whereas there were significant DC differences up to several orders of magnitude for protons and helium ions due mainly to the improved representation of the detailed anatomical structures in the MRCPs over the VRCPs.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.74.1-74.1
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• 2014

We study a wraping instability of a geometrically thin, non-self-gravitating disk surrounding binary supermassive black holes on a circular orbit. Such a circumbinay disk is subject to not only tidal torques due Line 8 to the binary gravitational potential but also radiative rorques due to radiation emitted from each accretion disk. We find tat a circumbinary disk initially aligned with the binary orbital plane is unstable to radiation-driven warping beyond the marginally stable warping radius, which is sensitive to both the ratio of vertical to horizontal shear viscosities and the mass-to-energy conversion efficiency. As expected, the tidal torques give no contribution to the growth of warping modes but tend to align the circumbinary disk with the orbital plane. Since the tidal torques can suppress the warping modes in the inner part of circumbinary disk, the circumbinaary disk starts to be warped at the radii larger than the marginally stable warping radius. If the warping radius is of the order of 0.1 pc, a resultant semi-major axis is estimated to be of the order of 10-2 pc to 10-4 pc for 107 Msun black hole. We also discuss the posibility that the central objects of observed warped maser disks in active galactic nuclei are binary supermassive black holes with a triple disk: two accretion disks around the individual black holes and one circumbinary disk surrounding them.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.4
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• pp.716-722
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• 2004

This study investigated the quality characteristics of sponge cakes with addition of mushroom (Pleurotus eryngii) powders prepared by different drying methods, hot air (HDMP: hot air dried mushroom powder) and freeze drying (FDMP: freeze dried mushroom powder). The specific gravities, viscosity, height, specific volume, color, texture and sensory evaluation of bread dough containing 3%, 5% and 7% mushroom powders were measured. The specific gravity and viscosity tended to increase according to the addition of mushroom powder. The height and specific volume tended to decrease according to the addition mushroom powder. Substituting mushroom powder for flour also resulted in decreased yellowness and lightness and increased redness of the cake crust. The hardness of cakes containing mushroom powders was higher than tat of control without mushroom powders. The color of cake crust became darker as the amount of mushroom powders increased. The results of sensory evaluation by QDA (quantitative descriptive analysis) to compare two different drying methods showed that overall acceptalility of sponge cakes containing 3% and 5% mushroom power were higher than that of control without mushroom powder.

• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.1
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• pp.141-163
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• 1999

Im Rahmen der Prinzipien und Parametertheorie ist die $koh\"{a}rente$ Konstruktion umstritten in bezug auf die Frage, ob sie yon der satzwertigen, $inkoh\"{a}renten$ Konstruktion(i.e. Small Clause) herleitbar ist oder nicht. Die derivationellen Analysen wie Evakuierungsanalyse, Verbanhebungsanalyse und Reanalyse gehen von der Annahme aus, $da{\ss}\;die\;koh\"{a}rente$ Konstruktion eine von der $inkoh\"{a}renten$ Konstruktion derivierte Variation ist. Im Gegensatz dazu ist nach der Unifikationsanalyse die $koh\"{a}rente$ Konstruktion die basisgenerierte monosententiale Konstruktion. In der vorliegenden Arbeit wird versucht, die empirische und theoretische $Unad\"{a}quatheit$ der derivationellen Analysen zu zeigen. Wenn die derivationellen Analysen korrekt $w\"{a}ren,\;mu{\ss}te$ auch nach der Derivaton beim langen Passiv das Akkusativkomplement der Infinitivkonstruktion ohne Kasuskonversion bleiben. Aber in der Tat wird der Nominativkasus dem Komplement der Infinitivkonstruktion zugewiesen. In der empirischen Gesichtspunkten steht das lange Passiv nicht im Einklang rnit den derivationellen Analysen. Ferner $mu{\ss}$ nach Chomskys $\"{O}konomieprinzip$ die Derivation obligatorisch sein. Aber die derivationellen Analysen, nach denen der grammatische Satz vom grammatischen Satz deriviert wird, ist nicht obligatorisch, sondern fakultativ. Sie sind theoretisch nicht $ad\"{a}quat$. In dieser Arbeit wird die Resultativkonstruktionen als weitere $koh\"{a}rente$ Konstruktion vorgeschlagen. Dabei wird die Evidenz gegen die Small Clause Struktur, die nach den derivationellen Analysen als $urspr\"{u}ngliche$ Struktur der koharenten Konstruktion angenommen wurde, zweierlei wie folgt gezeigt: Skopus und Idiomatisierung. Wenn die Resultativkonstruktionen als Small Clause analysiert werden, kann ein Adverb innerhalb des Small Clause auftreten, das den weiten Skopus $\"{u}ber$ den Gesamtsatz hat. Aber unter der Small Clause Analyse kann $tats\"{a}chlich$ das Adverb wegen der K-Kommandobedingung keinen weiten Skopus. D.h. das Adverb kann das finite Verb nicht k-kommandieren. Idiomatisierung bildet vor der Transformation im Lexikon eine syntaktische Einheit. In der Resultativkonstruktion, die das $inh\"{a}rente$ Reflexivum enthalt, $k\"{o}nnen\;das\;Resultativpr\"{a}dikat$ und das Verb wie ein reflexives Verb analysiert werden. Aber unter der Small Clause Analyse ist Idiomatisierung des $Resultativpr\"{a}dikats\;und\;Verbs\;nicht\;m\"{o}glich$, weil sie in der D-Struktur keine syntaktische Einheit bilden.

• Biomedical Science Letters
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• v.26 no.3
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• pp.210-216
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• 2020

The purpose of this study was to evaluate GDH & Toxin (GDT) tests for the identification of the presence of Clostridioides difficile (C. difficile) as well as to detect whether any toxin was present in the feces of patients suspected of diarrhea associated with C. difficile. Data related to the results of toxin and culture (TC) tests and GDT tests conducted on patients with diarrhea and suspected CDI between January 2017 and august 2018, positive test rates, patient ages and sexes, whether the patients were hospitalized, and turnaround time (TAT) were analyzed retrospectively. Of the 7,554 total tests conducted for CDI diagnosis, 1,010 TC tests (14.9%) were positive, while 92 GDT tests (12.0%) were positive. Of these positive cases, 815 (80.7%) identified through TC test and 80 (87%) identified through GDT test were inpatients. also, among the patients with positive test results, 497 (49.2%) diagnosed through TC test and 45 (48.9%) diagnosed through GDT test were aged 61 years or older. The total time required to complete a TC test was 83.6 hours, while the time required for a GDT test was 11.2 hours, equating to an approximately three-day difference between the two tests. The detection of toxin-producing C. difficile is important in CDI diagnosis, but the commonly used Enzymeimmunoassay (EIA) toxin tests with low sensitivity result in delayed CDI diagnosis time. Therefore, primary screening tests for CDI diagnosis using the GDT method and secondary tests using additional methods are considered most effective.

• 한국지구물리탐사학회:학술대회논문집
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• 2003.11a
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• pp.493-500
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• 2003

The effect of reductive treatment with elemental iron on the extent of mineralization by Fenton oxidation was studied for the explosive 2,4,6-trinitrotoluene (TNT) and hexahydro-l,3,5-trinitro-l,3,5-triazine (RDX) using a completely-stirred tank reactor (CSTR). The results support the hypothesis that TNT and RDX are reduced with elemental iron to products that are oxidized more rapidly and completely by Fenton's reagent. Iron pretreatment enhanced the extent of TOC removal by approximately $20\%\;and\;60\%$ for TNT and RDX, respectively. Complete TOC removal was achieved for TNT and RDX solutions with iron pretreatment under optimal conditions. On the other hand, without iron pretreatment, complete mineralization of TNT and RDX solutions were not achieved even with much higher $H_2O_2$ and $Fe^{2+}$ concentrations. The bench-scale iron treatment-Fenton oxidation integrated system showed more than $95\%$ TOC removal for TNT and RDX solutions under optimal conditions. The proposed zero-valent iron-Fenton process was evaluated with pink water from the Iowa Army ammunition plant. Results from batch and column experiments show that TNT, RDX, and octahydro-l,3,5,7-tetranitro-l,3,5,7-tetrazocine (HMX) were completely removed from the pink water and that triaminotoluene (TAT) and ${NH_4}^+$ were recovered as products in reduction with zero-valent iron. By using an integrated system, $83.3\pm4.2\%$ of TOC was removed in a CSTR with 10 mM of $Fe^{2+}$ and 50 mM of $H_2O_2$. These results suggest that the reduction products of TNT and RDX are more rapidly and completely mineralized by Fenton oxidation and that a sequential iron treatment-Fenton oxidation process may be a viable technology for pink water treatment.

• Journal of Embryo Transfer
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• v.3 no.1
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• pp.13-23
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• 1988

These studies were undertaken to examine the interaction of tamoxifen with sex steroid hormones in rat uterine activity. The uterine wet weights of the immature Tat uterus were examined after the administration of estradiol-l7$\beta$(1$\mu$g), tamoxifen(50$\mu$g), progesterone(lmg). The uterotropic activity in immature ovariectomized rats was observed under various treatment conditions following pretreatment with above drugs. The results obtained were as follows:1) Tamoxifen produced significant increase (p <0.01) in uterine wet weight compared with control group, although the increase was not as great as that seen with estradiol-17$\beta$. Administration of estradiol-17$\beta$ together with tamoxifen inhibited significantly the increase of uterine wet weight by estradiol-17$\beta$ (p < 0.01). Coadministration of progresterone with tamoxifen partly blocked the increase of tamoxifen-induced uterine wet weights by progesterone. 2) Estradiol-17$\beta$after the estradiol-17$\beta$ pretreatment discontinued the declining uterine wet weights due to the absence of estrogen support, but uteri continued to increase in weight if daily estradiol-17 $\beta$ was maintained. Administration of tamoxifen on the fourth day of estradiol-17$\beta$ treatment reduced uterine wet weights within 24 hours, and the weights continued to decline with additional tamoxifen. 3) The modest growth of the uterus induced by three daily injections of 5Opg tamoxifen remained stable for five days, with or without additional tamoxifen treatment. Coadministration of tamoxifen with estradiol17$\beta$ increased slightly the increase of uterine wet weight by tamoxifen. Coadministration of tamoxifen with progesterone inhibited the increase of uterine wet weight by tamoxifen. 4) The modest growth of the uterus induced by three daily injections of lmg progesterone reduced uterine wet weight to the control level for five days. Commencement of tamoxifen or estadiol-17 $\beta$ injections on the fourth day of progesterone treatment rapidly elevated uterine wet weight.

• Journal of Nutrition and Health
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• v.22 no.6
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• pp.438-446
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• 1989

This study was designed to compare various dietary assessment methods and to determine the appropriate method that would be reliable for monitoring the adherence to a fat-modified diet. Dietary intake data was collected from the twenty-two (12 males, 10 females), type IIa hypercholesterolemic patients by the 24-hour dietary recall and the food records of various durations(9, 7, 4, 3days). Intakes of energy, protein, fat, carbohydrates, cholesterol, polyunsaturated fatty acids, saturated fatty acids, monounsaturated fatty acids, P/S ratio, and alcohol were analyzed by a computer-assisted method using the Natinal Heart, Lungand Blood Institute Nutrition Data System. The nutrient intake data of the 24-hour recall method were consistently higher than tat of the food record method. In all subjects, food record keeping of the 7 consecutive days provided acceptable dietary data (within 5% difference) when compared to that of the 9 consecutive days. Food records of 4 consecutive days however, were found to be adequate for female subjects, showing a sex difference. Except for P/S ratio, nutrient intakes did not vary significantly between weekdays and weekend-days. Among other components, alcohol and P/S ratio were shown to be the two most varied components in this study.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.31 no.3
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• pp.31-38
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• 2003

In the present work, a nonlinear inverse perturbation method which has been used in the structural optimization, is adopted so as to identify the structural damages. Unlike the structural optimization, a larger number of constrained equations than the number of unknown parameters are often required detect structural damage. Therefore, nonlinear least squares method is utilized to solve the problem. Because only a limited number of sensors are available I real situation of damage detection, the determination of sensor location becomes one of the most important issues. Hence, this work concentrates on the issue of sensor placement in the framework of nonlinear inverse perturbation method, and the performances of various methodologies concerning to sensor placement are compared with each other. The comparisons show tat the successive elimination method gets good performance for sensor placement. From the several numerical studies, it is confirmed that the inverse perturbation method, combined with the successive elimination method, is very promising in structural damage detection.