• 대한방사선기술학회지:방사선기술과학
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• 제45권5호
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• pp.433-438
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• 2022

Targeted radionuclides treatment (TRT) requires the establishment of treatment plans that consider various factors, such as the type of radionuclides, target organs, and administration methods. For this reason, in this study, the absorption dose of a single cell was analyzed according to the type of radioisotope used to treat target radionuclides. In this study, a simulation was performed on beta rays used in the treatment of target radionuclides at the cell level using MCNPX (ver. 2.5.0). First, according to the calculation formula, the beam path according to the type of radioisotope for treatment was calculated. Second, the amount of self-radiation by beta rays emitted from cell diameters of 5 ㎛ and 10 ㎛ cell nuclei was evaluated. As a result, it showed a high range proportional to the maximum energy of the beta-ray, and the highest self-dose distribution from 177 Lu radiation sources among therapeutic radioisotopes. This was analyzed as a result that is inversely proportional to the maximum energy of the beta-ray, and it suggests that the selection of a nuclide considering the range of the beta-ray is necessary in the treatment of target radionuclides in the future.

• 인간행동과 음악연구
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• 제16권2호
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• pp.79-108
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• 2019

본 연구에서는 음악중재가 인터넷 중독 청소년의 심리·정서 반응에 미치는 영향을 체계적으로 고찰함으로써 중재 효과에 영향을 미치는 주요 변인을 분석하고자 하였다. 이를 위해 국내 인터넷 중독 관련 연구들이 발표되기 시작한 1995년부터 2018년까지 인터넷 중독 청소년 관련 음악중재 문헌을 대상으로 9개의 전자데이터베이스에서 인터넷 중독 청소년 관련 용어, 음악중재 관련 용어, 심리정서변인 관련 용어를 조합하여 검색하여 선정 기준에 부합하는 9편을 최종 선정하였다. 연구 결과, 인터넷 게임중독 청소년 대상의 연구 비중이 높았고, 중학생을 남녀 혼합 형태로 진행한 경우가 많았다. 또한 심리적 변인에서 자기통제력이나 불안을 목표로 하여 자기표현을 위해 대중가요를 활용한 송라이팅을 집단형태로 시행한 연구가 효과를 보이는 것으로 나타났다. 음악중재 논거에 대한 분석 결과는 적절한 논거를 제시한 연구가 제한적임을 보여주고 있어 음악중재의 타당성을 입증할 수 있는 체계적인 연구가 추후 필요할 것으로 사료된다. 본 연구는 인터넷 중독 청소년 대상 심리·정서 반응에 영향을 미치는 음악 중재를 개발하는 데 중요한 기초자료로 활용될 수 있을 것이다.

• Journal of Korean Medical Science
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• 제33권51호
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• pp.325.1-325.10
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• 2018

Background: To evaluate survival outcomes and prognostic factors for overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) who received sunitinib (SU) and pazopanib (PZ) as first-line therapy in real-world Korean clinical practice. Methods: Data of 554 patients with mRCC who received SU or PZ at eight institutions between 2012 and 2016 were retrospectively reviewed. Based on the targeted therapy, the patients were divided into SU (n = 293) or PZ (n = 261) groups, and the clinicopathological variables and survival rates of the two groups were compared. A multivariable Cox proportional hazard model was used to determine the prognostic factors for OS. Results: The median follow-up was 16.4 months (interquartile range, 8.3-31.3). Patients in the PZ group were older, and no significant difference was observed in the performance status (PS) between the two groups. In the SU group, the dose reduction rate was higher and the incidence of grade 3 toxicity was more frequent. The objective response rates were comparable between the two groups (SU, 32.1% vs. PZ, 36.4%). OS did not differ significantly between the two groups (SU, 36.5 months vs. PZ, 40.2 months; log-rank, P = 0.955). Body mass index, Eastern Cooperative Oncology Group PS > 2, synchronous metastasis, poor Heng risk criteria, and liver and bone metastases were associated with a shorter OS. Conclusion: Our real-world data of Korean patients with mRCC suggested that SU and PZ had similar efficacies as first-line therapy for mRCC. However, PZ was better tolerated than SU in Korean patients.

• Journal of Gastric Cancer
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• 제20권1호
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• pp.29-40
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• 2020

Purpose: Gastrointestinal stromal tumors (GISTs) frequently harbor activating gene mutations in either KIT or platelet-derived growth factor receptor A (PDGFRA) and are highly responsive to several selective tyrosine kinase inhibitors. In this study, a targeted next-generation sequencing (NGS) assay with an Oncomine Focus Assay (OFA) panel was used for the genetic characterization of molecular targets in 30 Korean patients with GIST. Materials and Methods: Using the OFA that enables rapid and simultaneous detection of hotspots, single nucleotide variants (SNVs), insertion and deletions (Indels), copy number variants (CNVs), and gene fusions across 52 genes relevant to solid tumors, targeted NGS was performed using genomic DNA extracted from formalin-fixed and paraffin-embedded samples of 30 GISTs. Results: Forty-three hotspot/other likely pathogenic variants (33 SNVs, 8 Indels, and 2 amplifications) in 16 genes were identified in 26 of the 30 GISTs. KIT variants were most frequent (44%, 19/43), followed by 6 variants in PIK3CA, 3 in PDGFRA, 2 each in JAK1 and EGFR, and 1 each in AKT1, ALK, CCND1, CTNNB1, FGFR3, FGFR4, GNA11, GNAQ, JAK3, MET, and SMO. Based on the mutation types, majority of the variants carried missense mutations (60%, 26/43), followed by 8 frameshifts, 6 nonsense, 1 stop-loss, and 2 amplifications. Conclusions: Our study confirmed the advantage of using targeted NGS with a cancer gene panel to efficiently identify mutations associated with GISTs. These findings may provide a molecular genetic basis for developing new drugs targeting these gene mutations for GIST therapy.

• 대한방사성의약품학회지
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• 제7권2호
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• pp.79-84
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• 2021

Radiopharmaceuticals are important for tumor diagnosis and therapy. To deliver a radiotracer at the desired target excluding non-targeted tissues is difficult The development of a targeted tracer that has a good clearance profile while maintaining high biostability and biocompatibility is key to optimizing its biodistribution and transport across biological barriers. Improving the hydrophilicity of radiotracers by PEGylation can reduce serum binding, allowing the tracer to circulate without retention and reducing its affinity for non-targeted tissues. In this study, we synthesized a new benzamido tracer (SnBz-PEG₃₆) with the introduction of a low molecular weight polyethylene glycol unit (PEG₃₆, ~2,100 Da). The tumor targeting efficiency and biodistribution of [¹³¹I]-Bz-PEG₃₆ or radiotracer-loaded liposomes were evaluated after their administration to normal mice or mouse tumor models including CT26 (xenograft) and 4T1 (xenograft and orthotopic). Most of the radiotracer was cleared out rapidly (1-24 h post-administration) through the kidney and there was little tumor uptake.

• 대한방사성의약품학회지
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• 제8권1호
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• pp.9-15
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• 2022

Anti-cancer and therapeutic effects using therapeutic radioisotopes have been demonstrated by various studies, and it is well-known that therapeutic radioisotopes are useful in cancer treatment. Recently, one of the therapeutic radioisotopes, scandium is emerging as a radioisotope applicable to PET imaging (⁴³Sc, ⁴⁴Sc) and therapy (⁴⁷Sc) in cancer theranostic approach. However, ⁴⁷Sc has little known radiobiological and therapeutic efficacy compared to other therapeutic radioisotopes. Here, we investigated the quality and therapeutic efficacy of ⁴⁷Sc radioisotope produced by our production/isolation technology at the research reactor 'HANARO' in KAERI (Korea Atomic Energy Research Institute). We showed that the therapeutic efficacy of ⁴⁷Sc, produced by our production/isolation technology, effectively suppressed epidermal growth factor receptor (EGFR)-targeted non-small cell lung cancer (NSCLC) cells. Consequently, these results suggest that the high quality of the produced ⁴⁷Sc by our production/isolation technology enables the development of therapeutic strategies for cancer treatment and radiopharmaceuticals using ⁴⁷Sc.

• 인간행동과 음악연구
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• 제17권1호
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• pp.71-96
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• 2020

본 연구는 국내 음악치료 및 물리치료 분야에서 리듬청각자극(RAS)을 적용하여 수행된 연구를 비교분석하였다. 이를 위해 1999년부터 2018년 11월까지 발표된 학위 논문과 학술지 게재 연구 중 RAS 및 보행기능 관련 주제어를 검색하여 기준에 부합한 45개의 연구를 선정하였고, 세부중재방법과 리듬자극의 유형, 기술된 치료 원리의 측면에서 분석하였다. 분석 결과, 두 영역에서의 연구 모두 일정한 간격의 리듬을 핵심적인 치료 자극으로 사용하고 RAS의 기본 절차를 따른 점에서는 공통적이었지만, 목표기능이나 구체적인 리듬제공방법에 있어서는 차이가 있었다. 음악치료 연구에서는 모두 보행기능이 목표 변인이었던 데 비해, 물리치료 연구에서는 균형이나 근력, 고유수용성감각 등 관련 신체기능이 목표에 포함되었다. 또한 음악치료 연구에서는 다양한 요소를 포함한 '음악'이 리듬자극으로 활용된 반면, 물리치료 연구에서는 메트로놈을 리듬자극으로 활용한 연구가 음악을 활용한 연구보다 많았다. RAS 원리와 관련하여 단순한 기법 설명 외에 동조화와 같이 치료의 원리가 충분히 기술된 연구는 물리치료보다는 음악치료 분야에서 많이 확인되었다. 이러한 결과는 음악치료 연구에서는 리듬과 더불어 음악의 다양한 요소가 보행에 미칠 수 있는 영향이 고려되어 음악의 역할이 적극적으로 활용된 반면, 물리치료 연구에서는 보행에 영향을 미치는 다양한 신체기능에 대한 개입이 포함된 경향이 있음을 보여준다. 두 가지 측면 모두 재활에 있어 중요한 부분임을 고려할 때, 본 연구는 다학제간 연구를 기반으로 한 RAS 연구의 기법의 확장 적용에 대한 시사점을 제시한다고 할 수 있다.

• 대한감각통합치료학회지
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• 제8권1호
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• pp.61-72
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• 2010

목적 : 체계적 고찰을 통해 시운동기술 평가를 위해 사용된 도구, 치료접근방법, 치료의 효과를 알아보고, 아동의 시운동 기술에 가장 적합한 치료방법과 평가도구를 제시하고자 한다. 연구 방법 : 체계적 고찰을 사용하였다. 2001년 1월부터 2010년 6월까지 학회지에 게재된 논문을 PubMed을 통하여 검색하였다. 주요 검색용어는"visual motor and occupational therapy", "visuomotor and occupational therapy"," perception and motor and occupational therapy"이었고, 161개의 논문 중 총 13개 논문을 대상으로 분석하였다. 결과 : 1. 시운동기술 치료가 필요한 대상 진단군은 발달장애아동이 20.00%로 가장 많았고, 글씨쓰기에 문제가 있는 아동이 13.33%이었다. 결과 : 2. 시운동기술을 측정하기 위해 사용된 평가도구는 Developmental Test of Visual Perception(DTVP)을 사용한 논문이 33.33%로 가장 많았고, Developmental Test of Visual Motor Integration(VMI)을 사용한 논문이 26.67%이었다. 결과 : 3. 시운동기술과 관련하여 가장 많이 사용된 치료접근방법은 발달적 기술기반 프로그램으로 58.82%를 차지 하였고, 감각통합과 감각기반 치료는 23.53%를 보였다. 결과 : 4. 시운동기술과 관련하여 작업치료 효과가 유의하게 나타난 경우는 72.73%이었고, 유의하지 않는 경우가 9.09%이었다. 부모 직접적 또는 간접적 접근과 집중행동 치료에서 효과가 유의하게 나타났다. 결론 : 아동 작업치료에서 시운동기술을 평가하기 위해 사용된 도구는 DTVP와 VMI가 60%를 차지하였고, 70%이 상에서 치료에 대한 효과가 있는 것으로 나타났다. 아동의 작업수행과 관련된 영역에 대한 작업치료의 효과를 분석하는 연구가 지속되어야 할 것으로 보인다.

• 대한통합의학회지
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• 제6권1호
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• pp.91-98
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• 2018

Purpose : The aim of this study is to determine changes to the thickness of core muscles, e.g., transversus abdominis (TrA), external oblique (EO), and internal oblique (IO), after plank and Kegel exercises and to compare the effects of the two exercise methods. Method : The study divided men and women in their 20s into two groups, Kegel and plank, by randomly allocating 30 males and 30 females to the targeted groups. To achieve the purpose of this study, we examined the thickness of core muscles after the participants performed plank or Kegel exercises. Results : 1. In the Kegel group, abdominal muscle thickness increased with time, and there was a statistically significant difference in the thickness of the TrA. 2. In the plank group, abdominal muscle thickness increased with time, and there was a statistically significant difference in the thickness of the TrA. 3. After the experiment, muscle thickness of the abdominal muscles in the plank exercise group were higher, but there was no significant difference between the Kegel exercise group and the plank exercise group. Conclusion : Both plank and Kegel exercises are recommended for core muscle stabilization, and based on the results of this study, Kegel exercise is either used as a core stabilizing exercise or as a plank exercise for the weaker patients or women.

• The Journal of Korean Physical Therapy
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• 제27권6호
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• pp.425-429
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• 2015

Purpose: This study was to identify the whether there is any correlation between Gross Motor Function Measures (GMFM) and Functional independence Measurement for children (WeeFIM) in order to identify a relevance of daily life motor with gross motor function of children with cerebral palsy. Methods: Subjects were instructed to evaluated by an occupational therapist using WeeFIM (reliability 0.83-0.99) and by a physical therapist using GMFM (reliability 0.93). 10 male children and 13 female children among 23 children being diagnosed as cerebral palsy were targeted for this study. A correlation between GMFM and WeeFIM was analyzed with Kendall correlation. Results: Participants showed significant correlation between GMFM and WeeFIM in all categories, except in the GMFM's walking running jumping category, standing category of GMFM and self care, sphincter control, communication category of WeeFIM. Lying rolling and sitting and crawling kneeling area of GMFM showed a significant correlation with self care(r=0.35, 0.39, 0.4), sphincter control (r=0.45, 0.43, 0.61), mobility transfer (r=0.44, 0.36, 0.64), locomotion (r=0.41, 0.35, 0.74), communication (r=0.4, 0.44, 0.51), and social cognition (r=0.43, 0.51, 0.64) area of WeeFIM (p<0.05). Standing of GMFM and mobility transfer (r=0.74), locomotion (r=0.47) and social cognition (r=0.4) area of WeeFIM showed a significant correlation (p<0.05). Conclusion: These findings indicated significant correlation between activity of daily living (ADL) and gross motor function of children with cerebral palsy. However, because there are a few results that are not significant, both assessment tools should be used for evaluations so that treatment can be achieved with an accurate assessment and establish a therapeutic plan.