• Korean Journal of Construction Engineering and Management
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• v.18 no.2
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• pp.58-70
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• 2017

The planning for material lifting operations is one of the key processes in high-rise building construction. Several previous studies have used rough calculations by referring to existing practices or establishing a target value for lifting cycle time or operating rate. Therefore, the purpose of this study is to propose a material lifting process optimization method for reducing the lifting cycle time and increasing the operating rate. In this study, we improve the cyclic operation network (CYCLONE) modeling method that considers the duration and zone information of each work task. This method can be used to hand over work tasks to another crew group in the work process. According to this methodology, this study optimizes the material lifting process, performs a sensitivity analysis, and evaluates the field applicability of the proposed material lifting process optimization method. Therefore, the optimized process was then applied to a high-rise building construction site. The lifting work process time and operating rate for the simulated as - is lifting process data, optimized process data, and field application result data were compared for each lifting height. From this comparison, the effectiveness of the optimization methodology was confirmed.

• Analytical Science and Technology
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• v.31 no.4
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• pp.171-178
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• 2018

Recently, for successful lactation, many breastfeeding mothers seek various products, including herbal medicine, dietary supplements, and prescribed medicines, to improve milk production. As demand for galactogogues grows, it is highly possible that pharmaceutical galactogogues may be adulterated with illegal products to maximize their efficacy. For continuous control and supervision of illegal products, we developed and validated a simple and sensitive LC-MS/MS method capable of simultaneously determining five galactogogues. Chromatographic separation was conducted using an Agilent Poroshell $120SB-C_{18}$ column with a mobile phase consisting of 20 mM ammonium formate (pH 5.4) and 100 % acetonitrile. The total run time was 13 min per analyte. The proposed method was performed according to the guidelines of the International Conference of Harmonization and it produced reliable results. This method showed high sensitivity and specificity, with a limit of detection (LOD) and limit of quantitation (LOQ) of 0.01-0.82 ng/mL and 0.02-2.45 ng/mL, respectively, for the solid- and liquid-type samples. Specificity was evaluated by analyzing matrix-blank samples spiked with the target compounds at LOQ levels, which provided a good separation of all peaks without interference. Additionally, the repeatability and intermediate precision were typically <15 %, whereas the recovery was 80-120 % of the values obtained using blank samples. Thus, we concluded that this method could be used for the identification and quantification of galactogogues in food or herbal products.

• The Journal of Engineering Geology
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• v.19 no.3
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• pp.295-306
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• 2009

The risk assessment of groundwater and soil in Sasang industrial complex in Busan Metropolitan City was carried out in order to estimate risks to human health and the environment. The carcinogenic risk (CR) of receptors to soil and air was not identified. However, the CRs for TCE and PCE were 6.7E-6 and 1.0E-5, respectively. Hazard quotient (HQ) and hazard index (HI) did not appear through air exposure pathways. Yet the HQ and HI of soil were 3.4E-5 and 5E-5, respectively, and lower than the critical value (1.0). On the contrary, HQ and HI with respect to groundwater were calculated as 0.7 (not hazardous) and 1.4 (hazardous). The constituent reduction factor (CRF) for TCE in the study area was determined as 2.5, and thus remediation work is demanded. As a result of sensitivity analysis for 18 exposure factors, eight exposure factors (life time of carcinogens, age, body weight, exposure duration, exposure frequency, dermal exposure frequency, water ingestion rate, and soil ingestion rate) varied with the variation of risk.

• Archives of design research
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• v.13
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• pp.153-162
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• 1996

The residence space has been in the trend of being expanded with the J'l'cent economic growth Therefore PAC may be said to have [wen from business use to home US(: the progressed living standard as the goods ior Uw "ummel' S('dSOn rest'ntly though sold in Uw fast for mainly buslTw"s use. PAC has been in the demand day ;lner day and in the tn'nd on the bc,ing the necessJty of the n'sent wf',lther warming phenomenon This study is the case study nf the products development and design process of PAC which has bpcn llrivcn and developed by Gold Star Co. ,Ltd. Which .is the firm for home electric appliances representing Korea. This studies for the development and the design of the products by the firm thus emphasizing the visulizing it based on this study. For example as they being the goods for the summer season I have tried to know the physical quakity and the characters of koreans by the weather conditions and estimated the demand by setting up the target customers of the PAC as the customers' environment. And I analyzed the acts in the living room in the apartments as the living envinorment which has the direct relation with PAC and also became a help to the moulding work of PAC by analyzing the complete interior image in the living room. In the practical moulding work the Design concept was classified into the envinorment of customer, living and products to drive as the below. Firstly - New shape (Round slim) has been realized which leads the minimizing the moulding space and visul sense of opening as its being spacious. The 2nd - the high class sense of the products which are harmonious with the atmosphere of the living room by making it interiorized has been visible. The 3rd - The shape stimulating the sensitivity of the users and surface treatment are emphasized by making it be touched. The 4th - During inviting use of technology image which appears in the electronics products are attemptedby making it be high quality.king it be high quality.

• Journal of Environmental Health Sciences
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• v.46 no.1
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• pp.45-64
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• 2020

Objectives: Limited information is available on the presence and associated ecological risks of pharmaceutical residues in aquatic environments near pharmaceutical manufacturing areas in Korea. In this study, we investigated the current state of pharmaceutical contamination and its associated ecological risks in streams near a pharmaceutical manufacturing complex. Methods: Seven pharmaceuticals (acetaminophen, clarithromycin, diclofenac, diphenhydramine, ibuprofen, mefenamic acid and roxithromycin) were measured in water samples collected from the streams near a pharmaceutical manufacturing complex. A predicted no-effect concentration (PNEC) was derived using either the assessment factor method or species sensitivity distribution method. In addition, a hazard quotient for each pharmaceutical was calculated by dividing its measured environmental concentration by its PNEC. Results: Samples collected downstream from the wastewater treatment plant (WWTP) had higher concentrations of pharmaceuticals than those collected from the reference site (upstream). Moreover, pharmaceutical concentrations were greater in ambient water than in the final effluent from the WWTP, which suggested that non-point sources were contributing to the contamination of the ambient water environment. Some of the target pharmaceuticals exhibited a hazard quotient >1, indicating that their potential ecological effects on the aquatic environment near the pharmaceutical industrial area should not be ignored. Conclusion: This study demonstrated that the pharmaceutical manufacturing area was contaminated with residual drugs, and that there was a possible non-point source near the WWTP effluent discharge area. The results of this study will aid in the development of management plans for pharmaceuticals, particularly in hotspots such as pharmaceutical industrial sites and their vicinities.

• Journal of Environmental Health Sciences
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• v.46 no.1
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• pp.1-10
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• 2020

Objectives: This study intends to evaluate the ecological risk of lead (Pb), arsenic (As), and their compounds according to the 2010 action plan on inventory and management for national priority chemicals and provide calculations of risks to the environment. By doing so, we aim to inform risk management measures for the target chemicals. Methods: We conducted species sensitivity distribution (SSD) analysis using the collected ecotoxicity data and obtained predicted no effect concentrations (PNECs) for the in-water environment using a hazardous concentration of 5% (HC5) protective of most species (95%) in the environment. Based on the calculated PNECs for aquatic organisms, PNEC values for soil and sediment were calculated using the partition coefficient. We also calculated predicted exposure concentration (PEC) from nation-wide environmental monitoring data and then the hazard quotient (HQ) was calculated using PNEC for environmental media. Results: Ecological toxicity data was categorized into five groups and five species for Pb and four groups and four species for As. Based on the HC5 values from SSD analysis, the PNEC value for aquatic organisms was calculated as 0.40 ㎍/L for Pb and 0.13 ㎍/L for As. PNEC values for soil and sediment calculated using a partition coefficient were 77.36 and 350.50 mg/kg for Pb and 24.20 and 112.75 mg/kg for As. The analysis of national environmental monitoring data showed that PEC values in water were 0.284 ㎍/L for Pb and 0.024 ㎍/L for As, while those in soil and sediment were respectively 45.9 and 44 mg/kg for Pb, and 11.40 and 19.80 mg/kg for As. Conclusions: HQs of Pb and As were 0.70 and 0.18 in water, while those in soil and sediment were 0.59 and 0.13 for Pb and 0.47 and 0.18 for As. With HQs <1 of lead and arsenic in the environment, their ecological risk levels are found to be low.

• The Korean Journal of Nuclear Medicine
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• v.25 no.2
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• pp.245-251
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• 1991

결핵성 병변의 단순 x-ray 촬영이나 CT, MRI 소견은 매우 다양하며, 결핵과 전이암 혹은 원발성 암과 감별이 어려운 경우가 있어 결핵으로 확진하기 위하여서 조직 생검이나 수술 등 침습적인 진단 방법을 이용하여야 하였다. 그러므로 이러한 결핵 병변을 비 침습적인 방법으로 정확히 감별할 수 있는 방법을 연구하던 바, 결핵균에 대한 항체를 동위원소에 부착시켜 신티그래피로 진단할 수 있는지의 가능성을 동물실험을 통하여 알아보고자 하였다. 15마리의 가토에서 M.tuberculosis H37Rv를 슬관절에 주입시켜 결핵병변을 유발시키고, 대조군으로 2마리의 가토의 고환에 T.pallidum을 주입하여 매독병변을 유발시킨 후 M.bovis BCG에 대한 특이항체 (specific polyclonal antibody)와 정상 가토의 immunoglobulin을 I-131에 부착시켜 각각의 가토에 주입하여 preset time 10분간 감마카메라로 주사한 결과 다음과 같은 결과를 얻었다. (1) 8마리의 결핵에 감염된 가토에 M.bovis BCG에 대한 $F(ab')_2$를 1 mCi의 I -131 labeling 시킨후 주사한 결과 모두에서 주사후 2시간 부터 72시간까지 병소가 hot uptake으로 보였으며 주사후 24 시간에 가장 높은 target/background ratio를 보였다. (2) 2마리의 매독에 감염된 가토에서 anti-BCG $F(ab')_2$를 주사한 결과 2시간에서는 병소에 hot activity를 보였으나 24시간부터 급격히 activity가 감소하였다. (3) $F(ab')_2$ 대신에 intact antibody를 결핵에 감염된 가토에 투여한 결과 specific polyclonal antibody나 정상가토의 immunoglobulin 모두 결핵병소에 96시간까지 hot uptake를 보였다. 그러므로 결핵균에 대한 specific antibody fragment를 이용하면 방사면역 신티그램으로 진단이 가능하리라 사료되었고, intact antibody를 사용할 경우 sensitivity는 높으나 specificity는 적을 것으로 사료되었다.

• Research in Plant Disease
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• v.23 no.4
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• pp.363-366
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• 2017

Barley mild mosaic virus (BaMMV), Barley yellow mosaic virus (BaYMV) and Barley yellow dwarf virus (BYDV) have been identified as an important causative agents for an economically important disease of winter barley in Korea. In this study, a multiplex reverse transcription polymerase chain reaction (mRT-PCR) method was used for the simultaneous detection. Three sets of virus-specific primers targeted to the capsid protein coding genes of BaMMV, BaYMV and BYDV were used to amplify fragments that were 594 bp, 461 bp, and 290 bp, respectively. Several sets of primers for each target virus were evaluated for their sensitivity and specificity by multiplex RT-PCR. The optimum primer concentrations and RT-PCR conditions were determined for the multiplex RT-PCR. The mRT-PCR assay was found to be a better and rapid virus diagnostic tool of specific barley diseases and potential for investigating the epidemiology of these viral diseases.

• Korean Journal of Microbiology
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• v.41 no.3
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• pp.168-176
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• 2005

Vibrio vulnificus, one of the marine bacterial pathogens causing septicemia, was detected using molecular methods, namely, PCR and/or Southern hybridization, and real-time PCR. Extracted and purified total DNAs by using commercial kits were used as templates for PCR. Multiplex-PCR was conducted by employing three sets of primers for the genes, hemolysin (vvhA), phosphomannomutase (pmm), and metalloprotease (vvpE), for V vulnificus virulence. The presence of DMSO ($5\%$) and BSA ($0.1\%$) in PCR reaction mixture improved a detection efficiency by higher PCR band intensities. TaqMan real-time PCR was carried out by using gene segment of vvhA as a target. Detection limit of PCR/Southern hybridization without enrichments was to be around $10^2\;cells\;g^{-1}$ of sample. However, those three methods using the enrichment at $35^{\circ}C$ in APW showed high sensitivity ($2\~10\;cells\;g^{-1}$ of sediments). Highly sensitive detection of V vulnificus by real-time PCR was achieved within $5\~6$ hr, whereas the detection by PCR/Southern hybridization required about 36 hr. Thus, it was evident that real-time PCR is the most rapid and efficient method for detecting V vulnificus in tidal flat sediments.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.3
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• pp.499-508
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• 2016

This paper reports the results of an in-depth study on sensitivity analysis based on promoting activities, the relative importance and priority setting in their sub-elements by AHP(Analytic Hierarchy Process) method. For this purpose, lifelong education experts, education administrators, lifelong educators from Daejeon lifelong education organizations participated in this Priority Analysis on the Lifelong Education Enhancing Plan using the AHP. The analysis resulted in the relative importance of promoting activities; 1) realizing of lifelong education system oriented by universities, 2) setting up the integrated online and offline lifelong education, 3) strengthening the lifelong education of local universities, 4) offering customized lifelong education by generation and target group, 5) strengthening the lifelong education of local governments, and 6) advancing the quality of lifelong education by focusing on the professionalism and transparency. This suggests that realization of a lifelong education system oriented by universities and the reorganization of an university system for adult learners have greater importance among other tasks and elements in carrying out the 3rd lifelong education enhancing plan.