• 대한의용생체공학회:의공학회지
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• 제23권5호
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• pp.341-349
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• 2002

본 논문에서는 혈중 목표 농도 자동 조절기(Target-controlled infusion system. TCI)를 개발하는 것으로써, 마취의가 혈중 목표 농도를 설정하면 사용약제의 약동학적 모델링에 의해서 주입속도를 자동적으로 계산하여 마취의 깊이를 예측하는 약동학적 모델의 수립과 검증 방법을 설명한다. 정확한 약동학적 모델의 구축은 시스템의 성능에 큰 영향을 미치므로 먼저 PART 1에서는 약동학적 모델을 구축하되 3-콤파트먼트 모델과 4-콤파트먼트 모델로 해석하였다. 기존의 TCI에서 사용하고 있는 3-콤파트먼트 모델에 가상의 효과처 구획(Effect Site Compartment)을 만들고 이를 네 버내 구획으로 가정한 4-콤파트먼트 모델(Four-Compartment Model)을 수립하였고, matlab 5.0을 이용하여 비교 분석하였다. 모델은 혈중 목표 농도 주입(Plasma Targeting)과 효과처 목표 농도 주입(Effect Site Targeting), 혈중 농도 유지를 위한 주입율 계산과 기타 마취 상태를 추정하는 정보를 포함한다. 시뮬레이션의 결과를 바탕으로 4-콤파트먼트 모델을 디지털 z-변환을 거쳐 디지털시그널프로세서에 프로그램하고 TCI시스템의 적용가능성을 평가하였다. 정맥 마취용 TCI는 오동작에 대한 검증이 반드시 요구되므로 구축한 모델링에 대한 시뮬레이션의 평가 방법을 설정하였다. 기존의 TCI시스템과는 달리 약동학적 약물 전달 속도 상수(k-파라미터)를 독립적으로 조절할 수 있는 기능이 추가되어 다양한 약제의 사용이 가능할 뿐만 아니라 새로운 약동학적 모델의 개발과 평가에 기여하게 되고, 환자의 체형과 병명에 따른 약동학적 모델의 변화에 대응할 수 있게 하였다.

• BMB Reports
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• 제50권11호
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• pp.554-559
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• 2017

MicroRNAs (miRNAs) are ~22nt-long single-stranded RNA molecules that form a RNA-induced silencing complex with Argonaute (AGO) protein to post-transcriptionally downregulate their target messenger RNAs (mRNAs). To understand the regulatory mechanisms of miRNA, discovering the underlying functional rules for how miRNAs recognize and repress their target mRNAs is of utmost importance. To determine functional miRNA targeting rules, previous studies extensively utilized various methods including high-throughput biochemical assays and bioinformatics analyses. However, targeting rules reported in one study often fail to be reproduced in other studies and therefore the general rules for functional miRNA targeting remain elusive. In this review, we evaluate previously-reported miRNA targeting rules and discuss the biological impact of the functional miRNAs on gene-regulatory networks as well as the future direction of miRNA targeting research.

• 한국안전학회지
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• 제25권5호
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• pp.62-68
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• 2010

The main purpose of this study was to examine relative effects on safety behaviors between global feedback and specific feedback at a construction site. Participants were 30 full-time workers at a construction site. Five safety related behaviors were identified as critical behaviors. An ABCB within-group design was adopted. After baseline (A), participants received global feedback on their average percentage of all five target safety behaviors (B). In the next phase, participants received specific feedback on the percentages of individual target behaviors (C). In the final phase, the global feedback condition was reintroduced (B). Results showed that both global feedback and specific feedback were effective in increasing the frequencies of safety behaviors and there were no differences in the effectiveness between the two types of feedbacks.

• 통합자연과학논문집
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• 제10권1호
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• pp.20-26
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• 2017

Chemerin receptor, which predominantly expressed in immune cells as well as adipose tissue, was found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. Chemerin is a widely distributed multifunctional secreted protein implicated in immune cell migration, adipogenesis, osteoblastogenesis, angiogenesis, myogenesis, and glucose homeostasis. Recent studies suggest chemerin may play an important role in the pathogenesis of obesity and insulin resistance and it becomes a potential therapeutic target for treating type II diabetes. The crystal structure of chemerin receptor has not yet been resolved. Therefore, in the present study, homology modelling of CMKLR1 was done utilizing the crystal structure of human angiotension receptor in complex with inverse agonist olmesartan as the template. Since the template has low sequence identity, we have incorporated both threading and comparative modelling approach to generate the three dimensional structure. 3D models were generated and validated. The reported models can be used to characterize the critical amino acid residues in the binding site of CMKLR1.

• 한국안전학회지
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• 제11권1호
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• pp.60-66
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• 1996

As the recently proposed JTC has been proven to be effective for implementation of real-time target tracking system, the interest on the electronic support system for the real-time JTC tracker has been increased. Accordingly, we proposed a tracking system which is based on BPEJTC and adaptive the fixed site. But because the EOTS is generally needed in the moving site such as aircraft and vehicles, and there are many different tracking algorithm to adopt the BPEJTC, we present an advanced version of BPEJTC dniver which has synchronization input so as to be used for the target pointer. In addition to the designed system architecture, some experimental results conducted by this system are illustrated.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2004년도 임시총회 및 추계학술발표회
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• pp.286-289
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• 2004

On site, In situ soil remediation technologies are very important among the remediation technologies and in general efficiency of these technologies are turned to site characterization and environmental condition. specially using of only one technology has so many limitation factors. for example, existing state of tailing and channeling and so on. actually, filled land have high concentration cation exchange capacity because of existence in abundance soil organic matter. Therefore we used various on site in Situ technologies by phase for overcome the limitation factors. Target site is petroleum (diesel) impacted filled land and using technologies are SVE(Soil Vapor Extraction), BV(Bioventing), Bioremediation, Soil flushing, Chemical oxidation.

• 정보보호학회논문지
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• 제29권1호
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• pp.93-103
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• 2019

최근 드라이브 바이 다운로드 공격 기반의 웹사이트를 통한 랜섬웨어 악성코드 유포로 인해 웹사이트 서비스 마비, 일반 이용자 PC 파일 손상 등의 피해가 발생하고 있다. 따라서 악성코드 경유지 및 유포지 사이트의 현황과 추이 파악을 통해 악성코드 유포의 공격 대상 웹사이트 업종, 유포 시간, 악용되는 어플리케이션 종류, 유포되는 악성 코드 유형에 대한 특성을 분석하는 것은 공격자의 공격활동을 예측하고 대응이 가능하다는 점에서 의미가 크다. 본 논문에서는 국내 343만개의 웹사이트를 대상으로 악성코드 유포여부를 점검하여 탐지된 악성코드 경유지 사이트, 익스플로잇 사이트, 악성코드 유포지 사이트별로 어떠한 특징들이 나타나는지를 도출하고, 이에 대한 대응방안을 고찰하고자 한다.

• 한국태양에너지학회 논문집
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• 제33권5호
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• pp.1-8
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• 2013

Wind resource data of short-term period has to be corrected a long-term period by using MCP method that Is a statistical method to predict the long-term wind resource at target site data with a reference site data. Because the field measurement for wind assessment is limited to a short period by various constraints. In this study, 2 different MCP methods such as Linear regression and Matrix method were chosen to compare the predictive accuracy between the methods. Finally long-term wind speed, wind power density and capacity factor at the target site for 20 years were estimated for the variability of wind and wind energy. As a result, for 20 years annual average wind speed, Yellow sea off shore wind farm was estimated to have 4.29% for coefficient of variation, CV, and -9.57%~9.53% for range of variation, RV. It was predicted that the annual wind speed at Yellow sea offshore wind farm varied within ${\pm}10%$.

• 환경영향평가
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• 제20권1호
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• pp.13-24
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• 2011

This study was carried out to analyze ecological characteristics and select target species for effective restoration plans of wildlife corridors at Galmachi of Sungnam City. The actual vegetation in study area was physiognomically mixed with deciduous broad leaved forests dominated by oaks and artificially planted species. And it is a secondary forest formatted by sprout originated stand and being on early succession stage as a young stand. So study site was regarded as not suitable for the habitats for wildlife. The number of mammal species at study site was total 22 species, but most of these species were found as not so many in individual numbers. The individual number of hare was approximately 4 to 8, while the raccoon dog and water deer with 2 to 3 and 1 to 2, respectively. As such, it was estimated as a low population density due to discontinuation of ecosystem and the man-made impacts. In this study, raccoon dog and water deer were selected as the target species because of their migration patterns and ecological value in local ecosystem. It was suggested to establish a wildlife corridors of an over-bridge type at the peak area of Galmachi, known to be the mostly-used migratory route for 2 target species.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 1999년도 정기총회 및 춘계 학술발표회
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• pp.38-38
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• 1999