• Journal of Pharmacopuncture
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• v.19 no.3
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• pp.213-224
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• 2016

Objectives: Ginseng Rh2+ is enzyme-treated ginseng extract containing high amounts of converted ginsenosides, such as compound k, Rh2, Rg3, which have potent anticancer activity. We conducted general and genetic toxicity tests to evaluate the safety of ginseng Rh2+. Methods: An acute oral toxicity test was performed at a high-level dose of 4,000 mg/kg/day in Sprague-Dawley (SD) rats. A 14-day range-finding study was also conducted to set dose levels for the 90-day study. A subchronic 90-day toxicity study was performed at dose levels of 1,000 and 2,000 mg/kg/day to investigate the no-observed-adverse-effect level (NOAEL) of ginseng Rh2+ and target organs. To identify the mutagenic potential of ginseng Rh2+, we conducted a bacterial reverse mutation test (Ames test) using amino-acid-requiring strains of Salmonella typhimurium and Escherichia coli (E. coli), a chromosome aberration test with Chinese hamster lung (CHL) cells, and an in vivo micronucleus test using ICR mice bone marrow as recommended by the Korean Ministry of Food and Drug Safety. Results: According to the results of the acute oral toxicity study, the approximate lethal dose (ALD) of ginseng Rh2+ was estimated to be higher than 4,000 mg/kg. For the 90-day study, no toxicological effect of ginseng Rh2+ was observed in body-weight changes, food consumption, clinical signs, organ weights, histopathology, ophthalmology, and clinical pathology. The NOAEL of ginseng Rh2+ was established to be 2,000 mg/kg/day, and no target organ was found in this test. In addition, no evidence of mutagenicity was found either on the in vitro genotoxicity tests, including the Ames test and the chromosome aberration test, or on the in vivo in mice bone marrow micronucleus test. Conclusion: On the basis of our findings, ginseng Rh2+ is a non-toxic material with no genotoxicity. We expect that ginseng Rh2+ may be used as a novel adjuvant anticancer agent that is safe for long-term administration.

• Korean journal of food and cookery science
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• v.26 no.5
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• pp.627-635
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• 2010

This study was performed to determine the optimal manufacturing conditions of cookies prepared with Hizikia fusiformis. The variables in Hizikia fusiformis cookies production were the amounts of Hizikia fusiformis powder, butter, and sugar. Six sensory characteristics were used for sensory evaluations, including color, appearance, taste, brittleness, hardness, and overall acceptability. The optimal amounts of the three variables were found to be 6.00 g for Hizikia fusiformis powder, 100.00 g for butter, and 70.00 g for sugar against flour powder 200 g, which satisfies a target sensory score (7.0/9.0) according to the response surface method. Cookies with these optimal amounts of Hizikia fusiformis powder, butter, and sugar were tasted by 114 consumers and showed a high acceptability score (7.21). Females preferred the flavor of Hizikia fusiformis significantly more than males did (p<0.05). Older consumers (${\geq}30$ years old) scored significantly higher than younger consumers (${\leq}29$ years old) in texture (p<0.05). Spread ratio and hardness scores of Hizikia fusiformis cookies were lower than those of control cookies. Color analysis results of Hizikia fusiformis cookies were significantly lower in brightness and redness, and higher in yellowness than control cookies (p<0.01).

• Preventive Nutrition and Food Science
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• v.1 no.2
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• pp.256-261
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• 1996

Carotenoids are abundant int he Korean food supply. The intake of foods rich in carotenoids appears to be associated with optimal health, and a reduction in the risk of cancer, cardiovascular disease, macular degeneration and cataract formation. Specific dietary carotenoids may be responsible for these specific protective effects. Hydrocarbon carotenoids such as $\alpha$-,$\beta$-carotenes and lycopene may reduce the risk of cancer and heart disease, whereas oxygenated carotenoids, such as lutein and zeaxanthin, may be important in protection of the eye. Dietary carotenoids, such as lutein, cryptoxanthin, $\alpha$-carotene, $\beta$-carotene and lycopene can be readily obtained from the diet, Green leafy vegetables, such as spinach and broccoli, contain both oxygenated and hydrocarbon carotenoids ; yellow or orange vegetables, such as carrots, have high levels of $\alpha$-carotene and $\beta$-carotene ; and tomatoes contain high amounts of lycopene. Besides being important vitamin A sources, provitamin A carotenoids such as $\alpha$-carotene, $\beta$-carotene and cryptoxanthin, participate in the cell defense systems that are associated with radical quenching. Non-provitamin A carotenoids, such as lutein and lycopene, major carotenoids in human plasma, have also been reported to possess strong antioxidant capability. The alteration of dietary sources of carotenoids can modify their levels in the circulation and target tissues, and thus prevent or delay the onset of these chronic diseases.

• Transactions of Materials Processing
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• v.26 no.2
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• pp.87-94
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• 2017

Center pillar, which is installed in the center of flank of car body, supports roof and door and ensures the safety of driver by reducing the damage of car body caused by impact. Recently, high-strength steel is widely used to manufacture the center pillar due to high stiffness and fuel efficiency. In this study, material properties of the high-strength steel, whose tensile strength is more than 780MPa, were obtained to produce the center pillar. Stamping was performed by considering the design parameters (blank holder force, press stroke, blank size and pad pressure) used in the actual filed. The drawbeads were included in the stamping process to reduce the amounts of wrinkling and spring back. Using the commercial software, Autoform R5.2 and Minitab, effects of design parameters of the stamping process upon spring back were analyzed and applied to the design process. The restriking process meets the target of under 0.5mm in the amount of spring back.

• Journal of Environmental Science International
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• v.23 no.11
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• pp.1881-1888
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• 2014

Greenhouse gas (GHG) emissions from dye wastewater treatment processes were estimated by analysing their mass and energy balances, which were then used as baseline information for environmental assessment. The total GHG emissions from dye wastewater treatment plants were divided into direct emissions from the treatment processes and indirect ones from electricity usage. The amounts of $CO_2$, $CH_4$ and $N_2O$ emissions were calculated according to the Intergovernmental Panel on Clime Change (IPCC) guideline for the GHG target management system. For 3 years between 2011 and 2013, direct and indirect emissions were on average 8,742.7 and 7,892.0 Ton.$CO_2eq/year$, respectively, with the former exhibiting 52.6 %. Also, compared to 2012, in 2013, the eco-efficiency indicator by the GHG emissions was found to be more than 1, suggesting that environmental quality was effectively improved.

• BMB Reports
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• v.30 no.3
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• pp.234-236
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• 1997

Chronic hepatitis C virus (HCV) infection is associated with the rapid development of cirrhosis and hepatocellular carcinoma. It has been reported that the amount of HCV RNA may be correlated with the progression of hepatitis and may be a prognostic marker for treatment of HCV patients. The direct detection of HCV RNA by reverse transcription-polymerase chain reaction (RT-PCR) is widely used to determine the presence of circulating virions. The most relevant limit of this approach is the lack of quantitative information about the viral titer. In the present study, we developed the method for HCV quantitation using competitive reverse transcription (CRT)-PCR using the deleted HCV standard. The serially diluted standard was added in titrated amounts to the target HCV RNA. The mixture was then reverse transcribed and amplified in the same reaction tube. The methods were evaluated using over 110 HCV-PCR positive samples in Koreans. About 59% of the samples were judged to contain $10^{5}-10^{6}$ copies of HCV RNA in 1 ml of serum.

• Journal of KIISE:Computing Practices and Letters
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• v.16 no.7
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• pp.819-823
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• 2010

The skyline query is one of the effective methods to deal with the large amounts and multi-dimensional data set. By utilizing the concept of 'dominate' the skyline query can pinpoint the target data so that the dominated ones, about 95% of them, can efficiently be excluded as an unnecessary data. Most of the skyline query algorithms, however, have been developed in terms of the numerical data set. This paper pioneers an entirely new domain, the categorical data, on which the corresponding ranking measures for the skyline queries are suggested. In the experiment, the ACM Computing Classification System has been exploited to which our methods are significantly represented with respect to performance thresholds such as the processing time and precision ratio, etc.

• KSTLE International Journal
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• v.4 no.2
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• pp.56-59
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• 2003

Boron carbide thin coatings were deposited on silicon wafers by DC magnetron sputtering using a ${B}_4$C target with Ar as processing gas. Various amounts of methane gas (${CH}_4$) were added in the deposition process to better understand their influence on tribological properties of the coatings. Reciprocating wear tests employing an oscillating friction wear tester were performed to investigate the tribological behaviors of the coatings in ambient environment. The chemical characteristics of the coatings and worn surfaces were studied using X-ray Photoelectron Spectroscopy (XPS) and Auger Electron Spectroscopy (AES). It revealed that ${CH}_4$addition to Ar processing gas strongly affected the tribologcal properties of sputtered boron carbide coating. The coefficient of friction was reduced approximately from 0.4 to 0.1, and wear resistance was improved considerably by increasing the ratio of ${CH}_4$gas component from 0 to 1.2 vol %. By adding a sufficient amount of ${CH}_4$(1.2 %) in the deposition process, the boron carbide coating exhibited lowest friction and highest wear resistance.

• Journal of Institute of Control, Robotics and Systems
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• v.19 no.7
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• pp.599-604
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• 2013

Path planning of mobile robots has a purpose to design an optimal path from an initial position to a target point. Minimum driving time, minimum driving distance and minimum driving error might be considered in choosing the optimal path and are correlated to each other. In this paper, an efficient driving trajectory is planned in a real situation where a mobile robot follows a moving object. Position and distance of the moving object are obtained using a web camera, and the rotation angular and linear velocities are estimated using Kalman filters to predict the trajectory of the moving object. Finally, the mobile robot follows the moving object using a single curvature trajectory by estimating the trajectory of the moving object. Using the estimation by Kalman filters and the single curvature in the trajectory planning, the total tracking distance and time saved amounts to about 7%. The effectiveness of the proposed algorithm has been verified through real tracking experiments.

• Korean Journal of Computational Design and Engineering
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• v.17 no.1
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• pp.26-34
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• 2012

Assembly scheduling in shipbuilding is responsible for determine assembly process orders and departmental production schedule for the block, the basic composite unit of ships. It is necessary much more information to decide production scheduling as the characteristic of shipbuilding which has been more complex and more various and also, a lot of waste of time and of human power is generated in the course of data processing. The target shipbuilding manufacturer of this study use empirical techniques, based on the user's discretion, to compile and to apply data which are scattered in DB storages separately. Because of that reason, the user should not only be performed identification and screening operations but also modification and verification for vast amounts of data, so it is hard to keep the consistency of the data and also the operation time is not constant. Accordingly, the object in this study is by presenting an efficient DB framework to reduce wasting time and man-hour at experienced-oriented process, abate user's manual operations and support an efficient scheduling in assembly processes.