• 동양고전연구
• /
• 제35호
• /
• pp.75-100
• /
• 2009

인간은 누구나 스스로의 내면에 있는 '참 나'의 모습을 귀중한 보배로 여기고 이러한 자아를 찾으려 부단한 노력을 한다. 인생의 어떤 문제에 부딪히게 될 때, 각자의 방법으로 문제를 풀 수 있는 힘과 지혜의 방법을 활용하여 그러한 문제들이 어떻게 풀려나오게 되는지를 관찰도 하면서 용맹 정진하는 모습을 많이 보아왔다. 그리고 이러한 경험의 산물로 그 혹독한 과정과 그것을 통하여 얻어낸 자신의 체득(體得)을 수많은 선인들이 그들의 대표적 통로인 시문(詩文)들을 통해 세상에 내 놓은 것을 보면서 우리들 또한 자신들의 해답과 과정을 비교하며 배운다. 그들의 시문 속에는 일상생활 속에서 진정한 '참 나'로 돌아가려고 자신의 내면에 존재하는 근본을 믿고, 그 근본을 의지하여 해답을 찾아내려는 노력을 기울여 드디어는 속박된 인생의 굴레에서 벗어나 차츰 자유로워지는 모습을 느끼게 되는 것을 알 수 있다. 인간의 마음속에 숨어있는 편협 되고, 어리석고, 성내고, 대아적(對我的)인 생각들이 조금씩 사라지면서 진정한'참 나'의 모습인 자유인으로 되어 가는 것을 보면서 누구나 이러한 경지의 인간으로 거듭나기를 갈구 한다. 이것이 우리가 세상에 태어나서 진정으로 이루고자 하는 희구(希求)인 것이다. 여기에 그러한 삶의 모습을 우리에게 제시해준 예를 도연명을 통해서 살펴보고자 한다. 도연명과 같이 세상의 명리(名利)를 버리고 자신의 도(道)를 따르겠다는 일은 쉽지 않은 일이다. 그래서 동양에서는 이와 같은 출처진퇴(出處進退)의 슬기를 높이 샀던 것이다. 이것은 오히려 출사(出仕)보다도 더 처절한 고통의 극복과 용기가 있어야 이루어지는 것이다. 명리(名利)를 버리고 물러나 돌아가는 곳은 인간의 굴레가 압박하는 곳이 아니라 만물이 공존공영(共存共榮)하는 즉, 생육화성(生育化成)하는 곳이다. 그곳에 진정으로 인생의 자유가 살아 숨 쉬는 영원한 진리가 있기 때문이다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권8호
• /
• pp.3829-3833
• /
• 2016

Inhibition of cancer-associated fibroblasts (CAFs) may improve the efficacy of cancer therapy. Polysaccharide extracted from polygonatum can selectively inhibit the growth of prostate-CAFs (p<0.001) without inhibiting the growth of normal fibroblasts (NAFs). Polysaccharides from polygonatum stimulate autophagy of prostate-CAFs. 3-methyl-adenine(3-MA) is an autophagy inhibitor. 3-MA was added to prostate-CAFs with polysaccharide from polygonatum to determine whether autophagy plays an important role in the restrained effect. Finally, polysaccharide from polygonatum treatment significantly increased the activation of Beclin-1 and LC3, key autophagy proteins. Polysaccharide from polygonatum stimulates autophagy of prostate-CAFs and inhibits prostate-CAF growth, indicating that a novel anti-cancer strategy involves inhibiting the growth of prostate-CAFs.

• Interaction and multiscale mechanics
• /
• 제5권2호
• /
• pp.145-155
• /
• 2012

The thin-plate structure and the box-beam structure are two typical welded structures in railway vehicles. Because of their structure complexity, bigger size and multi-seams, welding residual distortion which occur in welding process bring unfavorable effect on the quality of welding products manufacturing and service. As a result, welding distortion forecasting and control become an important and urgent research topic in railway vehicles. In this paper, three different numerical methods are presented corresponding to three typical types of welded structures of railway vehicles and welding deformation are simulated. Consistence of numerical results and experimental data proves the correctness of models and feasibility of simulation methods.

• 한국조경학회지
• /
• 제26권4호
• /
• pp.113-124
• /
• 1999

The purpose of this study is to search into the relation between the chinese seclusion culture and the gentleman's gardens by means of the historical and aesthetic approach. The periodic limits of this study is from pre-Qin to Tand. For gentleman's gardens in Tang dynasty at once got out of the noble's gardens which had imitated the imperial gardens until Tang, and became the origin of the gardens of the literati appearing in post-Tang dynasty. The major findings are as follows : First, in pre-Qin period, the origin of the seclusion culture is classified as the metaphysical seclusion of Taoism and the physical seclusion of Confucianism. Although Pu, Yuan, and Uou which could be said the first step of the chinese gardens were inquired, the clear relation between the seclusion and them is not found. Second, during Qin-Han dynasty, the role of the gardens, as the settings of the seclusion, are comparatively minor, too. But uan Kuang-Han's garden considerably escaped from that of pre-Qin in the aspect of function, and it has the characteristics of recreation. Third, during Wei-Chin and Liu dynasty, two types of the seclusions emerged. One is the small seclusion, and the other the Great Seclusion. Though, as formerly, the contemporary gardens did not escaped from the imperial gardens, Shi Chong's garden can be the setting of the Court Seclusion. But the seven Righteous in Bamboos' and Tao Yuan-Ming's settings of the seclusion were real natural environments rather than gardens. Forth, in Tang dynasty, in spite of relatively low status, Bai Ju-Yi's theory of the middle Seclusion enabled gentlemen to make seclusion in sinecures unlike the court Seclusion. The theoretical background of the Middle Seclusion was Zen Buddhism and the State Examinations System and Bai Ju-Yi's private social position also had an important effect on it. In Tang dynasty, there being nobiliary gentleman's gardens, Bai Ju-Yi's garden, Lushan Caotangyuan, was the setting of the Middle Seclusion. It can be called a real gentleman's garden, for it is simple and small unlike the imperial gardens or the nobiliary gentleman's gardens.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권1호
• /
• pp.373-376
• /
• 2015

Background: EVA1A (eva-1 homolog A) is a novel gene that regulates programmed cell death through autophagy and apoptosis. Our objective was to investigate the expression profiles and potential role of EVA1A in normal and neoplastic human pancreatic tissues. Materials and Methods: The expression pattern of EVA1A in normal pancreatic tissue was examined by indirect immunofluorescence and confocal microscopy. Protein levels in paraffin-embedded specimens from normal and diseased pancreatic and matched non-tumor tissues were evaluated by immunohistochemistry. Results: EVA1A colocalized with glucagon but not with insulin, demonstrating production in islet alpha cells. Itwas strongly expressed in chronic pancreatitis, moderately or weakly expressed in the plasma membrane and cytoplasm in pancreatic acinar cell carcinoma, and absent in normal pancreatic acinar cells. Although the tissue architecture was deformed, EVA1A was absent in the alpha cells of pancreatic ductal adenocarcinomas, intraductal papillary mucinous neoplasms, mucinous cystadenomas, solid papillary tumors and pancreatic neuroendocrine tumors. Conclusions: EVA1A protein is specifically expressed in islet alpha cells, suggesting it may play an important role in regulating alpha-cell function. The ectopic expression of EVA1A in pancreatic neoplasms may contribute to their pathogenesis and warrants further investigation.

• Journal of Ginseng Research
• /
• 제44권5호
• /
• pp.673-679
• /
• 2020

Background: Panax notoginseng saponin (PNS) is the extraction from the roots and rhizomes of Panax notoginseng (Burk.) F. H. Chen. PNS is the main bioactive component of Xuesaitong, Xueshuantong, and other Chinese patent medicines, which are all bestselling prescriptions in China to treat cardiocerebrovascular diseases. Notoginsenoside R₁ and ginsenoside Rg₁, Rd, Re, and Rb₁ are the principal effective constituents of PNS, but a systematic research on the rare saponin compositions has not been conducted. Objective: The objective of this study was to conduct a systematic chemical study on PNS and establish the HPLC fingerprint of PNS to provide scientific evidence in quality control. In addition, the cytotoxicity of the new compounds was tested. Methods: Pure saponins from PNS were isolated by means of many chromatographic methods, and their structures were determined by extensive analyses of NMR and HR-ESI-MS studies. The fingerprint was established by HPLC-UV method. The cytotoxicity of the compounds was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5 -diphenyltetrazolium bromide assay. Results and Conclusion: Three new triterpenoid saponins (1-3) together with 25 known rare saponins (4-28) were isolated from PNS, except for the five main compounds (notoginsenoside R1 and ginsenoside Rg1, Rd, Re, and Rb1). In addition, the HPLC fingerprint of PNS was established, and the peaks of the isolated compounds were marked. The study of chemical constituents and fingerprint was useful for the quality control of PNS. The study on antitumor activities showed that new Compound 2 exhibited significant inhibitory activity against the tested cell lines.

• Journal of Acupuncture Research
• /
• 제17권2호
• /
• pp.53-68
• /
• 2000

As compared with acupuncture, The moxibustion occurred differently in the background of formation and also disagreed in the process of development. From the Jin(晉) dynasty to the Song(宋) dynasty, The school that attached importance to moxibustion had occupied superority by far and had schemed the development of moxibustion. But after the Song(宋) dynasty, The school that attached importance to acupuncture rose. Therefore, The school that attached importance to moxibustion, even if the power decreased, still had kept in existence and had achieved the development of moxibustion. Especially, Among the chinese physicians that recognized "Moxibustion can cure all disease, so don't discuss the weakness the firmness the chills the fever and cauterize the skin" till the Song(宋) dynasty, Ge Hong(葛洪) put in order the basic theory for moxibustion in (A handbook of prescriptions for emergencies). Wang Tao(王燾) only respected the moxibustion and said "Moxibustion has a strange effect, then all acupuncture herb-med(medical decoction) herb-ex are unattainable to it" in volume 14 (Medical secrets of an official). Dou Cai(實材) insisted that moxibustion is prime for supporting the Yang(陽) and always must be cauterized with moxa on Guan Yuan(關元) Qi Hai(氣海) Ming Guan(命關), Zhons Wan(中脘) etc. for supporting the Yang of Pi Shen(脾腎) in

• Journal of the Optical Society of Korea
• /
• 제17권1호
• /
• pp.27-32
• /
• 2013

Based on the dispersive feature of the dielectric function of noble metals and the wave vector conservation in physics, both the plasma effect and the complex refractive index, which are profoundly correlated to the complex dielectric function and permeability, have been studied and analyzed. The condition to induce a bulk or a surface plasma in the visible region will not be satisfied, and there will be one solution for the real and the imaginary parts of the refractive index, restricting it only to region I of the complex plane. The results given in this work will aid in understanding the properties of light transmission at the metal/dielectric interface as characterized by the law of refraction in nature.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권8호
• /
• pp.3117-3120
• /
• 2015

Objective: Interferon-${\gamma}$ (IFN-${\gamma}$) and signal transducers and activators of transcription (STATs) each play an important role in carcinogenesis associated with viral infection. Cervical cancer is almost invariably associated with infection by human papillomavirus (HPV), and previous studies suggested that dysregulation of the signal pathway involved in IFN-${\gamma}$ and STATs is associated. Our objective was to evaluate the association of SNPs in STAT2, STAT3, and IFN-${\gamma}$ with cervical cancer susceptibility in Chinese Han women in Hunan province. Materials and Methods: Genomic DNA was extracted from peripheral blood samples of 234 cervical cancer patients and 216 healthy female controls. STAT2 and STAT3 genotyping was performed using polymerase chain reaction-restriction enzyme (PCR-RE) analysis. IFN-${\gamma}$ genotyping was detected by PCR-amplification of specific allele (PASA). Results: For STAT2 rs2066807 polymorphisms, there was no significant difference of genotype distribution (P=0.827) and allele frequencies (P=0.830, OR=1.09, 95% CI: 0.51-2.31) between cases and controls. For STAT3 rs957970 polymorphisms, there was no significant difference of genotype distribution (P=0.455) and allele frequencies (P=0.560, OR=0.92, 95% CI: 0.71-1.20) between cases and controls. For IFN-${\gamma}$ +874A/T polymorphisms, there was no significant difference of genotype distribution (P=0.652) and allele frequencies (P=0.527, OR=1.12, 95% CI: 0.79-1.59) between cases and controls. Conclusion: These results suggest that polymorphisms in STAT2, STAT3 and IFN-${\gamma}$ genes are not likely to be strong predictors of cervical cancer in Han women in southern China.

• Animal Bioscience
• /
• 제37권1호
• /
• pp.95-104
• /
• 2024

Objective: In the present study, we aimed to investigate the effects of enzymolysis fermentation of Chinese herbal medicines (CHMs) on egg production performance, egg quality, lipid metabolism, serum reproductive hormone levels, and the mRNA expression of the ovarian hormone receptor of laying hens in the late-laying stage. Methods: A total of 360 Hy-Line Brown laying hens (age, 390 days) were randomly categorized into four groups. Hens in the control (C) group were fed a basic diet devoid of CHMs, the crushed CHM (CT), fermented CHM (FC), and enzymatically fermented CHM (EFT) groups received diets containing 2% crushed CHM, 2% fermented CHM, and 2% enzymatically fermented CHM, respectively. Results: Compared with crushed CHM, the acid detergent fiber, total flavonoids, and total saponins contents of fermented CHM showed improvement (p<0.05); furthermore, the neutral and acid detergent fiber, total flavonoids, and total saponins contents of enzymatically fermented CHM improved (p<0.05). At 5 to 8 weeks, hens in the FC and EFT groups showed increased laying rates, haugh unit, albumin height, yolk color, shell thickness, and shell strength compared with those in the C group (p<0.05). Compared with the FC group, the laying rate, albumin height, and Shell thickness in the EFT group was increased (p<0.05). Compared with the C, CT, and FC groups, the EFT group showed reduced serum total cholesterol and increased serum luteinizing hormone levels and mRNA expressions of follicle stimulating hormone receptor and luteinizing hormone receptor (p<0.05). Conclusion: These results indicated that the ETF group improved the laying rate and egg quality and regulated the lipid metabolism in aged hens. The mechanism underlying this effect was likely related to cell wall degradation of CHM and increased serum levels of luteinizing hormone and mRNA expression of the ovarian hormone receptor.