• 한국임상약학회지
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• 제18권2호
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• pp.106-113
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• 2008

The aim of this study was to evaluate the bioequivalence of two domperidone preparations. Bioequivalence assessment was conducted on 34 healthy volunteers who received two tablets (Domperidone Maleate, 12.72 mg/tablet) in the fasting state, in a randomized balanced $2{\times}2$ cross-over study design. This whole study was performed according to the implementation guidelines of the Korea Food Drug Administration. After dosing of two tablets, blood samples were collected serially for a period of 36 hours. Plasma was analyzed for domperidone by using LC/MS/MS assay method. The analysis system was validated in specificity, accuracy, precision, and linearity. $AUC_t$, (the area under the plasma concentration-time curve from the zero-time to 36 hr) was calculated through the trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma domperidone concentration-time data of each volunteer. No significant sequence effect was found for the bioavailability parameters indicating that the cross-over design was properly performed. The 90%-Confidence intervals of the $AUC_t$ ratio and the $C_{max}$ were from log 0.8007 to log 1.1240 and log 0.8645- log 1.2483, respectively. These values were within the acceptable bioequivalence intervals between 0.80 and 1.25. Therefore, this study demonstrated that two formulations have bioequivalence with respect to the rate and extent of absorption.

• 해양환경안전학회지
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• 제19권1호
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• pp.71-77
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• 2013

Smart work는 정보통신기술을 이용하여 시간과 공간의 제약 없이 언제, 어디서든 근로자가 업무를 수행할 수 있는 유연한 근무형태를 의미한다. 스마트워크의 유형에는 모바일 오피스, 홈 오피스, 센터근무, 원격협업으로 분류할 수 있다. 태블릿PC나 스마트폰을 이용한 스마트워크 방식을 모바일 오피스라고 하며, 이동통신망과 휴대 단말기를 이용한 서비스를 제공하는 방식이다. 모바일 오피스는 무선환경과 스마트기기를 이용하여 움직이는 사무실을 구현하는 것으로 언제, 어디서나 사내 시스템에 접속하여 정보 검색은 물론 결재, 승인 등의 업무를 수행할 수 있다. 이러한 모바일 오피스 시스템을 조선소에 적용한다면, 실시간 처리로 근로자들의 생산성과 업무 효율성을 향상 시킬 수 있다. 따라서 본 연구는 조선업을 위한 HSE관리 모바일 어플리케이션 개발을 위해 기능을 추출하고 설계하는 것이 목적이다. 모바일용 HSE 관리 어플리케이션을 개발하기 위해 10개의 기능들을 추출하였고, ooCBD 방법론을 이용하여 설계하였다.

• Journal of Pharmaceutical Investigation
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• 제5권4호
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• pp.7-16
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• 1975

The drug release property from the coated tablets which contain 291mg of acetylsalicylic acid were estimated from comparison of the blood level and the urinary excretions after oral ingestion of coated tablets and noncoated tablet in human. The coating materials are 2-methyl-5-vinylpyridine-methylacrylic acid copolymer(MPM), dimethyl aminoethyl methacrylate methyl methacrylate copolymer(EE), polyvinyl acetal diethyl aminoacetate(AEA), and shellac. Each of 7 subjects ingested 873mg of acetylsaliylic acid. All tablets are coated approximately $3.5{\pm}0.5%(w/w)$ per tablet with each of the coating materials and met K.P.II. standard for potency and disintegration time. The availability was decreased in the following order:MPM coated tablets>EE coated tablets>AEA coated tablets>> shellac coated tablets.

• Journal of Pharmaceutical Investigation
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• 제17권3호
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• pp.101-110
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• 1987

In order to reduce gastric irritation in the stomach of iron preparations, ferroglycine fumarate (FGF) granules coated with hydroxyethylcellulose was made by matrix granulator, and the constrained optimization method, employing the Lagrange equation, was successfully applied to the manufacturing process design of controlled release tablets. The effects of stearic acid and dried corn starch on tablet hardness, friability, dissolution rate $t_{50%}$ and tablet volume were found to be very significant. In rabbit test, pharmacokinetic parameters $(K_a,\;C_{max}\;and\;AUC^{0-12})$ and urinary excretion rate $(K_e)$ of the controlled release FGF tablets were higher than those of controlled release ferroglycine sulfate tablets which were manufactured in the same optimal conditions. Controlled release FGF tablets were more stable than controlled release ferroglycine sulfate tablets in accelerated storage conditions.

• 한국콘텐츠학회지
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• 제10권2호
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• pp.17-24
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• 2012

• 스마트미디어저널
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• 제3권3호
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• pp.46-50
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• 2014

모바일 기기는 우리 삶에 많은 변화를 만들고 있다. 현재 가장 널리 쓰이는 모바일 운영체제로는 구글의 안드로이드와 애플사의 iOS, Microsoft사의 Windows Mobile이 있다. 그중에서도 안드로이드는 스마트폰과 태블릿 PC뿐만 아니라 자동차 분야까지 다양한 전자분야에서 연구되고 있다. MOST(Meclia Oriented Systems Transport)는 자동차산업 분야에서 고속 멀티미디어 통신에 사용되는 표준이다. 본 논문에서 안드로이드를 기반으로 MOST 네트워크를 이용해 차량용 인포테인먼트 소프트웨어를 설계한 결과를 제시한다.

• Journal of Pharmaceutical Investigation
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• 제24권2호
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• pp.67-72
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• 1994

Bioequivalence (BE) test of biphenyl dimethyl dicarboxylate (DDB) tablets was performed. Normal healthy male volunteers (n = 20) were randomly divided into 2 groups, and reference $(Nissel{\circledR})$ and test $(Livital{\circledR})$ tablets of DDB $(25mg{\times}8\;Tab.\;= \;200\;mg)$ were given orally by balanced two-period cross-over design. The serum concentration was determined by high performance liquid chromatography. The pharmacokinetic parameters, AUC, $C_{max}$, and $T_{max}$ obtained after drug administration were statistically analyzed. Statistical evaluation of the data involved an analysis of variance (ANOVA) for cross-over design. The results were within 20% differences of mean value in AUC, $C_{max}$, and $T_{max}$ between reference and test tablets. The results of ANOVA showed no significant differences for "between group or subject" and "period". The test tablet was bioequivalent with the reference tablet in the AUC, $C_{max}$, and $T_{max}$.

• 감성과학
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• 제17권2호
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• pp.35-44
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• 2014

본 연구에서는 VDT(Visual Display Terminals) 환경에서 배경색과 가독성의 상관관계를 알아보았다. 본 실험에 앞서 예비실험으로 색 온도가 다른 White 지각도를 알아보았으며, 실험 자극물은 태블릿 PC를 활용하였다. 실험 환경은 주광과 야외광이 함께 공존할 수 있는 창가에서 실험 자극물을 제시하였다. White 지각도의 인식과 선호 결과 중 단파장계열의 Nearly Whites 색 에서 백색에 대한 높은 선호도와 인식도를 보였다. 이러한 예비실험 결과를 바탕으로 본 연구에서는 동일한 실험 환경과 실험 기기를 가지고 빨간색, 초록색, 파란색, 노란색의 총 4가지 Nearly Whites와 한 가지 백색을 배경색으로 사용하여 배색 평가, 가독성, 피로도를 조사하였다. 또한, 글자는 검은색으로 제한하였다. 그 결과, 초록색의 Nearly White 배경색에서 가독성과 배색 평가가 높게 나타났으며, 가독 시 느끼는 피로도는 가장 낮은 것으로 나타났다. 이와 반대로 빨간색의 Nearly White 배경색에서는 가독성과 배색 평가가 가장 낮게 나타났으며, 가독 시 느끼는 피로도는 가장 높은 것으로 나타났다. 이러한 연구 결과를 통해서 VDT 환경에서의 가독성을 향상시키며, 눈의 피로도를 낮출 수 있는 배경색을 제안해 보고자한다.

• Journal of Pharmaceutical Investigation
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• 제36권4호
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• pp.277-282
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• 2006

Lisinopril is one of the angiotensin-converting enzyme inhibitors, which have been used for treatment of hypertension and heart failure. The aim of this study was to evaluate the bioequivalence of two lisinopril tablet, $Lisihexal^{\circledR}$ and $Zestril^{\circledR}$ as a test and reference, respectively. The study was came out on 28 healthy male Korean volunteers in $2{\times}2$ crossover design. An analytical method with LC-MS-MS was developed for the quantification of lisinopril and enalapril(IS) using SPE method. The condition was selective, sensitive and precise in human plasma, that was enough for the pharmacokinetic study of lisinopril. The pharmacokinetic parameters such as $AUC_t,\;AUC_{inf},\;C_{max},\;T_{max}\;and\;t_{1/2}$ were calculated and ANOVA test was used for the statistical analysis of the parameters using log transformed $AUC_t,\;AUC_{inf}\;and\;C_{max}$. $t_{1/2}$ of test and reference drugs were calculated $11.4{\pm}5.1\;and\;16.1{\pm}9.9\;hr$, respectively. The 90% confidence intervals of $AUC_t,\;AUC_{inf}\;and\;C_{max}$ were log 0.9245$\sim$log 1.0603, log 0.9270$\sim$log 1.0601 and log 0.9548$\sim$log 1.1009, within the acceptable range of log 0.8 to log 1.25 by KFDA bioequivalence criteria. Two medications of lisinopril were evaluated bioequivalent and thus may be prescribed interchangeably.

• Journal of Pharmaceutical Investigation
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• 제41권4호
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• pp.217-225
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• 2011

The aim of this work was to prepare porous osmotic pump tablets for controlled delivery of Aceclofenac. Aceclofenac solid dispersion was prepared to improve the solubility by using the drug - carrier (Mannitol) ratio of 1:1. The osmotic pump tablets were prepared using the solid dispersed product of Aceclofenac. The formulation contains potassium chloride as osmotic agent, cellulose acetate as semipermeable membrane, poly ethylene glycol (PEG 4000) as pore former and sodium lauryl sulphate (SLS) as solubility enhancer. The formulations were designed by the general factors such as osmotic agent and pore former. All formulations were evaluated for various physical parameters and, the in vitro release studies were conducted as per USP. The drug release kinetic studies such as zero order, first order, and Higuchi and Korsmeyer peppas were determined and compared. All the formulations gave more controlled release compared to the marketed tablet studied. Numerical optimization techniques were applied to found out the best formulation by considering the parameter of in vitro drug release kinetics and dissolution profile standards. It was concluded that the porous osmotic pump tablets (F7) composed of Aceclofenac solid dispersion/Potassium chloride/Lactose/Sodium lauryl sulphate/Magnesium Stearate (400/40/95/10/5, mg/tab) and coating composition with Cellulose acetate/ PEG 4000 (60/40 %w/w) is the most satisfactory formulation. The porous osmotic pump tablets provide prolonged, controlled, and gastrointestinal environment-independent drug release.