Journal of Pharmaceutical Investigation
- Volume 17 Issue 3
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- Pages.101-110
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- 1987
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Pharmaceutical Studies on Ferroglycine Fumarate (II) -Studies on Optimization of Controlled Release Ferroglycine Fumarate Tablets-
푸마르산철글리신 복합체의 약제학적 연구 (제2보) -지속성 푸마르산철글리신 정제의 최적화에 관한 연구-
- Shin, Hyun-Jong (BoRyung Pharm. Co., Ltd.) ;
- Lee, Wan-Ha (College of Pharmacy, Sung Kyun Kwan University)
- Published : 1987.09.20
Abstract
In order to reduce gastric irritation in the stomach of iron preparations, ferroglycine fumarate (FGF) granules coated with hydroxyethylcellulose was made by matrix granulator, and the constrained optimization method, employing the Lagrange equation, was successfully applied to the manufacturing process design of controlled release tablets. The effects of stearic acid and dried corn starch on tablet hardness, friability, dissolution rate
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