• Title/Summary/Keyword: TRAP1

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The Role of Collagen Membrane as a Scaffold of Etchant for Regional Acceleratory Phenomenon

  • Shin, Seung-Woo;Pyo, Sung-Woon;Bae, Sun-Sook;Lee, Pil-Woo;Heo, Hyun-A;Lee, Won
    • Journal of Korean Dental Science
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    • v.4 no.2
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    • pp.39-45
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    • 2011
  • Purpose: The goal of this research is to find the role of collagen membrane, which can reduce physical damage, as a scaffold for possible alternative to the corticotomy which causes Regional Acceleratory Phenomenon (RAP). Materials and Methods: The experiments were carried out on 12 New Zealand white rabbits, approximately 3.5 kg in bodyweight. We made an incision on the skin of the mandibular border and applied 37% phosphoric acid and collagen membrane to the mandibular bone surface of the first group (experimental group), and only phosphoric acid to the second group (control group). After 3 days, 1 week, and 2 weeks, 4 rabbits each were sacrificed and specimens were obtained. Each specimen was stained by H&E and Tartrate-resistant acid phosphatase (TRAP), and histological changes were observed by light microscope. Results: The demineralization of the experimental group was weak compared to the control group. It also showed a gradual increase of demineralization (after 3 days, 1 week, and 2 weeks) and the control group showed more extensive demineralization than the experimental group. Conclusion: This study demonstrates the amount of demineralization as a result of using phosphoric acid, and as time went by, demineralization increased. The absorbable collagen membrane was used as a scaffold to increase bone demineralization effect and prevent dispersion to adjacent tissues, but rather the amount of bone demineralization decreased. Therefore, the role of collagen membrane as a scaffold for RAP was weak.

Electrical Characteristics of Al2O3/TaAlO4/SiO2 Multi-layer Films by Different Tunnel Oxide Thicknesses and Annealing Treatment (터널링 산화막 두께 변화 및 열처리에 따른 Al2O3/TaAlO4/SiO2 다층막의 전기적 특성에 관한 연구)

  • Park, Jung-Tae;Kim, Hyo-June;Choi, Doo-Jin
    • Journal of the Korean Ceramic Society
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    • v.47 no.5
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    • pp.461-466
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    • 2010
  • In this study, $Al_2O_3/TaAlO_4/SiO_2$ (A/TAlO/S) structures with tantalum aluminate charge trap layer were fabricated for Nand flash memory device. We evaluated the memory window and retention characteristic as the thickness of the tunnel oxide was varied among 3 nm, 4 nm, and 5 nm. All tunnel oxide thicknesses were measured by ellipsometer and TEM (Transmission Electron Microscope). The A/TAlO/S multi-layer film consisted of 5 nm tunnel oxide showed the best result of memory window of 1.57 V and retention characteristics. After annealing the 5 nm tunnel oxide A/TAlO/S multi-layer film at $900^{\circ}C$. The memory window decreased to 1.32 V. Moreover, the TEM images confirmed that the thickness of multi-layer structure decreased 14.3% after annealing and the program conditions of A/TAlO/S multi-layer film decreased from 13 V to 11 V for 100 ms. Retention properties of both as-deposited and annealed films stably maintained until to $10^4$ cycles.

Effect of Drynariae Rhizoma in RANKL-induced Osteoclast Differentiation (골쇄보가 RANKL에 의해 유도되는 파골세포의 분화에 미치는 영향)

  • Kwak, Seong-Cheoul;Moon, Seo-Young;Kwack, Han-Bok;Jeon, Byung-Hun;Min, Oh-Jae;Choi, Min-Kyu;Kim, Jeong-Joong;Jang, Sung-Jo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.26 no.4
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    • pp.506-510
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    • 2012
  • Bone homeostasis is regulated by the balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Osteoporosis, rheumatoid arthritis and periodontal disease are related with up-regulated osteoclast formation and its activity. Gol-Swae-Bo(Drynariae Rhizoma) is widely used on skeletal disease. In this study, we sought to examine the effect of Drynariae Rhizoma in RANKL-induced osteoclast differentiation. The extract of Drynariae Rhizoma inhibited RANKL-induced osteoclast differentiation in a dose dependent manner without cytotoxicity. receptor activator of nuclear factor-${\kappa}B$ ligand(RANKL) mediated $I{\kappa}B$ degradation in bone marrow macrophages(BMMs). However, the extract of Drynariae Rhizoma inhibited RANKL induced $I{\kappa}B$ degradation in BMMs. And mRNA expression of OSCAR, TRAP, c-Fos and NFATc1 was suppressed by the extract of Drynariae Rhizoma. Moreover, the extract of Drynariae Rhizoma inhibited the protein expression of NFATc1 and c-Fos induced by RANKL. After all the analysis, these results suggest that Drynariae Rhizoma may be good candidate of medicine in the treatment of bone-related disease.

Low-Temperature Growth of N-doped SiO2 Layer Using Inductively-Coupled Plasma Oxidation and Its Effect on the Characteristics of Thin Film Transistors (플라즈마 산화방법을 이용한 질소가 첨가된 실리콘 산화막의 제조와 산화막 내의 질소가 박막트랜지스터의 특성에 미치는 영향)

  • Kim, Bo-Hyun;Lee, Seung-Ryul;Ahn, Kyung-Min;Kang, Seung-Mo;Yang, Yong-Ho;Ahn, Byung-Tae
    • Korean Journal of Materials Research
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    • v.19 no.1
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    • pp.37-43
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    • 2009
  • Silicon dioxide as gate dielectrics was grown at $400^{\circ}C$ on a polycrystalline Si substrate by inductively coupled plasma oxidation using a mixture of $O_2$ and $N_2O$ to improve the performance of polycrystalline Si thin film transistors. In conventional high-temperature $N_2O$ annealing, nitrogen can be supplied to the $Si/SiO_2$ interface because a NO molecule can diffuse through the oxide. However, it was found that nitrogen cannot be supplied to the Si/$SiO_2$ interface by plasma oxidation as the $N_2O$ molecule is broken in the plasma and because a dense Si-N bond is formed at the $SiO_2$ surface, preventing further diffusion of nitrogen into the oxide. Nitrogen was added to the $Si/SiO_2$ interface by the plasma oxidation of mixtures of $O_2/N_2O$ gas, leading to an enhancement of the field effect mobility of polycrystalline Si TFTs due to the reduction in the number of trap densities at the interface and at the Si grain boundaries due to nitrogen passivation.

Biological and Meteorological Factors Affecting the Responsiveness of Matsucoccus thunbergianae Males to Synthetic Pheromone (합성(合成)페로몬에 대한 솔껍질깍지벌레 수컷의 반응(反應)에 관여하는 생물적(生物的), 기상적(氣象的) 요인(要因))

  • Wi, An-Jin;Park, Seung-Chan
    • Journal of Korean Society of Forest Science
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    • v.90 no.1
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    • pp.139-145
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    • 2001
  • Behavior of Matsucoccus thunbergianae Miller and Park males immediately after emergence from their cocooning site, and meteorological factors affecting the responsiveness of the flying males to synthetic pheromone were studied. On Pinus thunbergii saplings, newly emerged males walked around to locate females. The males lanuched themselves into flight after up to three times of copulation. Without the presence of females, the males took off within five minutes whereas when the females were placed nearby but copulation was artifically prohibited the males did not take off. In a wind tunnel, the presence of female pheromone discouraged male take off. More males were flying in sunny area than in shade, but light intensity had no effect on the responsiveness of males toward the pheromone source. Wind speed was the main meteorological factor that affected the male responsiveness. Most males, after hitting the substrate near pheromone source with various posture, stood on their feet and approached the source.

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Experiencing Coercive Control in Female Victims of Dating Violence (데이트 폭력 여성피해자의 강압적 통제 경험)

  • Kwon, Jinsook;Park, Sihyun
    • Journal of Korean Academy of Nursing
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    • v.49 no.1
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    • pp.46-58
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    • 2019
  • Background: Dating violence refers to violence occurring between people in an intimate relationship. Forms of dating violence are often categorized into physical, psychological, and sexual violence, and most existing literature has followed this frame. However, few studies have focused on the phenomenon of living under the perpetrator's coercive control in victims of dating violence, although those experiences are known to be signs of severe forms of violence later on. Purpose: The purpose of this study was to explore the experiences of being coercively controlled in female victims who had experienced dating violence. Method: For this study, in-depth interviews were conducted with a total of 14 female victims, and all interviews were audio-recorded and transcribed. The data were analyzed using the phenomenological analysis method suggested by Colaizzi. Results: Three themes were derived in chronological order: idealizing the relationship (period of potential control), facing severer tyranny (period of coercive control), and escaping from the unending trap (period of post-control). The results showed that the victims experienced perpetrators' control with specific patterns. The perpetrators' controlling behaviors were invisible, literally benevolent, at the beginning; however, severe forms of violence seemed to appear as their relationship deepened and the perpetrators failed to control the victims. Conclusion: Findings from this study presented vivid experiences of female victims who needed help and care. Hopefully, the results can benefit in terms of developing evidence-based prevention strategies for victims as well as assessing the risks of severe forms of dating violence, such as physical attack or murder.

Effects of a Mixture of Cynanchi Wilfordii Radix and Humuli Lupuli Flos Extract on Estrogenic Activities and Anti-Osteoclastogenesis (백수오(白首烏)와 비주화(啤酒花) 복합물의 에스트로겐 활성과 파골세포 분화 억제효과)

  • Park, Dongjun;Lee, Hong Gu;Min, Kyoungin;Park, Hyoungkook;Jin, Mu Hyun;Cho, Ho Song
    • The Korea Journal of Herbology
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    • v.37 no.5
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    • pp.1-8
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    • 2022
  • Objectives : This study aimed to investigate the synergistic effect of combining Cynanchi Wilfordii Radix extract with Humuli Lupuli Flos extract on estrogenic and anti-osteoclastogenic activity. Methods : Estrogenic effect of a mixture of Cynanchi Wilfordii Radix extract and Humuli Lupuli Flos extract (CWHL), Cynanchi Wilfordii Radix extract, Humuli Lupuli Flos extract, caudatin (an active ingredient of Cynanchi wilfordii Radix extract) and 8-prenylnaringenin (an active ingredient of Humuli Lupuli Flos extract) were examined by proliferation E-screen assay and expression of estrogen inducible gene, pS2 via Real Time-PCR (RT-PCR) in MCF-7 estrogen responsive cells. And their estrogenic activities were investigated how to modulate Estrogen receptor 𝛽 by binding affinity assay. Inhibitory effect of CWHL, Cynanchi Wilfordii Radix extract, Humuli Lupuli Flos extract, caudatin and 8-prenylnaringenin on RANKL-induced osteoclast differentiation were tested by TRAP (Tartrate-resistant acid phosphatase) staining in osteoclastogenic RAW 264.7 cells. Results : CWHL, Humuli Lupuli Flos extract and 8-prenylnaringenin accelerated the proliferation of MCF-7 and the expression of pS2 in MCF-7. CWHL, Cynanchi Wilfordii Radix extract, Humuli Lupuli Flos extract, caudatin and 8-prenylnaringenin bind to estrogen receptor 𝛽. CWHL, Cynanchi Wilfordii Radix extract, Humuli Lupuli Flos extract, caudatin and 8-prenylnaringenin inhibited RANKL-induced osteoclastogenesis in osteoclastogenic RAW 264.7. CWHL is more effective for all markers than Cynanchi Wilfordii Radix extract or Humuli Lupuli Flos extract alone. Conclusions : CWHL may a potential therapeutic agent for menopause and osteoporosis as a natural food resource. CWHL as a natural food source has therapeutic potential in cases of menopause and osteoporosis.

Changes in insect diversity and composition after construction of an onshore wind farm (육상풍력발전단지 조성에 따른 곤충군집 변화에 관한 연구)

  • Jin Lee;Sung-Soo Kim;Moon-Jeong Jang
    • Korean Journal of Environmental Biology
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    • v.40 no.4
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    • pp.591-603
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    • 2022
  • This study was conducted to identify changes of insect compositions and diversity after construction of an onshore wind farm. We investigated insect fauna and compositions between a grassland deforested by the construction and a forest located at Yeongdeok and Yeongyang, Gyeongsangbuk-do, Korea. Insects were collected using a sweeping net and light trap. A total of 11 orders, 50 families, and 246 species, and 1,076 individuals were collected at study sites. By taxonomic group, Lepidoptera species were the most frequently found with 141 species, 417 individuals (38.8%), followed by Hymenoptera (20.6%), Hemiptera (16.2%), and Orthoptera (12.3%). There were also significant differences in insect species and community compositions between sites. Creating open-field deforested forests are beneficial for some insect groups such as Hymenoptera and Orthoptera. Our results suggest that deforesting by the construction of an onshore wind farm might affect the composition and diversity of insects. Results of this study provide basic data for research on onshore wind farms.

Surface Engineering of GaN Photoelectrode by NH3 Treatment for Solar Water Oxidation

  • Soon Hyung Kang;Jun-Seok Ha
    • Journal of Electrochemical Science and Technology
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    • v.14 no.4
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    • pp.388-396
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    • 2023
  • Photoelectrochemical (PEC) water splitting is a vital source of clean and sustainable hydrogen energy. Moreover, the large-scale H2 production is currently necessary, while long-term stability and high PEC activity still remain important issues. In this study, a GaN-based photoelectrode was modified by an additional NH3 treatment (900℃ for 10 min) and its PEC behavior was monitored. The bare GaN exhibited a highly crystalline wurtzite structure with the (002) plane and the optical bandgap was approximately 3.2 eV. In comparison, the NH3-treated GaN film exhibited slightly reduced crystallinity and a small improvement in light absorption, resulting from the lattice stress or cracks induced by the excessive N supply. The minor surface nanotexturing created more surface area, providing electroactive reacting sites. From the surface XPS analysis, the formation of an N-Ga-O phase on the surface region of the GaN film was confirmed, which suppressed the charge recombination process and the positive shift of EFB. Therefore, these effects boosted the PEC activity of the NH3-treated GaN film, with J values of approximately 0.35 and 0.78 mA·cm-2 at 0.0 and 1.23 VRHE, respectively, and an onset potential (Von) of -0.24 VRHE. In addition, there was an approximate 50% improvement in the J value within the highly applied potential region with a positive shift of Von. This result could be explained by the increased nanotexturing on the surface structure, the newly formed defect/trap states correlated to the positive Von shift, and the formation of a GaOxN1-x phase, which partially blocked the charge recombination reaction.

Timing of Diapause Induction and Number of Generations of Helicoverpa armigera (Hüber) (Lepidoptera: Noctuidae) in Suwon, Korea (수원지방에서 왕담배나방 (밤나방과) 휴면 유기시기와 연간 발생 세대)

  • Jung, Jin Kyo;Seo, Bo Yoon;Park, Chang-Gyu;Ahn, Seung-Joon;Kim, Ju Il;Cho, Jum Rae
    • Korean journal of applied entomology
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    • v.54 no.4
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    • pp.383-392
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    • 2015
  • We investigated the induction of pupal diapause and number of generation for H. armigera using outdoor rearing and sex pheromone trapping in Suwon, Korea. Over-wintering pupae were induced when neonate larvae were reared in the outdoors from late Aug. to early Oct. in 2013 and 2014. H. armigera adults emerged from late May to early Jun. for 2013 colonies and from late May to late Jun. for 2014 colonies. The colonies placed after mid September produced only diapause pupae, to show environmental conditions that day-lengths on the rearing start date were 11 h 49 min~12 h 24 min, and mean temperatures before pupation were $14.8{\sim}20.7^{\circ}C$. Summer diapause was not observed in all colonies. The peak occurrence of H. armigera adults from sex pheromone trap in Suwon and Hwaseong were pooled and showed four generations (1st: from late Apr. to mid Jun., 2nd: from mid Jun. to late Jul., 3rd: from mid Jul. to late Aug., 4th: from late Aug. to mid Oct.). A degree-day model for development of H. armigera developed by Mironidis and Savopoulou-Soultani (2008) was used to validate the number of generation from field observations using pheromone traps. The 3rd and over-wintering generations were mainly overlapped. It was decided that H. armigera has one over-wintering and three complete generations in a year, and diapause is induced from offsprings of the 3rd and 4th generations adults. It is expected that larvae of the 1st and 2nd generations give a damage to ear zone in maize fields in which have been planted during April.