• Archives of Pharmacal Research
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• v.25 no.1
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• pp.11-24
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• 2002

The antitumor antibiotic (+)-CC-1065 can alkylate N3 of guanine in certain sequences. A previous high-field $^1H$ NMR study on the$(+)-CC-1065d[GCGCAATTG*CGC]_2$ adduct ($^*$ indicates the drug alkylation site) showed that drag modification on N3 of guanine results in protonation of the cross-strand cytosine [Park, H-J.; Hurley, L. H. J. Am. Chem. Soc.1997, 119,629]. In this contribution we describe a further analysis of the NMR data sets together with restrained molecular dynamics. This study provides not only a solution structure of the (+)-CC-1065(N3- guanine) DNA duplex adduct but also new insight into the molecular basis for the sequence- specific interaction between (+)-CC-1065 and N3-guanine in the DNA duplex. On the basis of NOESY data, we propose that the narrow minor groove at the 7T8T step and conformational kinks at the junctions of 16C17A and 18A19T are both related to DNA bending in the drugDNA adduct. Analysis of the one-dimensional $^1H$ NMR (in $H_2O$) data and rMD trajectories strongly suggests that hydrogen bonding linkages between the 8-OH group of the (+)-CC-1065 A-sub-unit and the 9G10C phosphate via a water molecule are present. All the phenomena observed here in the (+)-CC-1065(N3-guanine) adduct at 5'$-AATTG^*$are reminiscent of those obtained from the studies on the (+)-CC-1065(N3-adenine) adduct at $5'-AGTTA^*$, suggesting that (+)-CC-1065 takes advantage of the conformational flexibility of the 5'-TPu step to entrap the bent structure required for the covalent bonding reaction. This study reveals a common molecular basis for (+)-CC-1065 alkylation at both $5'-TTG^*$ and $5'-TTA^*$, which involves a trapping out of sequence-dependent DNA conformational flexibility as well as sequence-dependent general acid and general base catalysis by duplex DNA.

• Fashion & Textile Research Journal
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• v.21 no.3
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• pp.267-276
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• 2019

This study develops 3D-printed-garment collections for a fashion show presentation. A design concept using traditional patterns that consisted of garments regarding the limitation of the printing technology was investigated in order to develop the collection. The structures of the connecting joints of the textile parts which could be easily and sturdily interconnected were invented. Wearability as garments that could be naturally worn on the human body were sought. As a result, four 3D-printed-garments were developed. The 1st garment composed of objects based on a 'Yeon-Dang-Cho'-pattern was constructed as a geometric robe style using a FDM 3D printer and transparent TPU filaments. The 2nd and 3rd 3D-printed-garments composed of an object based on a 'Boe-Sang-Hwa'-pattern was constructed as a distorted one-piece exaggerating the silhouettes of shoulders and waist parts as well as a straight asymmetric tunic style that used the same printer and material as the 1st garment. The last garment composed of an object based on a 'Boe-Sang-Hwa'-pattern printed using a SLA 3D printer and flexible-liquid-resin was constructed attaching the objects on the fabric material by the hot-press machine. The four developed garments were presented in the opening fashion show of 'the 6th International 3D-printing Korea Expo'. This study provides a basic case for related studies to adapt 3D-printing technology in textile pattern development of garment construction.

• Fashion & Textile Research Journal
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• v.24 no.5
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• pp.505-518
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• 2022

3D printing technology, also known as additive manufacturing(AM), has not been actively used in the clothing industry despite its potential for economic, environmental, and labor efficiency. Therefore, this study aims to propose a new 3D printing method for the clothing industry, which will be more readily accessible. This roll-type printing method can print wide-sized patterns at once using a 3D modeling program and a FDM 3D printer and help overcome the limitations imposed by the size of the printer. Then, to demonstrate the practical application cases of this printing method, bags of three designs were developed. Prior to product development, a thickness test was performed for stable printing using TPU(Thermoplastic Poly Urethane) filament, and a thickness of 0.45 mm was found to be most suitable for it. Next, the time efficiency test showed that the roll-type printing method takes less time compared to the general printing method in printing wide-sized patterns. Based on these tests, three bags, , and , were developed to confirm the suitability of the roll-type printing method for product development. The advantages of 3D roll-type printing can lie in overcoming of the spatial limitation, and the environmental sustainability as it can reduce waste from the production process. This study is significant in that it presents a new 3D printing method to improve the space limitations and time inefficiency of 3D printers.

• Wind and Structures
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• v.36 no.6
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• pp.405-421
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• 2023

Strong wind is the main factors of wind-damage of high-rise buildings, which often creates largely economical losses and casualties. Wind pressure plays a critical role in wind effects on buildings. To obtain the high-resolution wind pressure field, it often requires massive pressure taps. In this study, two traditional methods, including bilinear and bicubic interpolation, and two deep learning techniques including Residual Networks (ResNet) and Generative Adversarial Networks (GANs), are employed to reconstruct wind pressure filed from limited pressure taps on the surface of an ideal building from TPU database. It was found that the GANs model exhibits the best performance in reconstructing the wind pressure field. Meanwhile, it was confirmed that k-means clustering based retained pressure taps as model input can significantly improve the reconstruction ability of GANs model. Finally, the generalization ability of k-means clustering based GANs model in reconstructing wind pressure field is verified by an actual engineering structure. Importantly, the k-means clustering based GANs model can achieve satisfactory reconstruction in wind pressure field under the inputs processing by k-means clustering, even the 20% of pressure taps. Therefore, it is expected to save a huge number of pressure taps under the field reconstruction and achieve timely and accurately reconstruction of wind pressure field under k-means clustering based GANs model.

• Journal of Bio-Environment Control
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• v.30 no.4
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• pp.448-454
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• 2021

This study was conducted to the effect of low air temperature and light intensity conditions on yield and quality of tomato at the early stage of growth in Korea. Inplastic greenhouses, low temperature and low temperature with shade treatments were performed from 17 to 42 days after plant. Tomato growing degree days were decreased 5.5% due to cold treatment during the treatment period. Light intensity decreased 74.7% of growing degree days due to shade. After commencing treatments, the plant growth decreased by low temperature and low radiation except for height. Analysis of the yield showed that the first harvest date was the same, but the yield of the control was 3.3 times higher than low temperature with shade treatment. The cumulative yields at 87 days after transplanting were 1734, 1131, and 854 g per plant for control, low temperature, and low temperature with shade, respectively. The sugar and acidity of tomatoes did not differ between treatment and harvesting season. To investigate the photosynthetic characteristics according to the treatment, the carbon dioxide reaction curve was analyzed using the biochemical model of the photosynthetic rate. The results showed that the maximum photosynthetic rate, J (electric transportation rate), TPU (triose phosphate utilization), and R_d (dark respiration rate) did not show any difference with temperature, but were reduced by shading. Vcmax (maximum carboxylation rate) was decreased depending on the low temperature and the shade. Results indicated that low temperature and light intensity at the early growth stage can be inhibited the growth in the early stage but this phenomenon might be recovered afterward. The yield was reduced by low temperature and low intensity and there was no difference in quality.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.2
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• pp.153-160
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• 2015

The objective of this study is to construct the TPU aerodynamic database with wind tunnel test data of overall wind loads and responses on tall buildings. In this study, wind tunnel tests were conducted to investigate characteristics of wind forces and the effect of wind load combination by cross-correlation analysis among along-wind overturning moment, across-wind overturning moment and torsional moment on a tall building with various side ratios(D/B=0.33, 0.50, 0.77, 0.83, 0.91, 1.0, 1.1, 1.2, 1.3, 2.0 and 3.0) for different terrain roughnesses. The results of wind tunnel tests were compared with those of past literatures. As a result, there was no significant effects of changing of terrain roughnesses on moment coefficients and power spectral densities of across-wind overturning moment coefficients and torsional moment coefficients with various side ratios. Further, these results were good agreement with those of past literatures. From cross-correlation analysis, the across-wind overturning moment coefficients were highly correlated with the torsional moment coefficients. The results of this study will be helpful for practical designers in preliminary design stage.

• Journal of Environmental Science International
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• v.29 no.10
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• pp.989-996
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• 2020

This study was conducted to determine the effect of low temperature and low radiation conditions on the yield and quality of hot pepper at an early growth stage in Korea. In plastic greenhouses, low temperature, low temperature with covered shading treatments were set 17 to 42 days after transplanting. The pepper growing degree days decreased by 5.5% due to the low temperature during the treatment period. Radiation decreased by 74.7% due to the covered shading. After commencing treatments, pepper plant growth decreased with low temperature and low radiation. Analysis of the yield showed that the first harvest was delayed by low radiation. The cumulative yields of 119 days after transplanting were 1,956, 2,171, and 2,018 g/㎡ for control, low temperature, and low temperature with low radiation respectively. Capsaicin and dihydrocapsaicin concentrations in pepper fruit decreased with low temperature and low radiation. To investigate the photosynthetic characteristics according to the treatment, the carbon dioxide reaction curve was analyzed using the biochemical model of photosynthesis. Results showed that the maximum photosynthetic rate, V_cmax (maximum carboxylation rate), J (electric transportation rate), and TPU (triose phosphate utilization) decreased at low temperatures; the maximum photosynthetic rate, J, and g_m (dark respiration rate) were reduced by shading. These results indicate that low temperature and low radiation can retard early growth, yield, and quality, but these can also be recovered 119 days after planting. Based on the results, the yield and quality of pepper can recover from abiotic stresses with proper cultivation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.9
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• pp.175-181
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• 2019

In the case of a conventional single stage decompression regulator used for large depressurization in the hydrogen fuel cell system of a fuel cell electric vehicle (FCEV), problems can arise, such as pulsation, slow response, hydrogen brittleness, leakage, high weight, and high cost due to high decompression. Most of these problems can be overcome easily using two decompression mechanisms (two-stage structures). In addition, a wide outlet-pressure control range can be secured if an electronic solenoid is applied to the second decompression. Accordingly, it is necessary to improve the precision of the outlet pressure of a two-stage pressure-reducing regulator and develop techniques, such as leakage prevention, durability, light weight, and price reduction. Therefore, to improve the outlet pressure accuracy and prevent leakage, the structural part before and after decompression to improve the air tightness were divided and the analysis was carried out assuming that the valve part was closed (open ratio: 0%) after each initial internal pressure application.

• Fashion & Textile Research Journal
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• v.24 no.6
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• pp.667-685
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• 2022

This paper aims to investigate 4D printing materials for soft robots. 4D printing is a targeted evolution of the 3D printed structure in shape, property, and functionality. It is capable of self-assembly, multi-functionality, and self-repair. In addition, it is time-dependent, printer-independent, and predictable. The shape-shifting behaviors considered in 4D printing include folding, bending, twisting, linear or nonlinear expansion/contraction, surface curling, and generating surface topographical features. The shapes can shift from 1D to 1D, 1D to 2D, 2D to 2D, 1D to 3D, 2D to 3D, and 3D to 3D. In the 4D printing auxetic structure, the kinetiX is a cellular-based material design composed of rigid plates and elastic hinges. In pneumatic auxetics based on the kirigami structure, an inverse optimization method for designing and fabricating morphs three-dimensional shapes out of patterns laid out flat. When 4D printing material is molded into a deformable 3D structure, it can be applied to the exoskeleton material of soft robots such as upper and lower limbs, fingers, hands, toes, and feet. Research on 4D printing materials for soft robots is essential in developing smart clothing for healthcare in the textile and fashion industry.