• 한국군사과학기술학회지
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• 제21권6호
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• pp.865-876
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• 2018

This study focuses on the operating requirements of multi-resolution modeling(MRM) in training war-game model and proposes solutions for major issues of multi-resolution interoperation between Combat21 model and tank multi-purpose simulator(TMPS). We study the operating requirements of MRM through interviews with defense M&S experts and literature surveys and report the various issues that could occur with low-resolution model Combat21 and high-resolution model TMPS linked, for example, when to switch objects, what information to exchange, what format to switch to, and how to match data resolutions. This study also addresses the purpose and concept of training using multi-resolution interoperation, role of each model included in multi-resolution interoperation, and issue of matching damage assessments when interoperated between models with different resolutions. This study will provide the common goals and directions of MRM research to MRM researchers, defense modeling & simulation organizations and practitioners.

• 한국자기공명학회논문지
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• 제18권2호
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• pp.58-62
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• 2014

Human transmembrane proteins (hTMPs) are closely related to transport, channel formation, signaling, cell to cell interaction, so they are the crucial target of modern medicinal drugs. In order to study the structure and function of these hTMPs, it is important to prepare reasonable amounts of proteins. However, their preparation is seriously difficult and time-consuming due to insufficient yields and low solubility of hTMPs. We tried to produce large amounts of Syndecan-4 transmembrane domain (Syd4-TM) that is related to the healing wounds and tumor for a long time. In this study, we performed the structure determination of Syd4-TM combining the Polarity Index at Slanted Angle (PISA) wheel pattern analysis based on $^{15}N-^1H$ 2D SAMPI-4 solid-state NMR of expressed Syd4-TM and Molecular Dynamics (MD) simulation using Discovery Studio 3.1.

• 국제학술발표논문집
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• The 6th International Conference on Construction Engineering and Project Management
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• pp.294-298
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• 2015

In the United States, the completion of Construction Work Zone (CWZ) impact assessments for all federally-funded highway infrastructure improvement projects is mandated, yet it is regarded as a daunting task for state transportation agencies, due to a lack of standardized analytical methods for developing sounder Transportation Management Plans (TMPs). To circumvent these issues, this study aims to create a spatiotemporal modeling framework, dubbed "SWAT" (Spatiotemporal Work zone Assessment for TMPs). This study drew a total of 43,795 traffic sensor reading data collected from heavily trafficked highways in U.S. metropolitan areas. A multilevel-cluster-driven analysis characterized traffic patterns, while being verified using a measurement system analysis. An artificial neural networks model was created to predict potential 24/7 traffic demand automatically, and its predictive power was statistically validated. It is proposed that the predicted traffic patterns will be then incorporated into a what-if scenario analysis that evaluates the impact of numerous alternative construction plans. This study will yield a breakthrough in automating CWZ impact assessments with the first view of a systematic estimation method.

• 한국진공학회:학술대회논문집
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• 한국진공학회 1995년도 제9회 학술발표회 논문개요집
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• pp.61-62
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• 1995

Seiko Seiki develops and munufactures magnetic Bearing type Turbomolecular Pumps (MB-TMP), Seiko shipped 14,000 MB-TMPs and holds the world's largest share in the MB-TMP field. It developed a new 300 (l/s) class turbomolecular pump.

• 진공이야기
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• 제2권3호
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• pp.23-29
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• 2015

Cryopump(cryogenic pump), with integrating cryogenic skills into vacuum technology, is the most popular high vacuum pump system, which is widely used at the commercial vacuum industries with TMP. Hyunmin GVT, Inc. is the domestic unique professional manufacturer of the cryopump systems. About ten years ago, while GVT succeeded in domestically producing cryopump systems, this high technology initiated from US became localized completely. But the process of the home production was not easy. It was possible through many trials and errors and after efforts and sacrifices of our engineers. Now many users and customers have the benefit of the advantage and excellence of the domestic cryopump systems. Especially, these days GVT is conducting researches and developments regarding low vibration cryopump and large-sized CWPs and Cryo-TMPs.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3581-3586
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• 2014

Aim: To investigate the effects of tetramethypyrazine (TMP) on proliferation and apoptosis of the human gastric carcinoma cell line 7901 and its possible mechanism of action. Methods: The viability of TMP-treated 7901 cells was measured with a 3-(4, 5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT) and cell apoptosis was analyzed by flow cytometry. The distribution of cells in different phases of cell cycle after exposure of TMPs was analyzed with flow cytometry. To investigate the molecular mechanisms of TMP-mediated apoptosis, the expression of NF-${\kappa}Bp65$, cyclinD1 and p16 in SGC-7901 cells was analyzed by reverse transcription-polymerase chain reaction (RT-PCR) and western blotting. Results: TMP inhibited the proliferation of human gastric carcinoma cell line 7901 in dose and time dependent manners. Cell growth was suppressed by TMP at different concentrations (0.25, 0.5, 1.0, 2.0 mg/ml), the inhibition rate is 0.46%, 4.36%, 14.8%, 76.1% (48h) and 15.5%, 18.5%, 41.2%, 89.8% (72h) respectively. When the concentration of TMPs was 2.0mg/ml, G1-phase arrest in the SGC-7901 cells was significant based on the data for cell cycle distribution. RT-PCR demonstrated that NF-${\kappa}Bp65$ and cyclin D1 mRNA expression was significantly down-regulated in 7901 cells treated with 2.0 mg/ml TMP for 72h (p<0.05), while the p16 mRNA level was up-regulated (p<0.05). The protein expression of NF-${\kappa}Bp65$ and cyclin D1 decreased gradually with the increase in TMP concentration, compared with control cells (p<0.05), while expression of protein p16 was up-regulated (p<0.01). Conclusion: TMP exhibits significant anti-proliferative and pro-apoptotic effects on the human gastric carcinoma cell line SGC-7901. NF-${\kappa}Bp65$, cyclinD1 and p16 may also play important roles in the regulation mechanisms.

• 셀메드
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• 제3권2호
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• pp.17.1-17.10
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• 2013

Reproductive dysfunction is a major health concern amongst the inhabitants of Tana River County. An ethno botanical study was conducted in Garsen, Itsowe and Ngao sub divisions of Tana River County to document the utilization of medicinal plants for the management of female reproductive ailments. The target population was practicing herbalists from Pokomo, Ormo and Giryama communities in the study area. Structured questionnaires and focussed group discussions were used to collect data. Forty eight plant species distributed in 40 genera and 29 families were documented as being important for the management of pregnancy related complications, menstrual disorders, infertility, fibroids and as contraceptives. The species most frequently cited by the herbalists were fourteen. Fifty two percent of the plant species were probably being mentioned for the first time as being useful in reproductive health management. In conclusion, Tana River has a pool of TMPs with a wealth of indigenous knowledge that needs to be exploited. The plants used to treat dysmenorrhea for example may be important analgesic agents that need further investigation while those with anti-fertility properties may contain steroidal phyto chemical compounds. Such species therefore need further investigation to establish their efficacy and mechanism of action.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2010년도 제39회 하계학술대회 초록집
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• pp.18-18
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• 2010

Methods of the characteristics evaluation of turbo-molecular pumps (TMP) are well-defined in the international measurement standards such as ISO, PNEUROP, DIN, JIS, and AVS. The Vacuum Center in the Korea Research Institute of Standards and Science has recently designed, constructed, and established the integrated characteristics evaluation system of TMPs based on the international documents by continuously pursuing and acquiring the reliable international credibility through measurement perfection. The measurement of TMP pumping speed is normally performed with the throughput and orifice methods dependent on the mass flow regions. However, in the UHV range of the molecular flow region, the high uncertainties of the gauges, mass flow rates, and conductance are too critical to precisely accumulate reliable data. With UHV gauges of uncertainties less than 15% and a calculated conductance of the orifice, about 35% of pumping speed uncertainties are experimentally derived in the pressure range of less than $10^{-6}$ mbar. In order to solve the uncertainty problems of pumping speeds in the UHV range, we introduced an SRG with 1% accuracy and a constant volume flow meter (CVFM) to measure the finite mass flow rates down to $10^{-3}$ mbar-L/s with 3% uncertainty for the throughput method. In this way we have performed the measurement of pumping speed down to less than $10^{-6}$ mbar with an uncertainty of 6% for a 1000 L/s TMP. In this article we suggest that the CVFM has an ability to measure the conductance of the orifice experimentally with flowing the known mass through the orifice chambers, so that we may overcome the discontinuity problem encountering during introducing two measurement methods in one pumping speed evaluation sequence.

• 대한기계학회논문집A
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• 제37권10호
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• pp.1279-1289
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• 2013

터보분자펌프는 회전하는 로터 블레이드의 고속회전을 통해 진공을 생성하는 고진공, 고청정 펌프로 로터의 고속회전에 따른 구조적 안전성이 우선 평가되어야 한다. 본 논문에서는 터보분자펌프의 배기성능 및 구조적 안전성에 영향을 미치는 인자 중에서 블레이드 각도, 길이, 블레이드가 시작되는 부분의 라운드 크기, 회전속도를 선정하여 그들의 변화에 대한 변위 및 응력 응답을 관찰하는 민감도 평가 및 최적설계를 수행하였다. 일반적인 유한요소해석기법인 H-기법이 아닌 형상요소해석기법인 P-기법을 사용함으로써 복잡한 형상의 유한요소생성 모델링 시간을 단축시켜 해석의 효율성을 높일 수 있었다.

• 한국진공학회지
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• 제19권4호
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• pp.249-255
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• 2010

터보분자펌프(TMP)의 특성평가는 ISO, PNEUROP, DIN, JIS, AVS 등 세계 여러 나라의 표준제정기구에서 제정한 국제규격에 그 근거를 두고 있다. 한국표준과학연구원에서는 이러한 국제규격에 기반을 둔 터보분자펌프의 특성평가시스템을 자체 설계/제작하여 그 신뢰성을 확인하기 위해 개발품 및 상용품의 평가에 주력하고 있다. 터보분자펌프의 배기속도 측정방법으로서 기체흐름 영역에 따른 throughput method와 orifice method를 적용하고 있으나 측정게이지, 유량계 및 orifice conductance의 불확도 등 실질적으로 정확한 배기속도를 제시하기 위한 조건들의 제약 때문에 많은 측정오차를 포함하고 있다고 볼 수 있다. 이러한 배기속도의 측정오차를 줄이기 위한 하나의 고찰로서 본 논문에서는 $10^{-1}$ Pa-L/s 영역까지의 유량 주입범위를 가지는 기 구축된 정적법을 이용한 유량주입에 기반을 둔 throughput method를 이용하여 1000 L/s TMP의 측정 능력을 검증하고자 한다. 또한 분자류 영역인 orifice method를 사용할 경우 고진공영역, 미세유량 주입영역으로 진입할수록 커질 수밖에 없는 배기속도 측정 불확도를 최소화시키기 위해 검증된 유량을 이용한 conductance 값을 제시하여, 기 언급한 두 가지 배기 속도 측정 방법의 연속성을 유지하기 위한 실험적인 방법론을 제기하고자 한다.