• Journal of the Korea Institute of Military Science and Technology
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• v.21 no.6
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• pp.865-876
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• 2018

This study focuses on the operating requirements of multi-resolution modeling(MRM) in training war-game model and proposes solutions for major issues of multi-resolution interoperation between Combat21 model and tank multi-purpose simulator(TMPS). We study the operating requirements of MRM through interviews with defense M&S experts and literature surveys and report the various issues that could occur with low-resolution model Combat21 and high-resolution model TMPS linked, for example, when to switch objects, what information to exchange, what format to switch to, and how to match data resolutions. This study also addresses the purpose and concept of training using multi-resolution interoperation, role of each model included in multi-resolution interoperation, and issue of matching damage assessments when interoperated between models with different resolutions. This study will provide the common goals and directions of MRM research to MRM researchers, defense modeling & simulation organizations and practitioners.

• Journal of the Korean Magnetic Resonance Society
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• v.18 no.2
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• pp.58-62
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• 2014

Human transmembrane proteins (hTMPs) are closely related to transport, channel formation, signaling, cell to cell interaction, so they are the crucial target of modern medicinal drugs. In order to study the structure and function of these hTMPs, it is important to prepare reasonable amounts of proteins. However, their preparation is seriously difficult and time-consuming due to insufficient yields and low solubility of hTMPs. We tried to produce large amounts of Syndecan-4 transmembrane domain (Syd4-TM) that is related to the healing wounds and tumor for a long time. In this study, we performed the structure determination of Syd4-TM combining the Polarity Index at Slanted Angle (PISA) wheel pattern analysis based on $^{15}N-^1H$ 2D SAMPI-4 solid-state NMR of expressed Syd4-TM and Molecular Dynamics (MD) simulation using Discovery Studio 3.1.

• International conference on construction engineering and project management
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• 2015.10a
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• pp.294-298
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• 2015

In the United States, the completion of Construction Work Zone (CWZ) impact assessments for all federally-funded highway infrastructure improvement projects is mandated, yet it is regarded as a daunting task for state transportation agencies, due to a lack of standardized analytical methods for developing sounder Transportation Management Plans (TMPs). To circumvent these issues, this study aims to create a spatiotemporal modeling framework, dubbed "SWAT" (Spatiotemporal Work zone Assessment for TMPs). This study drew a total of 43,795 traffic sensor reading data collected from heavily trafficked highways in U.S. metropolitan areas. A multilevel-cluster-driven analysis characterized traffic patterns, while being verified using a measurement system analysis. An artificial neural networks model was created to predict potential 24/7 traffic demand automatically, and its predictive power was statistically validated. It is proposed that the predicted traffic patterns will be then incorporated into a what-if scenario analysis that evaluates the impact of numerous alternative construction plans. This study will yield a breakthrough in automating CWZ impact assessments with the first view of a systematic estimation method.

• Proceedings of the Korean Vacuum Society Conference
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• 1995.06a
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• pp.61-62
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• 1995

Seiko Seiki develops and munufactures magnetic Bearing type Turbomolecular Pumps (MB-TMP), Seiko shipped 14,000 MB-TMPs and holds the world's largest share in the MB-TMP field. It developed a new 300 (l/s) class turbomolecular pump.

• Vacuum Magazine
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• v.2 no.3
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• pp.23-29
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• 2015

Cryopump(cryogenic pump), with integrating cryogenic skills into vacuum technology, is the most popular high vacuum pump system, which is widely used at the commercial vacuum industries with TMP. Hyunmin GVT, Inc. is the domestic unique professional manufacturer of the cryopump systems. About ten years ago, while GVT succeeded in domestically producing cryopump systems, this high technology initiated from US became localized completely. But the process of the home production was not easy. It was possible through many trials and errors and after efforts and sacrifices of our engineers. Now many users and customers have the benefit of the advantage and excellence of the domestic cryopump systems. Especially, these days GVT is conducting researches and developments regarding low vibration cryopump and large-sized CWPs and Cryo-TMPs.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3581-3586
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• 2014

Aim: To investigate the effects of tetramethypyrazine (TMP) on proliferation and apoptosis of the human gastric carcinoma cell line 7901 and its possible mechanism of action. Methods: The viability of TMP-treated 7901 cells was measured with a 3-(4, 5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT) and cell apoptosis was analyzed by flow cytometry. The distribution of cells in different phases of cell cycle after exposure of TMPs was analyzed with flow cytometry. To investigate the molecular mechanisms of TMP-mediated apoptosis, the expression of NF-${\kappa}Bp65$, cyclinD1 and p16 in SGC-7901 cells was analyzed by reverse transcription-polymerase chain reaction (RT-PCR) and western blotting. Results: TMP inhibited the proliferation of human gastric carcinoma cell line 7901 in dose and time dependent manners. Cell growth was suppressed by TMP at different concentrations (0.25, 0.5, 1.0, 2.0 mg/ml), the inhibition rate is 0.46%, 4.36%, 14.8%, 76.1% (48h) and 15.5%, 18.5%, 41.2%, 89.8% (72h) respectively. When the concentration of TMPs was 2.0mg/ml, G1-phase arrest in the SGC-7901 cells was significant based on the data for cell cycle distribution. RT-PCR demonstrated that NF-${\kappa}Bp65$ and cyclin D1 mRNA expression was significantly down-regulated in 7901 cells treated with 2.0 mg/ml TMP for 72h (p<0.05), while the p16 mRNA level was up-regulated (p<0.05). The protein expression of NF-${\kappa}Bp65$ and cyclin D1 decreased gradually with the increase in TMP concentration, compared with control cells (p<0.05), while expression of protein p16 was up-regulated (p<0.01). Conclusion: TMP exhibits significant anti-proliferative and pro-apoptotic effects on the human gastric carcinoma cell line SGC-7901. NF-${\kappa}Bp65$, cyclinD1 and p16 may also play important roles in the regulation mechanisms.

• CELLMED
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• v.3 no.2
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• pp.17.1-17.10
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• 2013

Reproductive dysfunction is a major health concern amongst the inhabitants of Tana River County. An ethno botanical study was conducted in Garsen, Itsowe and Ngao sub divisions of Tana River County to document the utilization of medicinal plants for the management of female reproductive ailments. The target population was practicing herbalists from Pokomo, Ormo and Giryama communities in the study area. Structured questionnaires and focussed group discussions were used to collect data. Forty eight plant species distributed in 40 genera and 29 families were documented as being important for the management of pregnancy related complications, menstrual disorders, infertility, fibroids and as contraceptives. The species most frequently cited by the herbalists were fourteen. Fifty two percent of the plant species were probably being mentioned for the first time as being useful in reproductive health management. In conclusion, Tana River has a pool of TMPs with a wealth of indigenous knowledge that needs to be exploited. The plants used to treat dysmenorrhea for example may be important analgesic agents that need further investigation while those with anti-fertility properties may contain steroidal phyto chemical compounds. Such species therefore need further investigation to establish their efficacy and mechanism of action.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.08a
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• pp.18-18
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• 2010

Methods of the characteristics evaluation of turbo-molecular pumps (TMP) are well-defined in the international measurement standards such as ISO, PNEUROP, DIN, JIS, and AVS. The Vacuum Center in the Korea Research Institute of Standards and Science has recently designed, constructed, and established the integrated characteristics evaluation system of TMPs based on the international documents by continuously pursuing and acquiring the reliable international credibility through measurement perfection. The measurement of TMP pumping speed is normally performed with the throughput and orifice methods dependent on the mass flow regions. However, in the UHV range of the molecular flow region, the high uncertainties of the gauges, mass flow rates, and conductance are too critical to precisely accumulate reliable data. With UHV gauges of uncertainties less than 15% and a calculated conductance of the orifice, about 35% of pumping speed uncertainties are experimentally derived in the pressure range of less than $10^{-6}$ mbar. In order to solve the uncertainty problems of pumping speeds in the UHV range, we introduced an SRG with 1% accuracy and a constant volume flow meter (CVFM) to measure the finite mass flow rates down to $10^{-3}$ mbar-L/s with 3% uncertainty for the throughput method. In this way we have performed the measurement of pumping speed down to less than $10^{-6}$ mbar with an uncertainty of 6% for a 1000 L/s TMP. In this article we suggest that the CVFM has an ability to measure the conductance of the orifice experimentally with flowing the known mass through the orifice chambers, so that we may overcome the discontinuity problem encountering during introducing two measurement methods in one pumping speed evaluation sequence.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.10
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• pp.1279-1289
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• 2013

In recent times, turbomolecular pumps (TMPs) have been used frequently to generate and maintain high and clean vacuum. Because of the high-speed rotation of the rotor, its structural safety should be treated as the first design concern. This paper presents the structural analysis and optimization of rotor blades of a TMP. To increase the numerical efficiency in the finite element modeling and analysis, the P-method provided in Pro/ENGINEER was used for simulation. The structural responses for several types of rotor blades were investigated, and the effects of the blade angle, blade length, and round size are thoroughly studied for each type of TMP blade. In addition, structural optimization to reduce and even the maximum stress at each stage of the TMP by changing the size of rounds between the blade and the hub was performed very successfully by using the P-method.

• Journal of the Korean Vacuum Society
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• v.19 no.4
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• pp.249-255
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• 2010

Methods of the characteristics evaluation of turbo-molecular pumps (TMP) are well-defined in the international measurement standards such as ISO, PNEUROP, DIN, JIS, and AVS. The Vacuum Center in the Korea Research Institute of Standards and Science (KRISS) has recently designed, constructed, and established the integrated characteristics evaluation system of TMPs based on the international documents by continuously pursuing and acquiring the reliable international credibility through measurement perfection. The measurement of TMP pumping speed is normally performed with the throughput and orifice methods dependent on the mass flow regions. However, in the UHV range of the molecular flow region, the high uncertainties of the gauges, mass flow rates, and conductance are too critical to precisely accumulate reliable data. In order to solve the uncertainty problems of pumping speeds in the UHV range, we introduced a SRG with 1% accuracy and a constant volume flow meter (CVFM) to measure the finite mass flow rates down to $10^{-1}$ Pa-L/s with 3% uncertainty for the throughput method. In this way we have performed the measurement of pumping speed down to $10^{-4}$ Pa with an uncertainty of less than 6% for a 1000 L/s TMP. In this article we suggest that the CVFM has an ability to measure the conductance of the orifice experimentally with flowing the known mass through the orifice chambers, so that we may overcome the discontinuity problem encountering during introducing two measurement methods in one pumping speed evaluation sequence.