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Synthesis and Anti-Inflammatory and Analgesic Activities of 2,4-Di-n-butyl-3,5-diarylimino-1,2,4-thiadiazolidines

  • Pandeya, S.N.;Naik, P.R.;Singh, S.;Singh, P.N.
    • Archives of Pharmacal Research
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    • v.14 no.1
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    • pp.78-80
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    • 1991
  • Ten 1,2,4-thiadiazolidines were synthesized and screened for their anti-inflammatory and analgesic activities. Butyl isothiocyanate was used as a starting material. Several compounds showed significant anti-inflammatory and analgesic activities. The unsubstituted and o-methyl, p-acetoxy and o-chloro substituted compounds were found to be more potent anti-inflammatory and analgesic agents than the other compounds.

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Synthesis of Some Palladium (II) Complexes of 1, 2-Diaminocyclohexane and Dicarboxylates as Cisplatin Analogues of Palladium Series

  • Kim, Jong-Yoon
    • Archives of Pharmacal Research
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    • v.15 no.4
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    • pp.336-342
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    • 1992
  • Ten [$Pd^{II}$(dicarboxylato)(1, 2-diaminocyclohexane)] complexes were prepared after the antitumor-active Pt(II)1, 2-diaminocyclohexane complexes as the cisplatin analogues of palladium series. They were characterized by means of elemental analysis, IR and NMR spectroscopy. As a result, the dicarboxylate ligands were conformed to be chelated with Pd(II) within the scope studied. The stability differences beween the dicarboxylato complexes according to the chelate ring size could not be differentiated due to generally lower thermodynamic stability of the dicarboxylato Pd(II) complexes.

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On the Root Rot of Ginseng(I) (인삼근부병에 관한 연구 1)

  • 김종희;이민웅
    • Korean Journal of Microbiology
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    • v.12 no.2
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    • pp.94-98
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    • 1974
  • This study was conducted from April 1 to September 31, 1973. Ten strains of Fusarium spp. were isolated from the diseased ginseng in two local areas at Kangwha-Gun nad Kumsan-Gun in Korea. Among of them, 2 strains ($G_1$, $G_4$) did not have virulence to ginseng in reinoculation. Their cultural, morphological characteristic and hose virulence to pea seedling were examined. Taxonomical identification of 8 isolates followed by the method of Wollenweber, Snyder nad Toussoun, Booth, Matuo and Snyder. All of eight strains were identified as the Fusarium solani f.sp.pisi(Jones) Synd. et Hans.

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Chronic exposure of nicotine modulate the expressions of cerebellar glial glutamate transporters in rats

  • Lim, Dong-Koo
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.287.1-287.1
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    • 2002
  • To study the expressions of glutamate transporter subtypes in cerebellar astrocytes following the chronic exposure of nicotine from mating, rats were treated with nicotine (25 ppm) from the beginning of mating through drinking water. After delivery. each group was divided into two groups. Groups were exposed to either distilled water or nicotine. From 7 day-old pups at each group. cerebellar astrocytes were prepared. Ten days after culture. the expressions of glutamate transporter subtypes (GLAST and GLT-1) were determined using immunochemistry and immunoblot. (omitted)

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On Estimation of the sentence "Two thirds of them died and seven out of ten died of cold damage" ("기사망자(其死亡者) 삼분유이(三分有二) 상한십거기칠(傷寒十居其七)"에 대한 소고(小考) - 상한(傷寒)에 의한 질환(疾患)-특이(特異) 사망률(死亡率을 중심(中心)으로 -)

  • Eom, Seok-Ki;Kim, Se-Hyun;Eo, Wan-Kyu
    • Journal of Korean Medical classics
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    • v.21 no.4
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    • pp.75-83
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    • 2008
  • Based on the sentence "The number of my family member and relatives reached around 200, but since the first year of Geonan(建安) era, two thirds of them died and seven out of ten died of cold damage in less than ten years" in Sanghanjapbyeongron(Treatise on Cold Damage and Miscellaneous Diseases), which is allegedly known to be written by Jangnunggyeong(張仲景), we analyzed the sentence by three factors of time, location and people. These factors are used in the investigation of the disease outbreak, and through this analysis, following conclusions were made. 1. Approximate 10 year crude mortality rate since A.D 196(the first yea of Geonan era) in Jangsa(長沙) province was 67 out of 100 in the population. Approximate 10 year disease-specific mortality rate of cold damage since A.D 196(the first yea of Geonan era) in Jangsa(長沙) province was 47 out of 100 in the population. Regardless of age, gender or other demographic variables, approximate 10 year proportionate mortality ratio since A.D 196(the first yea of Geonan era) in Jangsa province was 70.2%, which lead to the assumption that 70% of death is cold-damage related. 2. Increased disease-specific mortality rate by cold damage in Jangsa(長沙) province for about 10 years since A.D 196(the first yea of Geonan era), and followed increased crude mortality rate in the population, threatened the stability of nation or local government. This is due to the repeated war in late Han Dynasty with political chaos and repeated flood caused by geographical disadvantage in Jangsa province.

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Effects of an Educational Program for Obesity Improvement by Changing the Living Habits and Improving the Self-esteem of Obese Elementary School Children (초등학교 비만아동의 생활습관 변화와 자아존중감 향상을 통한 비만개선프로그램의 시행효과)

  • Jeong, Woon-Seon;Lee, Hye-Sang;Park, Ung-Im
    • Journal of the Korean Home Economics Association
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    • v.43 no.12 s.214
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    • pp.125-134
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    • 2005
  • This study was conducted to develop a comprehensive program for improving obese children's living habits such as wearing clothing and eating, and their self-esteem. Thirteen obese elementary school children, six boys and seven girls in the 4th to 6th grade, voluntarily participated in a ten-week intervention program. During the program, the obese children filled out a checklist consisted of daily ambient temperature inside the house, weight of clothing, meal diary, time taken for physical exercise, time taken for watching TV, etc. After carrying out the program, its effect was testified and evaluated. Percent body fat of the children measured using a body composition analyzer was reduced by $1.9\%$ after the program (p<.01). Wearing behavior of clothing was positively changed in view of the high correlation between ambient temperature and clothing weight (r=-.917, p<.01). Ability of dietary self control was improved and eating time was lengthened. Self-esteem was improved in global self-worth, athletic competence, and behavior/conduct. It was suggested that active interest of the family would be helpful and that an intervention program over longer than ten week would be necessary to improve childhood obesity.

Growing Three Wild Herbaceous Plants, Allium victorialis var. platyphyllum, Ligularia stenocephala, and Panax ginseng in the Understory of Larix kaempferi Plantation

  • Song, Jae Mo;Yi, Jae-Seon;Cheong, Eun Ju
    • Journal of Korean Society of Forest Science
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    • v.108 no.4
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    • pp.522-530
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    • 2019
  • Two edible plants, Allium victorialis var. platyphyllum and Ligularia stenocephala, and one medicinal plant, Panax ginseng, were cultivated in the understory of an artificial Larix kaempferi plantation for ten years. Growth characteristics (number of leaves and flower stalks per plant, and leaf length and width), survival rate, and yield (fresh weight of plants) per unit area (1 ㎡) were investigated one year after planting, and six and ten years following cultivation. P. ginseng and L. stenocephala survived at a high percentage for two years after planting. Results showed that P. ginseng had longer and thicker roots when aged; however, a large number of plants died and the yield was low. In contrast, almost half of A. victorialis var. platyphyllum died within two years of planting. The surviving plants grew well for ten years and the yield was increased. The leaf length and width of L. stenocephala increased; however, the survival rate and the number of leaves per plant decreased as the period of cultivation was extended. In contrast, A. victorialis var. platyphyllum survived at a lower rate (50%) than the two other crops (98% for L. stenocephala and 83% for P. ginseng) during the early cultivation period, with little change in the survival rate over an extended time; however, the yields increased. This species showed an increase in the number of flower stalks and leaves, and as a result, the larger leaves increased the yield. We evaluated the understory cultivation of three crops in a L. kaempferi plantation under natural conditions, with no irrigation or fertilization, and Allium victorialis var. platyphyllum showed the greatest growth potential among the three tested crops.

Evaluation of Marginal Gap of Fixed Dental Prostheses Fabricated by Soft Metal Material Using Dental CAD/CAM (치과용 캐드캠을 이용하여 연질금속 재료로 제작한 고정성 보철물의 변연 간격 평가)

  • Kim, Jae-Hong;Kim, Won-Soo;Kim, Ki-Baek
    • Journal of dental hygiene science
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    • v.14 no.3
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    • pp.349-355
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    • 2014
  • The purpose of this study was to evaluate marginal gap of fixed dental prostheses (FDPs) fabricated by soft metal material with using dental computer aided design/computer aided manufacturing (CAD/CAM) system and to compare gap of its by a conventional method. Ten same cases of study models were manufactured and scanned for digital models fabricating. Ten FDPs were fabricated by soft metal material using dental CAD/CAM (SMB group). Then, ten FDPs were fabricated by cast metal using lost wax technique and casting method (LWC group). Marginal gap was measured by silicone replica technique. Gap was measured by digital microscope (${\times}160$). Mann-Whitney test for statistical analysis was executed (${\alpha}=0.05$). The mean (standard deviations) of marginal gap was $76.5{\mu}m$ (35.2) for the SMB group, and $82.9{\mu}m$ (22.1) for the LWC group. Statistically significant differences were not found between SMB and LWC. As results, FDPs fabricated by soft metal material were clinically acceptable range.

Long Term Changes of the Amount of Surface Runoff in Forest Fire Area (산불발생지에 있어서 표면유출수량의 장기적인 변화에 관한 연구)

  • Ma, Ho-Seop;Jeong, Won-Ok
    • Journal of Korean Society of Forest Science
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    • v.98 no.4
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    • pp.458-463
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    • 2009
  • The purpose of this study was to evaluate the changes of surface runoff by comparisons between burned and unburned area after forest fire. The amount of surface runoff in burned area was more high 1.72 times in the year of fire, 1.44 times in one year later, 1.38 times in five years later and 1.16 times in ten years later than those of unburned area. Therefore, surface runoff in the burned area almost tended to be stabilized like unburned area ten year later after forest fire. The most affecting factors on the amount of surface runoff in burned and unburned area were number of unit rainfall, number of rainfall accumulated and unit rainfall. But coverage was shown to mitigate the amount of surface runoff in burned and unburned area.

Efficacy of Cyanobacterial Biofertilizer (CBB) on Leaf Yield and Quality of Mulberry and its Impact on Silkworm Cocoon Characters

  • Dasappa D.M. Ram Rao;Ramaswamy S.N.
    • International Journal of Industrial Entomology and Biomaterials
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    • v.13 no.1
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    • pp.15-22
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    • 2006
  • An experiment was conducted to study the efficiency of cyanobacterial biofertilizer (CBB) with chemical (NPK) fertilizer on quantitative and qualitative characters of mulberry variety Kanva-2. Their influences on silkworm growth and cocoon characters were also studied. Ten different CBB and NPK fertilizer treatments were given to 5000 plants of established mulberry garden. Treatments were of four types viz., (i) T1 to T7: single and combination dose of CBB+50% NPK (ii) T8: combination dose of CBB + 25%NPK, (iii) T9: CBB only and (iv) T10: control-l00% NPK. Soil pH decreased and nutrients status increased in CBB (T1- T9) treated plots. Average of ten crops data on quantitative traits revealed that T7 (CBB [N. muscorum (1.0 g), A. variahilis (1.0) and S. millei (1.0 g)] + 50% NPK) was very effective in improving growth parameters. Leaf yield was also found high in treatment T7 (32.12 tons/ha/yr.) followed by T10 (31.17 tons/ha/yr.) and T8 (27.67 tons/ha/yr.). Leaf quality characters were found high in T7 and low in T9. Most of the quality traits in T7 are on par with control no. The results revealed that reduction in the dose of chemical fertilizers in T7 did not affect the leaf yield and leaf quality traits of mulberry. This clearly indicates that the efficiency of CBB (T7) provides nitrogen, increases essential nutrients available in soil, maintain soil pH and supply growth substances required for the improvement of leaf yield and leaf quality of mulberry. Bioassay study also revealed no significant difference in silkworm growth and cocoon characters between treatments T7 and T10. Economics calculated revealed that T7 is highly economical and beneficial over T10 by gaining an amount of Rs. 660/-/acre/crop. Thus, treatment T7 containing N. muscorum (1.0 g), A. variahilis (1.0 g) and S. millei (1.0 g) + 50% NPK fertilizers can be recommended to sericulturists mainly to reduce the use of NPK fertilizers, by saving 50% of its cost and to improve soil fertility conditions, which in turn improves leaf yield and quality of mulberry.