• Journal of Chest Surgery
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• 제51권2호
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• pp.114-121
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• 2018

Background: Unfractionated heparin is commonly used for anticoagulation in extracorporeal membrane oxygenation (ECMO). Several studies have shown that nafamostat mesilate (NM) has comparable clinical outcomes to unfractionated heparin. This study compared anticoagulation with NM and heparin in a large-animal model. Methods: Beagle dogs (n=8; weight, 6.5-9 kg) were placed on venovenous ECMO. Blood samples were taken every hour and the following parameters were compared: hemoglobin level, activated partial thromboplastin time (aPTT), thromboelastography (TEG) data, platelet function, and inflammatory cytokine levels. Results: In both groups, the aPTT was longer than the baseline value. Although the aPTT in the NM group was shorter than in the heparin group, the TEG parameters were similar between the 2 groups. Hemoglobin levels decreased in both groups, but the decrease was less with NM than with heparin (p=0.049). Interleukin $(IL)-1{\beta}$ levels significantly decreased in the NM group (p=0.01), but there was no difference in the levels of tumor necrosis factor alpha or IL-10 between the 2 groups. Conclusion: NM showed a similar anticoagulant effect to that of unfractionated heparin, with fewer bleeding complications. NM also had anti-inflammatory properties during ECMO. Based on this preclinical study, NM may be a good alternative candidate for anticoagulation in ECMO.

• 한국수소및신에너지학회논문집
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• 제31권5호
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• pp.405-410
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• 2020

In this literature, we are introduce a basic design of multi energy hub based on natural gas governor station. Multi energy hub consists of turbo expender generator, phosphoric acid fuel cell, pressure swing adsorption, H₂ charging station, utilities and etc. We design a hybrid energy hub system that provides energy using these complex energies, and calculates the amount of electricity that can be produced and the amount of hydrogen charged through the process analysis. TEG and phosphoric acid fuel cell produce 2,290 to 2,380 kW and can supply electricity to 500 houses. In addition, By-product H₂ gas is refined to H₂ vehicle fuel. This will help maximize the balance of energy demand and supply and improve national energy efficiency by integrating unused decompression energy power generation technology and various power generation/heat source technologies.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권8호
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• pp.3168-3186
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• 2020

Automatic topic essay generation (TEG) is a controllable text generation task that aims to generate informative, diverse, and topic-consistent essays based on multiple topics. To make the generated essays of high quality, a reasonable method should consider both diversity and topic-consistency. Another essential issue is the intrinsic link of the topics, which contributes to making the essays closely surround the semantics of provided topics. However, it remains challenging for TEG to fill the semantic gap between source topic words and target output, and a more powerful model is needed to capture the semantics of given topics. To this end, we propose a pretraining-based contextual self-attention (PC-SAN) model that is built upon the seq2seq framework. For the encoder of our model, we employ a dynamic weight sum of layers from BERT to fully utilize the semantics of topics, which is of great help to fill the gap and improve the quality of the generated essays. In the decoding phase, we also transform the target-side contextual history information into the query layers to alleviate the lack of context in typical self-attention networks (SANs). Experimental results on large-scale paragraph-level Chinese corpora verify that our model is capable of generating diverse, topic-consistent text and essentially makes improvements as compare to strong baselines. Furthermore, extensive analysis validates the effectiveness of contextual embeddings from BERT and contextual history information in SANs.

• 에너지공학
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• 제29권1호
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• pp.75-84
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• 2020

본 연구에서는 간단하면서, 효과적이고, 지속가능성이 높은 3차원 프린터를 활용한 마찰 전기 발전기 제작 방식을 소개하고자 합니다. 본 연구는 매크로 사이즈의 표면 패턴을 생성하는 방식으로써, 새롭게 소개되는 마찰전기 발전기 제작 방식입니다. 모든 실험은 특별히 제작된 test-bed에서 수행되었으며, test-bed는 마찰을 일으키는 무게와 빈도수, 상대 습도 등을 조정할 수 있는 실험 환경입니다. 추가적으로, 본 연구를 통하여 본연구진은 어떠한 공정을 거치지 않은 마찰전기 발전기에 비해 공정을 거친 마찰전기 발전기가 1.6배가량 전압의 성능이 향상된 것을 확인하였습니다. 기존의 마이크로 그리고 나노 사이즈의 패턴들과 비교하여 3차원 프린터를 활용한 본 연구의 방식은 제작이 훨씬 빠르고, 용이하며, 대량 생산에 적합한 방법이 될 수 있습니다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2014년도 추계학술대회
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• pp.577-580
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• 2014

본 논문에서는 자동 스위칭 기능을 갖는 이중 입력 에너지 하베스팅 회로를 제안한다. 열전소자와 진동소자로부터 출력되는 에너지는 최대 가용전력지점이 개방전압의 1/2로 같기 때문에 동일한 MPPT(Maximum Power Point Tracking) 제어회로를 사용할 수 있다. 제안된 회로는 하나의 MPPT 제어회로를 사용하고, 자동 스위칭 기능을 적용하여 열전소자의 출력과 진동소자의 출력을 모니터링하여 전압이 더 큰 소자로부터 최대 가용전력을 수확한다. 수확된 에너지는 전하펌프 회로에 의해 승압된 후 저장 커패시터에 저장되고 PMU(Power Management Unit)를 통해 부하에 공급된다. 제안된 회로는 $0.35{\mu}m$ CMOS 공정으로 설계하였으며, 모의실험을 통해 동작을 검증하였다. 설계된 최초의 칩 면적은 PAD를 포함하여 $1.4mm{\times}1.2mm$이다.

• 한국전기전자재료학회논문지
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• 제36권3호
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• pp.292-297
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• 2023

Triboelectric devices are attracting attention from researchers as self-powered electronic systems that can instantly convert mechanical input into electrical energy output. To improve triboelectric energy harvesting performance, increasing the number of contacts as well as the contact area has been carried out by numerous researchers. In this study, we design a shaker-type energy harvester which is called as maracas triboelectric generator (M-TEG), inspired by the structure of maracas, one of the musical percussion instruments. A tripod frame is inserted to the inside of a cylindrical case, which is a device with the electrodes of aluminum and copper. Then, the triboelectric energy harvesting characteristics between polypropylene (PP) balls and the electrodes are measured. The M-TEG with the frame generates the energy harvesting signals up to ~100 V and ~2.5 ㎂ due to larger contact area and numbers, which enhances the voltage and current output by 250% and 610% compared to that without the frame, respectively. This study presents the feasibility of self-powered sensors and toys using improved triboelectric energy performance with a low-cost and simple manufacturing process in the interesting structure.

• 한국동물위생학회지
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• 제45권1호
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• pp.55-61
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• 2022

In veterinary medicine, a variety of disease are known to cause coagulation abnormalities. Identification of these coagulation abnormalities have been relied on traditional coagulation assays(platelet concentration, aPTT, PT, D-dimer, fibrinogen) which take only a small part of the coagulation pathways rather than global hemostatic capacity. Among of the hypercoagulable diseases, cardiovascular disease, such as mitral valvular disease, was not regarded as the cause of the hypercoagulability. The value of a thromboelastography (TEG) as an early predictor of coagulopathy, especially hypercoagulability, has been founded. It was associated with decreased R and K values, and increased MA and α angle. The objective of this study was to compare thromboelastography results and those of traditional coagulation tests between twenty adult dogs with mitral insufficiency (MVI group) and eleven adult healthy dogs (Healthy group). As a results, MA values in the patients with mitral insufficiency (68.8±7.8 mm) were significantly higher than the normal patients (60.4±4.8 mm) (P value<0.05). Although a little report has been reported in veterinary medicine, platelet activation seems to be related with hypercoagulability in MVI patients in human medicine. The result of this report can support this pathophysiology in veterinary medicine. In addition to traditional coagulation assay, global assessment of coagulopathy using TEG, especially ability to detect hypercoagulability, may be useful for customized treatment in MVI patients. To achieve this, further study is needed to define pathophysiology and effect of medication.

• Restorative Dentistry and Endodontics
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• 제47권4호
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• pp.42.1-42.11
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• 2022

Objective: This study investigated the effects of various concentrations of sodium hypochlorite (NaOCl) on human whole-blood clotting kinetics, the structure of the blood clots formed, and transforming growth factor (TGF)-β1 release. Materials and Methods: Human whole blood was collected from 5 healthy volunteers and divided into 4 groups: CG (control, 0.5 mL of blood), BN_0.5 (0.5 mL of blood with 0.5 mL of 0.5% NaOCl), BN₃ (0.5 mL of blood with 0.5 mL of 3% NaOCl), and BN_5.25 (0.5 mL of blood with 0.5 mL of 5.25% NaOCl). The effects of NaOCl on clotting kinetics, structure of fibrin and cells, and release of TGF-β1 were assessed using thromboelastography (TEG), scanning electron microscopy (SEM), and enzyme-linked immunosobent assay, respectively. Statistical analysis was conducted using the Kruskal Wallis and Mann-Whitney U tests, followed by the post hoc Dunn test. A p value < 0.05 indicated statistical significance. Results: The blood samples in BN_0.5 and BN₃ did not clot, whereas the TEG of BN_5.25 showed altered clot formation. Samples from the CG and BN₃ groups could only be processed with SEM, which showed that the latter lacked fibrin formation and branching of fibers, as well as clumping of red blood cells with surface roughening and distortion. TGF-β1 release was significantly highest in BN₃ when all groups were compared to CG (p < 0.05). Conclusions: Each concentration of NaOCl affected the release of TGF-β1 from blood clots and altered the clotting mechanism of blood by affecting clotting kinetics and cell structure.

• 한국전자통신학회논문지
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• 제19권3호
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• pp.589-602
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• 2024

열전 발전기(TEG)는 일반적으로 열 변환 효율이 높지 않다. 열전 발전기 모듈의 성능은 재료의 특성, 다리의 개수 외에도 다리의 형상에 따라 달라진다. 본 연구에서는 폐열을 효율적으로 수확할 수 있도록 열전소자의 다리 형상을 원통형, 큐브형 등 다양한 기하학적 구조로 모델링하여 전기적 특성을 수치상으로 비교하였다. 다리 형상에 따른 온도분포 및 발전량을 비교하였고 기존 Cube 모양이 가장 높게 나타났다. 냉각효과를 적용한 발전량을 비교한 결과 자연대류에서는 Cone, 강제대류에서는 Hourglass 모양이 가장 높았다. 본 연구 결과에 따르면 기하학적 구조가 열전 발전기의 효율에 영향을 미칠 수 있음을 확인하였다

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1998년도 춘계학술발표회논문집(2)
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• pp.697-702
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• 1998

방사선에 의해 유발되는 난소내 난포의 폐쇄가 apoptosis를 매개로 하여 일어나는지 조사하고자 면역조직화학적 방법을 이용하여 실험을 수행하였다. 미성숙 생쥐 (3주, ICR)에 감마선을 조사하였으며, 조직절편을 제작한 후 TUNEL 방법에 의한 in situ 3'end labelling 면역조직화학 염색을 실시하였다. 전반적인 난소의 상태를 파악하고자, 일반적인 hematoxylin-eosin(HE) 염색을 실시하여 대조하였다. 면역조직화학 염색은 apoptosis가 일어난 난포를 시각적으로 구분해낼 수 있는 효과적인 방법임이 실험적으로 확인되었다. ApopTeg/HE 비율을 볼 때, R군은 6h에서 12h 에 높은 값을 보였고, 8d군에서 다시 증가하는 양상을 보였으며 이같은 결과는 실험동물의 난소내 과립세포의 apoptosis가 방사선 조사후 6시간부터 일어나기 시작하여 점차 증가된다는 사실을 나타낸 것이다. 결론적으로 방사선에 의한 난포의 폐쇄는 과립세포의 apoptosis를 매개로 하여 일어남을 알았다.