• Nuclear Medicine and Molecular Imaging
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• v.40 no.5
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• pp.237-242
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• 2006

Knowledge of molecular mechanisms governing malignant transformation brings new opportunities for therapeutic intervention against cancer using novel approaches. One of them is gene therapy based on the transfer of genetic material to an organism with the aim of correcting a disease. The application of gene therapy to the cancer treatment has led to the development of new experimental approaches such as suicidal gene therapy, inhibition of oncogenes and restoration of tumor-suppressor genes. Suicidal gene therapy is based on the expression in tumor cells of a gene encoding an enzyme that converts a prodrug into a toxic product. Representative suicidal genes are Herpes simplex virus type 1 thymidine kinase (HSV1-tk) and cytosine deaminase (CD). Especially, physicians and scientists of nuclear medicine field take an interest In suicidal gene therapy because they can monitor the location and magnitude, and duration of expression of HSV1-tk and CD by PET scanner.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2002.11a
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• pp.328.2-328
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• 2002

General modeling of a resonant shunting damper has been made Iron piezoelectric sensor/actuator equation. It is found that an additional damping, which is augmented to a system, is generated by the shunt damping effect The transfer function of the tuned electrical absorber is derived for both series and parallel shunt circuit. The governing equations and associated boundary conditions are derived using Hamilton's Principle. The shunt voltage equation is also derived from the charge generated in PZT due to beam vibration. The frequency response function of the obtained mathematical model is compared with that of the tuned eledtrical absorber and experimental work. The vibration amplitude is reduced about 15 dB at targeted second mode frequency.

• Journal of Internet Computing and Services
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• v.21 no.1
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• pp.87-93
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• 2020

The popularity of social media has led to a variety of communicative behaviors among users. This study targeted Facebook as a representative social medial platform because it has the most subscribers in order to investigate factors that influence Facebook usage. In particular, because a person's behavior is based on how they are perceived by others, self-conscious behavior was examined in the study. Facebook usage and news consumption were examined to ascertain the effects of self-consciousness. An online survey was conducted to examine how private SC and public SC (SCs), affects Facebook usage (profiles and writing posts) and news consumption (clicking "like" and sharing news). 616 participants completed the survey, and results indicated that public SC was positively related to the degree of profile updating and post writing. On the other hand, private SC was positively related to the degree of news sharing. These results suggest that psychological elements significantly predict a user's behavior on Facebook.

• The Korean Journal of Food And Nutrition
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• v.24 no.3
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• pp.329-339
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• 2011

The purpose of this study was to compare the effects of service failure magnitude on perceived justice, positive emotion, and revisit intention at restaurants between a collectivist culture(Korea) and an individualistic culture(United States). The results showed that the higher a customer's perception of service failure magnitude, the lower the perceived recovery justices in both cultures. The distributive, procedural, and interactional justices had a favorable effect on positive emotions in both cultures. Other findings revealed that interactional justice was the best predictor of revisit intention in Korea, while distributive justice was the best determinant of revisit intention in the United States. This research suggests that global restaurant managers need to understand how cultural orientation influences consumer perceptions of service failures in order to develop a highly targeted and effective service recovery.

• Korean Journal of Adult Nursing
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• v.24 no.3
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• pp.244-252
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• 2012

Purpose: The purpose of the study was to develop a knowledge scale of risk factors for fall among community-dwelling older adults. Further, the validity and reliability of the scale was developed. Methods: A preliminary scale was developed through content validity by five experts and targeted subjects using the CVI (Content Validity Index). Following the establishment of content validity, the scale was used with 359 community-dwelling older adults to further establish both validity and reliability of the scale. Specifically, construct validity using known-group comparison technique, and reliability using Cronbach's ${\alpha}$ were established. Results: After content validity testing, 44 preliminary items were selected. Construct validity was established by known group-comparison, in which scores between the fall and no fall groups were compared. The Cronbach's ${\alpha}$ of the final scale was .83. Conclusion: Reliability and validity of the scale were confirmed. This tool may be used for measuring knowledge of fall risk factor for the community-dwelling older adults.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.5947-5954
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• 2012

The cancer stem cell (CSC) model states that cancers are organized in cellular hierarchies, which explains the functional heterogeneity often seen in tumors. Like normal tissue stem cells, CSCs are capable of self-renewal, either by symmetric or asymmetric cell division, and have the exclusive ability to reproduce malignant tumors indefinitely. Current systemic cancer therapies frequently fail to eliminate advanced tumors, which may be due to their inability to effectively target CSC populations. It has been shown that embryonic pathways such as Wnt, Hedgehog, and Notch control self-renewal and cell fate decisions of stem cells and progenitor cells. These are evolutionary conserved pathways, involved in CSC maintenance. Targeting these pathways may be effective in eradicating CSCs and preventing chemotherapy or radiotherapy resistance.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3577-3581
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• 2012

Small cell lung cancer (SCLC) is characterized by a short cell doubling time, rapid progression and early occurrence of blood-borne and lymph metastasis. The malignancy is the highest of all lung cancer types. Although SCLC has a relatively good initial response to chemotherapy as well as radiotherapy, relapse or disease progression may occur quickly after the initial treatment. Drug resistance, especially multi-drug resistance, is the most important cause of failure of SCLC chemotherapy. This article provides a brief update of research on mechanisms of drug resistance in SCLC and reversal strategies.

• IEMEK Journal of Embedded Systems and Applications
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• v.4 no.2
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• pp.50-54
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• 2009

In this paper, we address a novel system-level power management technique which is specifically targeted for an ARM 11 MPCore system. Our proposed solution is a DPM technique which includes process monitoring, real time power analysis, and policy application to reduce the power consumption while meeting the performance requirement. One of the main contributions of this paper is that we systematically infer QoS requirements of processes without getting any additional information from the application. When multiple processes are running under various user level policies, priorities of the policy application are determined in such a way that the overall system performance is maintained while power consumption is effectively managed. Experimental results show that our DPM technique is very effective in reducing power consumption without violating system's QoS requirements.

• Journal of IKEEE
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• v.11 no.4
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• pp.358-363
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• 2007

This paper presents a floating point unit(FPU) with 3 stages for a 3D graphics shader engine. It targeted to accelerate 3D graphics in portable device environments. In order to design a balanced architecture for a shader engine, we analyzed shader assembly instructions and estimated the performance of FPU with the method we propose. The proposed unit handles 4-dimensional data through separated two paths that are lead to general operation module and special function module. The proposed FPU is compiled as a form of the cascade FPU with 3 stages to efficiently handle a matrix operation with relatively low hardware overhead. Except some complex instructions that are executed using macro instructions, all instructions complete an operation in a single instruction cycle at 100MHz frequency. A special function module performs all operations in a single clock cycle using the Newton Raphson method with the look-up table.

• Asia-Pacific Journal of Business
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• v.7 no.2
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• pp.61-76
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• 2016

This study aims to establish ways of how languages are used as determination factors for investment decisions among Asian countries where used languages are diversified. According to the analysis result, language segmentation of the investing country increases investment whereas the language segmentation of the invested countries is analyzed as the decreasing factor of investment. Also, it is analyzed that the further the linguistic distance between the investing country and the invested country the more investment increases. In the aspects of approached language distance and investment time selection, along with the increased linguistic distance, the elasticity to foreign direct investment is apprehended to be more flexible than other forms of investment. Such result shows the more segmented the languages of the targeted invested country the more investment cost will increase and therefore the results in linguistic distance can be explained as diversification of the invested country and the result to the forming of bridgehead at the invested area.