• Tuberculosis and Respiratory Diseases
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• 제82권3호
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• pp.179-189
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• 2019

Although recent advances in molecular targeted therapy and immuno-oncology have revolutionized the landscape of lung cancer therapeutics, cytotoxic chemotherapy remains an essential component of lung cancer treatment. Extensive evidence has demonstrated the clinical benefit of chemotherapy, either alone or in combination with other treatment modalities, on survival and quality of life of patients with early and advanced lung cancer. Combinational approaches with other classes of anti-neoplastic agents and new drug-delivery systems have revealed promising data and are areas of active investigation. Chemotherapy is recommended as a standard of care in patients that have progressed after tyrosine kinase inhibitors or immune checkpoint inhibitors. Chemotherapy remains the fundamental means of lung cancer management and keeps expanding its clinical implication. This review will discuss the current position and future role of chemotherapy, and specific consideration for its clinical application in the era of precision medicine.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권2호
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• pp.733-750
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• 2019

Software Defined Networking (SDN) is a new network paradigm, allowing administrators to manage networks through central controllers by separating control plane from data plane. So, one or more controllers must locate outside switches. However, this separation may cause delay problems between controllers and switches. In this paper, we therefore propose a Priority-based Scheduling policy for OpenFlow (PSO) to reduce the delay of some significant traffic. Our PSO is based on packet prioritization mechanisms in both OpenFlow switches and controllers. In addition, we have prototyped and experimented on PSO using a network simulator (ns-3). From the experimental results, PSO has demonstrated low delay for targeted traffic in the out-of-brand control network. The targeted traffic can acquire forwarding rules with lower delay under network congestion in control links (with normalized load > 0.8), comparing to traditional OpenFlow. Furthermore, PSO is helpful in the in-band control network to prioritize OpenFlow messages over data packets.

• International Journal of Computer Science & Network Security
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• 제22권5호
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• pp.255-265
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• 2022

Educational programs for students with intellectual disabilities have undergone drastic changes in pursuit of the general curriculum. Accordingly, teachers in various fields, including mathematics, strive to find effective methods that enhance learning. The objective of this systematic review is to examine the field of teaching mathematics to students with intellectual disabilities to investigate relevant effective teaching strategies and required teaching skills. To achieve this goal, studies published during the period 2018-2021 were reviewed. Findings indicate the inclusion of nine studies that met the inclusion criteria out of 55 studies. The included studies found that the system of least prompts (SLP) in conjunction with feedback and error correction, and schema-based instruction are generally the most effective strategies in teaching mathematical skills to students with intellectual disabilities. Addition is the most targeted skill, followed by subtraction and algebra problem solving. The least targeted skills are multiplication, recognition of geometric shapes, calculating price after discount, rapid recognition of numbers, and rapid problem solving. The paper provides recommendations and suggests venues of future research.

• 대한방사성의약품학회지
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• 제8권2호
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• pp.157-166
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• 2022

Targeted alpha therapy began to be applied to the treatment of late-stage cancer patients because of its dramatic therapeutic efficacy in patients who have no responses with beta-emitting radiopharmaceuticals. However, its strong cytotoxicity may cause side effects due to undesirable uptake in non-target tissues. In order to use alpha-emitting radiopharmaceuticals for early-stage patients as well as late-stage cancer patients, therefore, modifications on their chemical structures are required. In this review, the recent progress in the development of alpha-emitting radiopharmaceuticals is discussed.

• 대한수의학회지
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• 제63권2호
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• pp.8.1-8.3
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• 2023

A 13-year-old neutered male Maltese dog presented to our hospital with lethargy and anorexia. Laboratory abnormalities included severe non-regenerative anemia (hematocrit, 12.9%; reticulocyte count 12.8 K/µL). The cytology of bone marrow revealed erythroid hypercellularity with mild myelofibrosis. Therefore, late-stage precursor-targeted immune-mediated anemia (PIMA) was diagnosed. Multimodal treatment including 2 immunosuppressant drugs (prednisolone and mycophenolate mofetil), antithrombic drug (clopidogrel), and blood transfusion was performed. The dog showed complete remission from PIMA, and the total duration of follow-up was 622 days. This is the first case report of canine PIMA managed successfully with prednisolone and mycophenolate mofetil in Korea.

• Korean Chemical Engineering Research
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• 제61권4호
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• pp.570-575
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• 2023

Targeted anticancer drug delivery systems are needed to enhance therapeutic efficacy by selectively delivering drugs to tumor cells while minimizing off-target effects, improving treatment outcomes and reducing toxicity. In this study, a silica-based nanocarrier capable of targeting drug delivery to cancer cells was developed. First, silica nanoparticles were synthesized by the Stöber method using the surfactant cetyltrimethylammonium bromide (CTAB). Increasing the ratio of EtOH in the solvent produced uniformly spherical silica nanoparticles. Washing the nanoparticles removed unreacted residues, resulting in a non-toxic carrier for drug delivery in cells. Upon surface modification, the pH-responsive polymer, polyethyleneimine (PEI) exhibited slow doxorubicin release at pH 7.4 and accelerated release at pH 5.5. By exploiting this feature, we developed a system capable of targeted drug release in the acidic tumor microenvironment.

• Korean Journal of Radiology
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• 제23권6호
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• pp.625-637
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• 2022

With regard to the indolent clinical characteristics of prostate cancer (PCa), the more selective detection of clinically significant PCa (CSC) has been emphasized in its diagnosis and management. Magnetic resonance imaging (MRI) has advanced technically, and recent international cooperation has provided a standardized imaging and reporting system for prostate MRI. Accordingly, prostate MRI has recently been investigated and utilized as a triage tool before biopsy to guide tissue sampling to increase the detection rate of CSC beyond the staging tool for patients in whom PCa was already confirmed on conventional systematic biopsy. Radiologists must understand the current paradigm shift for better PCa diagnosis and management. This article reviewed the recent literature, demonstrating the diagnostic value of pre-biopsy prostate MRI with targeted biopsy and discussed unsolved issues regarding the paradigm shift in the diagnosis of PCa.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2004년도 추계학술대회 및 총회
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• pp.384.2-384.2
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• 2004

• 한국고분자학회지:고분자과학과기술
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• 제8권5호
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• pp.622-627
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• 1997

• 대한약학회:학술대회논문집
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• 대한약학회 2001년도 Proceedings of the Pharmaceutical Society of Korea
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• pp.230.3-231
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• 2001