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http://dx.doi.org/10.22643/JRMP.2022.8.2.157

Recent Progress in Alpha-emitting Radiopharmaceutical Development for Clinical Application  

Choong Mo Kang (RI Translational Research Team, Division of Applied RI, Korea Institute of Radiological & Medical Sciences)
Yearn Seong Choe (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Publication Information
Journal of Radiopharmaceuticals and Molecular Probes / v.8, no.2, 2022 , pp. 157-166 More about this Journal
Abstract
Targeted alpha therapy began to be applied to the treatment of late-stage cancer patients because of its dramatic therapeutic efficacy in patients who have no responses with beta-emitting radiopharmaceuticals. However, its strong cytotoxicity may cause side effects due to undesirable uptake in non-target tissues. In order to use alpha-emitting radiopharmaceuticals for early-stage patients as well as late-stage cancer patients, therefore, modifications on their chemical structures are required. In this review, the recent progress in the development of alpha-emitting radiopharmaceuticals is discussed.
Keywords
Targeted alpha therapy; Alpha-emitting radiopharmaceuticals; Cancer; Pretargeted radioimmunotherapy; Radioimmunotherapy; Side effect;
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Times Cited By KSCI : 6  (Citation Analysis)
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