• Journal of Information Technology Applications and Management
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• v.12 no.1
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• pp.173-189
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• 2005

The technology acceptance model (TAM) is a lot of cited in information technology adoption and usage researches. TAM has a base in psychological research, is parsimonious, explains usage behavior quite well, and can be operationalized with valid and reliable instruments. But TAM has been conducted primarily in volitional environments of the adoption of new technology. This paper discusses technology acceptance in accounting information systems to examine TAM with subjective norm and perceived behavioral control in mandated using environments. The results show that in mandatory environments such as accounting information systems, subjective norm is not a significant effect on the behavioral intention. Perceived usefulness and perceived behavioral control are significant the factor on the behavioral intention. The implications of finding are that perceived usefulness and perceived behavioral control play major role in technology acceptance rather than subjective norm in accounting information systems with mandatory environments.

• Journal of Digital Convergence
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• v.7 no.3
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• pp.13-24
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• 2009

Technology Acceptance Model (TAM) has been a basis model for testing technology use. Post researches of TAM have been conducted with the updating the TAM by adding new independent variables in order to increase the explanatory power of the model. However, the problem is that different independent variables have to be required to keep the explanatory power whenever adopting particular technology. This might reduce the generality of the research model. Thus in order to increase the generality of the model, this study reviewed the previous researches and collected the independent variables used, and regrouped them into three basic independent constructs. New research model was designed with three basic independent constructs with three constructs selected for the involuntary information technology usage environment. Finally, this study concluded that new technology acceptance model could be used to explain the use of new technology without any adding new particular independent variables.

• Proceedings of the Korea Association of Information Systems Conference
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• 2004.05a
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• pp.304-315
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• 2004

본 연구는 인터넷 환경 하에서 Davis의 기술수용모델(TAM)을 확장한 것이다. 본래의 TAM 모델에서는 인지된 사용용이성(perceived ease of use) 및 인지된 사용편이성(perceived usefulness)이 시스템 사용을 설명할 때 가장 중요한 요인이라고 제안하고 있다. 그러나 TAM 모델은 실제 시스템 사용의 약 $40\%$만 설명하고 있어 이 모델의 확장이 필요한 편이다. 본 연구에서는 기존의 TAM 모델에, Flow 이론에서 언급된 "인지된 즐거움 (perceived enjoyment)" 및 혁신확산이론(IDT)에서 언급된 "일치성(compatibility)"을 추가하여 TAM 모델을 확장하여 사용하였다. 본 연구자가 근무하는 대학의 대학포탈(university portals) 웹사이트를 사용하여 이 모델을 평가하였다.

• Journal of the Korean Data and Information Science Society
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• v.13 no.1
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• pp.87-96
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• 2002

This study is design ed to assess Information Technology (IT) acceptance models among Theory of Planned Behavior (TPB), Technology Acceptance Model (TAM) and the revised TAM using structural equation modeling. Research results show that the revised TAM with perceived ease of use, perceived usefulness and IT usage variables is slightly outperformed TPB and TAM. From a managerial standpoint, the findings of this study reveal that in order to foster IT usage, it is important to encourage a positive perceived ease of use and usefulness.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1998.10a
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• pp.32-35
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• 1998

Technology Acceptance Model (TAM) has been widely used for predicting behavioral processes in which information technologies were accepted, but several previous studies point out that TAM may not explain the adoption process of complex information technologies effectively. This study empirically tests the limitation of TAM, and suggests a proposed research model by incorporating the concept of the perceived behavioral control into TAM. Study findings indicate the proposed model can predict the adoption process better than TAM does.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2003.05a
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• pp.338-341
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• 2003

TIn this study, by formulating input layer, category later, and output layer from data, and in using TAM(Topographic Attentive Mapping) network that created fuzzy rule, it categorized into companies went bankrupt with finances in the black figures, and in the red figures.

• Communications of the Korean Mathematical Society
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• v.37 no.3
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• pp.881-891
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• 2022

In the present paper, we have studied Miao-Tam equation on three dimensional almost coKähler manifolds. We have also proved that there does not exist non-trivial solution of Miao-Tam equation on the said manifolds if the dimension is greater than three. Also we give an example to verify the deduced results.

• Journal of Life Science
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• v.17 no.8 s.88
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• pp.1053-1062
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• 2007

In the present work, we show that tamoxifen(Tam)-induced cytotoxicity is due to the mitochondrial-dependent pathway triggered by the intracellular $Ca^{2+}$ increase in MCF-7 human breast cancer cells. Tam induced the intracellular $Ca^{2+}$ increase. According to the experimental results with $Ca^{2+}$ channel blockers, Tam-induced $Ca^{2+}$ uptake seemed to depend on the voltage-sensitive $Ca^{2+}$ channel at the early stage, but at later stages the intracellular $Ca^{2+}$ increases are more likely due partly to the release of stored $Ca^{2+}$ and partly to the capacitative $Ca^{2+}$ or other entry pathways. Tam-induced $Ca^{2+}$ increase led to the release of cytochrome c from mitochondria into the cytosol and the change of mitochondrial membrane potential. In MCF-7 cells, caspase-7 plays a key role in the downstream of apoptosis because caspase-3 is absent. In the cells treated with Tam, caspase-7 cleavage was increased almost two-fold. There was no marked alteration in the level of anti-apoptotic Bcl-2 protein; however, the cells showed increased expression of pro-apoptotic Bax protein more than two-fold in response to Tam. These results imply that the apoptotic signaling pathway activated by Tam is likely to be mediated via the mitochondrial-dependent pathway.

• Asia pacific journal of information systems
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• v.10 no.2
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• pp.1-22
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• 2000

This paper presents an exploratory research on the application of the Technology Acceptance Model(TAM) to the domain of object orientation to investigate the validity of TAM in the perspective of its causal relationships. In the Management Information Systems(MIS) area, TAM has been applied to computer usage behavior as a specific technology adoption model. This paper also suggests the factors that affect the technology acceptance of object orientation in U.S. organizations through a modified TAM. Two major research questions are addressed. First, this research investigates the effect of these external variables on the dependent variable, the actual usage of object orientation in the viewpoint of knowledge interaction between structured methods and object orientation. Second, is TAM valid for the technology acceptance of object orientation in terms of its causal relationships? This study empirically explores the impact of the external variables on the level of actual usage of object orientation via the mediating variables in TAM. A structured questionnaire is administered to Data Processing Management Association(DPMA) professionals in US. The result of this study reveals one important contradictory finding that is not consistent with expectations based on related theory. TAM does not accommodate the technology acceptance of object orientation perhaps because object orientation is a complex and organization-level adoptive technology or the measures for the mediating constructs in TAM may not be appropriate in industry settings.

• BMB Reports
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• v.51 no.9
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• pp.450-455
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• 2018

Tamoxifen (TAM) is commonly used to treat estrogen receptor (ER)-positive breast cancer. Despite the remarkable benefits, resistance to TAM presents a serious therapeutic challenge. Since several HOX transcription factors have been proposed as strong candidates in the development of resistance to TAM therapy in breast cancer, we generated an in vitro model of acquired TAM resistance using ER-positive MCF7 breast cancer cells (MCF7-TAMR), and analyzed the expression pattern and epigenetic states of HOX genes. HOXB cluster genes were uniquely up-regulated in MCF7-TAMR cells. Survival analysis of in slico data showed the correlation of high expression of HOXB genes with poor response to TAM in ER-positive breast cancer patients treated with TAM. Gain- and loss-of-function experiments showed that the overexpression of multi HOXB genes in MCF7 renders cancer cells more resistant to TAM, whereas the knockdown restores TAM sensitivity. Furthermore, activation of HOXB genes in MCF7-TAMR was associated with histone modifications, particularly the gain of H3K9ac. These findings imply that the activation of HOXB genes mediate the development of TAM resistance, and represent a target for development of new strategies to prevent or reverse TAM resistance.