• Journal of Information Technology Applications and Management
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• 제12권1호
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• pp.173-189
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• 2005

The technology acceptance model (TAM) is a lot of cited in information technology adoption and usage researches. TAM has a base in psychological research, is parsimonious, explains usage behavior quite well, and can be operationalized with valid and reliable instruments. But TAM has been conducted primarily in volitional environments of the adoption of new technology. This paper discusses technology acceptance in accounting information systems to examine TAM with subjective norm and perceived behavioral control in mandated using environments. The results show that in mandatory environments such as accounting information systems, subjective norm is not a significant effect on the behavioral intention. Perceived usefulness and perceived behavioral control are significant the factor on the behavioral intention. The implications of finding are that perceived usefulness and perceived behavioral control play major role in technology acceptance rather than subjective norm in accounting information systems with mandatory environments.

• 디지털융복합연구
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• 제7권3호
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• pp.13-24
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• 2009

Technology Acceptance Model (TAM) has been a basis model for testing technology use. Post researches of TAM have been conducted with the updating the TAM by adding new independent variables in order to increase the explanatory power of the model. However, the problem is that different independent variables have to be required to keep the explanatory power whenever adopting particular technology. This might reduce the generality of the research model. Thus in order to increase the generality of the model, this study reviewed the previous researches and collected the independent variables used, and regrouped them into three basic independent constructs. New research model was designed with three basic independent constructs with three constructs selected for the involuntary information technology usage environment. Finally, this study concluded that new technology acceptance model could be used to explain the use of new technology without any adding new particular independent variables.

• 한국정보시스템학회:학술대회논문집
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• 한국정보시스템학회 2004년도 춘계학술대회
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• pp.304-315
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• 2004

본 연구는 인터넷 환경 하에서 Davis의 기술수용모델(TAM)을 확장한 것이다. 본래의 TAM 모델에서는 인지된 사용용이성(perceived ease of use) 및 인지된 사용편이성(perceived usefulness)이 시스템 사용을 설명할 때 가장 중요한 요인이라고 제안하고 있다. 그러나 TAM 모델은 실제 시스템 사용의 약 $40\%$만 설명하고 있어 이 모델의 확장이 필요한 편이다. 본 연구에서는 기존의 TAM 모델에, Flow 이론에서 언급된 "인지된 즐거움 (perceived enjoyment)" 및 혁신확산이론(IDT)에서 언급된 "일치성(compatibility)"을 추가하여 TAM 모델을 확장하여 사용하였다. 본 연구자가 근무하는 대학의 대학포탈(university portals) 웹사이트를 사용하여 이 모델을 평가하였다.

• Journal of the Korean Data and Information Science Society
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• 제13권1호
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• pp.87-96
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• 2002

This study is design ed to assess Information Technology (IT) acceptance models among Theory of Planned Behavior (TPB), Technology Acceptance Model (TAM) and the revised TAM using structural equation modeling. Research results show that the revised TAM with perceived ease of use, perceived usefulness and IT usage variables is slightly outperformed TPB and TAM. From a managerial standpoint, the findings of this study reveal that in order to foster IT usage, it is important to encourage a positive perceived ease of use and usefulness.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 1998년도 추계학술대회 논문집
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• pp.32-35
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• 1998

Technology Acceptance Model (TAM) has been widely used for predicting behavioral processes in which information technologies were accepted, but several previous studies point out that TAM may not explain the adoption process of complex information technologies effectively. This study empirically tests the limitation of TAM, and suggests a proposed research model by incorporating the concept of the perceived behavioral control into TAM. Study findings indicate the proposed model can predict the adoption process better than TAM does.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2003년도 춘계 학술대회 학술발표 논문집
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• pp.338-341
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• 2003

본 논문에서는 데이터에서 입력층, 카테고리층, 출력층을 형성하고 퍼지룰을 생성해 내는 TAM 네트워크를 이용하여, 부도난 중소기업중에서도 흑자도산기업과 적자도산기업으로 분류하고, 각각에 대한 패턴을 분석하였다.

• 대한수학회논문집
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• 제37권3호
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• pp.881-891
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• 2022

In the present paper, we have studied Miao-Tam equation on three dimensional almost coKähler manifolds. We have also proved that there does not exist non-trivial solution of Miao-Tam equation on the said manifolds if the dimension is greater than three. Also we give an example to verify the deduced results.

• 생명과학회지
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• 제17권8호통권88호
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• pp.1053-1062
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• 2007

유방암 치료제로 사용되는 탐옥시펜 (Tam)은 MCF-7 세포주에서 세포증식을 억제하며 세포사멸을 유도한다. 본 연구에서는 Tam의 세포독성 효과가 세포 내 칼슘이온 농도 증가에 따른 미토콘드리아-의존 기작에 의하여 일어난다는 것을 보여준다. Tam에 의해 유도된 세포 내 칼슘이온 농도 증가는 주로 외부로부터의 칼슘 유입에 의한 것으로 생각된다. 칼슘 채널 억제제를 이용한 실험 결과에 의하며, 칼슘 증가 초기 단계는 주로 전압의존 칼슘채널에 의한 것이며 후기에는 세포 내 저장된 칼슘의 유출, 혹은 다른 방법에 의한 칼슘 유입으로 생각된다. Tam에 의한 세포 내 칼슘 증가는 미토콘드리아로부터의 cytochrome c 방출과 미토콘드리아막의 탈분극에 의한 membrane potential 변화를 초래하였다. 세포사멸에 주도적인 역할을 하는 caspase의 확인에 있어서는, MCF-7 세포는 caspase-3이 결핍되어서 caspase-7이 중심적인 역할을 하는 것으로 이미 알려져 있다. 본 연구에서 확인한 결과 Tam 처리시 caspase-7이 활성화되었으며, 또한 세포사멸 조절 단백질인 Bcl-2 종류 단백질들의 발현을 조사 한 결과 세포사멸 억제 단백질인 Bcl-2의 발현에는 변화가 없었으나 촉진단백질인 Bax는 Tam 처리시 단백질 양이 2배로 증가되었다. 이상의 결과에 의하면, Tam에 의해 유도되는 세포사멸과정은 세포질 내 칼슘이온 농도증가에 의한 미토콘드리아의 변화가 주도적인 역할을 하는 것으로 생각된다.

• Asia pacific journal of information systems
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• 제10권2호
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• pp.1-22
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• 2000

This paper presents an exploratory research on the application of the Technology Acceptance Model(TAM) to the domain of object orientation to investigate the validity of TAM in the perspective of its causal relationships. In the Management Information Systems(MIS) area, TAM has been applied to computer usage behavior as a specific technology adoption model. This paper also suggests the factors that affect the technology acceptance of object orientation in U.S. organizations through a modified TAM. Two major research questions are addressed. First, this research investigates the effect of these external variables on the dependent variable, the actual usage of object orientation in the viewpoint of knowledge interaction between structured methods and object orientation. Second, is TAM valid for the technology acceptance of object orientation in terms of its causal relationships? This study empirically explores the impact of the external variables on the level of actual usage of object orientation via the mediating variables in TAM. A structured questionnaire is administered to Data Processing Management Association(DPMA) professionals in US. The result of this study reveals one important contradictory finding that is not consistent with expectations based on related theory. TAM does not accommodate the technology acceptance of object orientation perhaps because object orientation is a complex and organization-level adoptive technology or the measures for the mediating constructs in TAM may not be appropriate in industry settings.

• BMB Reports
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• 제51권9호
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• pp.450-455
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• 2018

Tamoxifen (TAM) is commonly used to treat estrogen receptor (ER)-positive breast cancer. Despite the remarkable benefits, resistance to TAM presents a serious therapeutic challenge. Since several HOX transcription factors have been proposed as strong candidates in the development of resistance to TAM therapy in breast cancer, we generated an in vitro model of acquired TAM resistance using ER-positive MCF7 breast cancer cells (MCF7-TAMR), and analyzed the expression pattern and epigenetic states of HOX genes. HOXB cluster genes were uniquely up-regulated in MCF7-TAMR cells. Survival analysis of in slico data showed the correlation of high expression of HOXB genes with poor response to TAM in ER-positive breast cancer patients treated with TAM. Gain- and loss-of-function experiments showed that the overexpression of multi HOXB genes in MCF7 renders cancer cells more resistant to TAM, whereas the knockdown restores TAM sensitivity. Furthermore, activation of HOXB genes in MCF7-TAMR was associated with histone modifications, particularly the gain of H3K9ac. These findings imply that the activation of HOXB genes mediate the development of TAM resistance, and represent a target for development of new strategies to prevent or reverse TAM resistance.