• Journal of Periodontal and Implant Science
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• v.48 no.6
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• pp.347-359
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• 2018

Purpose: Periodontitis and rheumatoid arthritis (RA) share a similar inflammatory pathogenesis. Porphyromonas gingivalis (Pg) can induce anticyclic-citrullinated peptide autoantibodies (anti-CCP antibodies), a key factor in the development of RA. This study aimed at evaluating the relationships between the 2 diseases and identifying the clinical implications thereof, with a focus on periodontal pathogens in Korean adults. Methods: A total of 260 RA patients and 86 age- and sex-matched control patients without arthritis were enrolled in this prospective cross-sectional study. Periodontal indices and the prevalence and amount of periodontal pathogens were compared between the groups. Correlations between periodontal and RA indices were examined, as were correlations between 9 periodontal pathogens and RA indices. Results: The RA group had significantly higher values than the control group for all investigated periodontal indices (P<0.05) except the number of teeth. The gingival index (GI) was correlated with the disease activity score 28 (DAS28) (r=0.125, P=0.049), RA disease duration (r=0.253, P<0.001), erythrocyte sedimentation rate (ESR) (r=0.162, P=0.010), and anti-CCP antibody titer (r=0.205, P=0.004). Probing pocket depth (PPD) was correlated with ESR (r=0.139, P=0.027) and anti-Pg antibody titer (r=0.203, P=0.001). Bleeding on probing (BOP) was correlated with DAS28 (r=0.137, P=0.030), RA disease duration (r=0.202, P=0.001), ESR (r=0.136, P=0.030), anti-Pg antibody titer (r=0.177, P=0.005), and anti-CCP antibody titer (r=0.188, P=0.007). Clinical attachment level (CAL) and periodontitis severity were correlated with anti-Pg antibody titer (the former r=0.201, P=0.002; the latter r=0.175, P=0.006). The quantity of Pg was positively correlated with the serum anti-Pg antibody titer (r=0.148, P=0.020). Conclusions: The GI, BOP, and PPD showed positive relationships with several RA indices. The anti-Pg antibody titer had positive relationships with PPD, BOP, CAL, and periodontitis severity. Thus, increasing values of periodontal indices could be used as a risk indicator of disease development in RA patients, and an increasing anti-Pg antibody titer could be considered as a warning sign in RA patients suffering with periodontitis.

• The Journal of Korean Medicine
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• v.25 no.2
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• pp.207-219
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• 2004

Objectives : We investigated to find the relationship between single-nucleotide polymorphism (SNP) of IL4R, IL-10 and bee venom therapy efficacy in patients with RA treated with bee venom for 8 weeks. Methods : Korean RA patients (n=114) and healthy subjects (n=109) were included in this prospective study. Korean bee venom was dissolved in saline (diluted 1:3000) and administrated into acupuncture points. Bee venom therapy was applied twice a week and continued for 8 weeks. The clinical response was evaluated using various assessments before and after treatment. Disease severity was measured by determining the number of tender joints and swollen joints. Laboratory studies included ESR, CRP, and rheumatoid factor. Genotyping for IL-4R and IL-10 polymorphism was done by pyrosequencing analysis. Results : 1. In IL4R genotypes, there was significant difference between RA ptitients tind controls group. 2. In IL4R genotypes, there was significant difference among Good, Mild and Bad responders to in RA patients, but in the frequency of alleles and carriers, there were no significant difference. 3. There was no significant difference between RA patients and controls group in IL-10 gene genotypes. 4. In IL-10 genotypes, there was no significant difference among Good, Mild and Bad responders to in RA patients. 5. There was no significant difference in the improvement of ESR, CRP and KHAQ scores after bee venom therapy in RA patients among the IL4R or IL-10 genotypes. Conclusions : In IL-4R genotypes, there was significant difference between RA patients and control group, and among Good, Mild and Bad responders in RA patients. However, in IL-10 genotypes, there was no significant difference between RA patients and controls group and among Good, Mild and Bad responders in RA patients.

• Tuberculosis and Respiratory Diseases
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• v.63 no.2
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• pp.145-153
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• 2007

Background: Asthma is a syndrome that is characterized by a variable degree of airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Colchicine is an inexpensive and safe medication with unique anti-inflammatory properties. IL-1Ra (Interleukin-1 receptor antagonist) mediates the anti-inflammatory effect in human inflammatory diseases, including asthma. This study examined whether IL-1Ra mediates the anti-inflammatory effect of colchicine in normal human bronchial epithelial cells (NHBE), RAW 264.7 cells (murine macrophage cell line), and a mouse lung. Methods: NHBE, RAW 264.7 cells and BALB/c mice were stimulated with colchicine, and the increase in the IL-1Ra level was estimated by ELISA, Western analysis and RT-PCR analysis. Results: Colchicine stimulated NHBE and RAW 264.7 cells to release IL-1Ra into the supernatant in a dose-and time-dependent manner. The major isoform of IL-1Ra in NHBE and RAW 264.7 cells is type I icIL-1Ra, and sIL-1Ra, respectively. IL-1Ra up-regulation was blocked by PD98059, a specific inhibitor in MAPK pathways. Colchicine also stimulated the secretion of IL-1Ra into the bronchoalveolar lavage (BAL) fluid of BALB/c mouse. Conclusion: Colchicine stimulates an increase in the IL-1Ra level both in vivo and in vitro, and might have an anti-inflammatory effect.

• Biomolecules & Therapeutics
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• v.25 no.2
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• pp.105-111
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• 2017

It has been known that RA, one of major constituents of Perilla frutescens which has been used as a traditional folk remedy for sedation in oriental countries, shows the anxiolytic-like and sedative effects. This study was performed to know whether RA may enhance pentobarbital-induced sleep through ${\gamma}-aminobutyric$ acid $(GABA)_A-ergic$ systems in rodents. RA (0.5, 1.0 and 2.0 mg/kg, p.o.) reduced the locomotor activity in mice. RA decreased sleep latency and increased the total sleep time in pentobarbital (42 mg/kg, i.p.)-induced sleeping mice. RA also increased sleeping time and number of falling sleep mice after treatment with sub-hypnotic pentobarbital (28 mg/kg, i.p.). In electroencephalogram (EEG) recording, RA (2.0 mg/kg) not only decreased the counts of sleep/wake cycles and REM sleep, but also increased the total and NREM sleep in rats. The power density of NREM sleep showed the increase in ${\delta}-waves$ and the decrease in ${\alpha}-waves$. On the other hand, RA (0.1, 1.0 and $10{\mu}g/ml$) increased intracellular $Cl^-$ influx in the primary cultured hypothalamic cells of rats. RA (p.o.) increased the protein expression of glutamic acid decarboxylase ($GAD_{65/67}$) and $GABA_A$ receptors subunits except ${\beta}1$ subunit. In conclusion, RA augmented pentobarbital-induced sleeping behaviors through $GABA_A-ergic$ transmission. Thus, it is suggested that RA may be useful for the treatment of insomnia.

• Resources Recycling
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• v.16 no.2 s.76
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• pp.17-22
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• 2007

The report of an investigation into the performance of mortar specimens made with recycled fine aggregate (RA) exposed to sodium sulfate solution for 360 days is presented in this paper. Mechanical properties of mortar specimens such as visual examination, compressive strength, expansion and mass loss were periodically monitored. From the test results, it was found that mortar specimens with higher replacement levels of Rh exhibited poor performance in sodium sulfate solution. However, compared to mortar specimens without RA, those with lower replacement levels of RA (up to 50% by mass) was more resistant to sulfate attack. Through the x-ray diffraction analysis, it was confirmed that the main products causing sulfate deterioration in RA mortar specimens were the formation of gypsum and thaumasite.

• Information and Communications Magazine
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• v.34 no.2
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• pp.3-5
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• 2017

• Journal of the Korean Society of Physical Medicine
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• v.11 no.3
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• pp.97-104
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• 2016

PURPOSE: Bridge exercise is widely used in rehabilitation exercise for trunk stabilization through various applications in clinical practice. However, there is a lack of studies changing the base of support for the shoulders. The purpose of this study is to investigate the changes in the base of support for the shoulders of trunk muscle activation during bridge exercise. METHODS: 20 healthy subjects (10 men, 10 women) in their twenties were participated in this study. They performed 5 bridge exercises (bridge exercise with their shoulders on a stable table (1/2 knee height, knee height), and on a sling (1/2 knee height, knee height), conventional bridge exercise. The surface electromyography were used for rectus abdominis (RA), internal oblique (IO), external oblique (EO), and erector spinae (ES). RESULTS: During bridge exercise that their shoulders on the sling of 1/2 knee height, the RA, EO, IO muscle activities were significant increased. And during bridge exercise that their shoulders on the stable surface of knee height, the IO/RA ratio were higher than other positions but there were no significant difference between positions for EO/RA, IO/RA ratio. CONCLUSION: Based on this result, using various bases of support and changing the height of bridging exercise may be used to provide effective trunk stabilization exercises.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.5
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• pp.275-281
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• 2018

Along with the growing market for pets and the increasing interest in pet management, the need for pet management systems is increasing. Development of IoT-related technologies has made it possible to develop the related systems. This paper implements a variety of functions through Bluetooth 4.0 and LoRa communication between devices using Arduino and Android applications depending on distances. In the paper, users can receive real-time location information through the communication between Android applications and devices attached to pets, store pet information, manage pet information, and store stroll courses more conveniently with the developed system.

• Journal of Radiation Protection and Research
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• v.9 no.1
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• pp.11-18
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• 1984

A Standard gamma-ray ionization chamber system was developed with a well type ionization chamber and micro current measuring circuit. Micro current was measured by the automatic Townsend balance with stepwise compensation method. For gamma emitting nuclides such as $^{241}Am,\;^{133}Ba,\;^{60}Co,\;^{134}Cs,\;^{137}Cs,\;and\;^{22}Na$ relative calibration factors to $^{226}Ra$ reference source were calculated and detection .efficiency curve was determined as a fudnction of gamma energy.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05a
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• pp.124-124
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• 2002

In order to determine the effect of the DNA repair inhibitors, cytosine arabinoside(Ara C)and 3-aminobenzamide(3AB) on the frequenceis of chromosomal aberrations and micronuclei induced by radiation. After in vitro exposure of human lymphocytes to x-ray(1-3Gy) DNA repair inhibitors, Ara C and 3AB were treated and the frequencies of micronuclei, translocation and dicentric chromosomes were analysed using FISH technique with DNA probe for chromosome 4.(omitted)