• Annals of Pediatric Endocrinology and Metabolism
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• 제22권1호
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• pp.15-26
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• 2017

The prevalence of type 2 diabetes (T2D) is increasing worldwide. Patients with T2D suffer from various diabetes-related complications. Since there are many patients with T2D that cannot be controlled by previously developed drugs, it has been necessary to develop new drugs, one of which is a glucagon-like peptide-1 (GLP-1) based therapy. GLP-1 has been shown to ameliorate diabetes-related conditions by augmenting pancreatic ${\beta}-cell$ insulin secretion and having the low risk of causing hypoglycemia. Because of a very short half-life of GLP-1, many researches have been focused on the development of GLP-1 receptor (GLP-1R) agonists with long half-lives such as exenatide and dulaglutide. Now GLP-1R agonists have a variety of dosing-cycle forms to meet the needs of various patients. In this article, we review the physiological features of GLP-1, the effects of GLP-1 on T2D, the features of several GLP-1R agonists, and the therapeutic effect on T2D.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.615-618
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• 2016

Ethyl acetate extracts obtained from culture of endophytic fungi Aspergillus sp isolated from Piper crocatum Ruiz & Pav, have been shown to possess cytotoxic activity against T47D breast cancer cells. Investigations were here conducted to determine bioactive compounds responsible for the activity. Bioassay guided fractionation was employed to obtain active compounds. Structure elucidation was performed based on analysis of LC-MS, $^1H$-NMR, $^{13}C$-NMR, COSY, DEPT, HMQC, HMBC data. Cytotoxity assays were conducted in 96 well plates against T47D and Vero cell lines. Bioassay guided isolation and chemical investigation led to the isolation of pyrophen, a 4-methoxy-6-(1'-acetamido-2'-phenylethyl)-2H-pyran-2-one. Further analysis of its activity against T47D and Vero cells showed an ability to inhibit the growth of T47D cells with IC50 values of $9.2{\mu}g/mL$ but less cytotoxicity to Vero cells with an $IC_{50}$ of $109{\mu}g/mL$. This compound at a concentration of 400 ng/mL induced S-phase arrest in T47D cells.

• 한국정보통신학회논문지
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• 제17권5호
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• pp.1138-1144
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• 2013

최대주기를 갖는 수열들의 상호상관함수에 대한 연구는 수십년간 이루어져 왔다. 본 논문에서는 n=2m을 만족하고 최대주기 $2^n-1$을 가지면서 Niho type의 데시메이션 $d=2^{m-2}(2^m+3)$에 대하여 비선형수열$S_a^r(t)=Tr_1^m\{[Tr_m^n(a{\alpha}^t+{\alpha}^{dt})]^r\}$의 상호상관함수 값을 구한다. 특히, $d{\equiv}1(mod\;2^m-1)$을 만족하는 d를 Niho type의 데시메이션 이라고 한다. 그리고 위상이동차 ${\tau}=(2^m+1)k(0{\leq}k{\leq}2^m-2)$인 경우에 대하여 $S_a^r(t)$의 상호상관함수 값의 분포를 분석하고 실험 결과를 제시한다.

• KSBB Journal
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• 제14권2호
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• pp.235-240
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• 1999

Trigonopsis variabilis ATCC10679 (TW)의 변이균주를 선별하기 위하여 쉽고 간편한 균주 선별방법을 개발하였다. 변이 균주(T26)의 D-Amino acid oxidase (D-AAO)는 야생균주(TW)의 D-AAO 효소보다 cephalosporin C에 대한 기질특이성이 약 30% 높았다. 이들 두 균주에서 D-AAO 유전자를 클로닝하여 각 유전자를 비교해본 결과 811번 우치의 T가 C로 변경되었으며 이에 따른 아미노산은 Phe-258이 Ser-258로 바뀌었다.

• 한국의류학회지
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• 제25권5호
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• pp.925-932
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• 2001

The influence of ultraviolet(UV)-ray in sun light on human skin has been noted. Textiles can provide protection against harmful UV-radiation. Normally UV-absorbing finishes are used to get better protection. The purpose of this study is to evaluate the UV-cut properties of cotton fabrics treated with UV-absorber. 2,2-dihydroxy-4,4-dimethoxbenzophenone, as UV-absorber was applied to 100% cotton fabric. Reagents added in finishing solution were Triton X-100, polyethylene glycol 400, and $MgCl_2{\cdot}6H_2O$, and C.I. Direct Red 81. Both untreated and treated cotton fabrics were exposed to a xenon arc lamp for 20 and 80 hours. UV absorption spectra of finishing solutions and UV transmission spectra of fabrics were measured by the UV/VIS spectrophotometer. The results of this study can be summarized as follows. The results of this study can be summarized as follows. Absorption and the related transmission spectra were modified in a controlled way with UV-absorber. Absorption effect of UV-absorber was improved by adding Triton X-100, PEG 400, and $MgCl_2{\cdot}6H_2O$ in finishing solution. The UV absorption of finishing solution was in the following order: U/D/T/P/M>D/T/P/M> D/T> D/P, D>U/T/P/M>U/T>T/P/M>T. The UV transmittance of cotton fabrics was remarkably decreased by the application of UV-absorber and additives. The UV-cut properties were most improved by the application of U/D/T/P/M.

• 대한수학회보
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• 제43권1호
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• pp.125-140
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• 2006

Let $g(n,\;l_1,\;l_2,\;d,\;t,\;q)$ be the number of general4-regular graphs on n labelled vertices with $l_1+2l_2$ loops, d double edges, t triple edges and q quartet edges. We use inclusion and exclusion with five types of properties to determine the asymptotic behavior of $g(n,\;l_1,\;l_2,\;d,\;t,\;q)$ and hence that of g(2n), the total number of general 4-regular graphs where $l_1,\;l_2,\;d,\;t\;and\;q\;=\;o(\sqrt{n})$, respectively. We show that almost all general 4-regular graphs are 2-connected. Moreover, we determine the asymptotic numbers of general 4-regular graphs with given connectivities.

• 대한소아치과학회지
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• 제11권1호
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• pp.181-189
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• 1984

1,840 school children aged 6 to 13 years who live in inland area in CHOONG CHUNG BUK DO were surveyed epidemiologically on the dental caries prevalence. The results were as follows; 1. The prevalence of dental carries was 76.35 percentage in male, 76.15 percentage in female, and 76.25 percentage in both sexes. 2. d.m.f rate was 77.72 percentage in male, 80.07 percentage in female, and 78.86 percentage in both sexes. D.M.F rate was 30.73 percentage in male, 38.52 percentage in female, and 34.51 percentage in both sexes. 3. d.m.f.t. rate and index was 27.94 percentage,2.55T, and d.m.f.s. rate & index was 13.62 percentage, 6.22T. 4. D.M.F.T rate & index in permanent teeth was 4.86 percentage,0.72T, and D.M.F.S. rate & index was 1.20 percentage,0.89T. 5. The filling rate was 3.90 percentage in decidious teeth, 2,00 percentage in permanent teeth.

• 대한수학회지
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• 제56권5호
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• pp.1355-1370
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• 2019

A curve $X{\subset}\mathbb{P}^r$ has maximal rank if for each $t{\in}\mathbb{N}$ the restriction map $H^0(\mathcal{O}_{\mathbb{P}r}(t)){\rightarrow}H^0(\mathcal{O}_X(t))$ is either injective or surjective. We show that for all integers $d{\geq}r+1$ there are maximal rank, but not arithmetically Cohen-Macaulay, smooth curves $X{\subset}\mathbb{P}^r$ with degree d and genus roughly $d^2/2r$, contrary to the case r = 3, where it was proved that their genus growths at most like $d^{3/2}$ (A. Dolcetti). Nevertheless there is a sector of large genera g, roughly between $d^2/(2r+2)$ and $d^2/2r$, where we prove the existence of smooth curves (even aCM ones) with degree d and genus g, but the only integral and non-degenerate maximal rank curves with degree d and arithmetic genus g are the aCM ones. For some (d, g, r) with high g we prove the existence of reducible non-degenerate maximal rank and non aCM curves $X{\subset}\mathbb{P}^r$ with degree d and arithmetic genus g, while (d, g, r) is not realized by non-degenerate maximal rank and non aCM integral curves.

• 한국가금학회지
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• 제2권1호
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• pp.7-15
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• 1975

5주령시 병아리에 대하여 볶은 콩을 이용한 고열량 사료 1030Cal구 ($T_2$ 구)를 만들고 이를 830Cal의 관용사료구(C구)와 5주간 비교시험 한 결과 다음과 같은 성적을 얻었다. 1) 증체량에 있어서 $T_1$, $T_2$구는 C구에 비하여 증체량이 높으며 5%수준의 유의차가 있었다. 한편 L.S.D.-Test에 의하면 $T_1$과 C구 사이에만 5%의 유의차를 보였다. 2) 사료섭취량에 있어서는 $T_2$, $T_1$, C구의 순으로 사료를 절약할 수 있는데 L.S.D.-Test에 의하면 $T_2$구와 C구간에 1%의 유의차가 있으며 약 9%의 사료가 절약되었고 $T_1$구와 C구간에는 5%의 유의성이 있고 약 3%의 사료가 절약되었다. 3) 경제성에 있어서 추일수당 사료비는 $T_1$, $T_2$구 모두 C구보다 고가의 경향이 있어 볶은 콩의 실용가치를 감소시킨다. 그러나 육계 판매가격에 있어서 $T_1$구는 24.85원의 이익으로 C구 26.43원보다 하회하는 결과를 보인다. (중략)

• 전자공학회논문지
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• 제52권2호
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• pp.182-192
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• 2015

본 논문에서는 GBCA(Gadolinium Based Contrast Agent)를 이용한 MRI 검사 시 다양한 MR 시퀀스에 따른 GBCA 몰농도별 조영증강 변화를 알아보기 위해 자체 제작한 MR 팬텀을 사용하여 정량적으로 평가 분석하고자 하였다. MR 팬텀을 제작하기 위해 28개의 용기에 500 mmol Gadoteridol을 saline과 혼합하여 각각 500 부터 0 mmol 까지 몰농도를 서로 다르게 하였다. 제작된 MR phantom을 1.5T MRI 장비에서 물리학적 기전이 서로 다른 T1 SE, T2 FLAIR, T1 FLAIR, 3D FLASH, T1 3D SPACE, 3D SPCIR 시퀀스로 스캔하여 신호강도 변화를 측정 한 후 비교 분석 하였다. T1 Spin echo는 Total SI(Signal Intensity)가 15608.7, Max peak는 1 mmol에서 1352.6, T2 FLAIR는 Total SI가 9106.4, Max peak는 0.4 mmol에서 1721.6, T1 FLAIR에서는 Total SI가 20972.5, Max peak는 1 mmol에서 1604.9, 3D FLASH는 Total SI가 20924.0, Max peak는 40 mmol에서 1425.7, 3D SPACE 1mm는 Total SI가 6399.0, Max peak는 3 mmol에서 528.3, 3D SPACE 5mm는 Total SI가 6276.5, Max peak는 2 mmol에서 514.6, 3D SPCIR의 경우는 Total SI가 1778.8, Max peak는 0.4 mmol에서 383.8의 신호강도를 보였다. T1 SE를 포함한 대부분의 시퀀스에서 몰농도가 높았을 때 보다는 대체적으로 일정이상 희석이 이루어진 비교적 낮은 농도에서 높은 신호강도를 보였다. 또한 서로 다른 물리학적 기전의 다양한 MR시퀀스에서 GBCA의 조영증강 패턴 역시 모두 달랐다. 본 연구를 통해 얻어진 시퀀스에 따른 GBCA 농도별 반응에 대한 정량적 데이터를 통하여 실제 임상에서의 조영증강검사에 있어서 효율적인 MR검사 프로토콜에 활용할 수 있을 것으로 사료된다.