• Journal of Korean Biological Nursing Science
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• v.22 no.4
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• pp.249-259
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• 2020

Purpose: Carbapenemase-producing Enterobacteriaceae (CPE) are associated with considerable mortality. This study was aimed to identify survival factors among medical care unit patients with CPE. Methods: We conducted a retrospective cohort; data were collected from September 2017 to June 2019 through electronic medical records. The data collected were general characteristics, disease-related characteristics, severity-related characteristics, and treatment-related characteristics. Data were analyzed based on frequency, mean, standard deviation, Chi-square test, Fisher's exact test, t-test, Pearson's correlation coefficient, and Cox proportional hazard model using SPSS/WIN 21.0 program. Results: Seventy-seven patients were included (59 survivors and 18 deceased) in the study. Univariate analysis identified factors for survival associated with acquired CPE as age (t= -1.56, p= .037), simplified acute physiology 3 (SAPS3) score of admission date (t= -2.85, p= .006), Glasgow coma scale (GCS) of CPE acquisition date (t= 2.38, p= .020), artery catheter at CPE acquisition date (χ²= 4.58, p= .032), vasoconstrictor agents use at CPE acquisition date (χ²= 6.81, p= .009), platelet at CPE acquisition date (t= 2.27, p= .025), lymphocyte at CPE acquisition date (t= 2.01, p= .048), calcium at CPE acquisition date (t= 2.68, p= .009), albumin at CPE acquisition date (t= 2.29, p= .025), and creatinine at CPE acquisition date (t= 2.24, p= .028). Multivariate Cox proportional hazard model showed that GCS at CPE acquisition date (HR= 1.14, 95% CI= 1.05-1.22), lymphocyte at CPE acquisition date (HR= 1.05, 95% CI= 1.00-1.10), and creatinine at CPE acquisition date (HR= 1.25, 95% CI= 1.04-1.49) were independent survival factors among medical intensive care unit patients with CPE. Conclusion: Based on the study results, it is necessary to develop nursing interventions that can aid in the management of patients with CPE and identify their effects.

• Journal of Yeungnam Medical Science
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• v.37 no.2
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• pp.90-97
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• 2020

Background: To minimize damage to the ovarian reserve, it is necessary to evaluate the follicular density in the ovarian tissue surrounding endometriosis on preoperative imaging. The purpose of the present study was to evaluate the usefulness of subtraction pelvic magnetic resonance imaging (MRI) to detect ovarian reserve. Methods: A subtracted T1-weighted image (^subT1WI) was obtained by subtracting unenhanced T1WI from contrast-enhanced T1WI (^ceT1WI) with similar parameters in 22 patients with ovarian endometriosis. The signal-to-noise ratio (SNR) in ovarian endometriosis, which was classified into the high signal intensity and iso-to-low signal intensity groups on the T2-weighted image, was compared to that in normal ovarian tissue. To evaluate the effect of contrast enhancement, a standardization map was obtained by dividing ^subT1WI by ^ceT1WI. Results: On visual assessment of 22 patients with ovarian endometriosis, 16 patients showed a high signal intensity, and 6 patients showed an iso-to-low signal intensity on T1WI. Although SNR in endometriosis with a high signal intensity was higher than that with an iso-to-low signal intensity, there was no difference in SNR after the subtraction (13.72±77.55 vs. 63.03±43.90, p=0.126). The area of the affected ovary was smaller than that of the normal ovary (121.10±22.48 vs. 380.51±75.87 ㎟, p=0.002), but the mean number of pixels in the viable remaining tissue of the affected ovary was similar to that of the normal ovary (0.53±0.09 vs. 0.47±0.09, p=0.682). Conclusion: The subtraction technique used with pelvic MRI could reveal the extent of endometrial invasion of the normal ovarian tissue and viable remnant ovarian tissue.

• IMMUNE NETWORK
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• v.13 no.5
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• pp.222-226
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• 2013

Translocations involving chromosome 21q22 are frequently observed in hematologic malignancies including acute myeloid leukemia (AML), most of which have been known to be involved in malignant transformation through transcriptional dysregulation of Runt-related transcription factor 1 (RUNX1) target genes. Nineteen RUNX1 translocational partner genes, at least, have been identified, but not Homeobox A (HOXA) genes so far. We report a novel translocation of RUNX1 into the HOXA gene cluster in a 57-year-old female AML patient who had been diagnosed with myelofibrosis 39 months ahead. G-banding showed 46,XX,t(7;21)(p15;q22). The involvement of RUNX1 and HOXA genes was confirmed by fluorescence in situ hybridization.

• Natural Product Sciences
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• v.12 no.3
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• pp.134-137
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• 2006

Four lignan compounds including gomisin J (1), schizandrin (2), gomisin A (3), and angeloyl gomisin H (4) have been isolated from the MeOH extract of Schizandra chinensis fruits. The evaluation for protective effect of compounds 1-4 against tert-butyl hydroperoxide (t-BHP)-induced cytotoxicity in hippocampal HT22 cell line was conducted. Compound 1 showed significant protective effect with an $EC_{50}$ value of $43.3{\pm}2.3\;{\mu}M$, whereas compounds 2-4 were inactive. Trolox, one of the well-known antioxidant, used as a positive control, and also showed protective effect with an $EC_{50}$ value of $213.8{\pm}8.4\;{\mu}M$. These results suggest that compound 1 may possess the neuroprotective activity against oxidant-induced cellular injuries.

• Journal of the Korea Society of Computer and Information
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• v.22 no.11
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• pp.81-88
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• 2017

The purpose of this study was to investigate the effects of mindfulness meditation programs based on stress management on the perceived stress, self-control, self-esteem and satisfaction with life scale in nursing college students. A quasi-experimental study with a non-equivalent control group pretest-posttest design was used. Participants consisted of an experimental group(n=18) and a control group(n=22). The experimental group received the mindfulness meditation program for 60 minutes a week for 13 sessions. Data were analyzed using descriptive statistics, ${\chi}^2-test$, Fisher's exact test, t-test, Mann-Whitney U test. The results showed there were significant decrease for perceived stress(t=-9.43, p=.025) and improved self-esteem(t=1.98, p=.038) in the experimental compared to group control group. These findings indicate that mindfulness meditation programs is effective to psychological well-being in nursing college students. Therefore this program needs to be considered as a nursing curriculum for students.

• Korean Journal of Pharmacognosy
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• v.50 no.2
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• pp.118-123
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• 2019

Glutamate acts as an important neurotransmitter in brain. However, high concentration of glutamate showed an excitatory neurotoxicity and resulted to neuronal cell death. Neuronal cell death is known for one of the reason of Alzheimer's disease, a neurodegenerative disease. We tried to find neuroprotective medicinal plants by neuroprotection activity against glutamate injured HT22 cells as a model system. In the course of bioscreening of various medicinal plants, Taraxacum platycarpum extract showed significant neuroprotective activity. We tried to elucidate mechanisms of neuroprotective activity. T. platycarpum extract reduced ROS and intracellular $Ca^{2+}$ concentration increased by glutamate induced neurotoxicity. In addition, mitochondrial membrane potential was restored to the control level. Also, glutathione level, glutathione reductase and glutathione peroxidase activity were increased by T. platycarpum extract treatment. These data suggested that T. platycarpum showed neuroprotective activity via antioxidative activity.

• Fire Science and Engineering
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• v.28 no.5
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• pp.98-103
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• 2014

This study investigated the confidence, satisfaction, and psychological safety and identified factors affecting the satisfaction of 41 paramedic students. Data, which consists of pre and post-confidence items on visual analogue scale, 21 satisfaction items and 10 psychological safety items was analyzed using SPSS WIN 21.0 program. After the simulation education, the students were told to write what they felt about the education. Then the students' comments, which were categorized as effectiveness and difficulty, were analyzed. Satisfaction of general characteristics showed a significant difference in age (t = -2.22, p = 0.03) and psychological safety of general characteristics showed a significant difference in gender (t = 3.70, p = 0.00) and age (t = -3.65, p = 0.00). Pre-confidence is low (4.37); however, post-confidence increased to 6.22. It showed a significant difference in pre and post-confidence (t = -5.878, p = 0.000). Satisfaction was correlated with psychological safety (r = 0.516, p = 0.001). The variables affecting satisfaction were psychological safety (t = 3.021, p = 0.005) and post-confidence (t = 1.936, p = 0.061). These variables accounted for 27.6% of the satisfaction according to a regression analysis. The simulation education may be the new effective paramedic education strategy of emergency childbirth. Repetitive simulation learning with further development of various scenarios, more education time, and more faculties will be able to train field compatible paramedics.

• The Korean Journal of Malacology
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• v.13 no.2
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• pp.185-192
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• 1997

1990젼 3월부터 1991년 2월까지 전라북도 군산시 내초도 연안에 서식하는 동죽의 성장을 조사하였다. 1.조사해역의 연간 수온분포는 2.0-26.3$^{\circ}C$이고, 간석지 온도는 0.7-36.2$^{\circ}C$이었다. 2. 동죽의 패각에 나타나는 윤문은 연 1회 형성되며 윤문 형성시기는 3-4월로 조사되었다. 3. 초륜 형성기간은 9개월(0.75년)로 나타났다. 4. 각장(SL: mm)과 체중(TW: G)간의 관계는 TW=1.090 x $10^{-4}$ S $L^{3.2798}$( $r^{2}$=0.99)이었으며, 각장과 각고(SH:mm)간의 관계는 SH=0.865 SL + 0.250( $r^{2}$=0.99)이고, 각장과 각폭(SW: mm) 간의 관계는 SW=0.599 SL - 0.203 ( $r^{2}$=0.98; 각장 22 mm미만), SW=0.724 SL - 2.796( $r^{2}$=0.91; 각장 22 mm이상)이었다.5. 연령(t)에 대한 각장(S $L_{t}$ )의 Bertalanffy성장식은 $L_{t}$ =51.399(1- $e^{0.585}$8(t+0.064)이고, 연령(t)에 대한 체중 (T $W_{t}$ )의 Bertalanffy성장식은 $W_{t}$ =44.467(1- $e^{0.585}$8(t+0.064)$^{3}$로 나타났다.타났다.

• Journal of Korea Multimedia Society
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• v.22 no.8
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• pp.913-922
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• 2019

The Internet of Things (IoT) envisions smart objects collecting and sharing data at a massive scale via the Internet. One challenging issue is how to disseminate data to relevant data consuming objects efficiently. In such a massive IoT network, Mission critical data dissemination imposes constraints on the message transfer delay between objects. Due to the low power and communication range of IoT objects, data is relayed over multi-hops before arriving at the destination. In this paper, we propose a quorum-based adaptive dissemination algorithm (QADA) for the critical data in the monitoring-based applications of massive IoTs. To design QADA, we first design a new stepped-triangular grid structures (sT-grid) that support data dissemination, then construct a triangular grid overlay in the fog layer on the lower IoT layer and propose the data dissemination algorithm of the publish/subscribe model that adaptively uses triangle grid (T-grid) and sT-grid quorums depending on the mission critical in the overlay constructed to disseminate the critical data, and evaluate its performance as an analytical model.

• Korean Journal of Mathematics
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• v.22 no.4
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• pp.591-598
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• 2014

Let D be an integral domain with quotient field K. In [1], the authors called D a finitely valuative domain if, for each $0{\neq}u{\in}K$, there is a saturated chain of rings $D=D_0{\varsubsetneq}D_1{\varsubsetneq}{\cdots}{\subseteq}$ $D_n=D[x]$, where x = u or $u^{-1}$. They then studied some properties of finitely valuative domains. For example, they showed that the integral closure of a finitely valuative domain is a Pr$\ddot{u}$fer domain. In this paper, we introduce the notion of finitely t-valuative domains, which is the t-operation analog of finitely valuative domains, and we then generalize some properties of finitely valuative domains.