• Herbal Formula Science
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• v.21 no.1
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• pp.161-176
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• 2013

Objectives : To clarify the anti-arthritic activity of Ostericum koreanum Maxim. (OS) plus Aralia continentalis Kitagawa (AC) in vivo. Methods : All mice were immunized with bovine type II collagen. After a second collagen immunization, mice were treated with OS plus AC once a day for 7 weeks. Oral administration of OS plus AC (200 or 50 mg/kg) significantly suppressed the progression of CIA, which extend is comparable to that of methotrexate (MTX, 0.3 mg/kg), a positive control. The severity of arthritis within the knee joints was evaluated by histological assessment of cartilage destruction and pannus formation. Results : Administration of OS plus AC significantly suppressed the progression of CIA and inhibited the production of TNF-${\alpha}$ and IL-6 in serum. The erosion of cartilage was dramatically reduced in mouse knees after treatment with OS plus AC. In conclusion, our results demonstrates that OS plus AC significantly suppressed the progression of CIA and that this action was characterized by the decreased production of IL-6, IFN-${\gamma}$ and collagen II specific antibody in serum, CD3+CD69+ T cells, MHC class II+/CD11c+ (in DLN), CD11b+Gr-1+ cells (in PBMC), CD11b +Gr-1+ cells, B220+/CD23+ (in paw joint). Conclusions : The the levels of IFN-${\gamma}$ in the culture supernatant of splenocytes stimulated with CD3/CD28 or collagen were dramatically decreased, while those of IL-4 was increased. In the serum of OS and AC-treated mice, the levels of IgM RA factor were decreased.

• Smart Structures and Systems
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• v.26 no.1
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• pp.35-47
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• 2020

This paper proposes the use of transmissibility functions combined with a machine learning algorithm, Artificial Neural Networks (ANNs), to assess damage in a truss bridge. A new approach method, which makes use of the input parameters calculated from the transmissibility function, is proposed. The network not only can predict the existence of damage, but also can classify the damage types and identity the location of the damage. Sensors are installed in the truss joints in order to measure the bridge vibration responses under train and ambient excitations. A finite element (FE) model is constructed for the bridge and updated using FE software and experimental data. Both single damage and multiple damage cases are simulated in the bridge model with different scenarios. In each scenario, the vibration responses at the considered nodes are recorded and then used to calculate the transmissibility functions. The transmissibility damage indicators are calculated and stored as ANNs inputs. The outputs of the ANNs are the damage type, location and severity. Two machine learning algorithms are used; one for classifying the type and location of damage, whereas the other for finding the severity of damage. The measurements of the Nam O bridge, a truss railway bridge in Vietnam, is used to illustrate the method. The proposed method not only can distinguish the damage type, but also it can accurately identify damage level.

• Physical Therapy Rehabilitation Science
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• v.5 no.3
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• pp.132-137
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• 2016

Objective: Eversion of the foot is created with internal rotation of the shank, and inversion of the foot is created with external rotation of the shank. The purpose of the study was to investigate the effect of continuous changes in the angle of the subtalar joint on lower extremity alignments. Design: Cross-sectional study. Methods: Seventeen healthy young adult subjects recruited. The subjects were asked to stand up in a natural standing position on a footplate with eye open and equal weight on each foot for 10s in two different conditions: The right subtalar joint was everted continuously $0^{\circ}-20^{\circ}$ and in separate segments of $0^{\circ}$, $5^{\circ}$, $10^{\circ}$, $15^{\circ}$, $20^{\circ}$. The averages of three trials were used. The observation of the changes in the lower extremity was performed with the use of 3-dimensional motion analysis. For data analysis, the SPSS 18.0 software using paired t-test and repeated measures analysis of variance (ANOVA) was applied. Results: The angle was significantly increased at the horizontal rotation angle of the shank, thigh, and ankle without anterior rotation of the pelvis (p<0.05). The maximum horizontal rotation angle at the thigh on $20^{\circ}$ was $-4.52^{\circ}$ in static, and $-3.10^{\circ}$ in the dynamic conditions compared to $0^{\circ}$. Conclusions: Increased unilateral foot pronation, thigh, shank, ankle horizontal rotation variance was significantly effective. The observation of the changes in foot abduction with the use of a 3-dimensional motion analysis augmented in predicting the angle values of each segment of the lower extremity. In further studies, a comparison of the right and left subtalar joints need to be investigated.

• Archives of Plastic Surgery
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• v.35 no.6
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• pp.637-644
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• 2008

Purpose: The survival of bone marrow derived stem cell was reported several times. But the survival of adipose tissue derived stem cells(hASCs) was not mentioned on. We studied the adipose tissue derived stem cell's survival and effect on articular cartilage in rabbits. Methods: Osteoarthritis was induced in twenty New Zealand white rabbits by intraarticular injection of monosodium iodoacetate(MIA). After four weeks, hASCs were also injected into the knee joints space without any vehicle, but the control group received phosphate buffered saline only. The histologic grade of articular cartilage was measured in 4 and 8 weeks after the transplantation of hASC and the viability of injected stem cells measured by Fluorescent in situ Hybridization (FISH) examination. Results: After 4 and 8 weeks from hASCs transplantation, histologic grade was not significantly difference between two groups(p>0.05), and the Y chromosome of the transplanted hASCs was not detected in articular cartilage. Conclusion: We found that direct injection of hASC in joint space didn't work on damaged articular cartilage repair.

• Korean Journal of Applied Biomechanics
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• v.25 no.3
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• pp.293-300
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• 2015

Objective : The purpose of this study was to compare the kinematic data of the horizontal rotation movements of shoulder, hip, knee during two-handed backhand drive stroke according to two different ball directions. Methods : The kinematic variables were analyzed such as the joint angles of the lower body, horizontal rotation angles of the shoulder, hip, inter-knee segment, body twist angle and difference in angle of forward swing. Two-handed backhand drive stroke was analyzed through a three-dimensional motion analysis. The collected data were analyzed by a paired t-test, and the statistical significant value was set at ${\alpha}=.05$. Results : The findings of this study were as follows; First, there was no difference in the total angles of lower limb joints from the forward swing position to impact posterior. Second, there was no difference in the horizontal rotation angles of E1 shoulder, hip, and E2 shoulder but the horizontal rotation angles of E1 knee, E2 hip, knee, E3, and E4 shoulder, hip, and knee were different in all events. Third, there was no difference in the body twist angle of the maximum horizontal rotation. In addition, there was no difference in the angle of the body twist by the ball direction in the shoulder-hip, the hip-knee and the shoulder-knee. Conclusion : Horizontal rotation angle determines ball directions.

• Physical Therapy Korea
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• v.9 no.3
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• pp.23-37
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• 2002

This study examined the muscle recruitment order during extension of the hip joint in normal subjects, and evaluated whether the external support obtained from wearing a lumbosacral corset had an effect on muscle recruitment leading to increased lumbar stability. The subjects were 40 normal adults (32 male, 8 female) with no history of low back pain and no pathological findings in the nervous or musculoskeletal systems. All subjects extended their hip joints under 3 positions (prone, sidelying, standing). During extension, the onsets of contraction of the rectus abdominis, gluteus maximus, and semitendinosus muscles were measured. Electromyographic activity was measured using a surface electrode, and the muscle contraction onset time was designated as the point exceeding a threshold of 25 ms, using a mean plus twice of the standard deviation. To compare the average order of muscle contraction onset time, a Freedman two-way analysis of variance by ranks was used. The relative difference between muscle contraction onset time wearing and not wearing a lumbosacral corset was measured using a paired t-test. A difference in the average muscle contraction onset order for the rectus abdominis, gluteus maximus, and semitendinosus muscles was observed (p<.05) among three positions. However, wearing a lumbosacral corset did not. change the contraction order. In addition, wearing a lumbosacral corset produced a significant difference (p<.05) in the relative onset time between the rectus abdominis and gluteus maximus in the standing position, but no difference was observed for the other muscles or positions. In the future, patients suffering from low back pain should be compared with normal subjects to determine the effectiveness of a lumbosacral corset in changing muscle recruitment order.

• Bulletin of the Korean Mathematical Society
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• v.27 no.2
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• pp.189-196
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• 1990

In this paper, we try to generalize ultraproducts in the category of locally convex spaces. To do so, we introduce D-ultracolimits. It is known [7] that the topology on a non-trivial ultraproduct in the category T $V^{ec}$ of topological vector spaces and continuous linear maps is trivial. To generalize the category Ba $n_{1}$ of Banach spaces and linear contractions, we introduce the category L $C_{1}$ of vector spaces endowed with families of semi-norms closed underfinite joints and linear contractions (see Definition 1.1) and its subcategory, L $C_{2}$ determined by Hausdorff objects of L $C_{1}$. It is shown that L $C_{1}$ contains the category LC of locally convex spaces and continuous linear maps as a coreflective subcategory and that L $C_{2}$ contains the category Nor $m_{1}$ of normed linear spaces and linear contractions as a coreflective subcategory. Thus L $C_{1}$ is a suitable category for the study of locally convex spaces. In L $C_{2}$, we introduce $l_{\infty}$(I. $E_{i}$ ) for a family ( $E_{i}$ )$_{i.mem.I}$ of objects in L $C_{2}$ and then for an ultrafilter u on I. we have a closed subspace $N_{u}$ . Using this, we construct ultraproducts in L $C_{2}$. Using the relationship between Nor $m_{1}$ and L $C_{2}$ and that between Nor $m_{1}$ and Ba $n_{1}$, we show thatour ultraproducts in Nor $m_{1}$ and Ba $n_{1}$ are exactly those in the literatures. For the terminology, we refer to [6] for the category theory and to [8] for ultraproducts in Ba $n_{1}$..

• Clinical and Experimental Pediatrics
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• v.46 no.10
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• pp.1040-1043
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• 2003

Henoch-Shonlein purpura(HSP) is a systemic small-vessel vasculitis that primarily affects the skin, gastrointestinal tract, joints, and kidneys. The nervous system may be involved, less commonly than other organs. When the central nervous system(CNS) was involved, headache, changes in mental status, seizures, and focal neurologic deficits have been reported. Hypertension, uremic encephalopathy, metabolic abnomalities, electrolyte abnormalities, or cerebral vasculitis were suggested as possible causes of the neurologic manifestation. Diagnosis of vasculitic involvement of CNS is difficult. Magnetic resonance imaging of the brain is the modality of choice for the evaluation of the CNS disease. Steroid or plasmapheresis are used in treatment of cerebral vasculitis. We experienced a case of 9-year-old boy who had presented with Henoch-Schonlein purpura nephritis complicating encephalopathy accompanied by hypertension and cerebral vasculitis. Brain MRI showed multiple small nodular-linear pattern enhancing lesions in whole cerebral hemispheres and focal increased T2 signal in the right basal ganglia. We used intravenous immunoglobulin in treatment of cerebral vasculitis. We report this case with a brief review of related literature.

• The Journal of Korean Physical Therapy
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• v.14 no.4
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• pp.323-330
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• 2002

This study purposes at applying knee joint taping to preventing muscle fatigue. Twenty six subjects between the ages of 20s and 30s were randomly sampled among healthy males, with an average age of 26yr(range, 22 to 31yr). None of the subjects had a recent or remote history of significant lower extremity injury, No subjects had a history of central nervous system equilibrium problems. To develop muscle fatigue, Isokinetic exercise, which is a repetition of flexion and extension knee joint to $180^{\circ}$/sec, was performed 50 times per person. During the exercise, change of proprioception were measured by applying taping on both knee joints. Analysis has carried out by means of one-way ANOVA with repeated measures and independent t-test at the significance level of $\alpha$=0.05 to detect statistic significance. The results of this study were as follows: First, it was found that the generation of lower extremity muscle fatigue significant affects on proprioception (p < 0.05). Second, the application of taping to knee joint after the generation of lower extremity muscle fatigue significant affect proprioception (p < 0.05). Third, while continual exercise after the generation of muscle fatigue, taping group was significant differences in proprioceptive loss than non-taping group(p < 0.05).

• Journal of muscle and joint health
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• v.9 no.1
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• pp.28-39
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• 2002

Objective. The 12 forms of Sun-style Tai Chi exercise has been developed specifically for arthritis patients in order to reduce their symptoms and to improve physical functioning. This quasi-experimental study examined the changes in pain, balance, muscle strength and physical functioning in women with osteoarthritis at the completion of the 12 week Tai Chi exercise program. Methods. The patients with osteoarthritis who signed the consent form were screened by their primary physician according to the inclusion criteria and invited to the study. Total of 66 osteoarthritis women with an average age of 63 years were participated in the Tai Chi exercise. At the completion of 12 weeks, 34 patients completed both pretest and posttest measures with 48% of overall dropout rate. Outcome measures were physical symptoms, balance, muscle strength, physical functioning, and depression. Paired t-test was utilized to examine differences between pre and post-measures. Results. After participating in the Tai Chi exercise program, the women with osteoarthritis showed significant improvements in their physical fitness measures, and consequently in their physical functioning. In physical fitness test, there were significant improvements in balance, flexibility, muscle strengths of knee, grip, and back muscles after the Tai Chi exercise. However, No significant differences were found in pain and stiffness of their knee joints and depression measure. Conclusion. The 12 forms of Tai Chi exercise has been found safely applicable to the older women with osteoarthritis for 12 weeks, and effective in improving balance, flexibility, and muscle strengths, and consequently lessening difficulties of performing their activities of daily life.