• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1967-1971
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• 2016

Background: In tumor cells, aberrant differentiation programs have been described. Several neuronal proteins have been found associated with morphological neuronal-glial changes in breast cancer (BCa). These neuronal proteins have been related to mechanisms that are involved in carcinogenesis; however, this regulation is not well understood. Microtubule-associated protein-tau (MAP-Tau) has been describing in BCa but not its variants. This finding could partly explain the neuronal-glial morphology of BCa cells. Our aim was to determine mRNA expression of MAP-tau variants 2, 4 and 6 in breast cancer cell lines. Materials and Methods: Cultured cell lines MCF-10A, MDA-MB-231, SKBR3 and T47D were observed under phase-contrast microscopy for neural morphology and analyzed for gene expression of MAP-Tau transcript variants 2, 4 and 6 by real-time PCR. Results: Regarding morphology like neural/glial cells, T47D line shown more cells with these features than MDA-MB-231 and SKBR. In another hand, we found much greater mRNA expression of MAP-Tau transcript variants 2, and to a lesser extent 4 and 6, in T47D cells than the other lines. In conclusion, regulation of MAP-Tau could bring about changes in cytoskeleton, cell morphology and motility; these findings cast further light on neuronal transdifferentiation in BCa.

• Journal of applied mathematics & informatics
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• 제25권1_2호
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• pp.17-33
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• 2007

Suppose F is an arbitrary field. Let ${\mid}F{\mid}$ be the number of the elements of F. Let $T_{n}(F)$ be the space of all $n{\times}n$ upper-triangular matrices over F. A map ${\Psi}\;:\;T_{n}(F)\;{\rightarrow}\;T_{n}(F)$ is said to preserve idempotence if $A-{\lambda}B$ is idempotent if and only if ${\Psi}(A)-{\lambda}{\Psi}(B)$ is idempotent for any $A,\;B\;{\in}\;T_{n}(F)$ and ${\lambda}\;{\in}\;F$. It is shown that: when the characteristic of F is not 2, ${\mid}F{\mid}\;>\;3$ and $n\;{\geq}\;3,\;{\Psi}\;:\;T_{n}(F)\;{\rightarrow}\;T_{n}(F)$ is a map preserving idempotence if and only if there exists an invertible matrix $P\;{\in}\;T_{n}(F)$ such that either ${\Phi}(A)\;=\;PAP^{-1}$ for every $A\;{\in}\;T_{n}(F)\;or\;{\Psi}(A)=PJA^{t}JP^{-1}$ for every $P\;{\in}\;T_{n}(F)$, where $J\;=\;{\sum}^{n}_{i-1}\;E_{i,n+1-i}\;and\;E_{ij}$ is the matrix with 1 in the (i,j)th entry and 0 elsewhere.

• BMB Reports
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• 제49권7호
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• pp.370-375
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• 2016

Ras oncoproteins are small molecular weight GTPases known for their involvement in oncogenesis, which operate in a complex signaling network with multiple effectors. Approximately 25% of human tumors possess mutations in a member of this family. The Raf1/MEK/Erk1/2 pathway is one of the most intensively studied signaling mechanisms. Different levels of regulation account for the inactivation of MAP kinases by MAPK phosphatases in a cell type- and stimuli-dependent manner. In the present study, using three inducible Ras-expressing NIH/3T3 cell lines, we demonstrated that MKP3 upregulation requires the activation of the Erk1/2 pathway, which correlates with the shutdown of this pathway. We also demonstrated, by applying pharmacological inhibitors and effector mutants of Ras, that induction of MKP3 at the protein level is positively regulated by the oncogenic Ras/Raf/MEK/Erk1/2 signaling pathway.

• 대한수학회보
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• 제44권1호
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• pp.83-86
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• 2007

We determine the largest integer i such that $0 and the coefficient of $t^{i}$ is odd in the polynomial $(1+t+t^{2}+{\cdots}+t^{n})^{n+1}$. We apply this to prove that the co-index of the tangent bundle over $FP^{n}$ is stable if $2^{r}{\leq}n<2^{r}+\frac{1}{3}(2^{r}-2)$ for some integer r.

• Korean Journal of Mathematics
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• 제27권3호
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• pp.735-741
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• 2019

Let ${\mathcal{H}}$ be a complex Hilbert space and ${\mathcal{B}}({\mathcal{H}})$ the algebra of all bounded linear operators on ${\mathcal{H}}$. In this paper, we prove that if ${\varphi}:{\mathcal{B}}({\mathcal{H}}){\rightarrow}{\mathcal{B}}({\mathcal{H}})$ is a unital surjective bounded linear map, which preserves m- isometries m = 1, 2 in both directions, then there are unitary operators $U,V{\in}{\mathcal{B}}({\mathcal{H}})$ such that ${\varphi}(T)=UTV$ or ${\varphi}(T)=UT^{tr}V$ for all $T{\in}{\mathcal{B}}({\mathcal{H}})$, where $T^{tr}$ is the transpose of T with respect to an arbitrary but fixed orthonormal basis of ${\mathcal{H}}$.

• 정보처리학회논문지A
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• 제18A권2호
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• pp.75-80
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• 2011

최근 청소로봇을 위한 여러 가지 알고리즘들이 개발되면서 다양한 청소로봇들이 개발되고 있다. 그 중 청소로봇이 청소하는데 있어 청소시간의 제약이 있을 경우 효율적으로 청소할 수 있는 알고리즘인 DmaxCoverage 알고리즘이 있는데 이 알고리즘을 구현하는데 장애물이 존재하지 않는 비어있는 공간을 찾기 위해 Rectangle Tiling기법을 사용하고 있다. Map을 그리드 형태의 수많은 사각형으로 나타낼 경우 사각형을 찾는 기법 중 수학적 방법으로 Rectangle Tiling이 최적의 값을 찾아줄 수 있다. Rectangle Tiling 기법은 그리드 형식의 map에서 생성될 수 있는 사각형들의 모든 경우의 수를 찾는 것이다. 이때 그리드선의 간격이 촘촘하고 map의 크기가 클 경우 많은 사각형이 생성됨으로 많은 시간을 소모해야 하는 문제점이 있다. 본 논문에서는 Rectangle Tiling에 근접한 정확성과 보다 개선된 속도를 제공하는 Four Direction Rectangle Scanning(FDRS)기법을 제안한다. FDRS기법은 존재하는 모든 사각형을 찾는 것이 아니라 물체가 존재하는 셀의 상하좌우만을 검색하여 빈 공간을 찾는 기법이다. 이 두 알고리즘을 비교하여 FDRS의 효율이 뛰어남을 실험을 통해 보여준다.

• 한국미생물·생명공학회지
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• 제26권4호
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• pp.338-344
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• 1998

게나 새우 등의 갑각류의 껍질에서 주로 얻어지는 생체적합성이 뛰어난 천연고분자인 chitosan에 음이온 수용성의 함인계 단량체인 mono(2-methacryloyl oxyethyl) acid phosphate를 그라프트 중합시켜 새로운 유도체인 chitosan-g-MAP을 합성하였다. 그라프트중합에서 개시제로는 ceric ammonium nitrate을 사용하여 개시제의 농도, 단량체의 농도, 반응온도, 반응시간에 따른 그라프트율, 단량체의 그라프트효율 및 단량체의 총전환율의 변화를 조사하여 최적조건을 규명하였다. 그라프트율은 개시제농도 3.5$\times$$10^{-3}$ M, 단량체농도 0.19 M, 반응온도 4$0^{\circ}C$에서 가장 높은 값을 나타내었고, 반응시간 4시간이 최적조건 이었다. Chitosan의 유리 아민의 함량과 그라프트된 단량체의 종류에 따른 항균성을 Candida albicans, Trichophyton rubrum 및 Trichophyton violaceum에 대하여 조사한 결과, pH 5.75에서 가장 우수한 항균능이 발현되고, 항균제의 농도에 따른 영향에서는 변형chitosan은 C. albicans와 T. violaceum에 대하여 100%의 우수한 항균력을 나타낸 반면, 탈아세틸화도가 다른 DA70과 DA-90인 chitosan은 T. rubrum균에 대해서만 변형 chitosan 보다 우수한 항균성을 나타내었다.

• 상하수도학회지
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• 제28권1호
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• pp.135-142
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• 2014

The performance of inorganic sludge separation system is evaluated. Anaerobic digester effluent sludge is used for feed sludge of this system and hydrocyclone is used for inorganic sludge separation. For phosphorus removal and recovery $MgCl_2$ is pumped into MAP growth tank, a component of inorganic sludge separation system. Using this system inorganic sludge which contained less than 40 % of organic matter can be discharged stably and the maximum amount of separated inorganic sludge is 13.4 % of influent sludge based on dry solid. The amount of phosphorus recovered as MAP(as P) is 16.7 % to influent T-P.

• BMB Reports
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• 제47권2호
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• pp.115-120
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• 2014

In this study, we show that Mycobacterium avium subsp. paratuberculosis MAP1305 induces the maturation of bone marrow-derived dendritic cells (BMDCs), a representative antigen presenting cell (APC). MAP1305 protein induces DC maturation and the production of pro-inflammatory cytokines (Interleukin (IL)-6), tumor necrosis factor (TNF)-${\alpha}$, and IL-$1{\beta}$) through Toll like receptor-4 (TLR-4) signaling by directly binding with TLR4. MAP1305 activates the phosphorylation of MAPKs, such as ERK, p38MAPK, and JNK, which is essential for DC maturation. Furthermore, MAP1305-treated DCs transform naive T cells to polarized $CD4^+$ and $CD8^+$ T cells, thus indicating a key role for this protein in the Th1 polarization of the resulting immune response. Taken together, M. avium subsp. paratuberculosis MAP1305 is important for the regulation of innate immune response through DC-mediated proliferation of $CD4^+$ and $CD8^+$ T cells.

• 충청수학회지
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• 제23권2호
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• pp.271-277
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• 2010

We prove the global (in time) vorticity existence for the 2-D Euler equations of a perfect incompressible fluid in $B^0_{{\infty},1}({\mathbb{R}}^2){\cap}L^p({\mathbb{R}}^2)$ with 1 < p < 2. Moreover, we prove that the particle trajectory map X(x, t) satisfies the following estimate: for some positive constant C $${\parallel}X^{\pm1}(\cdot,\;t)-id(\cdot){\parallel}_{B^1_{\infty,1}}{\leq}Ce^{e^{Ct}}$$, where id represents the identity map on ${\mathbb{R}}^2$.