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http://dx.doi.org/10.5483/BMBRep.2014.47.2.277

The Mycobacterium avium subsp. Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4  

Lee, Su Jung (Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, School of Medicine, Konkuk University)
Noh, Kyung Tae (Department of Infectious Diseases Research, Armed Forces Medical Research Institute)
Kang, Tae Heung (Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, School of Medicine, Konkuk University)
Han, Hee Dong (Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, School of Medicine, Konkuk University)
Shin, Sung Jae (Department of Microbiology and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine)
Soh, Byoung Yul (Department of Biochemistry, College of Medicine, Seonam University)
Park, Jung Hee (Division of Biotechnology, Advanced Institute of Environment and Bioscience, College of Environmental & Bioresources Sciences, Chonbuk National University)
Shin, Yong Kyoo (Department of Pharmacology, Chung-Ang University, College of Medicine)
Kim, Han Wool (Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University)
Yun, Cheol-Heui (Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University)
Park, Won Sun (Department of Physiology, School of Medicine, Kangwon National University)
Jung, In Duk (Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, School of Medicine, Konkuk University)
Park, Yeong-Min (Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, School of Medicine, Konkuk University)
Publication Information
BMB Reports / v.47, no.2, 2014 , pp. 115-120 More about this Journal
Abstract
In this study, we show that Mycobacterium avium subsp. paratuberculosis MAP1305 induces the maturation of bone marrow-derived dendritic cells (BMDCs), a representative antigen presenting cell (APC). MAP1305 protein induces DC maturation and the production of pro-inflammatory cytokines (Interleukin (IL)-6), tumor necrosis factor (TNF)-${\alpha}$, and IL-$1{\beta}$) through Toll like receptor-4 (TLR-4) signaling by directly binding with TLR4. MAP1305 activates the phosphorylation of MAPKs, such as ERK, p38MAPK, and JNK, which is essential for DC maturation. Furthermore, MAP1305-treated DCs transform naive T cells to polarized $CD4^+$ and $CD8^+$ T cells, thus indicating a key role for this protein in the Th1 polarization of the resulting immune response. Taken together, M. avium subsp. paratuberculosis MAP1305 is important for the regulation of innate immune response through DC-mediated proliferation of $CD4^+$ and $CD8^+$ T cells.
Keywords
Dendritic cells; MAPKs; MAP1305; Mycobacterium avium subsp. paratuberculosis; Th1 polarization;
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