• Journal of the Society of Disaster Information
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• v.14 no.4
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• pp.458-465
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• 2018

Purpose: Concrete track that affects on railway safety can detect cracks using image processing technique. However, since a condition of concrete track and surface noisy are obstructed to detect cracks, there is a need for a way to remove them effectively. Method: In this study, we proposed an image processing to detect cracks effectively for Korean railway and verified its performance through experiment. We developed image acquisition system for capture a railway concrete track and acquired railway concrete track images, randomly selected 2000 images and detected cracks in the image process using proposed Gabor Filter Bank methods. Results: As a result, 94% of detection rate are matched to the actual cracks in same quality and format railway concrete track image. Conclution: The crack detection method using Garbor Filter Bank was confirmed to be effective for crack image including noise in the Korean railway concrete track. This system is expected to become an automated maintenance system in the existing human-centered railway industry.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.143-150
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• 2021

To develop the technique for predicting the horizontal displacement of a retaining wall induced by an earthquake, an equation of motion that depicts the retaining wall-soil vibrating system was derived. The resulting differential equation was solved using the Runge-Kutta-Nystr?m method. Considering the pre-mentioned derivation process, the analysis procedures for obtaining horizontal displacement induced by an earthquake were programmed. The core algorithm of the displacement-force relationship, which is the main engine of the developed program, was suggested. Considering the results obtained by adopting the developed program to the assumed retaining wall under an earthquake, the relationships between the time-displacement, time-force, and displacement-force were reasonable. According to the results computed by the program, the displacements to the front direction of the wall occurred, and the displacement per cycle converged after some cycles elapsed. Displacements with a natural period were calculated, which showed that the maximum displacement was observed when the natural frequency was slightly different from the excitation frequency rather than the same values of the two frequencies. This happens because the vibrating system was modeled by two springs with different stiffness.

• Journal of Life Science
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• v.33 no.4
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• pp.371-381
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• 2023

Endocrine disrupting chemicals (EDCs), used in a variety of products in modern society, are hormone-like substances that cause various diseases. Humans are exposed to EDCs through their inclusion in pesticides, plastics, cosmetics, detergents, and drugs. Bisphenol A (BPA), one of the representative endocrine disruptors, is an estrogen-like substance that has been widely used commercially in plastic and epoxy resins. BPA is a chemical that can disrupt the endocrine system, leading to reduced reproductive function, obesity, cancer, and neurodevelopmental disorders. Since the adverse health effects of BPA began to be reported the use of BPA has been regulated worldwide. Various alternatives to BPA have been widely used worldwide; representatively, bisphenol S (BPS) and bisphenol F (BPF) are the most commonly used in commercial contexts. BPS and BPF may cause endocrine-disrupting effects like those of BPA due to their similar chemical structures. Recent studies have reported that BPS and BPF disrupt the neurodevelopmental process and cause neurodevelopmental disorders. Therefore, future studies will be required for safety verification of BPA alternatives and the development of new alternatives to BPA for brain health. In this review, we reviewed the effects of BPA and the alternatives, BPS and BPF, on the nervous system.

• Korean Journal of Microbiology
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• v.44 no.3
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• pp.228-236
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• 2008

Validation of viral safety is essential in ensuring the safety of mammalian cell culture-derived biopharmaceuticals, because numerous adventitious viruses have been contaminated during the manufacture of the products. Mammalian cells are highly susceptible to Reovirus type 3 (Reo-3), and there are several reports of Reo-3 contamination during the manufacture of biopharmaceuticals. In order to establish the validation system for the Reo-3 safety, a real-time RT-PCR method was developed for quantitative detection of Reo-3 in cell lines, raw materials, manufacturing processes, and final products as well as Reo-3 clearance validation. Specific primers for amplification of Reo-3 RNA was selected, and Reo-3 RNA was quantified by use of SYBR Green I. The sensitivity of the assay was calculated to be $3.2{\times}10^0\;TCID_{50}/ml$. The real-time RT-PCR method was proven to be reproducible and very specific to Reo-3. The established real-time RT-PCR assay was successfully applied to the validation of Chinese hamster ovary (CHO) cell artificially infected with Reo-3. Reo-3 RNA could be quantified in CHO cell as well as culture supernatant. When the real-time RT-PCR assay was applied to the validation of virus removal during a virus filtration process, the result was similar to that of virus infectivity assay. Therefore, it was concluded that this rapid, specific, sensitive, and robust assay could replace infectivity assay for detection and clearance validation of Reo-3.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.14 no.1
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• pp.179-193
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• 1994

In the development of engineering designs, decisions are required irrespective of the state of completeness and quality of information, and are formulated under conditions of uncertainty. Furthermore, under conditions of uncertainty the design invokes risks. Thus, in the design of the structures, the currently used deterministic design method does not provide a realistic assessment of the actual safety or the reliability of the structures. It is desirable that decisions required in The process of the design invariably must be made based on the reliability analysis. Properties of soil material are subject to more uncertainty than those of other structural material. In the field of soil mechanics and foundation engineering, it needed to develop reliability-based design methods. In order to simplify the reliability analysis or the reliability-based design process of the structures associated with the active earth pressure, it is necessary to find the variation and the distribution type of the active earth pressure calculated from the basic properties of soils. Monte Carlo simulation is performed to obtain the relationship between the variation of the active earth pressure for cohessionless soils calculated by using Rankine formula and the basic soil properties and the distribution type of the earth pressure. A series of regression equations obtained by utilizing the multi-linear regression analysis is suggested in this paper and the sensitivity of the basic soil properties to the variation of The earth pressure is investigated. The type of distribution of the active earth pressure was found to be the beta distribution in most cases or to be very similar to the beta distribution, if the basic soil variables are normally distributed.

• Journal of Korean Medical classics
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• v.23 no.4
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• pp.63-102
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• 2010

Purpose : To propose various types of clinical research which is feasible for botanical new drug (IND) development processes, and suggest essential steps to development of study protocol for IND. Methods : Literature-based discussions and one research group's experience is given regarding domestic act, regulation, and system. Results : In order to get an approval of IND for botanical drug in Korea there are several types of clinical research to conduct. In quality control steps for standardized medicinal herbs, case reports or case series can be conducted, and for good manufacturing practice(GMP) steps, we can conduct case reports, case series, and retrospective cohort studies. In addition, as long as we gathered good laboratory practice(GLP) data we can conduct up to quasi-experimental studies and clinical trials including investigator initiated trials. In order to conduct these studies development of study protocol is essential. First, we obtain historical evidence including target disease and indication, efficacy, safety, and endpoints by reviewing medical classics. Second, we obtain clinically and statistically important data by conducting non-clinical studies, observation studies, and quasi-experimental studies. Third, we generate research hypotheses and purposes and explore methodologies, endpoints, clinical practice guidelines, cost-effectiveness, and commercial potential. Finally, we develop study protocol with aid of biostatistician or expert in contract research organization. Discussions and conclusions : This study have obvious limitations in that most thoughts, suggestions, and proposes are from one research group's experience. Therefore, we hope to see various types of research in this topic and process from other research group as well.

• Journal of Korea Port Economic Association
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• v.36 no.2
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• pp.1-18
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• 2020

The Internet of things (IoT) has been applied to a variety of industrial uses such as public service sectors, medical industries, automotive industries, and so on. Led by smart cities, this is typical. However, from a logistics perspective, the level of application is insufficient. This study examines the applicability of IoT-related technology in a container terminal, an object of the present invention, to derive an applicable plan. Analytic network process (ANP) analysis reveals the following results for IoT applications in container terminals: operating systems (26.7%), safety/environmental/security systems (26.4%), equipment maintenance systems (25.3%), and facility maintenance systems (21.6 %). The second ANP analysis reveals the following results: Economy (40.2%), productivity (21.1%), service level (19.5%), and utilizing technology level (19.2%). The application or standard of evaluation is important when applying IoT technology to container terminals; however, it is not concentrated in a certain area. It is desirable to build each container system with linkage and efficiency from a macroscopic view.

• Journal of Navigation and Port Research
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• v.44 no.4
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• pp.298-304
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• 2020

The purpose of this study was to identify evaluation factors and analyze the relative importance among factors to select a suitable transportation method for transferring the increasing amount of transshipment at multiple terminals at the Busan new port. To accomplish this, the evaluation factors were selected through a literature survey and brainstorming of a group of experts associated with the port operation, and were classified into five major factors and 15 middle factors. The evaluation factors classified hierarchically were surveyed relative to workers in organizations such as shipping companies, port corporations, container terminals, and related ministries. The importance of each factor was calculated using the hierarchical analysis process (AHP). As a result of the importance analysis, priority was assigned in order of safety, productivity, investment efficiency, operational efficiency, and policy conformity. Through this, it was necessary to select a suitable transportation method for the transshipment cargo in terminals while focusing on the cargo and terminal security and preventing accidents. As a result of calculating from six ITT transportation candidates, the priority was determined in order of monorail, Autocon, and so on as ITT transportation suitable for the Busan new port..

• Journal of Advanced Marine Engineering and Technology
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• v.40 no.6
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• pp.484-492
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• 2016

The turbine is an important component and has a significant impact on the thermodynamic efficiency of the organic Rankine cycle. A precise preliminary design is essential to developing efficient turbines. In addition, performance analysis and structural analysis are needed to evaluate the performance and structural safety. However, there are only a few exclusive studies on the development process of the radial inflow turbines for the organic Rankine cycle (ORC). In this study, a preliminary design of the ORC radial inflow turbine was performed. Subsequently, the performance and structural analysis were also carried out. The RTDM, which was developed as an in-house code, was used in the preliminary design process. The results of the performance analysis were found to be in good agreement with target performances. Structural analysis of the designed turbine was also carried out in order to determine whether the material selection for this study is suitable for the flow conditions of the designed turbine, and it was found that the selected aluminum alloy is suitable for the designed turbine. However, the reliability of the preliminary design algorithms and numerical methods should be strictly verified by an actual experimental test.

• Journal of the Society of Naval Architects of Korea
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• v.36 no.4
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• pp.137-146
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• 1999

Inspection becomes to be important in the safety of structure and economical viewpoint, because structural damage accompanies lots of economical cost and social problems. Especially ship structure is composed of a lot of members and it is impossible to inspect all members continuously. The purpose of this paper is to get optimal inspection plan containing inspection time and method. Crack is one of major modes on the structural failure and can lead to collapse of structure. In this paper, the deteriorating process, which contains inspection to detect the crack before the propagation to large crack, is idealized as Markov chain model. Genetic algorithm is also used to accomplish the optimization of inspection plan. Especially, the probabilistic characteristics of cracks are changed, because ship is operating in corrosive environments and the scantling of structural members is reduced due to corrosion. Non-stationary Markov chain model is used to represent the process of corrosion in structural members. In this paper, the characteristics of indivisual inspection plan are compared by numerical examples for the change of corrosion rate, the cost due to scheduled system down and target failure probability. From the numerical example, it can be seen that the improvement of fatigue life for the members with short fatigue life is the most effective way in order to reduce total maintenance cost.