• Clinical and Experimental Reproductive Medicine
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• v.48 no.2
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• pp.111-123
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• 2021

Objective: Using domestic cats as a biomedical research model for fertility preservation, the present study aimed to characterize the influences of ovarian tissue encapsulation in biodegradable hydrogel matrix (fibrinogen/thrombin) on resilience to cryopreservation, and static versus non-static culture systems following ovarian tissue encapsulation and cryopreservation on follicle quality. Methods: In experiment I, ovarian tissues (n=21 animals; 567 ovarian fragments) were assigned to controls or hydrogel encapsulation with 5 or 10 mg/mL fibrinogen (5 or 10 FG). Following cryopreservation (slow freezing or vitrification), follicle viability, morphology, density, and key protein phosphorylation were assessed. In experiment II (based on the findings from experiment I), ovarian tissues (n=10 animals; 270 ovarian fragments) were encapsulated with 10 FG, cryopreserved, and in vitro cultured under static or non-static systems for 7 days followed by similar follicle quality assessments. Results: In experiment I, the combination of 10 FG encapsulation/slow freezing led to greater post-thawed follicle quality than in the control group, as shown by follicle viability (66.9%±2.2% vs. 61.5%±3.1%), normal follicle morphology (62.2% ±2.1% vs. 55.2%±3.5%), and the relative band intensity of vascular endothelial growth factor protein phosphorylation (0.58±0.06 vs. 0.42±0.09). Experiment II demonstrated that hydrogel encapsulation promoted follicle survival and maintenance of follicle development regardless of the culture system when compared to fresh controls. Conclusion: These results provide a better understanding of the role of hydrogel encapsulation and culture systems in ovarian tissue cryopreservation and follicle quality outcomes using an animal model, paving the way for optimized approaches to human fertility preservation.

• The Journal of the Korea Contents Association
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• v.21 no.1
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• pp.92-104
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• 2021

This study aims to analyze online news articles to identify social issues related to patient safety and compare the changes in these issues before and after the implementation of the Patient Safety Act. This study performed text mining through the R program, wherein 7,600 online news articles were collected from January 1, 2010, to March 5, 2020, and examined using keyword analysis, topic modeling, and word co-occurrence network analysis. A total of 2,609 keywords were categorized into 8 topics: "medical practice", "medical personnel", "infection and facilities", "comprehensive nursing service", "medicine and medical supplies", "system development and establishment for improvement", "Patient Safety Act" and "healthcare accreditation". The study revealed that keywords such as "patient safety awareness", "infection control" and "healthcare accreditation" appeared before the implementation of the Patient Safety Act. Meanwhile, keywords such as "patient safety culture". and "administration and injection" appeared after the act's implementation with improved ranking of importance pertaining to nursing-related terminology. Interest in patient safety has increased in the medical community as well as among the public. In particular, nursing plays an important role in improving patient safety. Therefore, the recognition of patient safety as a core competency of nursing and the persistent education of the public are vital and inevitable.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.12
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• pp.449-455
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• 2020

Inventory management is one of the important business functions for manufacturing companies to determine market responsiveness. Customers' needs are diversifying, and the life cycle of products is decreasing, thus increasing the importance of inventory management. However, for small-scale manufacturing companies, investing in an IT system for inventory management is practically difficult. In this study, we introduce an inventory and warehouse management model that can be applied simply and quickly in small-scale manufacturing companies. Firstly, we introduce the concept of the properties of inventory and provide an analytical methodology based on the age and quantity of the inventory. Secondly, in accordance with the properties of the inventory, we introduce location management rules for warehouse operation. To apply the proposed model, we studied a wallpaper manufacturing company and verified the applicability of the proposed methods in the field. The proposed model can be applied immediately as part of on-site improvement activities by small-scale manufacturing companies, and inventory management activities are expected to reduce bad long-term inventory and further secure storage capacity for warehouses.

• Journal of the Korean Association of Geographic Information Studies
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• v.23 no.4
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• pp.140-155
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• 2020

This study was conducted to identify the location characteristics of infected farms in the areas where livestock diseases were clustered(southern Gyeonggi-do and Chungcheong-do), analyze the probability of disease occurrence in poultry farms, find out the areas corresponding to the conditions, and use them as the basis for prevention of livestock diseases, selection of discriminatory prevention zones, and establishment of prevention strategies and as the basic data for complementary measures. The increase of one poultry farm within a radius of 3-kilometers increases the risk of HPAI infection by 10.9% compared to the previous situation. The increase of 1m in distance from major roads with two lanes or more reduces the probability of HPAI infection by 0.001% compared to the previous situation. If the distance of the poultry farm located with 15 kilometers from a major migratory bird habitat increases by 15 to 30 kilometers, the chance of infection with HPAI is reduced by 46.0%. And if the distance of the same poultry farm increase by more than 30 kilometers, the chances of HPAI infection are reduced by 88.5%. Based on the results of logistic regression, the predicted probability was generated and the actual area of the location condition with 'more than 15 poultry farms within 3km a radius of, within 1km distance from major roads, and within 30km distance from major migratory birds habitat was determined and the infection rate was measured. It is expected that the results of this study will be used as basic data for preparing the data and supplementary measures when the quarantine authorities establish discriminatory quarantine areas and prevention strategies, such as preventive measures for the target areas and farms, or control of vehicles, by identifying the areas where livestock diseases are likely to occur in the region.

• Korean Journal of Applied Biomechanics
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• v.31 no.1
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• pp.1-15
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• 2021

Objective: The aim of this study was to investigate 1) the difference in static lower extremity alignment (SLEA) according to a history of lateral ankle sprain (LAS), 2) to identify SLEA factors affecting LAS, and 3) to present the cut-off value and 4) the usefulness and limitations of the SLEA measurement. Method: This case-control study recruited 88 men (age: 27.78±4.69 yrs) and 39 women (age: 24.62±4.20 yrs) subjects with and without LAS. SLEA measurement protocol included Q angle, tibiofemoral angle, genu recurvatum, rear foot (RF) angle, tibal varum and torsion, navicular drop, ankle dorsiflexion range of motion (DF ROM). Independent t-test, logistic regression and receiver operating characteristic (ROC) curve were used for statistical analysis. Results: Men with a history of LAS had significantly smaller Q angles both in standing and in supine position, while women with a history of LAS had significantly greater DF ROM in non-weight bearing (NWB; p < 0.05). Logistic regression model suggests tibial varum (OR = 0.779, p = 0.021) and WB DF ROM (OR = 1.067, p = 0.045) were associated with LAS in men. In case of women, there were no significant SLEA factors for LAS, however, ROC curve analysis revealed standing RF angle (AUC = 0.647, p = 0.028) and NWB DF ROM (AUC = 0.648, p = 0.026) could be affecting factors for LAS. Conclusion: There are differences in SLEA according to the history of LAS, furthermore, the identified items were different by sex. In case of men, tibial varum and WB DF ROM affect LAS occurrence. Standing RF angle and NWB DF ROM of women could be a predictor for LAS. However, since the sensitivity and specificity in most of the SLEA measurements are low, kinematic in dynamic tasks should be considered together for a more accurate evaluation of LAS risk.

• The Korean Journal of Pain
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• v.34 no.1
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• pp.27-34
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• 2021

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a major reason for stopping or changing anticancer therapy. Among the proposed pathomechanisms underlying CIPN, proinflammatory processes have attracted increasing attention. Here we assessed the role of prostaglandin D2 (PGD2) signaling in cisplatin-induced neuropathic pain. Methods: CIPN was induced by intraperitoneal administration of cisplatin 2 mg/kg for 4 consecutive days using adult male Sprague-Dawley rats. PGD2 receptor DP1 and/or DP2 antagonists were administered intrathecally and the paw withdrawal thresholds were measured using von Frey filaments. Spinal expression of DP1, DP2, hematopoietic PGD synthase (H-PGDS), and lipocalin PGD synthase (L-PGDS) proteins were analyzed by western blotting. Results: The DP1 and DP2 antagonist AMG 853 and the selective DP2 antagonist CAY10471, but not the DP1 antagonist MK0524, significantly increased the paw withdrawal threshold compared to vehicle controls (P = 0.004 and P < 0.001, respectively). Western blotting analyses revealed comparable protein expression levels in DP1 and DP2 in the spinal cord. In the CIPN group the protein expression level of L-PGDS, but not of H-PGDS, was significantly increased compared to the control group (P < 0.001). Conclusions: The findings presented here indicate that enhanced PGD2 signaling, via upregulation of L-PGDS in the spinal cord, contributes to mechanical allodynia via DP2 receptors in a cisplatin-induced neuropathic pain model in rats, and that a blockade of DP2 receptor activation may present a novel therapeutic target for managing CIPN.

• KIPS Transactions on Computer and Communication Systems
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• v.10 no.3
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• pp.59-70
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• 2021

With the recent advancements in the Internet of Things, context-aware system that provides customized services become important to consider. The existing context-aware systems analyze data generated around the user and abstract the context information that expresses the state of situations. However, these datasets is mostly unstructured and have difficulty in processing with simple approaches. Therefore, providing context-aware services using the datasets should be managed in simplified method. One of examples that should be considered as the unstructured datasets is a deep learning application. Processes in deep learning applications have a strong coupling in a way of abstracting dataset from the acquisition to analysis phases, it has less flexible when the target analysis model or applications are modified in functional scalability. Therefore, an abstraction model that separates the phases and process the unstructured dataset for analysis is proposed. The proposed abstraction utilizes a description name Analysis Model Description Language(AMDL) to deploy the analysis phases by each fat client is a specifically designed instance for resource-oriented tasks in edge computing environments how to handle different analysis applications and its factors using the AMDL and Fat client profiles. The experiment shows functional scalability through examples of AMDL and Fat client profiles targeting a vehicle image recognition model for vehicle access control notification service, and conducts process-by-process monitoring for collection-preprocessing-analysis of unstructured data.

• Journal of Surface Science and Engineering
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• v.54 no.1
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• pp.1-11
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• 2021

Porous dendrite structure AuCu alloy was formed using a hydrogen bubble template (HBT) technique by electroplating to improve the catalytic performance of gold, known as an excellent oxygen reduction reaction (ORR) catalyst in alkaline medium. The rich Au surface was maximized by selectively electrochemical etching Cu on the AuCu dendrite surface well formed in a leaf shape. The catalytic activity is mainly due to the synergistic effect of Au and Cu existing on the surface and inside of the particle. Au helps desorption of OH- and Cu contributes to the activation of O2 molecule. Therefore, the porous AuCu dendrite alloy catalyst showed markedly improved catalytic activity compared to the monometallic system. The porous structure AuCu formed by the hydrogen bubble template was able to control the size of the pores according to the formation time and applied current. In addition, the Au-rich surface area increased by selectively removing Cu through electrochemical etching was measured using an electrochemical calculation method (ECSA). The results of this study suggest that the alloying of porous AuCu dendrites and selective Cu dissolution treatment induces an internal alloying effect and a large specific surface area to improve catalyst performance.

• Journal of the Korean Applied Science and Technology
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• v.38 no.1
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• pp.37-47
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• 2021

The purpose of this study was to identify relationship between resilience, social support, community resilience, and anxiety in nursing students. 252 participants were recruited from the university located in Gyeonggi-do and data were collected using self-reported questionnaires. Data were analyzed using the SPSS/WIN 25.0 program, with descriptive statistics x2-test, t-test, ANOVA, Pearson's correlation. The average score were resilience 3.10 out of 5, social support 4.22 out of 5, community resilience 3.21 out of 5, and anxiety 2.21 out of 4. In addition, social support(r=.32, p<.001) and community resilience(r=.18, p=.004) were positively correlated with resilience, but anxiety(r=-64, p<.001) was negatively correlated with resilience in university students. In conclusion, program and comprehensive support system are needed to strengthen social support and community resilience, to control and cope with anxiety in order to improve resilience of the university students.

• Journal of Advanced Navigation Technology
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• v.24 no.6
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• pp.566-572
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• 2020

In a wireless power transmitter, the characteristics and effects of wireless power transmission between two induction coils are investigated, and a power converter circuit and a battery charger/discharger circuit using wireless power transmission technology are proposed. The advantage of wireless power transmitters and wireless chargers is that, instead of the existing plug-in-mounted wired charger (OBC; on-board charger), the user can wirelessly charge the battery without connecting the power source when charging power to the battery. There is. In addition, the advantage of wireless charging can bring about an energy efficiency improvement effect by using the secondary side rectifier circuit and the receiving coil, but the large-capacity long-distance wireless charging method has a limitation on the transmission distance, so many studies are currently being conducted. The purpose of the study is to study the transmitter circuit and receiver circuit of a wireless power transmission device using a primary coil, a secondary coil, and a half bridge series resonance converter, which can transmit power of a non-contact type power transmitter. As a result, a new topology was applied to improve the power transmission distance of the wireless charging system, and through an experiment according to each distance, the maximum efficiency (95.8%) was confirmed at an output of 3 kW at an 8 cm transmission distance.