• Archives of Pharmacal Research
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• v.12 no.3
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• pp.207-213
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• 1989

This study was performed to investigate the mechanism of in vitro cytotosic actions of polyacetylenes which are panaxydol, panaxynol and panaxytriol isolated from Panax ginseng C. A. Meyer. DNA synthesis of L1210 cells was significantly inhibited with dose dependent pattern when L1210 cells were treated for 1 hour with over 5 .mu.g/ml of polyacetylenes. Panaxydol which had the most potent cytotoxicity among three polyacetylenes showed also the strongest inhibitory effect on DNA synthesis. Intracellular cyclic AMP levels of L1210 cells treated with 2.5 $\mu$g/ml of panaxydol or panaxytriol were significantly elevated on the incubation duration. The elevation of cyclic AMP levels by panaxytriol was higher than that by panaxydol, but no significant increase in cyclic AMP by panaxynol was observed. All three polyacetylenes had no effect on glycolysis of L1210 cells. Electron microscopic observations revealed that polyacetylenes caused damage to plasma membranes of L1210 cells in proportion to their cytotoxicities at each $ED_{50}$ value (panaxydol > panaxynol> panaxytriol). These results suggest that cytotoxicities of polyacetylenes against L1210 cells might be mediated by elevated cyclic AMP level, even though the relationship among their cytotoxicities, inhibitory effect on DNA synthesis and ability to elevation of cyclic AMP level are not fully agreed, and might be also related to membrane damage.

• Carbon letters
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• v.16 no.4
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• pp.233-240
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• 2015

Electrochemical synthesis was employed to prepare a novel hydroxyapatite/graphene (HAP/Gr) composite powder suitable for medical applications as a hard tissue implant (scaffold). The synthesis was performed in a homogeneous dispersion containing Na₂H₂EDTA·2H₂O, NaH₂PO₄ and CaCl₂ with a Ca/EDTA/PO₄³⁻ concentration ratio of 0.25/0.25/0.15M, along with 0.01 wt% added graphene nanosheets, at a current density of 137 mA cm⁻² and pH value of 9.0. The field emission scanning electron microscopy and transmission electron microscopy observations of the composite HAP/Gr powder indicated that nanosized hydroxyapatite particles were uniformly placed in the graphene overlay. Raman spectroscopy, Fourier transform infrared spectroscopy and X-ray diffraction confirmed graphene incorporation in the HAP/Gr powder. The electrochemically prepared HAP/Gr composite powder exhibited slight antibacterial effect against the growth of the bacterial strain Staphylococcus aureus.

• Journal of environmental and Sanitary engineering
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• v.13 no.1
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• pp.44-56
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• 1998

This study was performed to investigate the reaction characteristics of piggery wastewater for biological nutrient removal. The reaction characteristics were discussed the fraction of organics, the behavior of nitrogen, nitrification, denitrification, and the behavior of phosphorus. The fraction of readily biodegradable soluble COD was 11-12 percent. The ammonia nitrogen was removed via stripping, nitrification, autotrophic cell synthesis, and heterotrophic cell synthesis. The removal percents by each step were 12.1%, 68.9%, 15.0%, and 4.0%, respectively. Nitrification inhibition of piggery wastewater was found to occur at an influent volumetric loading rate over 0.2 NH$_{3}$-N kg/m$^{3}$/d. Denitrification rates were the highest in the raw wastewater and the lowest in the anaerobic effluent. The denitritation of piggery wastewater came out to be possible, and the rate of organic carbon consumption decreased about 10 percent. The phosphorus removed was released in the form of ortho-p in the aerobic fixed biofilm reactor, it was caused by autooxidation. The synthesis and release of phosphorus were related to the ORP and the boundary value for the phase change was about 170mV. In the synthesis phase, the phosphorus removal rate per COD removed was 0.023mgP$_{syn}$/mgCOD$_{rem}$. The phosphorus contents of the microorganism were 4.3-6.0% on a dry weight basis.

• Journal of the Korean Chemical Society
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• v.57 no.6
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• pp.769-777
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• 2013

The effect of operating conditions (temperature and the partial pressures of H2 and CO) on the reaction rate of Fischer-Tropsch synthesis (FTS) were investigated by carrying out experiments according to a Box-Behnken design (BBD), and were mathematically modeled by using response surface methodology (RSM). The catalyst used was a nano-structured cobalt/manganese oxide catalyst, which was prepared by thermal decomposition. The rate of synthesis was measured in a fixed-bed micro reactor with $H_2/CO$ molar feed ratio of 0.32-3.11 and reactor pressure in the range of 3-9.33 bar at space velocity of $3600h^{-1}$ and a temperature range of 463.15-503.15 K, under differential conditions (CO conversion below 2%). The results indicated that in the present experimental setup, the temperature and the partial pressure of CO were the most significant variables affecting reaction rate. Based on statistical analysis the quadratic model of reaction rate of FTS was highly significant as p-value 0.0002.

• Proceedings of the IEEK Conference
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• 2000.11b
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• pp.329-332
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• 2000

This paper proposed resource allocation algorithm for the minimum power consumption of functional unit in high level synthesis process as like DSP which is circuit to give many functional unit. In this paper, the proposed method though high level simulation find switching activity in circuit each functional unit exchange for binary sequence length and value bit are logic one value. To used the switching activity find the allocation with minimal power consumption, the proposed method visits all control steps one by one and determines the allocation with minimal power consumption at each control step.

• Journal of Environmental Impact Assessment
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• v.25 no.2
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• pp.141-154
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• 2016

This study was conducted laying the focus on finding the mutual action between the substantial ecological value and economic system in the national land, and calculating the environmental carrying capacity and sustainability of the national land using the emergy synthesis. Particularly, this study pays attention watchfully to the reality that the analytic framework to analyze sustainability is not arranged well, as the concept of sustainable development considering environmental carrying capacity, which becomes a widely discussed topic today, is defined differently according to the subjective views of respective researchers, and the situation which needs in-depth evaluation on the interaction between nature and economy which becomes the fundamental of sustainable development. This study also aims at groping for correct direction for the national land development by calculating the environmental carrying capacity and index value which is appropriate to the national land and providing the framework for preparing the policy to induce the sustainable use and management of the national land. The concept of emergy synthesis which is used for the evaluation of environmental carrying capacity and sustainability in the national land, as in this case, can notify the information on current situation of the national land as well as explain how the national land transforms according to time pass (the role of information synthesis), and gives knowledge if the national land policies advances toward the direction of sustainable development (the role of policy evaluation and observation). Emergy synthesis also can take role for selecting best policy on the process of decision making on the exploitation of the national land (the role on the process of decision making).

• Asian-Australasian Journal of Animal Sciences
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• v.18 no.3
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• pp.326-331
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• 2005

A rumen simulated continuous culture (RSCC) system was used to study the influence of supplementation of the three different types of protein sources such as urea, casein and soy protein on rumen microbial synthesis in terms of rumen microbial synchronization. The urea treatment showed the highest pH value. Ammonia nitrogen concentration was rapidly increased after feeding and not significantly different in the urea treatment (13.53 mg/100 ml). Protozoa numbers were not significantly different for soy protein and casein treatment compared to urea treatments during incubation. The average concentration of total VFA (mMol) was not detected with significant difference among treatments, but iso-butyrate production showed the highest for soy protein treatment among treatments (p<0.001). The lowest concentration in total iso-acids (iso-butyrate and iso-valerate) production was observed in urea treatment. The soy protein treatment showed no significantly change in acetate/propionate. The amounts of dry matter (DM) out flow showed no significant difference among treatments. Organic matter (OM) flow was the highest for urea treatments and the lowest for casein treatment (p<0.03). The nitrogen flow for casein treatment was not significantly different from other treatments. The efficiency of microbial protein synthesis in terms of microbial nitrogen (MN) synthesis (g MN/kg ADOM) digested in the rumen was highest for casein treatment (58.53 g MN/kg ADOM) compared to soy protein and urea (p<0.05). This result suggests that rumen ammonia releasing rate may influence on microbial protein synthesis in the rumen.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.17 no.5
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• pp.77-87
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• 2018

Traffic Density is the most important of the three primary macroscopic traffic stream parameters, because it is most directly related to traffic demand(Traffic Engineering, 2004). It is defined as the number of existing vehicles within a given distance at a certain time. However, due to weather, road conditions, and cost issues, collecting density directly on the field is difficult. This makes studies of density less actively than those of traffic volume or velocity. For these reasons, there is insufficient attempts on divers collecting methods or researches on the accuracy of measured values. In this paper, we used the 'Density Measuring System' based on the synthesise technology of several camera images as a method to measure density. The collected density value by the 'Density Mesuring System' is selected as the true value based on the density define, and this value was compared with the density calculated by the traditional measurement methods. As a result of the comparison, the density value using the fundamental equation method is the closest to the true value as RMSE shows 1.8 to 2.5. In addition, we investigated some issues that can be overlooked easily such as the collecting interval to be considered on collecting density directly by calculating the moment density and the average density. Despite the actual traffic situation of the experiment site is LOS B, it is difficult to judge the real traffic situation because the moment density values per second are observed max 16.0 (veh/km) to min 2.0 (veh/km). However, the average density measured for 15 minutes at 30-second intervals was 8.3-7.9 (veh/km) and it indicates precisely LOS B.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.29 no.9
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• pp.552-558
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• 2016

Goethite, ${\alpha}$-FeOOH have various applications such as absorbent, pigment and source for magnetic materials. Goethite particles were synthesized in a two step process, where $Fe(OH)_2$ were synthesized in nitrogen atmosphere using $FeSO_4$ as a raw material in the first process, and after that acicular goethite particles were obtained in an air oxidation process of $Fe(OH)_2$ in highly alkaline aqueous solution. Their phase and microstructure were investigated with XRD and FE-SEM. It was found that the morphology of goethite and the ratio of length-to-width (aspect ratio) of acicular goethite are dependent on the some factors such as R value ($OH^-/Fe^{2+}$), air flow rate and pH conditions. In particular, R value has the strongest influence on the synthesized goethite morphology. It is considered that the optimal value R is 4.5 because X-ray diffraction peaks of goethite have the highest intensity at that value. Morphology of goethite particles was controlled by air flow rates, showing that their size and aspect ratio are getting smaller and decrease, respectively as air flow rate increases. The largest goethite particle obtained is about 1,500 nm in length and 150 nm in diameter.

• Proceedings of the KIEE Conference
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• 2003.11c
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• pp.946-949
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• 2003

In this paper, a DDFS(Direct Digital Frequency Synthesis)chip has been designed focusing on the reduction of ROM size and implemented using FPGA. When calculating the sine value for the input phase value, we used the Taylor series expansion approximation method to reduce the number of addresses of ROM. We also used the piecewise straight line approximation method, ie, the stored value int the ROM is the difference of the sine value and the straight line approximation. Using this method, we could reduce four bits for each ROM data.