• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.89-93
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• 2016

Background: Limited data are available regarding the impact of time duration between chemoradiation (CRT) and surgery on pathological complete response (PCR). A PCR translates into better overall and disease free survival. The objective of this study was to determine effect of time duration on outcome after preoperative CRT in rectal cancer. Materials and Methods: A retrospective review of patients undergoing operations for rectal adenocarcinoma between January 2005 and December 2010 was performed. Patients were divided in two groups: Group 1 underwent surgery in ${\leq}8weeks$ post neoadjuvant CRT and Group 2 after 8 weeks. Patient characteristics, surgical procedure, histopathological details and number of loco-regional and distant failures were compared. Expected 5 year overall survival and disease free survival was calculated using Kaplan Meier curves and significance was determined using the log rank test. Results: There were 66 patients in group 1 and 93 in group 2. No significant difference in PCR was observed between the two. However, estimated 5 year DFS was significantly higher in Group 1 (66.7%) as compared to Group 2 (53.8%) (P=0.04). Estimated overall 5 year overall survival was not significantly different at 68.2% versus 54.3% (P= 0.09). Conclusions: Delaying surgery more than 8 weeks after preoperative CRT does not impact for PCR in rectal cancer.

• Tuberculosis and Respiratory Diseases
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• 제43권6호
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• pp.903-915
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• 1996

Background: Combination chemotherapy is now considered to be the cornerstone of small cell lung cancer (SCLC). management but the optimal management of limited SCLC is not well defined. The role of thoracic radiotherapy (TRT) is less well established. Recent meta-analyses reports revealed that TRT combined with chemotherapy produce "good" local control and prolonged survival. But other reports that survival was not changed. The liming, dose, volume and fractionation for TRT with the combined chemotherapy of SCLC remains unsettled. In this study, we analyzed the effects according to the timing of thoracic radiotherapy in limited SCLC. Method: All fifty one patients received cytoxan, adriamycin and vincristine(CAV) alternating with etoposide and cisplatin(VPP) every 3 weeks for 6 cycles were randomized prospectively into two groups: concurrent and sequential. 27 patients received 4500cGy in 30 fractions(twice daily 150cGy fractional dose) over 3 weeks 10 the primary site concurrent with the first cycle of VPP(concurrent gorup). 24 patients received 4000 to 5000cGy over 5 or 6 weeks after completion of sixth cycles of chemotherapy(sequential group). Results: 1. Response rates and response duration : Response rates were not significantly different between two groups(p=0.13). But response duration was superior in the concurrent group(p=0.03). 2. Survival duration was nor different between two groups(p=0.33). 3. Local control rate was superior in the concurrent group(p=0.00). 4. Side effects and toxicities: Hematologic toxicities, especially leukopenia, infection and frequency of radiation esophagitis were higher in the concurrent group (p=0.00, 0.03, 0.03). Conclusion: The concurrent use of TRT with chemotherapy failed to improve the survival of limited stage SCLC patients compared with the sequential use of TRT but response duration and local control rate were superior in the concurrent group. Frequency of radiation esophagitis, life threatening hematologic toxicities and infection were more frequent in the concurrent group than sequential group. So, the selection of an optimal schedule of chemotherapy combined with TRT that would lead to a major increase in survival with minimal toxicity is remained to be validated in large scale study in the future.

• 대한교통학회지
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• 제28권6호
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• pp.85-97
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• 2010

본 연구는 정류소에서 여러노선의 버스가 동시에 몰려들어오는 버스몰림운행의 실태를 파악하고 이로 인해서 야기되는 문제점을 개선하기 위하여 버스몰림 운행지속시간 모형을 추정하고 버스몰림운행에 영향을 미치는 요인을 분석하였다. 버스몰림지속시간의 관측치를 대상으로 8개의 지속시간에 대한 분포를 검토하여 가장 적합도가 높게 나타난 weibull 분포를 가정한 모형을 개발하였다. 18개 영향변수를 검토하였으며 정차면수, 정차면수당 노선수, 노선당 최대 승하차인원을 설명변수로 하는 버스몰림운행 지속시간 모형을 개발하였다. 중앙버스전용차로(도봉미아로)와 가로변 전용 및 일반차로(통일의주로)에 대한 모형을 각각 도출하여 비교하였다. 그 결과, 도봉미아로의 몰림지속시간은 통일의주로에 비해 교통량에 대한 영향을 많이 받으며, 통일의주로는 도봉미아로에 비해 정차면수와 정차면수당 노선수, 노선당 최대 승하차인원에 많은 영향을 받는 것으로 나타났다. 개발된 모형을 토대로 버스몰림운행 현상의 완화방안을 제시하였다.

• Journal of Preventive Medicine and Public Health
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• 제39권1호
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• pp.74-80
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• 2006

Objectives: The purpose of this study is to examine the factors affecting the rate and duration of breastfeeding. Methods: We analyzed the data from the year 2000 Korea National Fertility Survey that was collected through direct interviews. In particular, the mothers who delivered their last child and the child was under 1 year of age from January 1998 to June 2000 (N=1,066) were analyzed via a logistic model to assess the factors affecting the breastfeeding rate. Among the study subjects, those who had initiated breastfeeding (N=740) were analyzed through Cox's proportional hazard model to evaluate the factors affecting the duration of breastfeeding. Results: The multivariate logistic model showed that the delivery type and the baby's birth-weight have a statistically significant influence on the breastfeeding rate. Women who delivered their babies through Cesarean section were less likely than others to breastfeed. In contrast, the women whose babies weighed 2.5Kg or more were more likely than others to breastfeed. The results obtained from the survival analysis are as follows: the higher the mother's education level, the shorter is the breastfeeding duration. The mother's work status played a significant role in the early termination of breastfeeding. Women aged 35 or older showed a longer breastfeeding duration than the younger age groups, whereas the maternal age was not a significant factor in affecting whether or not a mother would breastfeed. Conclusions: Reducing the cases of operative delivery (Cesarean section) and low weight births, enlightening young and highly educated women on breastfeeding and improving the environment for breastfeeding on the job are important strategies to encourage women to breastfeed.

• Archives of Plastic Surgery
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• 제38권6호
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• pp.808-814
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• 2011

Purpose: Despite wide clinical use of breast implants, there is continued concern about the lifespan of these devices. The causes of explantation were infection, deflation of implant and patient's want. The deflation of saline-filled breast implant was related to strength and durability of implant shell. The purpose of this study is to evaluate the clinical durability of saline-filled breast implant through the analysis of duration until deflation occurred, causes, incidence and influencing factors. Methods: Retrospective analyses were conducted on clinical records for 19 cases of deflation of saline-filled breast implant from 201 cases of breast reconstruction with saline-filled implant between May 1995 and June 2011. The authors had been analyzed the causes of deflation, survival duration, symptom, sign, nipple excision, volume of implant, saline filling, method of reoperation, breast cancer stage and combined capsular contracture. Results: The causes of deflation were attributed to the cases that cannot be evaluated the causes in 15 cases, fall down in 1 case, mammography in 2 cases, accidental needle injury in 1 case. Mean survival duration was 4 years and 5 months. The duration of survival was less than 1 year for 5 cases, 1 year to 10 years for 10 cases, more than 10 years for 4 cases. The volume between 201 and 250 cc of deflated breast implant was rated as high by 14.0 percent. The deflation rate of underfilled implants was 11.4 percent, adequate filled implants was 9.3 percent. None of overfilled implant was deflated. The deflation of smooth surface implant was 5 of 152 cases. Textured implant was 14 of 49 cases. The capsular contracture of non-deflated breast implant was 28 of 182 cases and that of deflated breast implant was 6 of 19 cases. Conclusion: The patients who underwent saline-filled breast implant implantation should be informed that their implant could deflate. The analysis of clinical durability and causes of deflation in breast implant was important for the prediction and prevention of reopeation. The authors could suppose the causes of deflation of saline-filled breast implant through history, duration of survival, inspection of the shell of implant.

• 한국수산과학회지
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• 제36권5호
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• pp.463-468
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• 2003

This study observed change of survival rate, activity and foot structure of the equilateral venus (Gomphina veneriformis) exposed to cadmium. Survival rate and activity of the clam exposed to cadmium was reduced with increase of exposure duration and concentration. Change of survival rate and activity was observed in the early exposure time (7 days) in the condition of above 1 77 mg/L and 0.88 mg/L, respectively. Activity reduction of the clam exposed to cadmium seems to be caused by epidermal layer deformation, muscle fiber fragmentation and muscular layer collapse of the foot.

• The Korean Journal of Pain
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• 제3권1호
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• pp.21-26
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• 1990

One hundred among 320 patients who underwent splanchnic nerve block were evaluated retrospectively by telephone or letters. After splanchnic nerve block most of the patient experienced relatively good pain relief until death. The results were as follows 1) The duration of pain relief and survival time were well correlated. 2) The duration of survival time after the block was varied from 35 days to 240 days. These data suggest that the splanchnic nerve block is a satisfactory and reliable method for terminal cancer pain and results in a painless life until death.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1007-1010
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• 2015

Background: The clinical significance of bilateral breast cancer is unclear and its influence on prognosis is controversial. Materials and Methods: Between 2005 and 2009 we identified 110 cases of bilateral breast cancer (BBC) ; 49 patients had synchronous (duration between the occurrence of carcinoma in both breasts was less than 12 months) and 61 had metachronous (duration was more than one year with no ipsilateral local recurrence). We compared the patient characteristics including age, menopausal status, clinical stage, tumor size, histological classification, lymph node status, and hormone receptor and Her-2 status. We also compared the treatment given and overall and disease free survival (DFS) of both groups. Results: Synchronous cases tend to present more aggressively than metachronous cases and age at first presentation adversely affects survival. The 5 year overall survival was 78.7% for metachronous and 60% for synchronous. Patients with positive hormonal status had better five year disease free survival in metachronous compared to synchronous cases, at 76% and 63%, respectively. Age at first presentation >45years had better DFS (65%) compared to those with age ${\leq}45$ years (52%) at 5 years follow up. Conclusions: Patients with synchronous breast cancer may have worse prognosis. Young age and hormone receptor negative were risk factors in our study. Close follow up and early detection of contralateral breast cancer is mandatory.

• Journal of Korean Neurosurgical Society
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• 제60권2호
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• pp.195-204
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• 2017

Objective : This 2009-2011 nation-wide study of adult Koreans was aimed to provide characteristics, medical utilization states, and survival rates for newly diagnosed patients with primary nonmalignant and malignant spine tumors. Methods : Data for patients with primary spine tumors were selected from the Korean Health Insurance Review and Assessment Service database. The data included their age, sex, health insurance type, co-morbidities, medical cost, and hospital stay duration. Hospital stay duration and medical costs per person occurring in one calendar year were used. In addition, survival rates of patients with primary malignant spine tumors were evaluated. Results : The incidence rate of a primary spine tumor increased with age, and the year of diagnosis ($p{\leq}0.0001$). Average annual medical costs ranged from 1627 USD (pelvis & sacrum & coccyx tumors) to 6601 USD (spinal cord tumor) for primary nonmalignant spine tumor and from 12137 USD (spinal meningomas) to 20825 USD (pelvis & sacrum & coccyx tumors) for a primary malignant spine tumor. Overall survival rates for those with a primary malignant spine tumor were 87.0%, 75.3%, and 70.6% at 3, 12, and 24 months, respectively. The Cox regression model results showed that male sex, medicare insurance were significantly positive factors affecting survival after a diagnosis of primary malignant spine tumor. Conclusion : Our study provides a detailed view of the characteristics, medical utilization states, and survival rates of patients newly diagnosed with primary spine tumors in Korea.

• 한국사회복지학
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• 제39권
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• pp.5-40
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• 1999

이 연구의 목적은 실업자의 실업기간과 재취업 형태에 영향을 미치는 주된 요인이 무엇인지를 파악하고, 그에 기초하여 보다 바람직한 고용관련정책 마련에 필요한 기초자료를 제공하는 데 있다. 이를 위해 이 연구는 보건사회연구원과 노동연구원이 공동으로 실시한 '1998년도 전국 실업실태 및 복지욕구조사' 자료를 Weibull 모델과 Logistic모델을 이용하여 분석하였다. 분석한 결과, 전체 실업자를 대상으로 할 경우, 연령, 가구 월 평균소득, 가구주 여부, 결혼 여부, 이전 직장의 규모, 실직사유 등의 변수가 실업자의 실업기간에 영향을 미치는 주요 요인으로 파악되었고, 연령, 이전 직장의 직종과 근무형태, 고용보험가입 여부 등의 변수가 실업자의 재취업형태에 영향을 미치는 주요 요인으로 파악되었다. 이러한 실증적 분석의 결과를 바탕으로 이 연구는 불안정한고용상태와 실업, 그리고 실업과 불안정한 재취업의 순환을 반복할 수 있는 취약계층 근로자를 위한 보다 체계적인 실업대책의 필요성을 논하면서 정책적인 제언을 하고자 한다.