• Clean Technology
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• v.13 no.1 s.36
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• pp.34-45
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• 2007

Phase behavior of the ternary systems of water-insoluble simvastatin drug, which is well known to be effective drugs for hypercholesterolemia therapy, in solvent mixtures of dichloromethane and supercritical carbon dioxide was investigated to present a guideline of establishing operating conditions in the particle formation of the drugs by a supercritical anti-solvent recrystallization process utilizing dichloromethane as a solvent and carbon dioxide as an anti-solvent. The solubilities of simvastatin in the mixtures of dichloromethane and carbon dioxide were determined as functions of temperature, pressure and solvent composition by measuring the cloud points of the ternary mixtures at various conditions using a high-pressure phase equilibrium apparatus equipped with a variable-volume view cell. The solubility of the drug increased as the dichloromethane composition in solution and the system pressure increases at a fixed temperature. A lower solubility of the drug was obtained at a higher temperature. The second half of this work is focused on the particle formation of the simvastatin drug by a supercritical anti-solvent recrystallization process in a cylindrical high-pressure vessel equipped with an impeller. Microparticles of the simvastatin drug were prepared as functions of pressure (8 MPa to 12 MPa), temperature (303.15 K, 313,15 K), feed flow rate of carbon dioxide, and stirring speed (up to 3000 rpm), in order to observe the effect of those process parameters on the size and shape of the drug microparticles recrystallized.

• Korean Chemical Engineering Research
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• v.55 no.2
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• pp.225-229
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• 2017

Micron-sized dextran particles, which now attract wide attention as a promising drug delivery systems, can be prepared via the supercritical anti-solvent (SAS) process. In SAS process, dextran particles are obtained as a result of recrystallization of dissolved dextran in dimethyl sulfoxide (DMSO) on addition of supercritical $CO_2$ as an anti-solvent. In this work, with an intention to provide information on the feasible operating conditions of the process, the phase behavior of Dexran/DMSO/$CO_2$ is observed by measuring the cloud point in favor of a variable volume cell. From the experimental study, it is concluded that a feasible operating condition of the SAS process for preparation of dextran particles would be 300.15 K~330.15 K and 90 bar~130 bar, respectively, and solute concentration ranges from 5mg/ml to 20 mg/ml.

• Journal of Hydrospace Technology
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• v.2 no.1
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• pp.10-17
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• 1996

If a point impulse travels over free surface of water of finite depth, surface waves consist of divergent waves. The crestlines of those divergent waves are short and end on the cusp line if the impulse travels at a subcritical speed. But the crestlines become infinitely long and there are no cusps if the impulse travels at a supercritical speed.

• Nuclear Engineering and Technology
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• v.36 no.5
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• pp.403-414
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• 2004

An experimental study of heat transfer characteristics near the critical pressure has been performed with an internally-heated vertical annular channel cooled by R-134a fluid. Two series of tests have been completed: (a) steady-state critical heat flux (CHF) tests, and (b) heat transfer tests for pressure reduction transients through the critical pressure. In the present experimental range, the steady-state CHF decreases with increase of the system pressure for fixed inlet mass flux and subcooling. The CHF falls sharply at about 3.8 MPa and shows a trend towards converging to zero as the pressure approaches the critical point of 4.059 MPa. The CHF phenomenon near the critical pressure does not lead to an abrupt temperature rise of the heated wall, because the CHF occurs at remarkably low power levels. In the pressure reduction transients, as soon as the pressure passes below the critical pressure from the supercritical pressure, the wall temperatures rise rapidly up to very high values due to the departure from nucleate boiling. The wall temperature reaches a maximum at the saturation point of the outlet temperature, and then tends to decrease gradually.

• Proceedings of the KSME Conference
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• 2001.11b
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• pp.872-877
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• 2001

This study analyzed the design performance of the bottoming system of combined cycle power plants adopting a single-pressure once-through heat recovery steam generator with reheat. A computer program was constructed and parametric analyses were carried out to present the criteria for determining the reheat pressure and the location of the starring point of the reheater in the HRSG. The performance of the bottoming system was presented for the range from high subcritical to supercritical pressures. It was founded that the power of the bottoming system can be as high as that of the present triple-pressure bottoming system even with a higher exhaust gas temperature. A requirement for this high performance is a proper arrangement of the reheater.

• Journal of the Korean Chemical Society
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• v.32 no.4
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• pp.311-317
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• 1988

The solubilities of naphthalene in ammonia could be measured at various temperatures and pressures above the critical point of ammonia to represent the relationship between the solubility and the density of ammonia at desired temperature and pressure by means of a simple equation. This equation allows a calculation of the solubilities at higher and lower pressures. Using the equation, the solution energies, the solution entropies, and the second cross virial coefficients between naphthalene and ammonia have been determined to be compared with those in the case of the dissolution of naphthalene in supercritical carbon dioxide.

• Korean Chemical Engineering Research
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• v.54 no.2
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• pp.206-212
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• 2016

Experimental data are reported on the phase equilibrium of propoxylated neopentyl glycol diacrylate in supercritical carbon dioxide. Phase equilibria data were measured in static method at a temperature of (313.2, 333.2, 353.2, 373.2 and 393.2) K and at pressures up to 27.82 MPa. At a constant pressure, the solubility of propoxylated neopentyl glycol diacrylate for the (carbon dioxide + propoxylated neopentyl glycol diacrylate) system increases as temperature increases. The (carbon dioxide + propoxylated neopentyl glycol diacrylate) system exhibits type-I phase behavior. The experimental result for the (carbon dioxide + propoxylated neopentyl glycol diacrylate) system is correlated with Peng-Robinson equation of state using mixing rule. The critical property of propoxylated neopentyl glycol diacrylate is predicted with Joback and Lyderson method.

• Korean Chemical Engineering Research
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• v.50 no.4
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• pp.678-683
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• 2012

Ceria is one of the most important catalytic materials which can be used in three-way catalysts, waste water treatment, petroleum refining, etc. So far, many methods have been studied to produce ceria nanoparticles. In this study, ceria nanoparticles were prepared via solvothermal synthesis using supercritical methanol in short reaction time using a batch reactor. The size of synthesized ceria nanoparticles in supercritical methanol is 6 nm without capping agent, which is smaller than that made in supercritical water at the same conditions of $400^{\circ}C$ and 30 MPa. Size difference results from density and critical point difference between water and methanol and slow reaction rate at the surface of ceria particles in supercritical methanol which reduces crystal growth rate. Several organic compounds were added to modify the surface of ceria nanoparticles, and in-situ surface modification was confirmed by FT-IR and TGA analysis. Surface modified ceria nanoparticles have excellent dispersibility in organic solvent. Size and shape of surface modified ceria particles can be controlled by adjusting molar ratio of modifier to precursor and selection of modifier.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.50 no.5
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• pp.333-338
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• 2022

The single jet of decane/methylcyclohexane mixed fuel that is surrogate for kerosene was injected into supercritical environment and visualized using shadowgraph technique. The injection pressure drop of the fuel jet of T_r = 0.484 was kept constant at 0.5 MPa and the experiment was conducted above the critical point of the mixed fuel, and the reduced temperatures of the chamber was changed from 1.00 to 1.23, and the reduced pressures was 1.00 and 1.38. As an index for reducing the density of jets sprayed into the supercritical environment, the brightness intensity of the post-processed jet image was observed with the internal temperature and pressure of the chamber. It was confirmed that the decrease in the brightness intensity of the jet when the temperature inside the chamber increased, and when the pressure inside the chamber was higher at the same temperature, the decrease in the brightness intensity of the jet was delayed. When the pressure inside the chamber is high, it is thought that the change in brightness intensity is delayed due to the increase in the pseudo-critical temperature of the fuel and the increase in the temperature required to reduce the density of the fuel jet.

• Nuclear Engineering and Technology
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• v.50 no.7
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• pp.1051-1059
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• 2018

Fast periodic pulsed reactor is a type of reactor in which the fission bursts are formed entirely with external reactivity modulation with a specified time periodicity. This type of reactors could generate much larger intensity of neutron beams for experimental use, compared with the steady state reactors. In the design of fast periodic pulsed reactors, the time dependent simulation of the power pulse is majorly based on a point kinetic model, which is known to have limitations. A more accurate calculation method is desired for the design analyses of fast periodic pulsed reactors. Monte Carlo computer code MCNP6 is used for this task due to its three dimensional transport capability with a continuous energy library. Some new routines were added to simulate the rotation of the movable reflector parts in the time dependent calculation. Fast periodic pulsed reactor IBR-2M was utilized to validate the new routines. This reactor is periodically in prompt supercritical state, which lasts for ${\sim}400{\mu}s$, during the equilibrium state. This generates long neutron fission chains, which requires tremendously large amount of computation time during Monte Carlo simulations. Russian Roulette was applied for these very long neutron chains in MCNP6 calculation, combined with other approaches to improve the efficiency of the simulations. In the power pulse of the IBR-2M at equilibrium state, there is some discrepancy between the experimental measurements and the calculated results using the point kinetics model. MCNP6 results matches better the experimental measurements, which shows the merit of using MCNP6 calculation relative to the point kinetics model.