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http://dx.doi.org/10.9713/kcer.2017.55.2.225

Measurement of Phase Behavior for Dextran/DMSO/scCO2 System  

Rho, Seon-Gyun (Department of Fire Service Administration, Honam University)
Kang, Dong-Yuk (ISU Chemical)
Kang, Choon-Hyoung (School of Chemical Engineering, Chonnam National University)
Publication Information
Korean Chemical Engineering Research / v.55, no.2, 2017 , pp. 225-229 More about this Journal
Abstract
Micron-sized dextran particles, which now attract wide attention as a promising drug delivery systems, can be prepared via the supercritical anti-solvent (SAS) process. In SAS process, dextran particles are obtained as a result of recrystallization of dissolved dextran in dimethyl sulfoxide (DMSO) on addition of supercritical $CO_2$ as an anti-solvent. In this work, with an intention to provide information on the feasible operating conditions of the process, the phase behavior of Dexran/DMSO/$CO_2$ is observed by measuring the cloud point in favor of a variable volume cell. From the experimental study, it is concluded that a feasible operating condition of the SAS process for preparation of dextran particles would be 300.15 K~330.15 K and 90 bar~130 bar, respectively, and solute concentration ranges from 5mg/ml to 20 mg/ml.
Keywords
Supercritical fluid; Dextran particles; Variable volume cell; Cloud point; SAS;
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Times Cited By KSCI : 3  (Citation Analysis)
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