• Title/Summary/Keyword: Substitution Effect

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THE EFFECT OF SURFACE TREATMENT OF THE CERVICAL AREA OF IMPLANT ON BONE REGENERATION IN MINI-PIG (미니돼지에서 발치 후 즉시 임플란트 매식시 치경부 표면처리가 골재생에 미치는 효과)

  • Cho, Jin-Yong;Kim, Young-Jun;Yu, Min-Gi;Kook, Min-Suk;Oh, Hee-Kyun;Park, Hong-Ju
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.34 no.3
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    • pp.285-292
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    • 2008
  • Purpose: The present study was performed to evaluate the effect of surface treatment of the cervical area of implant on bone regeneration in fresh extraction socket following implant installation. Materials and methods: The four minipigs, 18 months old and 30 kg weighted, were used. Four premolars of the left side of both the mandible and maxilla were extracted. ${\phi}$3.3 mm and 11.5 mm long US II plus implants (Osstem Implant co., Korea) with resorbable blasting media (RBM) treated surface and US II implants (Osstem Implant co., Korea) with machined surface at the top and RBM surface at lower portion were installed in the socket. Stability of the implant was measured with $Osstell^{TM}$ (Model 6 Resonance Frequency Analyser: Integration Diagnostics Ltd., Sweden). After 2 months of healing, the procedures and measurement of implant stability were repeated in the right side by same method of left side. At four months after first experiment, the animals were sacrificed after measurement of stability of all implants, and biopsies were obtained. Results: Well healed soft tissue and no mobility of the implants were observed in both groups. Histologically satisfactory osseointegration of implants was observed with RBM surface, and no foreign body reaction as well as inflammatory infiltration around implant were found. Furthermore, substantial bone formation and high degree of osseointegration were exhibited at the marginal defects around the cervical area of US II plus implants. However, healing of US II implants was characterized by the incomplete bone substitution and the presence of the connective tissue zone between the implant and newly formed bone. The distance between the implant platform (P) and the most coronal level of bone-to-implant contact (B) after 2 months of healing was $2.66{\pm}0.11$ mm at US II implants group and $1.80{\pm}0.13$mm at US II plus implant group. The P-B distance after 4 months of healing was $2.29{\pm}0.13$mm at US II implants group and $1.25{\pm}0.10$mm at US II plus implants group. The difference between both groups regarding the length of P-B distance was statistically significant(p<0.05). Concerning the resonance frequency analysis (RFA) value, the stability of US II plus implants group showed relatively higher RFA value than US II implants group. Conclusion: The current results suggest that implants with rough surface at the cervical area have an advantage in process of bone regeneration on defect around implant placed in a fresh extraction socket.

The Causal Relationship between ICT Growth and Employment in Korea (한국의 ICT산업의 발전과 고용 간의 인과관계에 관한 실증적 분석)

  • Kim, Sukyeong;Lee, Sang-Yong Tom
    • Information Systems Review
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    • v.16 no.2
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    • pp.77-95
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    • 2014
  • From the success of TDX and CDMA to today's social media boom, Korea's ICT has achieved an amazing growth for the last couple of decades. However, in spite of ICT's role as an engine of growth in Korea, there have been concerns that ICT growth would negatively affect national employment due to the labor substitution effect. While some scholars insist that ICT would positively affect employment because it will enlarge the size of industry itself, many people blame ICT as a main culprit of rising unemployment rates. In this study, we try to empirically find the true effect of ICT growth on employment in Korea. We use the data of ICT productions, ICT investments, and various industries employments from 1995 to 2011. The methodologies we adopted for this study is Granger causality tests and impulse response functions based on vector autoregression (VAR) model. We find that ICT has negative impact on service industries, while it has positive impact on manufacturing industries. Meanwhile, ICT has no statistically significant impact on ICT industry itself. Since the impacts of ICT on employment are mixed, we can argue that ICT should not be blamed for the main cause of low employment. We suggest a direction of future policies to utilize ICT for vitalizing employments in Korea.

Effect of Triticale Dried Distillers Grains with Solubles on Ruminal Bacterial Populations as Revealed by Real Time Polymerase Chain Reaction

  • Wu, R.B.;Munns, K.;Li, J.Q.;John, S.J.;Wierenga, K.;Sharma, R.;Mcallister, T.A.
    • Asian-Australasian Journal of Animal Sciences
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    • v.24 no.11
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    • pp.1552-1559
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    • 2011
  • Real time PCR was used in this study to determine the effect of triticale dried distillers grains with solubles (TDDGS) as a replacement for grain or barley silage in finishing diets on the presence of six classical ruminal bacterial species (Succinivibrio dextrinosolvens, Selenomonas ruminantium, Streptococcus bovis, Megasphaera elsdenii, Prevotella ruminicola and Fibrobacter succinogenes) within the rumen contents of feedlot cattle. This study was divided into a step-wise adaptation experiment (112 days) that examined the effects of adaptation to diets containing increasing levels of TDDGS up to 30% (n = 4), a short-term experiment comparing animals (n = 16) fed control, 20%, 25% or 30% TDDGS diets over 28 days, and a rapid transition experiment (56 days) where animals (n = 4) were rapidly switched from a diet containing 30% TDDGS to a barley-based diet with no TDDGS. It was found that feeding TDDGS as replacement for barley grain (control vs. 20% TDDGS) decreased 16S rRNA copy numbers of starch-fermenting S. ruminantium and S. bovis (p<0.001 and p = 0.04, respectively), but did not alter 16S rRNA copy numbers of the other rumen bacteria. Furthermore, feeding TDDGS as a replacement barley silage (20% vs. 25% and 30% TDDGS) increased 16S rRNA copy numbers of S. ruminantium, M. elsdenii and F. succinogenes (p<0.001; p = 0.03 and p<0.001, respectively), but decreased (p<0.001) the 16S rRNA copy number of P. ruminicola. Upon removal of 30% TDDGS and return to the control diet, 16S rRNA copy numbers of S. ruminantium, M. elsdenii and F. succinogenes decreased (p = 0.01; p = 0.03 and p = 0.01, respectively), but S. dextrinosolvens and S. bovis increased (p = 0.04 and p = 0.009, respectively). The results suggest that replacement of TDDGS for grain reduces 16S rRNA copy numbers of starch-fermenting bacteria, whereas substitution for barley silage increases 16S rRNA copy numbers of bacteria involved in fibre digestion and the metabolism of lactic acid. This outcome supports the contention that the fibre in TDDGS is highly fermentable.

Genome-wide association study of carcass weight in commercial Hanwoo cattle

  • Edea, Zewdu;Jeoung, Yeong Ho;Shin, Sung-Sub;Ku, Jaeul;Seo, Sungbo;Kim, Il-Hoi;Kim, Sang-Wook;Kim, Kwan-Suk
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.3
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    • pp.327-334
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    • 2018
  • Objective: The objective of the present study was to validate genes and genomic regions associated with carcass weight using a low-density single nucleotide polymorphism (SNP) Chip in Hanwoo cattle breed. Methods: Commercial Hanwoo steers (n = 220) were genotyped with 20K GeneSeek genomic profiler BeadChip. After applying the quality control of criteria of a call rate ${\geq}90%$ and minor allele frequency (MAF) ${\geq}0.01$, a total of 15,235 autosomal SNPs were left for genome-wide association (GWA) analysis. The GWA tests were performed using single-locus mixed linear model. Age at slaughter was fitted as fixed effect and sire included as a covariate. The level of genome-wide significance was set at $3.28{\times}10^{-6}$ (0.05/15,235), corresponding to Bonferroni correction for 15,235 multiple independent tests. Results: By employing EMMAX approach which is based on a mixed linear model and accounts for population stratification and relatedness, we identified 17 and 16 loci significantly (p<0.001) associated with carcass weight for the additive and dominant models, respectively. The second most significant (p = 0.000049) SNP (ARS-BFGL-NGS-28234) on bovine chromosome 4 (BTA4) at 21 Mb had an allele substitution effect of 43.45 kg. Some of the identified regions on BTA2, 6, 14, 22, and 24 were previously reported to be associated with quantitative trait loci for carcass weight in several beef cattle breeds. Conclusion: This is the first genome-wide association study using SNP chips on commercial Hanwoo steers, and some of the loci newly identified in this study may help to better DNA markers that determine increased beef production in commercial Hanwoo cattle. Further studies using a larger sample size will allow confirmation of the candidates identified in this study.

Life Cycle Assessment of Timber Arch-Truss Bridge by Using Domestic Pinus rigida Glued-Laminated Timber (리기다소나무 구조용 집성재를 활용한 아치 트러스 목조교량의 전과정평가)

  • Son, Whi-Lim;Park, Joo-Saeng;Kim, Kwang-Mo
    • Journal of the Korean Wood Science and Technology
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    • v.42 no.1
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    • pp.1-12
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    • 2014
  • This study carried out life cycle assessment for evaluating environmental impacts of timber Arch-Truss bridge by using domestic Pinus rigida Miller glued-laminated timber throughout life cycle such as extraction, manufacturing, transportation, construction, use, dismantlement, transportation of waste, disposal and recycling. The life cycle GHG (GreenHouse Gas) emissions of the target bridge are 192.56 ton $CO_2$ eq. in 50 years. Especially, the life cycle GHG emissions of concrete used in the target bridge are 82.84 ton $CO_2$ eq. which accounts for 53.02% of the GWP (Global Warming Potential) in extraction and manufacturing stages. The target bridge is constructed of $116.57m^3$ of domestic Pinus rigida Miller glued-laminated timber and used timber has stored 104.72 ton $CO_2$. If an effect of carbon storage in timber is applied to the total GHG emissions of the target bridge, the GHG emissions can be reduced by 54.38%. In the case of substitution effect, if domestic Pinus rigida Miller glued-laminated timber replaces steel manufactures used in other bridge which has the same structure and life span as the target bridge, the GHG emissions in extraction and manufacturing stages can be reduced by 10.26% to 23.91%.

Effect of Cattle Manure Application on Forage Productivity and Soil Characteristics of Pasture (방목초지에서 우분 퇴비 시용이 목초생산 및 토양에 미치는 영향)

  • Hwang, Kyung-Jun;Ko, Seo-Bong;Park, Hyung-Soo;Park, Nam-Gun;Ko, Moon-Suck;Kim, Moon-Chul;Song, Sang-Teak
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.27 no.1
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    • pp.45-52
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    • 2007
  • This study was conducted from 2003 to 2005 at crop field of National Institute of Subtropical Agriculture, RDA, in Jeju. The treatment consisted of chemical fertilizer 100%(CF 100%, T1), cattle manure 100%(CM 100%, T2), CF 50%+CM 50%(T3), CF 25%+CM 75%(T4), CM 100%(1st yr.)+CF 100%(2nd yr,)+CM(3rd yr)(T5), CM 100%(1st yr.)+CF 100%(2nd yr.)+CF(3rd yr.)(T6). The highest substitution effect of chemical fertilizer for cattle manure indicated that the highest yield(Avg. 11,169 kg/ha) obtained from CM 100%(1 yr.)+CF 100%(2 yr.) treatment. The forage yield of CM 100%(1 yr.)+CF 100%(2 yr.) was 4% more than CM 100% application whereas was 3% less than CF 100% application. Changes of physical and chemical properties of soils for applications of CF 100% and CM 100% was clearly in cattle manure application. Especially, cattle manure application in pasture were superior to chemical fertilizer application with respect to organic matter(OM, %), total nitrogen(T-N, %), and avaliable phosphorous($P_2O_5$, %) contents of soils. In this present study, cattle manure application recorded slightly lower forage yields than CF 100% application but the combined use of cattle manure and chemical fertilizer was attribute to reduction of chemical fertilizer application rate as well as maintaining soil health on long-term basis.

Immunological Responses of Broiler Chicks Can Be Modulated by Dietary Supplementation of Zinc-methionine in Place of Inorganic Zinc Sources

  • Moghaddam, Hasan Nassiri;Jahanian, Rahman
    • Asian-Australasian Journal of Animal Sciences
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    • v.22 no.3
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    • pp.396-403
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    • 2009
  • Male broiler chicks were fed graded levels of organic zinc (zinc-methionine) supplementation to investigate the effects of partial or complete substitution of the organic zinc source for inorganic ones on the development of lymphoid organs and immunological responses. A total of 450 day-old male broilers were distributed into groups of 10 chicks and randomly assigned to nine experimental diets during a 42-day feeding trial. Dietary treatments consisted of two basal diets supplemented with 40 mg/kg added zinc as feed-grade Zn sulfate or Zn oxide in which, Zn was replaced with that provided from zinc-methionine (ZnMet) complex at the levels of 25, 50, 75 or 100%. Two randomly-selected birds from each pen replicate were bled and then slaughtered by cervical cutting on the final day of the trial to measure leukocyte subpopulations and relative weights of lymphoid organs. Among lymphoid organs, only thymus weight was affected (p<0.05) by dietary treatments. The sulfate-supplemented birds were heavier (p<0.01) in relative weight of thymus than oxide-supplemented birds. The 10 days of age-assessed cutaneous hypersensivity reaction was stronger in chicks fed ZnMet-containing diets. Dietary ZnMet supplementation caused (p<0.05) an increase in proportion of lymphocytes and consequently a decrease in heterophil to lymphocyte ratio. Diet fortification by zinc-methionine complex increased (p<0.01) Newcastle antibody titer at 19 days of age. Also, a similar response was observed in antibody titers at 6 and 12 d after infectious bronchitis vaccine administration. There was no significant effect of replacement of dietary zinc on antibody titer against infectious bursal disease virus (IBDV) at the 6th d post-vaccine inoculation; however, at d 12 after vaccination, ZnMet-fortified diets improved antibody titer against IBDV. Although dietary inclusion of ZnMet had no marked effect on primary antibody titer against sheep erythrocytes, effective responses were observed during secondary reaction from the viewpoint of both total antibody and immunoglobulin Y (IgY) titers. From the present findings, it can be concluded that dietary supplementation with organic zinc improves both cellular and humoral immune responses. It is necessary to replace 75% of supplemental inorganic zinc with organic ZnMet complex to achieve the optimum immunological responses in broiler chicks.

Designs for Self-enforcing International Environmental Coordination (원유공급 위기의 경제적 효과에 관한 연구)

  • Cho, Gyeong Lyeob;Sonn, Yang-Hoon
    • Environmental and Resource Economics Review
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    • v.16 no.1
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    • pp.27-63
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    • 2007
  • Using the CGE model, this paper investigates economic impacts of a shortage in crude oil resulting from voluntary export restraints, OPEC's agreement of a cut in oil production, and/or a storing on speculation. Unlike most previous studies considering oil price as the unpredictable variable, this study constructs the model to determine the oil price endogenously under the condition of an insufficient supply of crude oil. According to IEA's extraordinary steps for a shortage of crude oil, we investigate an economic impact of 7~12% shortage below the level of business as usual. The results show that oil price soars by 17.3~33.5%, the rate of economic growth falls by 0.52~0.96%p, and the consumer price index(CPI) rises by 0.8~1.51%p. These results imply that increasing in 1%p of oil price results in decreasing in 0.03%p of economic growth and increasing in 0.045%p of consumer price index. The production of electricity declines because of the increase in production cost. A shortage of crude oil has an effect on sources of electricity. Most reduction in electricity generation occurs from the reduction in the thermal power generation which is highly dependent on crude oil. The shortage of crude oil causes demand for petroleum to significantly decline but demand for coal and heat to increase because of the substitution effect with petroleum. Demand for gas rise in the first year but falls from the second year.

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A Study on Parody Expressed in Modern Fashion (현대 패션에 나타난 패러디(Parody)에 관한 연구)

  • 고현진;김민자
    • Journal of the Korean Society of Costume
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    • v.25
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    • pp.249-268
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    • 1995
  • Parody has recently prevailed as one of the important techniques of creation in art. The purposes of this study are to reaffirm the pos-ition of fashion as an art by clarifying parody depicted in fashion and to make an opportunity to reconsider the meaning of creation in fashion design through the significance of par-ody. For these purposes, documentary studies about parody in literature and art which had been discussed more often were preceded as a framework of this research. framework of this research. Basedd upon that, parody phenomena in fashion as well as art were analyzed. The synthetic results are as follows ; 1. Parody is a kind or critical technique and can be conceived as a process of creation. The established primary style (material) which is well-known and familiar is imitated and then is recreated in new manner through the three types of parodization, that is, the change of its external form, the change of its internal mean-ing and the shift from its place (i.e. displace-ment). 2. Parody in fashion is also analyzed based upon the three types of parodization which designer's will and expression is necessarily required. First, the parody through the change of external form is to have its effect of novelty, unexpectedness, playfulness, wit, mackery, satire, irony, paradox by changing the form of the original through imitation with similarity, transformation, exaggeration, em-phasis. Second, the parody through the change of internal meaning is to bring about paradox, irony, contempt, satire, unex-pectedness by applying the original to inappro-priate subject through its substitution, inver-sion. Third, the parody through displacement is to pursue a jarring incongruity that results from shifting the original to other context. Its effect consists of paradox, unexpectedness, playfulness, ridicule, mockery, satire, irony. In general, the parody technique in fashion can be used to have an intention of expressing seriousness, playfulness, satire, grotesque. The representative designers using the parody technique are Lagerfeld, Ricci, YSL, Yama-moto, Castelbajac, Gaultier, Mugler, West-sood, Steiner and so on. 3. Parody is the technique which imitates and then recreates the preceding style ; is at the same time the method which challenges the existing concept of originality-singleness and uniqueness. It reflects the more flexible concept of modern creation in art as well as fashion. The imitation as the creation, the characteristic of parody is recognized as an creative expressiveness, publicity, intention. Thus it differenciates from copy which is uncritical mimicry.

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Role of Ser-33 and Asp-112 Residues in In vivo Folding of E, coli Tryptophan Synthase $\alpha$ Subunit (트립토판 중합료소 $\alpha$ 소단위체의 대장균내 구조형성과정에서의 Ser-33과 Asp-112 잔기의 역할)

  • 유충배;신혜자;임운기
    • Journal of Life Science
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    • v.6 no.4
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    • pp.304-312
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    • 1996
  • In the present report, a p[ossibility of the interaction fo Ser-33 and Asp-112 residues in folding of tryptophan synthase $\alpha$ subunit was explored by examining the effect of single or double substitution of these residues on folding of $\alpha$ subunit in E. coli. $\alpha$ subunit of which Ser-33 was substituted with Leu (SL33) was accumulated as insoluble aggregate form, when overproduced in E. coli, whereas $\alpha$ subunit of which Asp-112 was replaced by Asn (DN112) or Gly (DG112) was accumulated as soluble form to the similar extent as wild type $\alpha$ subunit was. When these alterations were combined into one protein, the synergistic effect of residues 33 and 112 on the amount of aggregate form was shown. The amount of doubly altered SL33/DG112 $\alpha$ subunit as aggregate form was increased 5-13 fold that of SL33 $\alpha$ subunit, and the amount of SL33/DG112 $\alpha$ subunit as aggregate form was decreased 3-4 fold that of SL33 $\alpha$ subunit. Aggregates are derived from the specific association of partially folded or unassembled subunits in the folding process. Therefore, this result suggests that residues 33 and 112 of $\alpha$ subunit may unteract during the folding of this enzyme in E. coli.

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