Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Immunological Responses of Broiler Chicks Can Be Modulated by Dietary Supplementation of Zinc-methionine in Place of Inorganic Zinc Sources

  • Moghaddam, Hasan Nassiri (Department of Animal Sciences, Faculty of Agriculture, Ferdowsi University of Mashhad) ;
  • Jahanian, Rahman (Department of Animal Sciences, College of Agriculture, Isfahan University of Technology)
  • Received : 2008.08.26
  • Accepted : 2008.11.11
  • Published : 2009.03.01
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Abstract

Male broiler chicks were fed graded levels of organic zinc (zinc-methionine) supplementation to investigate the effects of partial or complete substitution of the organic zinc source for inorganic ones on the development of lymphoid organs and immunological responses. A total of 450 day-old male broilers were distributed into groups of 10 chicks and randomly assigned to nine experimental diets during a 42-day feeding trial. Dietary treatments consisted of two basal diets supplemented with 40 mg/kg added zinc as feed-grade Zn sulfate or Zn oxide in which, Zn was replaced with that provided from zinc-methionine (ZnMet) complex at the levels of 25, 50, 75 or 100%. Two randomly-selected birds from each pen replicate were bled and then slaughtered by cervical cutting on the final day of the trial to measure leukocyte subpopulations and relative weights of lymphoid organs. Among lymphoid organs, only thymus weight was affected (p<0.05) by dietary treatments. The sulfate-supplemented birds were heavier (p<0.01) in relative weight of thymus than oxide-supplemented birds. The 10 days of age-assessed cutaneous hypersensivity reaction was stronger in chicks fed ZnMet-containing diets. Dietary ZnMet supplementation caused (p<0.05) an increase in proportion of lymphocytes and consequently a decrease in heterophil to lymphocyte ratio. Diet fortification by zinc-methionine complex increased (p<0.01) Newcastle antibody titer at 19 days of age. Also, a similar response was observed in antibody titers at 6 and 12 d after infectious bronchitis vaccine administration. There was no significant effect of replacement of dietary zinc on antibody titer against infectious bursal disease virus (IBDV) at the 6th d post-vaccine inoculation; however, at d 12 after vaccination, ZnMet-fortified diets improved antibody titer against IBDV. Although dietary inclusion of ZnMet had no marked effect on primary antibody titer against sheep erythrocytes, effective responses were observed during secondary reaction from the viewpoint of both total antibody and immunoglobulin Y (IgY) titers. From the present findings, it can be concluded that dietary supplementation with organic zinc improves both cellular and humoral immune responses. It is necessary to replace 75% of supplemental inorganic zinc with organic ZnMet complex to achieve the optimum immunological responses in broiler chicks.

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References

  1. Abdukalykova, S. and C. A. Ruiz-Feria. 2006. Arginine and vitamin E improve the cellular and humoral immune response of broiler chickens. Int. J. Poult. Sci. 5:121-127 https://doi.org/10.3923/ijps.2006.121.127
  2. American Association of Feed Control Officials. 1990. Feed ingredient definitions. In: Official Publication of American Feed Control Official Inc, pp. 123-215
  3. Bartlett, J. R. and M. O. Smith. 2003. Effects of different levels of zinc on the performance and immunocompetence of broilers under heat stress. Poult. Sci. 82:1580-1588
  4. Beach, R. S., M. Gershwin, R. Makishima and L. Hurley. 1980. Impaired immunologic ontogeny in the postnatal zinc deprivation. J. Nutr. 110:805-815 https://doi.org/10.1016/S0271-5317(83)80123-7
  5. Blamberg, D. L., U. B. Blackwood, W. C. Supplee and G. F. Combs. 1960. Effect of zinc deficiency in hens on hatchability and embryonic development. Proc. Soc. Exp. Biol. Med. 104:217-220
  6. Chandra, R. K. and B. Au. 1980. Single nutrient deficiency and cell-mediated immune responses. 1. Zinc. Am. J. Clin. Nutr. 33:736-738
  7. Cook, J. K. A., T. F. Davison, M. B. Huggins and P. McLaughlan. 1991. Effect of in ovo bursectomy on the course of an infectious bronchitis virus infection in line C White Leghorn chickens. Arch. Virol. 118:225-234 https://doi.org/10.1007/BF01314032
  8. Corrier, D. E. and J. R. DeLoach. 1990. Evaluation of cellmediated, cutaneous basophil hypersensivity in young chickens by an interdigital skin test. Poult. Sci. 69:403-408 https://doi.org/10.2307/1592556
  9. Cunningham-Rundles, S. and W. F. Cunningham-Rundles. 1988. Zinc modulation of immune response. In: Nutrition and immunology (Ed. R. K. Chandra). Alan R. Liss Inc, New York, NY, pp. 197-214
  10. Dardenne, M. and J. M. Bach. 1993. Rationale foe the mechanism of zinc interaction in the immune system. In: Nutrient modulation of the immune response (Ed. S. Cunningham-Rundles). Marcel Dekker Inc, New York, NY, pp. 501-509
  11. Dowd, P., J. Kellerher and P. Guillou. 1986. T-lymphocyte subset and interleukin-2 production in the zinc deficient rats. Br. J. Nutr. 55:59-69 https://doi.org/10.1079/BJN19860010
  12. Duncan, D. B. 1955. Multiple range and multiple F tests. Biometrics, 11:1-42 https://doi.org/10.2307/3001478
  13. Ellis, R., E. R. Morris and A. D. Hill. 1982. Bioavailability to rats of iron and zinc in calcium-iron-phytate and calcium-zincphytate complex. Nutr. Res. 2:319-322 https://doi.org/10.1016/S0271-5317(82)80013-4
  14. Flinchum, J. D., C. F. Nockels and R. E. Moreng. 1989. Aged hens fed zinc-methionine had chicks with improved performance. Poult. Sci. 68(Suppl. 1):55(Abstr.)
  15. Fordyce, E. J., R. M. Forbes, K. R. Robbins and J. W. Erdman, Jr. 1987. Phytate×calcium/zinc molar ratios: Are they predictive of zinc bioavailability? J. Food Sci. 52:421-428
  16. Fraker, P. J., M. E. Gershwin, R. A. Good and A. S. Prasad. 1986. Interrelationships between zinc and immune function. FASEB J. 45:1474-1479 https://doi.org/10.1016/S0047-6374(96)01838-6
  17. Fraker, P. J., S. Haas and R. Leucke. 1977. Effects of zinc deficiency on the immune response of the young adult A/J mouse. J. Nutr. 107:1889-1895
  18. Hill, D. A., E. R. Peo, Jr., A. J. Lewis and J. D. Crenshaw. 1986. Zinc-amino acid complexes for swine. J. Anim. Sci. 63:121-130
  19. Hudson, B. P., W. A. Dozier, III, J. L. Wilson, J. E. Sander and T. L. Ward. 2004. Reproductive performance and immune status of caged broiler breeder hens provided diets supplemented with either inorganic or organic sources of zinc from hatchery to 65 wk of age. J. Appl. Poult. Sci. 13:349-359
  20. Jahanian, R., H. Nassiri Moghaddam and A. Rezaei. 2008a. Improved broiler chick performance by dietary supplementation of organic zinc sources. Asian-Aust. J. Anim. Sci. 21:1348-1354
  21. Jahanian, R., H. Nassiri Moghaddam, A. Rezaei and A. R. Haghparast. 2008b. The influence of dietary zinc-methionine substitution for zinc sulfate on broiler chick performance. J. Biol. Sci. 8:321-327 https://doi.org/10.3923/jbs.2008.321.327
  22. Khajarern, J., C. Ratanasethakul, S. Khajarern, T. L. Ward, T. M. Fakler and A. B. Johnson. 2002. Effect of zinc and manganese amino acid complexes (AvailaZ/M) on broiler breeder production and immunity. Poult. Sci. 81(Suppl. 1):40(Abstr.)
  23. Kidd, M. T., M. A. Qureshi, P. R. Ferket and L. N. Thomas. 2000. Turkey hen zinc source affects progeny immunity and disease resistance. J. Appl. Poult. Res. 9:414-423
  24. Kidd, M. T., N. B. Anthony and S. R. Lee. 1992. Progeny performance when dams and chicks are fed supplemental zinc. Poult. Sci. 71:1201-1206 https://doi.org/10.3382/ps.0711201
  25. Kidd, M. T., N. B. Anthony, L. A. Newberry and S. R. Lee. 1993. Progeny performance when dams and chicks are fed supplemental zinc. Poult. Sci. 72:1492-1499 https://doi.org/10.3382/ps.0721492
  26. Kidd, M. T. 2004. Nutritional modulation of immune function in broilers. Poult. Sci. 83:650-657
  27. Kidd, M. T., E. D. Peebles, S. K. Whitmarsh, J. B. Teatman and R. F. Wideman, Jr. 2001. Growth and immunity of broiler chicks as affected by dietary arginine. Poult. Sci. 80:1535-1542
  28. Kidd, M. T., P. R. Ferket and M. A. Qureshi. 1996. Zinc metabolism with special references to its role in immunity. World's Poult. Sci. J. 52:309-324 https://doi.org/10.1079/WPS19960022
  29. Kirchgessner, H., H. P. Roth and F. Weigand. 1976. Trace elements in human health and disease (Ed. A. S. Prasad). Academy Press, New York, NY, pp. 189-226
  30. Klasing, K. C. 1998. Nutritional modulation of resistance to infectious disease. Poult. Sci. 77:1119-1125 https://doi.org/10.1086/315904
  31. Lepage, K. T., S. E. Bloom and R. L. Taylor, Jr. 1996. Antibody response to sheep red blood cells in a major histocompatibility (B) complex aneuploid line of chickens. Poult. Sci. 75:346-350 https://doi.org/10.3382/ps.0750346
  32. Leucke, R., C. Simonel and P. Fraker. 1978. The effect of restricted dietary intake on the antibody mediated response of the zinc deficient A/J mouse. J. Nutr. 108:881-887
  33. Lucas, A. M. and C. Jamroz. 1961. Atlas of avian hematology. Agriculture Monograph 25. USDA, Washington, DC
  34. Marquardt, W. W., D. B. Synder, P. K. Savage, S. K. Kadavil and F. S. Yancey. 1984. Antibody response to Newcastle disease virus given by two different routes as measured by ELISA and hemagglutination-Inhibition test and associated tracheal immunity. Avian Dis. 29:71-79 https://doi.org/10.2307/1590695
  35. National Research Council. 1994. Nutrient Requirements of Poultry. 9th rev. ed. Natl. Acad. Press, Washington, DC
  36. O'Dell, B. L. 1992. Zinc plays both structural and catalytic roles in metalloproteins. Nutr. Rev. 50:48-50 https://doi.org/10.1111/j.1753-4887.1992.tb02513.x
  37. Phillips, I., M. Caswell, T. Cox, B. Groot, C. Friss, R. Jones, C. Nightingale, R. Preston and J. Waddell. 2004. Does the use of antibiotics in food animals pose a risk to human health? A critical review of published data. J. Antimicrobial. Chemotherapy, 53:28-52 https://doi.org/10.1093/jac/dkg483
  38. Pimentel, J. L., M. E. Cook and J. L. Greger. 1991. Research note: Bioavailability of zinc-methionine for chicks. Poult. Sci. 71:1637-1639
  39. Prasad, A. S. 1982. Zinc deficiency in human subjects. In: Clinical, biochemical, and nutritional aspects of trace elements (Ed. A. S. Prasad). Alan R. Liss Inc, New York, NY, pp. 3-62
  40. Prasad, A. S. 1993. Acquired zinc deficiency and immune dysfunction in sickle cell anemia. In: Nutrient modulation of the immune response (Ed. S. Cunningham-Rundles). Marcel Dekker, Inc, New York, pp. 393-410
  41. Qureshi, M. A. and G. B. Havenstein. 1994. A comparison of the immune performance of a 1991 commercial broiler with a 1957 randombred strain when fed "typical" 1957 and 1991 broiler diets. Poult. Sci. 73:1805-1812 https://doi.org/10.3382/ps.0731805
  42. Ratcliff, M. M. 2000. Dying inside the walls. J. Palliat. Med. 3:509-511 https://doi.org/10.1089/jpm.2000.3.4.509
  43. SAS Institute. 1999. SAS Statistics User's Guide. Statistical Analytical System. 5th rev. ed. Carry, NC, SAS Institute Inc
  44. Swinkels, J. W. G. M., E. T. Kornegay, K. E. Webb, Jr. and M. D. Lindemann. 1991. Comparison of inorganic and organic zinc chelate in zinc depleted and repleted pigs. J. Anim. Sci. 69 (Suppl. 1):358(Abstr.) https://doi.org/10.3382/japr.2008-00122
  45. Thompson, G., S. Naqi and B. Bauman. 1993. Respiratory immunity to IBV in immunocompetent and immunocompromised chickens. Proc. Xth Int. Congr. World Vet. Poult. Assoc. Sydney, Australia, p. 178
  46. Vallee, B. L. and D. S. Auld. 1990. The metallobiochemistry of zinc enzymes. In: Advances in enzymology (Ed. A. Meister). John Wiley Publishing, New York, pp. 283-429
  47. Virden, W. S., J. B. Yeatman, S. J. Barber, K. O. Willeford, T. L. Ward, T. M. Fakler and M. T. Kidd. 2002. Responses of chicks from broiler breeders fed supplemental zinc and manganese: Cellular immunity. Poult. Sci. 81(Suppl. 1):119(Abstr.)
  48. Virden, W. S., J. B. Yeatman, S. J. Barber, K. O. Willeford, T. L. Ward, T. M. Fakler, R. F. Wideman, Jr. and M. T. Kidd. 2004. Immune system and cardiac functions of progeny chicks from dams fed diets differing in zinc and manganese level and source. Poult. Sci. 83:344-351 https://doi.org/10.1586/14787210.6.1.121
  49. Wedekind, K. J., A. E. Hortin and D. H. Baker. 1992. Methodology for assessing zinc bioavailability: Efficacy estimates for zinc-methionine, zinc sulfate, and zinc oxide. J. Anim. Sci. 70:178-187 https://doi.org/10.1016/S0377-8401(96)01103-0
  50. Wedekind, K. J., A. J. Lewis, M. A. Giesemann and P. S. Miller. 1994. Bioavailability of zinc from inorganic and organic sources for pigs fed corn-soybean meal diets. J. Anim. Sci. 72:2681-2689

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