• Bioinformatics and Biosystems
• /
• v.2 no.1
• /
• pp.7-11
• /
• 2007

Methods for making scoring matrix based on phylogenetic tree for all possible exchanges of one amino acid with another. PFMT(Phylogenetic focused Mutation Tendency) matrix is different BLOSUM62 and PAM160 which are the most used scoring matrixes. This matrix calculates possibility of substitution from common ancestor to high spices. PFMT matrix scores substitution frequency in COGs databases which contain 152 KOGs's dataset. PFMT matrix usefully is able to compare between query sequence and sequences of more higher species and show detailed substitution relation of 20 amino acids.

• Mass Spectrometry Letters
• /
• v.10 no.4
• /
• pp.117-122
• /
• 2019

This study demonstrated the sensitivity of electron capture dissociation mass spectrometry (ECD-MS) to probe subtle conformational changes in gaseous melittin ions induced by the substitution of an amino acid. ECD-MS was performed for triply and quadruply-protonated melittin and its variants obtained by a single amino acid substitution, namely, D-Pro14, Pro14Ala, and Leu13Ala. Although native triply-protonted melittin showed only a few peptide backbone cleavage products, the D-Pro14 and Pro14Ala variants exhibited extensive backbone fragments, suggesting the occurrence of a significant structural or conformational change induced by a single amino acid substitution at Pro14. On the contrary, the substitution at Leu13, namely Leu13Ala (+3), did not cause significant changes in the ECD backbone fragmentation pattern. Thus, the sensitivity of ECD-MS is demonstrated to be good enough to probe the aforementioned conformational change in melittin.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2002.11a
• /
• pp.322-325
• /
• 2002

In this study, dielectric and piezoelectric properties of PSN-PZT Ceramic were investigated as a function of PNW substitution. With the increase of PNW substitution, teragonality, Curie temperature and mechanical quality factor were decreased but grain size and electromechanical coupling factor(kp) was gradully increased. At 4 mol [%] PNW substitution. maximum kp of 0.567 was shown.

• Journal of the Korean Operations Research and Management Science Society
• /
• v.39 no.2
• /
• pp.97-109
• /
• 2014

This paper considers a reverse supply chain with simultaneous recovery of used products and manufacturing of brand-new ones. Recovered products are downgraded and have to be sold in a market different from that of brand-new products at a different price. In case of a shortage of recovered product inventory, a brand-new item, if available, can be offered at the price of a recovered product. In other words, one-way demand substitution is allowed. We address the joint decision of when to manufacture brand-new product, when to recover returned product, and how to control demand substitution to maximize the hybrid production system's profits. To this end, we propose a Markov decision Process model and investigate the structure of the optimal policy. Performance comparison is numerically implemented between the models with and without downward demand substitution option under different operating conditions of the system parameters.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2000.11a
• /
• pp.229-233
• /
• 2000

In this study, the temperature coefficient of resonant frequency($TCF_r$), dielectric and piezoelectric properties of $Pb_{1-x}Sr_x[(Sb_{1/2}Nb_{1/2})_{0.035}(Mn_{1/3}Nb_{2/3})_{0.065}(Zr_{0.49},Ti_{0.51})_{0.90}]O_3$ ceramics were investigated with the Sr substitution to Pb site. The dielectric constant was increased according to the increase of Sr substitution and electromechanical coupling factor($k_t$) also showed the highest values of 0.485 when the Sr substitution was 5 mol%. Moreover, the mechanical quality factor($Q_{mt}$) showed the highest value of 233 when the Sr substitution was 2 mol%.

• Communications for Statistical Applications and Methods
• /
• v.27 no.4
• /
• pp.459-468
• /
• 2020

We examine the rate of substitution of jobs by artificial intelligence using a score called the "weighted ability rate of substitution (WARS)." WARS is a indicator that represents each job's potential for substitution by automation and digitalization. Since the conventional WARS is sensitive to the particular responses from the employees, we consider a robust version of the indicator. In this paper, we propose the individualized WARS, which is a modification of the conventional WARS, and compute robust averages and confidence intervals for inference. In addition, we use the clustering method to statistically classify jobs according to the proposed individualized WARS. The proposed method is applied to Korean job data, and proposed WARS are computed for five future years. Also, we observe that 747 jobs are well-clustered according to the substitution levels.

• Korean Journal of Breeding Science
• /
• v.40 no.3
• /
• pp.234-242
• /
• 2008

To identify low temperature-induced genes of wheat chromosome substitution line 5D, suppression subtractive hybridization (SSH) was performed with mRNAs from leaf samples that treated with low temperature ($4^{\circ}C$). A cDNA library was constructed using mRNA isolated from wheat chromosome substitution line 5D leaves treated with low temperature ($4^{\circ}C$). The nucleotide and deduced amino acid sequences of the putative gene products were compared. wfr-9 and wfr-32 showed identity over 90% related to vernalization gene. Other two genes, wfr-77 and wfr-83 which is related to freezing-resistant gene have also identity over 90%. This result suggest that those genes may be transcribed into antifreeze proteins which are accumulated within leaf apoplasts, when wheat chromosome substitution line 5D is acclimated during low temperature treatment.

• Bulletin of the Korean Chemical Society
• /
• v.11 no.6
• /
• pp.543-546
• /
• 1990

N- vs. S-Substitution reactions of 1-substituted tetrazoline-5-thiones with various allyl or benzyl halides were studied in order to find effective conditions for N-substitution reactions. When allyl or benzyl halides were reacted with 1-substituted tetrazoline-5-thiones in the presence of TMSI or $BF_3{\cdot}OEt_2$ (or other Lewis acids), N-substitution at 4-position in addition to S-substitution occurred. Reactions were performed either with or without a solvent such as dioxane or propionitrile in the presence of potassium iodide.

• ETRI Journal
• /
• v.43 no.6
• /
• pp.1113-1129
• /
• 2021

Lightweight ciphers are increasingly employed in cryptography because of the high demand for secure data transmission in wireless sensor network, embedded devices, and Internet of Things. The PRESENT algorithm as an ultralightweight block cipher provides better solution for secure hardware cryptography with low power consumption and minimum resource. This study generates the key using key rotation and substitution method, which contains key rotation, key switching, and binary-coded decimal-based key generation used in image encryption. The key rotation and substitution-based PRESENT architecture is proposed to increase security level for data stream and randomness in cipher through providing high resistance to attacks. Lookup table is used to design the key scheduling module, thus reducing the area of architecture. Field-programmable gate array (FPGA) performances are evaluated for the proposed and conventional methods. In Virtex 6 device, the proposed key rotation and substitution PRESENT architecture occupied 72 lookup tables, 65 flip flops, and 35 slices which are comparably less to the existing architecture.

• Journal of the Korean Magnetic Resonance Society
• /
• v.22 no.4
• /
• pp.115-118
• /
• 2018

Dipyrromethane 2 functionalized with 3-chloropropyl group on the meso carbon undergoes an unusual intramolecular electrophilic aromatic substitution reaction in the presence of $NaN_3$ instead of a simple nucleophilic substitution reaction. As a result, a new chiral dipyrromethane 1 was synthesized. In this reaction, the ${\beta}$-carbon of the pyrrole ring functions as a nucleophile while the carbon next to the chlorine atom acts as an electrophile. Interestingly, this reaction progresses even in the absence of an acid catalyst. Compound 1 was fully characterized by $^1H-^1H$ and $^1H-^{13}C$ COSY NMR spectroscopic analyses and the high resolution EI mass spectrometry.