• IMMUNE NETWORK
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• v.1 no.3
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• pp.236-243
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• 2001

Background: An immunological approach for aging mechanism appears to be important. Lymphocyte subsets analysis in peripheral blood is widely performed to assess the immune status and to diagnose and monitor various diseases. Some lymphocyte subsets are known to change with age, but only few data about age-related reference ragnes for these subsets in healthy individuals have been reported. So we attempted to report reference ranges for these subsets in each age group and review changes of the results with age for the secondary studies about immune cell function as lymphocyte blast transformation and immunoglobulin gene rearrangement (VDJ) including recombination activating genes (RAG-1 and RAG-2). Methods: Lymphocyte subset analysis was performed on 302 subjects, 189 males and 113 females with age group of all decades of life. Two color direct immunofluorescene flow cytometry (FCM) was done using $Simultest^{TM}$ IMK-Lymphocyte kit (Becton Dickinson, USA), $FACScan^{TM}$ (Becton Dickinson, USA) and $FACSCalibur^{TM}$ (Becton Dickinson, USA). Lymphocyte subsets analysed were T ($CD3^+$) and B cells ($CD19^+$), helper/inducer T ($CD4^+$) and suppressor/cytotoxic T cells ($CD8^+$), helper/suppressor ($CD4^+/CD8^+$) ratio and natural killer (NK) cells ($CD3^-CD16^+/CD56^+$). The absolute numbers of each subset were calculated from total lymphocyte counts. Data collected was analysed using SAS 6.12. A P-value of < 0.05 was considered significant. Results: We reported the counts and percentages of lymphocyte and these subsets in each age group. There were no statistically significant differences between male and female subjects. The percentage of $CD4^+$ T cells, and the count of NK cells did not show the significant difference among the various age groups. The age-related changes observed in our study were as following: 1) a decrease in the percentages of T cells, B cells and $CD8^+$ T cells ; 2) a decrease in the counts of B cells and $CD8^+$ T cells ; 3) an increase in the percentage and count of NK cells ; and 4) an increase in the $CD4^+/CD8^+$ ratio. Conclusion: The characteristics of aging process appeared to be showing a marked decrease of lympocyte subsets T and B cells as well as T8 ($CD8^+$). The age-related increase of the percentage of cells bearing NK marker can be interpreted as a compensatory consequence to cope with the decrease of T cells related to the thymic involution. These changes with age appeared to be for the secondary study about immune cell function as lymphocyte blast transformation and immunoglobulin gene rearrangement.

• Journal of Gastric Cancer
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• v.5 no.2
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• pp.106-112
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• 2005

Purpose: Considering that nutritional state correlates to immunity, we performed this study to evaluate the correlation by assessing the numerical changes of the levels of serum albumin and lymphocyte subsets. Materials and Methods: The study was performed on patients who were diagnosed as having gastric cancer and who underwent curative surgery from August 1998 to August 2004 in the Gyeongsang National University Hospital and whose peripheral blood lymphocyte subsets were tested prior to surgery. The study population was a total of 150 cases. Results: The change in the lymphocyte subsets in relation to the change in the level of serum albumin in all patients with gastric cancer was determined, and was compared to disease stages. When patients were classified by using the level of serum albumin with 3.2 mg/dl as the cut-off point (low group: serum albumin <3.2 mg/dl, normal group = serum albumin $\geq$ 3.2 mg/dl), the number of peripheral blood lymphocytes, CD3+ cells, CD4+ cells, CD8+ cells, and CD16+ 56 cells were, significantly lower in the group with the level of serum albumin below 3.2 mg/dl (low group) than it was in the group with a serum albumin level above 3.2 mg/dl (normal group) (P<0.05). In stage I (n=59), CD16+56 cells were significantly lower in the low group. In stage II (n=29), the number of CD16+56 cells was lower and the ratio of CD4+/CD8+ was higher in the low group than in the normal group significantly. In stage IV (n=33), except for CD19+ cells, the number of all lymphocyte subsets was significantly lower and the ratio of CD4+/CD8+ was significantly higher in the low group. Conclusion: The group with a low level of serum albumin had a low absolute number of lymphocyte subsets. Based on this, we reconfirmed that the nutritional state is closely related with the immune state in patients with gastric cancer.

• The Mathematical Education
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• v.11 no.1
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• pp.28-29
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• 1972

• Journal of the Korean Mathematical Society
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• v.31 no.1
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• pp.131-138
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• 1994

• East Asian mathematical journal
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• v.11 no.1
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• pp.115-120
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• 1995

• Kyungpook Mathematical Journal
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• v.32 no.3_spc
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• pp.607-628
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• 1992

• Kyungpook Mathematical Journal
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• v.33 no.1
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• pp.75-86
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• 1993

• Proceedings of the IEEK Conference
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• 2004.08c
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• pp.867-871
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• 2004

In this paper, a new analytic approach for shape preserving contrast enhancement is presented. Contrast enhancement is achieved by means of segmental histogram stretching modification which preserves the given image shape, not distorting the original shape. After global stretching, the image is partitioned into several level-sets according to threshold condition. The image information of each level-set is represented as typical value based on grouped differential values. The basic property is modified into common local schemes, thereby introducing the enhanced effect through extreme discrimination between subsets. The scheme is based on stretching the histogram of subsets in which the intensity gray levels between connected pixels are approximately same In spite of histogram widening, stretched by local image information, it neither creates nor destroys the original image, thereby preserving image shape and enhancing the contrast. By designing local histogram stretching operations, we can preserve the original shape of level-sets of the image, and also enhance the global intensity. Thus it can hold the main properties of both global and local image schemes, which leads to versatile applications in the field of digital epigraphy.

• Korean Journal of Mathematics
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• v.27 no.4
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• pp.1077-1108
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• 2019

The notions of intuitionistic fuzzy UP-subalgebras and intuitionistic fuzzy UP-ideals of UP-algebras were introduced by Kesorn et al. [13]. In this paper, we introduce the notions of intuitionistic fuzzy near UP-filters, intuitionistic fuzzy UP-filters, and intuitionistic fuzzy strong UP-ideals of UP-algebras, prove their generalizations, and investigate their basic properties. Furthermore, we discuss the relations between intuitionistic fuzzy near UP-filters (resp., intuitionistic fuzzy UP-filters, intuitionistic fuzzy strong UP-ideals) and their upper t-(strong) level subsets and lower t-(strong) level subsets in UP-algebras.

• Kyungpook Mathematical Journal
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• v.56 no.4
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• pp.1103-1113
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• 2016

In this paper, we study a directed simple graph ${\Gamma}_S(N)$ for a near-ring N, where the set $V^*(N)$ of vertices is the set of all left N-subsets of N with nonzero left annihilators and for any two distinct vertices $I,J{\in}V^*(N)$, I is adjacent to J if and only if IJ = 0. Here, we deal with the diameter, girth and coloring of the graph ${\Gamma}_S(N)$. Moreover, we prove a sufficient condition for occurrence of a regular element of the near-ring N in the left annihilator of some vertex in the strong zero-divisor graph ${\Gamma}_S(N)$.