• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 1999년도 추계학술대회-지능형 정보기술과 미래조직 Information Technology and Future Organization
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• pp.323-335
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• 1999

In this paper, we propose a new hybrid model of artificial neural networks(ANNs) and genetic algorithm (GA) to optimal feature transformation and feature weighting. Previous research proposed several variants of hybrid ANNs and GA models including feature weighting, feature subset selection and network structure optimization. Among the vast majority of these studies, however, ANNs did not learn the patterns of data well, because they employed GA for simple use. In this study, we incorporate GA in a simultaneous manner to improve the learning and generalization ability of ANNs. In this study, GA plays role to optimize feature weighting and feature transformation simultaneously. Globally optimized feature weighting overcome the well-known limitations of gradient descent algorithm and globally optimized feature transformation also reduce the dimensionality of the feature space and eliminate irrelevant factors in modeling ANNs. By this procedure, we can improve the performance and enhance the generalisability of ANNs.

• ETRI Journal
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• 제29권2호
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• pp.201-211
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• 2007

This paper focuses on the scheduling problem with the objective of maximizing system throughput, while guaranteeing long-term quality of service (QoS) constraints for non-realtime data users and short-term QoS constraints for realtime multimedia users in multiclass service high-speed uplink packet access (HSUPA) systems. After studying the feasible rate region for multiclass service HSUPA systems, we formulate this scheduling problem and propose a multi-constraints HSUPA opportunistic scheduling (MHOS) algorithm to solve this problem. The MHOS algorithm selects the optimal subset of users for transmission at each time slot to maximize system throughput, while guaranteeing the different constraints. The selection is made according to channel condition, feasible rate region, and user weights, which are adjusted by stochastic approximation algorithms to guarantee the different QoS constraints at different time scales. Simulation results show that the proposed MHOS algorithm guarantees QoS constraints, and achieves high system throughput.

• 한국정보보호학회:학술대회논문집
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• 한국정보보호학회 2006년도 하계학술대회
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• pp.649-653
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• 2006

In this paper, we propose a hybrid feature extraction method in which Principal Components Analysis is combined with optimized k-Means clustering technique. Our approach hierarchically reduces the redundancy of features with high explanation in principal components analysis for choosing a good subset of features critical to improve the performance of classifiers. Based on this result, we evaluate the performance of intrusion detection by using Support Vector Machine and a nonparametric approach based on k-Nearest Neighbor over data sets with reduced features. The Experiment results with KDD Cup 1999 dataset show several advantages in terms of computational complexity and our method achieves significant detection rate which shows possibility of detecting successfully attacks.

• Molecules and Cells
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• 제38권3호
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• pp.195-201
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• 2015

Antibodies are powerful defense tools against pathogens but may cause autoimmune diseases when erroneously directed toward self-antigens. Thus, antibody producing cells are carefully selected, refined, and expanded in a highly regulated microenvironment (germinal center) in the peripheral lymphoid organs. A subset of T cells termed T follicular helper cells (Tfh) play a central role in instructing B cells to form a repertoire of antibody producing cells that provide life-long supply of high affinity, pathogenspecific antibodies. Therefore, understanding how Tfh cells arise and how they facilitate B cell selection and differentiation during germinal center reaction is critical to improve vaccines and better treat autoimmune diseases. In this review, I will summarise recent findings on molecular and cellular mechanisms underlying Tfh generation and function with an emphasis on T cell costimulation.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권3호
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• pp.794-814
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• 2012

We propose a novel method for improving Wi-Fi positioning accuracy while reducing the energy consumption of mobile devices. Our method presents three contributions. First, we jointly and intelligently select the optimal subset of access points for positioning via maximum mutual information criterion. Second, we further propose local discriminant embedding algorithm for nonlinear discriminative feature extraction, a process that cannot be effectively handled by existing linear techniques. Third, to reduce complexity and make input signal space more compact, we incorporate clustering analysis to localize the positioning model. Experiments in realistic environments demonstrate that the proposed method can lower energy consumption while achieving higher accuracy compared with previous methods. The improvement can be attributed to the capability of our method to extract the most discriminative features for positioning as well as require smaller computation cost and shorter sensing time.

• ETRI Journal
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• 제31권2호
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• pp.121-128
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• 2009

In this paper, we describe a fixed-threshold sequential minimal optimization (FSMO) for structured SVM problems. FSMO is conceptually simple, easy to implement, and faster than the standard support vector machine (SVM) training algorithms for structured SVM problems. Because FSMO uses the fact that the formulation of structured SVM has no bias (that is, the threshold b is fixed at zero), FSMO breaks down the quadratic programming (QP) problems of structured SVM into a series of smallest QP problems, each involving only one variable. By involving only one variable, FSMO is advantageous in that each QP sub-problem does not need subset selection. For the various test sets, FSMO is as accurate as an existing structured SVM implementation (SVM-Struct) but is much faster on large data sets. The training time of FSMO empirically scales between O(n) and O($n^{1.2}$), while SVM-Struct scales between O($n^{1.5}$) and O($n^{1.8}$).

• 정보처리학회논문지B
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• 제10B권1호
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• pp.27-32
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• 2003

귀납법칙 생성 시스템은 데이터에서부터 법칙을 자동으로 발견하는 시스템으로서 현재 많은 연구가 진행되고 있다. 본 논문은 정보이론을 이용하여 데이터로부터 귀납법칙을 자동으로 생성하는 시스템을 제시하고 또한 귀납법칙 생성 시스템에 의하여 생성되는 규칙들 중에서 가장 좋은 성능을 보이는 규칙 집합을 구하기 위하여 이를 유전자 알고리즘과 결합시켜 최적화된 귀납법칙 집합을 탐색하는 방법을 제시하였다. 제안된 시스템의 성능을 평가하기 위하여 다수의 기계학습 데이터를 사용하여 기존의 다른 방법들과 비교하였으며, 제안된 시스템은 대부분의 경우에 좋은 정확도를 제공하였다.

• Journal of Information Processing Systems
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• 제18권1호
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• pp.146-158
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• 2022

With the success of the digital economy and the rapid development of its technology, network security has received increasing attention. Intrusion detection technology has always been a focus and hotspot of research. A hybrid model that combines particle swarm optimization (PSO) and kernel extreme learning machine (KELM) is presented in this work. Continuous-valued PSO and binary PSO (BPSO) are adopted together to determine the parameter combination and the feature subset. A fitness function based on the detection rate and the number of selected features is proposed. The results show that the method can simultaneously determine the parameter values and select features. Furthermore, competitive or better accuracy can be obtained using approximately one quarter of the raw input features. Experiments proved that our method is slightly better than the genetic algorithm-based KELM model.

• Fisheries and Aquatic Sciences
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• 제19권4호
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• pp.21.1-21.11
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• 2016

Background: The evaluation of suitable reference genes as normalization controls is a prerequisite requirement for launching quantitative reverse transcription-PCR (RT-qPCR)-based expression study. In order to select the stable reference genes in abalone Haliotis discus hannai tissues (gill and hepatopancreas) under heavy metal exposure conditions (Cu, Zn, and Cd), 12 potential candidate housekeeping genes were subjected to expression stability based on the comprehensive ranking while integrating four different statistical algorithms (geNorm, NormFinder, BestKeeper, and ${\Delta}CT$ method). Results: Expression stability in the gill subset was determined as RPL7 > RPL8 > ACTB > RPL3 > PPIB > RPL7A > EF1A > RPL4 > GAPDH > RPL5 > UBE2 > B-TU. On the other hand, the ranking in the subset for hepatopancreas was RPL7 > RPL3 > RPL8 > ACTB > RPL4 > EF1A > RPL5 > RPL7A > B-TU > UBE2 > PPIB > GAPDH. The pairwise variation assessed by the geNorm program indicates that two reference genes could be sufficient for accurate normalization in both gill and hepatopancreas subsets. Overall, both gill and hepatopancreas subsets recommended ribosomal protein genes (particularly RPL7) as stable references, whereas traditional housekeepers such as ${\beta}-tubulin$ (B-TU) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) genes were ranked as unstable genes. The validation of reference gene selection was confirmed with the quantitative assay of MT transcripts. Conclusions: The present analysis showed the importance of validating reference genes with multiple algorithmic approaches to select genes that are truly stable. Our results indicate that expression stability of a given reference gene could not always have consensus across tissue types. The data from this study could be a good guide for the future design of RT-qPCR studies with respect to metal regulation/detoxification and other related physiologies in this abalone species.

• IMMUNE NETWORK
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• 제3권2호
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• pp.89-95
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• 2003

Background: Unusually high amounts of N region addition and CDR3 length diversity were found in immunoglobulin (Ig) light chain Vk and Jk joins in patients with rheumatoid arthritis (RA). We sought to determine whether this finding is due to excessive activity of the enzyme responsible for N region addition (terminal deoxynucleotidyl transferase [TdT]) in B lineage cells in bone marrow or from positive antigenic selection of B cells with long CDR3 lengths. Methods: We used FACS to isolate $IgM^+/IgD^+$ B cells (predominantly naive) and $IgM^-/IgD^-$ B cells (predominantly class-switched) B cells from peripheral blood of a patient with RA known to have enrichment for long Vk CDR3s and from that of two normal controls. RT-PCR of VkIII transcripts was performed, followed by sequencing of individual cDNA clones. We analyzed the CDR3 lengths and N region additions in 97 clones. Results: There was enrichment for long CDR3 lengths (11 or 12 amino acids) in both $IgM^+/IgD^+$ and $IgM^-/IgD^-$ B cells in RA compared to B cell subsets in the normal controls. The $IgM^+/IgD^+$ B cell subset in RA was markedly enriched for N region addition and was similar to that seen in the $IgM^-/IgD^-$ subset. Conclusion: These data suggest that enrichment for N region addition and long CDR3 lengths in RA may result from unusually high or prolonged activity of TdT in bone marrow.