• Title/Summary/Keyword: Structure-activity relation

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A Study of 'Greimas' Semiological Approach in Animation Character (그레마스 기호학적 접근을 통한 애니메이선 캐릭터 분석 -장편 애니메이션 "슈렉" 을 중심으로-)

  • Lim, Woon-Joo
    • The Journal of the Korea Contents Association
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    • v.9 no.5
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    • pp.99-106
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    • 2009
  • The purpose of this study is to analyze character of animation, , on the basis of Greimas' semiotic theory. Animation consists of activities between characters shown in narrative. The characters' activities show their value system and meaning. Hierarchical value system is created in the process that unrevealed, latent value is generated and character's thought and activity enlarge their meanings by creating various relationships with other character. Form this viewpoint, the study tried to analyze systematic characteristic shown in animation character and meaning structure shown in correlation through Greimas' model actant and semiotic square model.

Matrix Metalloproteinases and Cancer - Roles in Threat and Therapy

  • Yadav, Lalita;Puri, Naveen;Rastogi, Varun;Satpute, Pranali;Ahmad, Riyaz;Kaur, Geetpriya
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.3
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    • pp.1085-1091
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    • 2014
  • Matrix metalloproteinases (MMPs) are a family of zinc dependent extracellular matrix (ECM) remodelling endopeptidases having the ability to degrade almost all components of extracellular matrix and implicated in various physiological as well as pathological processes. Carcinogenesis is a multistage process in which alteration of the microenvironment is required for conversion of normal tissue to a tumour. Extracellular matrix remodelling proteinases such as MMPs are principal mediators of alterations observed in the microenvironment during carcinogenesis and according to recent concepts not only have roles in invasion or late stages of cancer but also in regulating initial steps of carcinogenesis in a favourable or unfavourable manner. Establishment of relationships between MMP overproduction and cancer progression has stimulated the development of inhibitors that block proteolytic activity of these enzymes. In this review we discuss the MMP general structure, classification, regulation roles in relation to hallmarks of cancer and as targets for therapeutic intervention.

A Study on the Combustion Characteristics over Pd/cordierite Catalyst (Pd/cordierite 촉매상에서 메탄의 연소 특성 고찰)

  • Cho, Won-Ihl;Oh, Young-Sam;Park, Dal-Ryung;Baek, Young-Soon;Pang, Hyo-Sun;Mok, Young-Il
    • Journal of Energy Engineering
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    • v.6 no.1
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    • pp.34-40
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    • 1997
  • This study aims to investigate the application possibility on natural gas in relation to the catalytic combustion of methane on Pd/cordierite catalyst which is currently used as an automobile converter catalyst. The surface area of the catalyst tested was determined to be about 18.7㎡/g and to keep stable condition in structure at mid-high temperatures. The activation energy for methane combustion reaction was estimated to be 19.2 kcal/mol and a hysterisis on the catalyst activity was observed in terms of the catalyst deactivation as the reaction temperature was varied for the methane combustion. On Pd/cordierite catalyst, The characteristics of methane combustion were studied as functions of space velocity and air/fuel ratios below 700$^{\circ}C$.

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Masseteric EMG Signal Modeling Including Silent Period After Mechanical Stimulation (기계적 자극에 대한 휴지기를 포함한 교근의 근전도 신호 모델링)

  • Kim, Duck-Young;Lee, Sang-Hoon;Lee, Seung-Woo;Kim, Sung-Hwan
    • The Transactions of the Korean Institute of Electrical Engineers D
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    • v.50 no.11
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    • pp.541-549
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    • 2001
  • The term 'silent period(SP)' refers to a transitory, relative or absolute decrease electromyography(EMG) activity, evoked in the midst of an otherwise sustained contraction. Masseteric SP is elicited by a tap on the chin during isometric contraction of masseter muscle. In this paper, a new EMG signal generation model including SP in masseter muscle is proposed. This work is based on the anatomical structure of trigeminal nerve system that related on temporomandibular joint(TMJ) dysfunction. And it was verified by comparing the real EMG signals including SP in masseter muscle to the simulated signals by the proposed model. Through this studies, it was shown that SP has relation to variable neurophysiological phenomena. A proposed model is based on the control system theory and DSP(Digital Signal Processing) theory, and was simulated using MATLAB simulink. As a result, the proposed SP model generated EMG signals which are similar to real EMG signal including normal SP and an abnormal extended SP. This model can be applied to the diagnosis of TMJ dysfunction and can effectively explain the origin of extended SP.

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Hydrogenation of Ethyl Acetate to Ethanol over Bimetallic Cu-Zn/SiO2 Catalysts Prepared by Means of Coprecipitation

  • Zhu, Ying-Ming;Shi, Xin Wang Li
    • Bulletin of the Korean Chemical Society
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    • v.35 no.1
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    • pp.141-146
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    • 2014
  • A series of bimetallic Cu-Zn/$SiO_2$ catalysts were prepared via thermal decomposition of the as-synthesized $CuZn(OH)_4(H_2SiO_3)_2{\cdot}nH_2O$ hydroxides precursors. This highly dispersed Cu-solid base catalyst is extremely effective for hydrogenation of ethyl acetate to ethanol. The reduction and oxidation features of the precursors prepared by coprecipitation method and catalysts were extensively investigated by TGA, XRD, TPR and $N_2$-adsorption techniques. Catalytic activity by ethyl acetate hydrogenation of reaction temperatures between 120 and $300^{\circ}C$, different catalyst calcination and reduction temperatures, different Cu/Zn loadings have been examined extensively. The relation between the performance for hydrogenation of ethyl acetate and the structure of the Cu-solid base catalysts with Zn loading were discussed. The detected conversion of ethyl acetate reached 81.6% with a 93.8% selectivity of ethanol. This investigation of the Cu-Zn/$SiO_2$ catalyst provides a recently proposed pathway for ethyl acetate hydrogenation reaction to produce ethanol over Cu-solid base catalysts.

Effectiveness of Adaptive Navigation System for Group Activity at the Wiki-based Collaborative Learning (Wiki 기반 협력학습에서 적응적 내비게이션 시스템이 그룹 활동에 미치는 효과)

  • Han, Hee-Seop;Kim, Hyeoncheol
    • The Journal of Korean Association of Computer Education
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    • v.9 no.1
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    • pp.41-48
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    • 2006
  • The latest several studies show that Wiki is a very efficient tools for collaborative learning in the distributed environments. Even though Wiki supports efficient knowledge sharing between group members, there are still some problems to be solved for collaborative learning. Since the structure of group contents becomes more complex and the links between pages are dynamically changed, each member of group has difficulties to perceive the changed contents and links on group pages. We designed the adaptive navigation system to guide individual browsing paths of each member through the calculating of friendship and the state of pages. At first we developed the relation model between member and each pages by the historical log that stored the change of pages and the activity of members, and then we implemented the adaptive navigation system using the model. Experimental results show that this adaptive system is very effective to share the group knowledge and to promote collaborative learning activities.

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An Empirical Study on the Competition Factor Electronic Logistics Information and International Logistics Management (국제물류관리와 전자적물류정보의 경쟁요인에 관한 실증연구)

  • Kwak, Hyun
    • International Commerce and Information Review
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    • v.9 no.2
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    • pp.257-283
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    • 2007
  • As Global industrial structure is diversified, multinational corporations accomplished fast internationalization to introduction of new management policy by development of an IT technology. Enterprise' business environment is changing transcending border. To overcome raging waves of change accident and to be secured enterprise's future, the logistics is recognized the third profit source joining in curtailment of sale enlargement, production cost. To seek cost saving or reform in logistics class that is last area of pursuit of profits within ancient city life in the fast lane from these viewpoint, importance of study that integrates and manages international logistics bases supply neck walk is emphasized. Specially, to meet on in terms of competitive power security regarding curtailment of logistics cost is available through link between logistics bases, various consumer's request, merchandise and service logistics management that supply fixed quantity as is reliable in right place at good season was embossed by point game plan of business management, and SCM efficiency anger of mortification international logistics activity importance of study that see at that dominate competitive advantage point bring. This study analyzes interrelation and presents model for integration of international logistics bases supply network with supply network habit at factor and supply chain, and supply network activity in integration of supply chain process and production. Also, it establishes following method of study to achieve study purpose for actual proof analysis for integration sequence of international logistics bases supply network. Specially, immersion of network and supply network, very high interrelation appeared by thing which is with international logistics base supply network integration. The integration of international logistics base supply network means that the enterprises which give trust and sincerity deal with market environment change positively and can decide proceeding of various cooperative work. Also, it means the possibility by necessity of cooperative relation and interdependence to continuous immersion and normative immersion, for the maintain of long business relations.

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Study on Prescriptions about Monarch(jun)${\cdot}$Minister(chen)${\cdot}$Adjuvant(zou)${\cdot}$Guide(shi) Theory (군신좌사(君臣佐使)에 대한 연구)

  • Lee, Tae-Kyoung;Kang, Jung-Soo;Kim, Byoung-Soo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.21 no.3
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    • pp.596-604
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    • 2007
  • For countless time, many have been made in our oriental medicine. To understand such prescription and to use, we must study the monarch(jun), minister(chen), adjuvant(zou) and guide(shi) theory that is most of the prescription structure principle's the basis. The monarch is the center of the prescription. Two kind is greatly in the method to select the monarch, in the prescription. One method is that a medicinal herb of the high class of medical herb of the Sinnong's Classic becomes the monarch, and the other method is a medicinal herbs which there is most many qunantity in the prescription becomes the monarch. Additionally, a medicinal herbs name of a prescription name can become the monarch. The minister assist the monarch and this is a criteria of the prescription grouping with the monarch. The minister has close relation with the monarch. The adjuvant helps the monarch and the minister nature of drug or restains. So this makes the prescription effectiveness act accurately. The guide does the activity to help the harmony of the prescription and the activity to help the prescription to act in correct place. If we understand the monarch, minister, adjuvant and guide theory well, we have some advantage. The interpreting of the prescription comes to De easy. and, an application range of the prescription is enhanced. the increase and decrease of the medicinal herbs comes to be easy in the prescription. Finally that theory will be used for the principle to make new prescription.

The Program Development of Nursing Activities for Community Health Promotion (지역사회 건강증진 간호활동의 프로그램 개발)

  • Park, Jeong-Hee
    • Research in Community and Public Health Nursing
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    • v.10 no.2
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    • pp.291-306
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    • 1999
  • Health promotion has come to the fore through new concept approach in consequence of the increase of chronic diseases. increase of medical cost and social trend of putting more emphasis on the individual responsibility for health. Studies of health promotion can be classified into two types: one is micro intervention method which is mainly focused on modifying individual life style and the other. macro intervention method in which they put another emphasis on the environment the individual is surrounded. in addition to modifying individual life style. This study belongs to the later. This study aims to develop nursing activities and program it for the purpose of community health promotion. The process of the study can be briefed as follows: to draw out nursing contents to intervene for community health promotion: to promote community health to develop nursing action indicators; to develop nursing action indicators for the development of main nursing activities. And those developed nursing activities are programmed systematically. The community health promotion program is composed of a hierarchical structure with nursing process that the nurses are supposed to apply to perform professional nursing. the level of nursing perform. the main items of nursing process. health promotion nursing indicators. health promotion nursing activities. The conclusion of this study according to objectives are as follows. First. community health promotion contents at individual and community level are remained revised and complemented and those at organizational level are developed. The developed main contents of community health promotion nursing are as follows. 1) Revised individual level nursing contents: 35 items. 2) Developed organizational level nursing contents: 24 items. 3) Revised community level nursing contents: 36 items. Second. for the development of the health promotion nursing action indicators. principles were set up and applied as follows. 1. Developed indicators should be provided with such qualities as comprehensiveness. diversity. developability, availability. practicability. 2. Developed indicators should be provided with functional abilities to measure the conditions and changes in any phenomena or state. inspect the development of the states. control the implementing program. evaluate the result of program and grasp what nurses should do. 3. Developed indicators should be provided with relevance and sequence. 4. Developed indicators should be undergo inspections from the expert. The developed community health promotion action indicators developed in this study. observing above mentioned principles. are total 330 indicators of 95 items. Third. when the main nursing activities were developed for each nursing action indicator. five priciples were set up in accordance with each nursing action indicators to decide main nursing activities. Main nursing activities developed observing those principles. are total 1273. Forth. for the programming of the developed nursing activities. three principles were set up. 1. The nursing activities are systematized in line with (nursing process) (nursing client) (key items of nursing process) (nursing action indicators for health promotion) (nursing activities). 2. The program is constructed in downward and hierarchical order. 3. The program is constructed not in relation to same level activities but in relation to high and low level activities. The process step of programming of developed main health promotion nursing activities are; Step 1. The Developed nursing action indicators are classified into nursing process. Step 2. The main nursing activities are allocated per each nursing action indicators. Step 3. The statement of main nursing activities are inspected. Step 4. The items of main nursing activities allocated by a certain nursing action indicators are sequenced. taking into consideration the elaborateness of activity. the sequency of activity. familiarity of activity. the difficulty of activity. the interest of activity. the frequency of activity. Step 5. The whole developed program should undergo comprehensive and critical inspections.

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Reflective Abstraction and Operational Instruction of Mathematics (반영적 추상화와 조작적 수학 학습-지도)

  • 우정호;홍진곤
    • Journal of Educational Research in Mathematics
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    • v.9 no.2
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    • pp.383-404
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    • 1999
  • This study began with an epistemological question about the nature of mathematical cognition in relation to the learner's activity. Therefore, by examining Piaget's 'reflective abstraction' theory which can be an answer to the question, we tried to get suggestions which can be given to the mathematical education in practice. 'Reflective abstraction' is formed through the coordination of the epistmmic subject's action while 'empirical abstraction' is formed by the characters of observable concrete object. The reason Piaget distinguished these two kinds of abstraction is that the foundation for the peculiar objectivity and inevitability can be taken from the coordination of the action which is shared by all the epistemic subjects. Moreover, because the mechanism of reflective abstraction, unlike empirical abstraction, does not construct a new operation by simply changing the result of the previous construction, but is forming re-construction which includes the structure previously constructed as a special case, the system which is developed by this mechanism is able to have reasonability constantly. The mechanism of the re-construction of the intellectual system through the reflective abstraction can be explained as continuous spiral alternance between the two complementary processes, 'reflechissement' and 'reflexion'; reflechissement is that the action moves to the higher level through the process of 'int riorisation' and 'thematisation'; reflexion is a process of 'equilibration'between the assimilation and the accomodation of the unbalance caused by the movement of the level. The operational learning principle of the theorists like Aebli who intended to embody Piaget's operational constructivism, attempts to explain the construction of the operation through 'internalization' of the action, but does not sufficiently emphasize the integration of the structure through the 'coordination' of the action and the ensuing discontinuous evolvement of learning level. Thus, based on the examination on the essential characteristic of the reflective abstraction and the mechanism, this study presents the principles of teaching and learning as following; $\circled1$ the principle of the operational interpretation of knowledge, $\circled2$ the principle of the structural interpretation of the operation, $\circled3$ the principle of int riorisation, $\circled4$ the principle of th matisation, $\circled5$ the principle of coordination, reflexion, and integration, $\circled6$ the principle of the discontinuous evolvement of learning level.

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