• Structural Engineering and Mechanics
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• v.71 no.2
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• pp.197-210
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• 2019

Probabilistic buckling behavior of sandwich panel considering random system parameters using a radial basis function (RBF) approach is presented in this paper. The random system properties result in an uncertain response of the sandwich structure. The buckling load of laminated sandwich panel is obtained by employing higher-order-zigzag theory (HOZT) coupled with RBF and probabilistic finite element (FE) model. The in-plane displacement variation of core as well as facesheet is considered to be cubic while transverse displacement is considered to be quadratic within the core and constant in the facesheets. Individual and combined stochasticity in all elemental input parameters (like facesheets thickness, ply-orientation angle, core thickness and properties of material) are considered to know the effect of different degree of stochasticity, ply- orientation angle, boundary conditions, core thickness, number of laminates, and material properties on global response of the structure. In order to achieve the computational efficiency, RBF model is employed as a surrogate to the original finite element model. The stiffness matrix of global response is stored in a single array using skyline technique and simultaneous iteration technique is used to solve the stochastic buckling equations.

• Journal of the Korea Furniture Society
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• v.21 no.2
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• pp.157-166
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• 2010

Furniture in the modern living environment, inclusive the importance of its practical value, is a plastic element of indoor space, and its artistic value also holds an important position. Moreover, emotional design based on the emotional engineering in a structural change of modern society such as urbanization, small family, aging society is proposed as an important keyword in the modern design. Namely, furniture as an component of modern residential space has been advanced as a human-oriented environmental element considering people's emotional and mental value to the functional satisfaction and artistic and emotional satisfaction. Furniture is a living tool that is much contacted to people, which affects highly on people's body and mind. This means that people's volition action can be naturally induced by furniture design, and that furniture can display a role as an active tool of means to make people's interpersonal communication and interchange. Namely, I think furniture design of emotional interchange that understands furniture user's pattern behavior and pattern, and observes furniture form and structure and functionality on users' relationship affecting on people's emotional stability and interpersonal interchange of emotion, as an indispensable element necessary for producing more human and prosperous environment of life.

• BMB Reports
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• v.49 no.2
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• pp.73-80
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• 2016

Autophagy is a process tightly regulated by various autophagy-related proteins. It is generally classified into non-selective and selective autophagy. Whereas non-selective autophagy is triggered when the cell is under starvation, selective autophagy is involved in eliminating dysfunctional organelles, misfolded and/or ubiquitylated proteins, and intracellular pathogens. These components are recognized by autophagy receptors and delivered to phagophores. Several selective autophagy receptors have been identified and characterized. They usually have some common domains, such as motif, a specific cargo interacting (ubiquitin-dependent or ubiquitin-independent) domain. Recently, structural data of these autophagy receptors has been described, which provides an insight of their function in the selective autophagic process. In this review, we summarize the most up-to-date findings about the structure-function of autophagy receptors that regulates selective autophagy.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.149.6-149
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• 2001

We propose a neuron model that has the interactions between excitation and inhibition. By adopting the knowledge of the physiology, the neuron model by imitating structure of a neuron, has the system resemble a neuron. We considered a neuron system based on the arguments, and wished to examine whether the system had reasonable function Koch, Poggio and Torre believed that inhibition signal would shunt excitation signal on the dendrites. They believed that excitation signal operated input signals and inhibition did as delayed ones. Thus, they were sure that function for directional selectivity was arisen by the shunting. We construct the neuron system with Koch's concept. Our neuron model has 3-layer structure and ...

• Structural Engineering and Mechanics
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• v.64 no.3
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• pp.353-360
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• 2017

This study presents the Big Bang and Big Crunch (BB-BC) optimization algorithm for detection of structure damage in large severity. Local damage is represented by a perturbation in the elemental stiffness parameter of the structural finite element model. A nonlinear objective function is established by minimizing the discrepancies between the measured and calculated acceleration responses (AR) of the structure. The BB-BC algorithm is utilized to solve the objective function, which can localize the damage position and obtain the severity of the damage efficiently. Numerical simulations have been conducted to identify both single and multiple structural damages for beam, plate and European Space Agency Structures. The present approach gives accurate identification results with artificial measurement noise.

• Journal of the military operations research society of Korea
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• v.6 no.1
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• pp.79-92
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• 1980

In cost-only incentive contract the emphasis is the attainment of efficient and effective cost control. In contrast multiple incentives contract correlates contractor's profit motives with the generalized government objective function, the decision variables of which are performance or quality (technical progress), time or schedule (timely development and delivery) and the cost (efficient and effective cost control) Under multiple incentive structure, it is essential to formulate the trade-off curves between cost and performance, which are called iso-fee curves. Trade-off curves depict the combination of cost and performance achievement for which the contractor will be rewarded with the same fee. The basic function of trade-off curves is to show he the contractor will be motivated by incentive arragement to trade off or sacrifice the achievement in one incentive element for the acnievment in another.

• Applied Microscopy
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• v.46 no.2
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• pp.100-104
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• 2016

Electron microscopy is currently the only available technique with a spatial resolution sufficient to identify fine neuronal processes and synaptic structures in densely packed neuropil. For large-scale volume reconstruction of neuronal connectivity, serial block-face scanning electron microscopy allows us to acquire thousands of serial images in an automated fashion and reconstruct neural circuits faster by reducing the alignment task. Here we introduce the whole reconstruction procedure of synaptic network in the rat hippocampal CA1 area and discuss technical issues to be resolved for improving image quality and segmentation. Compared to the serial section transmission electron microscopy, serial block-face scanning electron microscopy produced much reliable three-dimensional data sets and accelerated reconstruction by reducing the need of alignment and distortion adjustment. This approach will generate invaluable information on organizational features of our connectomes as well as diverse neurological disorders caused by synaptic impairments.

• Nuclear Engineering and Technology
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• v.55 no.5
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• pp.1541-1558
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• 2023

The new Modified-690Gd alloy, namely as Ni-30Cr-(10-x) Fe-xGd (x = 0.5, 1.0, 1.5,2.0, 3.0 wt%) for function structure integrated thermal neutron shielding has been prepared and characterized. The Modified-690Gd alloy was mainly composed of γ austenite matrix and (Ni, Cr, Fe)₅Gd precipitated along grain boundaries. The new Modified-690Gd alloy had great mechanical properties, which had the tensile strength exceeding 620 MPa and the elongation being above 50%. Meanwhile, this alloy had excellent weldability and good corrosion resistance in boric acid. The new Modified-690Gd alloy is expected to be a kind of high efficiency thermal neutron shielding materials.

• Journal of the Korean Magnetic Resonance Society
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• v.12 no.1
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• pp.1-13
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• 2008

Acetyl-CoA carboxylase (ACC) catalyzes the first step in fatty acid biosynthesis: the synthesis of malonyl-CoA from acetyl-CoA. As essential regulators of fatty acid biosynthesis and metabolism, ACCs are regarded as therapeutic targets for the treatment of metabolic diseases such as obesity, In ACC, the biotinoyl domain performs a critical function by transferring an activated carboxyl group from the biotin carboxylase domain to the carboxyl transferase domain, followed by carboxyl transfer to malonyl-CoA. Despite the intensive research on this enzyme, only the bacterial and yeast ACC structures are currently available, To explore the mechanism of ACC holoenzyme function, we determined the structure of the biotinoyl domain of human ACC2 and analyze its characteristics using NMR spectroscopy. The 3D structure of the hACC2 biotinoyl domain has a similar folding topology to the previously determined domains from E. coli and P. Shermanii, however, the 'thumb' structure is absent in the hACC2 biotinoyl domain. Observations of the NMR signals upon the biotinylation indicate that the biotin group of hACC2 does not affect the structure of the biotinoyl domain, while the biotin group for E. coli ACC interacts directly with the thumb residues that are not present in the hACC2 structure. These results imply that, in the E. coli ACC reaction, the biotin moiety carrying the carboxyl group from BC to CT can pause at the thumb of the BCCP domain. The human biotinoyl domain, however, lacks the thumb structure and does not have additional non-covalent interactions with the biotin moiety; thus, the flexible motion of the biotinylated lysine residue must underlie the "swinging arm" motion. This study provides insight into the mechanism of ACC holoenzyme function and supports the "swinging arm" model in human ACCs.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.11a
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• pp.694-698
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• 2006

This paper presents an optimal design process using beads on a body panel to improve interior noise of a passenger vehicle. Except modification of structural members, it is difficult to find effective countermeasures that can work for the intermediate frequency range from 100 Hz to 300 Hz which lies between the booming and low medium frequency. In this study, it is a major goal to find additional counter-measures for this intermediate frequency range by performing optimal design of beads on body panels. The proposed method for design optimization consists of 4 sub-steps, that is, a) problem definition, b) cause analysis, c) countermeasure development and d) validation. The objective function is minimization of interior noise level. The major design variables are the geometrical shape of a bead and combination of beads on the critical panels. Sensitivity analysis and optimization are performed according to the predefined process for an optimal design. It is verified that the proposed design decreases the level of noise transfer function above 5 dB.