• Journal of Microbiology and Biotechnology
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• 제32권3호
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• pp.324-332
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• 2022

The incidence of stress-related type 2 diabetes (stress-T2D), which is aggravated by physiological stress, is increasing annually. The effects of Lactobacillus, a key component of probiotics, have been widely studied in diabetes; however, studies on the effects of postbiotics are still limited. Here, we aimed to examine the mechanism through which heat-killed Lactiplantibacillus plantarum LRCC5314 (HK-LRCC5314) alleviates stress-T2D in a cold-induced stress-T2D C57BL/6 mouse model. HK-LRCC5314 markedly decreased body weight gain, adipose tissue (neck, subcutaneous, and epididymal) weight, and fasting glucose levels. In the adipose tissue, mRNA expression levels of stress-T2D associated factors (NPY, Y2R, GLUT4, adiponectin, and leptin) and pro-inflammatory factors (TNF-α, IL-6, and CCL-2) were also altered. Furthermore, HK-LRCC5314 increased the abundance of Barnesiella, Alistipes, and butyrate-producing bacteria, including Akkermansia, in feces and decreased the abundance of Ruminococcus, Dorea, and Clostridium. Thus, these findings suggest that HK-LRCC5314 exerts protective effects against stress-T2D via gut microbiome modulation, suggesting its potential as a supplement for managing stress-T2D.

• 한국안전학회지
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• 제8권4호
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• pp.27-40
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• 1993

High temperature tensile tests, steady state creep tests, Internal stress tests and creep rupture tests using A17075 alloy( $T_{6}$ ) were performed over the temperature range of 9$0^{\circ}C$~50$0^{\circ}C$ (0.4 $T_{m}$ ~0.85 $T_{m}$ ) and stress range of 0.64~17.2(kgf/$\textrm{mm}^2$). The main results obtained in this paper were as follows. (1) The activation energies for yielding at the temperature of 0.4 $T_{m}$ ~0.75 $T_{m}$ were calculated to be 25.7~36.5kcal/mol, which were nearly equal to the activation energies for creep. (2) At around the temperature of 9$0^{\circ}C$~12$0^{\circ}C$ and under the stress level of 10~17.2(kgf/$\textrm{mm}^2$), and at around the temperature of 200~41$0^{\circ}C$ and under the stress level of 1.53~9.55(kgf/$\textrm{mm}^2$) and again at around the temperature of 470~50$0^{\circ}C$ and under the stress level of 0.62~l.02(kgf/$\textrm{mm}^2$), the applied stress dependence of steady state creep rate $n_{measu}$ measured were, respectively, 3.15, 6.62 and 1.1, which were in good agreement the calculated stress dependence $n_{ealeu}$ obtained by the difference of the applied stress dependence of the Internal stress and the ratio of the internal stress to the applied stress. (3) At the temperature range of 0.4~0.43 $T_{m}$ , and at the temperature range of 0.52~0.75 $T_{m}$ and again at the temperature range of 0.82~0.85 $T_{m}$ , the activation energies $Q_{measu}$ obtained by steady state creep rate, respective, 26. 16, 34.9, 36.2 and 36.1kcal/mol, which were in good agreement with those obtained with the activation energies under constant effective stress and the temperature dependence of Internal stress. (4) At the temperature range of the 0.52~0.73 $T_{m}$ and under the stress level of 1.53~9.55(kgf/$\textrm{mm}^2$), the stress dependence of rupture life(n’) measured was 6.3~6.6, which was in good agreement with the stress dependence of steady state creep rate(n). And at the same condition the activation energy for rupture( $Q_{f}$ ) measured was 32.0~36.9kca1/mol, which was also in good agreement with the activation energy obtained by steady state creep rate ( $Q_{c}$ ). (5) The rupture life( $t_{f}$ ) might be represented by athermal process attributed to the difference of the applied stress dependence of the internal stress and the ratio of the internal stress to the applied stress, and the thermal activated process attributied to the temperature dependence of the internal stress as $t_{f}$ = A'$\sigma$$_{a}$ ｛n(1-d $\sigma$$_{i}$ /d $\sigma$$_{a}$ )/(1-$\sigma$$_{i}$ / $\sigma$$_{a}$ )｝.exp[｛ $Q_{c}$ $^{*}$-( $n_{o}$ R $T^2$/ $E_{(T)}$) (d $E_{(T)}$/dT) - ( $n_{0}$ R $T^2$/ $\sigma$$_{a}$ - $\sigma$$_{i}$ ) (d $\sigma$$_{i}$ /dT)｝/RT]. (6) The relationship betwween Larson-Miller rupture parameter and logarithmic stress was linearly decreased, so creep rupture life of Al 7075 alloy seemed to be predicted exactly with Larson-Miller parameter.meter.

• Nutrition Research and Practice
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• 제18권1호
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• pp.1-18
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• 2024

BACKGROUND/OBJECTIVES: Endoplasmic reticulum (ER) stress in adipose tissue causes an inflammatory response and leads to metabolic diseases. However, the association between vitamin D and adipose ER stress remains poorly understood. In this study, we investigated whether 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃) alleviates ER stress in adipocytes. MATERIALS/METHODS: 3T3-L1 cells were treated with different concentrations (i.e., 10-100 nM) of 1,25(OH)₂D₃ after or during differentiation (i.e., on day 0-7, 3-7, or 7). They were then incubated with thapsigargin (TG, 500 nM) for an additional 24 h to induce ER stress. Next, we measured the mRNA and protein levels of genes involved in unfold protein response (UPR) and adipogenesis using real-time polymerase chain reaction and western blotting and quantified the secreted protein levels of pro-inflammatory cytokines. Finally, the mRNA levels of UPR pathway genes were measured in adipocytes transfected with siRNA-targeting Vdr. RESULTS: Treatment with 1,25(OH)₂D₃ during various stages of adipocyte differentiation significantly inhibited ER stress induced by TG. In fully differentiated 3T3-L1 adipocytes, 1,25(OH)₂D₃ treatment suppressed mRNA levels of Ddit3, sXbp1, and Atf4 and decreased the secretion of monocyte chemoattractant protein-1, interleukin-6, and tumor necrosis factor-α. However, downregulation of the mRNA levels of Ddit3, sXbp1, and Atf4 following 1,25(OH)₂D₃ administration was not observed in Vdr-knockdown adipocytes. In addition, exposure of 3T3-L1 preadipocytes to 1,25(OH)₂D₃ inhibited transcription of Ddit3, sXbp1, Atf4, Bip, and Atf6 and reduced the p-alpha subunit of translation initiation factor 2 (eIF2α)/eIF2α and p-protein kinase RNA-like ER kinase (PERK)/PERK protein ratios. Furthermore, 1,25(OH)₂D₃ treatment before adipocyte differentiation reduced adipogenesis and the mRNA levels of adipogenic genes. CONCLUSIONS: Our data suggest that 1,25(OH)₂D₃ prevents TG-induced ER stress and inflammatory responses in mature adipocytes by downregulating UPR signaling via binding with Vdr. In addition, the inhibition of adipogenesis by vitamin D may contribute to the reduction of ER stress in adipocytes.

• 소성∙가공
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• 제20권5호
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• pp.369-376
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• 2011

본 연구를 통하여 비이차 비등방 항복 응력 포텐셜들의 근접 짝되는 변형률 속도 포텐셜들에 대해서 정리하고 Yld2000-2d의 근접 짝되는 Srp2003-2d에 대해서 상세 설명하였다. 제안된 비이차 비등방 변형률 속도 포텐셜 Srp2003-2d 식 형태가 소개 되었고, 볼록성이 증명되었다. 아울러 이방성 상수를 구하는 방법이 제시되었다. Srp2003-2d의 소성 거동을 살펴보기 위하여 자동차 용 알루미늄 합금 판재 AA6022-T4와 항공재료용 알루미늄 합금 AA2090-T3에 응용되었다. Srp2003-2d는 항복 응력 포텐셜 Yld2000-2d와 거의 흡사한 짝됨을 보여 주었으며, 알루미늄 판재의 비등방성을 적절히 묘사하였다. Srp2003-2d는 알루미늄 판재의 성형 공정의 모사를 위하여 이상 공정 이론을 비롯한 강소성체 재료에 대한 정식화에 적절히 응용될 수 있을 것이다.

• 한국응용과학기술학회지
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• 제37권6호
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• pp.1687-1697
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• 2020

본 연구는 중년 여성의 뇌교육 명상 프로그램 참여에 따른 스트레스(신체적 스트레스, 심리적 스트레스), 우울, 회복탄력성(자기조절능력, 대인관계능력, 긍정성)의 정도 및 차이를 파악하는 비교서술연구이다. 대상자는 D광역시 D센터에서 뇌교육 명상 프로그램을 1년 이상 참여자 중 중년 여성 26명과 D광역시 J구에 거주하고 있는 자 중 뇌교육 명상 프로그램에 참여하지 않는 중년 여성 29명 총 55명으로 2019년 11월 4일~22일까지 3주 동안 자료를 수집하였다. 자료 분석 결과, 뇌교육 명상 프로그램에 참여군이 미참여군보다 신체적 스트레스(t=2.549, p=.014), 심리적 스트레스(t=2.352, p=.022), 회복탄력성의 상위요인인 자기조절능력(t=-2.219, p=.031), 긍정성(t=-2.387, p=.021)에서 통계적으로 유의한 차이가 있는 것으로 나타났다. 즉, 뇌교육 명상 프로그램 참여군은 미참여군보다 신체적 스트레스와 심리적 스트레스 점수가 낮았으며 자기조절능력과 긍정성 점수가 높은 것으로 나타났다. 따라서 중년 여성의 스트레스를 감소시키고 자기조절능력과 긍정성을 향상시키기 위해 뇌교육 명상 프로그램을 간호중재로서 활용할 수 있을 것으로 사료된다.

• Steel and Composite Structures
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• 제17권2호
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• pp.145-157
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• 2014

This study aimed to investigate the fatigue crack growth behavior of a kind of fiber metal laminates (FML) under four different stress levels. The FML specimen consists of three 2024-T3 aluminum alloy sheets and two layers of glass/epoxy composite lamina. Tensile-tensile cyclic fatigue tests were conducted on centrally notched specimen at four stress levels with various maximum values. A digital camera system was used to take photos of the propagating cracks on both sides of the specimens. Image processing software was adopted to accurately measure the length of the cracks on each photo. The test results show that: (1) a-N and da/dN-a curves of FML specimens can be divided into transient crack growth segment, steady state crack growth segment and accelerated crack growth segment; (2) compared to 2024-T3 aluminum alloy, the fatigue properties of FML are much better; (3) da/dN-${\Delta}K$ curves of FML specimens can be divided into fatigue crack growth rate decrease segment and fatigue crack growth rate increase segment; (3) the maximum stress level has a large influence on a-N, da/dN-a and da/dN-${\Delta}K$ curves of FML specimens; (4) the fatigue crack growth rate da/dN presents a nonlinear accelerated increasing trend to the maximum stress level; (5) the maximum stress level has an almost linear relationship with the stress intensity factor ${\Delta}K$.

• 동의신경정신과학회지
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• 제33권1호
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• pp.33-48
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• 2022

Objectives: Academic stress poses a significant risk for the mental health of medical students, and a feasible group intervention program for managing academic stress is required. The purpose of this study was to examine the clinical effectiveness of emotional freedom techniques (EFT) on the mental health of Korean medical students. Methods: The class of first-year medical school students (n=36) participated in an after-school EFT group intervention program comprising six sessions (15 minutes/session, three weeks) to analyze its clinical effectiveness as a single-group test-retest clinical study. The changes in the Perceived Stress Scale (PSS), Test Anxiety Inventory (TAI), Positive and Negative Affect Schedule (PANAS), and State-Trait Anxiety Inventory (STAI) scores were examined using a paired t-test and Cohen's D at post-EFT and two-week follow-up. Results: There were significant curtailments at post-EFT and follow-up measures in TAI-Total (t=2.704 and t=3.289), TAI-Worry (t=2.297 and t=2.454), TAI-Emotionality (t=2.763 and t=3.654), PSS-Negative Perspective (t=2.659 and t=3.877), and PANAS-Negative Affect (t=2.885 and t=3.259) subscales, however not in PSS-Positive Perspective (t=-1.279 and t=-1.101) and PANAS-Positive Affect (t=0.194 and t=-0.122) subscales. The trait anxiety (t=2.227) was significantly mitigated in the post-EFT measure and the state anxiety (t=2.30) in the follow-up measure. Conclusions: The EFT group intervention alleviated test stress, negative affect, and anxiety in the Korean medical students. This study contributes to an understanding of academic stress and EFT intervention in the competitive environment of medical education.

• Structural Engineering and Mechanics
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• 제55권4호
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• pp.857-869
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• 2015

The aluminum 7075-T6 is known as an alloy widely used in aircraft structural applications, which does not exhibit strain rate sensitivity during dynamic compressive tests. Despite mechanical importance of the material, there is not enough attention to determine appropriate sample dimensions such as a sample diameter relative to the device bar diameter and sample length to diameter (L/D) ratio for dynamic tests and how these two parameters can change mechanical behaviors of the sample under dynamic loading condition. In this study, various samples which have different diameters of 31.8, 25.4, 15.9, and 9.5 mm and sample L/D ratios of 2.0, 1.5, 1.0, 0.5, and 0.25 were tested using Split Hopkinson Pressure Bar (SHPB), as this testing device is proper to characterize mechanical behaviors of solid materials at high strain rates. The mechanical behavior of this alloy was examined under ${\sim}200-5,500s^{-1}$ dynamic strain rate. Aluminum samples of 2.0, 1.5 and 1.0 of L/D ratios were well fitted into the stress-strain curve, Madison and Green's diagram, regardless of the sample diameters. Also, the 0.5 and 0.25 L/D ratio samples having the diameter of 31.8 and 25.4 mm followed the stress-strain curve. As results, larger samples (31.8 and 25.4 mm) in diameters followed the stress-strain curve regardless of the L/D ratios, whereas the 0.5 and 0.25 L/D ratios of small diameter sample (15.9 and 9.5 mm) did not follow the stress-strain diagram but significantly deviate from the diagram. Our results indicate that the L/D ratio is important determinant in stress-strain responses under the SHPB test when the sample diameter is small relative to the test bar diameter (31.8 mm), but when sample diameter is close to the bar diameter, L/D ratio does not significantly affect the stress-strain responses. This suggests that the areal mismatch (non-contact area of the testing bar) between the sample and the bar can misrepresent mechanical behaviors of the aluminum 7075-T6 at the dynamic loading condition.

• 한국추진공학회지
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• 제1권1호
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• pp.104-110
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• 1997

고강도 알루미늄 합금 링롤재의 급냉, 링 팽창(expansion) 및 링 압축(compression) 응력제거처리 후 잔류응력을 예측하기 위하여 2차원 축대칭 열해석 및 탄소성 해석을 수행하였다. 급냉 및 응력제거처리 후 2단 과시효 처리(T73)된 링롤재에 대하여 3단계 절단법(Three step sectioning method)을 적용하여 링롤재의 두께에 따른 잔류응력 분포를 측정하였으며, 측정결과를 급냉 및 응력제거처리후 잔류응력 해석결과와 비교분석하였다. 링의 급냉후 원주 및 축방향의 잔류응력 해석값은 T73후 측정값과 비슷한 경향을 보였으며, 링의 내면과 외면에서 압축응력을 나타내었고 중심에서 인장응력을 나타내었다. 잔류응력은 링 팽창(T7351) 및 링 압축(T7352) 적용후 T73에 비해 현저히 감소하였으며, 축방향의 제거 효과가 원주방향보다 우수하게 나타났다. 또한 링 압축에 의한 제거효과가 링 팽창보다 크게 나타났다. 링롤재의 응력제거처리는 제거 효과 및 실용성 측면에서 링 압축 공정이 유리하며, 치수제어 및 장비용량 측면에서 링 팽창 공정이 유리하다는 결론을 얻었다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제1권3호
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• pp.141-157
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• 2001

Highly reliable packaged 64kbit ferroelectric memories with $0.8{\;}\mu\textrm{m}$ CMOS ensuring ten-year retention and imprint at 125^{\circ}C$ have been successfully developed. These superior reliabilities have resulted from steady integration schemes free from the degradation, due to layer stress and attacks of process impurities. The resent results of research and development for ferroelectric memories at Hynix Semiconductor Inc. are summarized in this invited paper.