• Journal of Microbiology and Biotechnology
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• v.32 no.3
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• pp.324-332
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• 2022

The incidence of stress-related type 2 diabetes (stress-T2D), which is aggravated by physiological stress, is increasing annually. The effects of Lactobacillus, a key component of probiotics, have been widely studied in diabetes; however, studies on the effects of postbiotics are still limited. Here, we aimed to examine the mechanism through which heat-killed Lactiplantibacillus plantarum LRCC5314 (HK-LRCC5314) alleviates stress-T2D in a cold-induced stress-T2D C57BL/6 mouse model. HK-LRCC5314 markedly decreased body weight gain, adipose tissue (neck, subcutaneous, and epididymal) weight, and fasting glucose levels. In the adipose tissue, mRNA expression levels of stress-T2D associated factors (NPY, Y2R, GLUT4, adiponectin, and leptin) and pro-inflammatory factors (TNF-α, IL-6, and CCL-2) were also altered. Furthermore, HK-LRCC5314 increased the abundance of Barnesiella, Alistipes, and butyrate-producing bacteria, including Akkermansia, in feces and decreased the abundance of Ruminococcus, Dorea, and Clostridium. Thus, these findings suggest that HK-LRCC5314 exerts protective effects against stress-T2D via gut microbiome modulation, suggesting its potential as a supplement for managing stress-T2D.

• Journal of the Korean Society of Safety
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• v.8 no.4
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• pp.27-40
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• 1993

High temperature tensile tests, steady state creep tests, Internal stress tests and creep rupture tests using A17075 alloy( $T_{6}$ ) were performed over the temperature range of 9$0^{\circ}C$~50$0^{\circ}C$ (0.4 $T_{m}$ ~0.85 $T_{m}$ ) and stress range of 0.64~17.2(kgf/$\textrm{mm}^2$). The main results obtained in this paper were as follows. (1) The activation energies for yielding at the temperature of 0.4 $T_{m}$ ~0.75 $T_{m}$ were calculated to be 25.7~36.5kcal/mol, which were nearly equal to the activation energies for creep. (2) At around the temperature of 9$0^{\circ}C$~12$0^{\circ}C$ and under the stress level of 10~17.2(kgf/$\textrm{mm}^2$), and at around the temperature of 200~41$0^{\circ}C$ and under the stress level of 1.53~9.55(kgf/$\textrm{mm}^2$) and again at around the temperature of 470~50$0^{\circ}C$ and under the stress level of 0.62~l.02(kgf/$\textrm{mm}^2$), the applied stress dependence of steady state creep rate $n_{measu}$ measured were, respectively, 3.15, 6.62 and 1.1, which were in good agreement the calculated stress dependence $n_{ealeu}$ obtained by the difference of the applied stress dependence of the Internal stress and the ratio of the internal stress to the applied stress. (3) At the temperature range of 0.4~0.43 $T_{m}$ , and at the temperature range of 0.52~0.75 $T_{m}$ and again at the temperature range of 0.82~0.85 $T_{m}$ , the activation energies $Q_{measu}$ obtained by steady state creep rate, respective, 26. 16, 34.9, 36.2 and 36.1kcal/mol, which were in good agreement with those obtained with the activation energies under constant effective stress and the temperature dependence of Internal stress. (4) At the temperature range of the 0.52~0.73 $T_{m}$ and under the stress level of 1.53~9.55(kgf/$\textrm{mm}^2$), the stress dependence of rupture life(n’) measured was 6.3~6.6, which was in good agreement with the stress dependence of steady state creep rate(n). And at the same condition the activation energy for rupture( $Q_{f}$ ) measured was 32.0~36.9kca1/mol, which was also in good agreement with the activation energy obtained by steady state creep rate ( $Q_{c}$ ). (5) The rupture life( $t_{f}$ ) might be represented by athermal process attributed to the difference of the applied stress dependence of the internal stress and the ratio of the internal stress to the applied stress, and the thermal activated process attributied to the temperature dependence of the internal stress as $t_{f}$ = A'$\sigma$$_{a}$ ｛n(1-d $\sigma$$_{i}$ /d $\sigma$$_{a}$ )/(1-$\sigma$$_{i}$ / $\sigma$$_{a}$ )｝.exp[｛ $Q_{c}$ $^{*}$-( $n_{o}$ R $T^2$/ $E_{(T)}$) (d $E_{(T)}$/dT) - ( $n_{0}$ R $T^2$/ $\sigma$$_{a}$ - $\sigma$$_{i}$ ) (d $\sigma$$_{i}$ /dT)｝/RT]. (6) The relationship betwween Larson-Miller rupture parameter and logarithmic stress was linearly decreased, so creep rupture life of Al 7075 alloy seemed to be predicted exactly with Larson-Miller parameter.meter.

• Nutrition Research and Practice
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• v.18 no.1
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• pp.1-18
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• 2024

BACKGROUND/OBJECTIVES: Endoplasmic reticulum (ER) stress in adipose tissue causes an inflammatory response and leads to metabolic diseases. However, the association between vitamin D and adipose ER stress remains poorly understood. In this study, we investigated whether 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃) alleviates ER stress in adipocytes. MATERIALS/METHODS: 3T3-L1 cells were treated with different concentrations (i.e., 10-100 nM) of 1,25(OH)₂D₃ after or during differentiation (i.e., on day 0-7, 3-7, or 7). They were then incubated with thapsigargin (TG, 500 nM) for an additional 24 h to induce ER stress. Next, we measured the mRNA and protein levels of genes involved in unfold protein response (UPR) and adipogenesis using real-time polymerase chain reaction and western blotting and quantified the secreted protein levels of pro-inflammatory cytokines. Finally, the mRNA levels of UPR pathway genes were measured in adipocytes transfected with siRNA-targeting Vdr. RESULTS: Treatment with 1,25(OH)₂D₃ during various stages of adipocyte differentiation significantly inhibited ER stress induced by TG. In fully differentiated 3T3-L1 adipocytes, 1,25(OH)₂D₃ treatment suppressed mRNA levels of Ddit3, sXbp1, and Atf4 and decreased the secretion of monocyte chemoattractant protein-1, interleukin-6, and tumor necrosis factor-α. However, downregulation of the mRNA levels of Ddit3, sXbp1, and Atf4 following 1,25(OH)₂D₃ administration was not observed in Vdr-knockdown adipocytes. In addition, exposure of 3T3-L1 preadipocytes to 1,25(OH)₂D₃ inhibited transcription of Ddit3, sXbp1, Atf4, Bip, and Atf6 and reduced the p-alpha subunit of translation initiation factor 2 (eIF2α)/eIF2α and p-protein kinase RNA-like ER kinase (PERK)/PERK protein ratios. Furthermore, 1,25(OH)₂D₃ treatment before adipocyte differentiation reduced adipogenesis and the mRNA levels of adipogenic genes. CONCLUSIONS: Our data suggest that 1,25(OH)₂D₃ prevents TG-induced ER stress and inflammatory responses in mature adipocytes by downregulating UPR signaling via binding with Vdr. In addition, the inhibition of adipogenesis by vitamin D may contribute to the reduction of ER stress in adipocytes.

• Transactions of Materials Processing
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• v.20 no.5
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• pp.369-376
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• 2011

A non-quadratic anisotropic strain rate potential was introduced as a conjugate potential of the yield stress potential Yld2000-2d to describe anisotropic behavior of sheet metals, in particular, aluminum alloy sheets under plane stress state. This strain-rate potential takes into account the anisotropic yield stresses and R-values measured along the directions measured at 0, 45 and 90 degrees from the rolling direction, as well as the balanced biaxial yield stress and strain-rate ratio. The convexity of the strain-rate potential was completely proven. The strain-rate potential was applied for two anisotropic aluminum alloy sheets, AA6022-T4 and AA2090-T3. The results verified that the strain rate potential properly described the anisotropic behavior of aluminum alloy sheets and was closely conjugate of Yld2000-2d under the plane stress state.

• Journal of the Korean Applied Science and Technology
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• v.37 no.6
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• pp.1687-1697
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• 2020

This study is a comparative descriptive research that identifies the degree and difference of the brain education meditation program from participation stress(physical stress, psychological stress), depression, resilience(self-control ability, interpersonal relationship ability, and positive) for middle-aged women. The subjects were 26 middle-aged women who participated in the brain education meditation program at the D metropolitan city D center for more than a year, 29 middle-aged women did not participate in the brain education meditation program and a total of 55 middle-aged women collected for three weeks from November 4 to 22, 2019. Data analysis fesult that the participating groups in brain education meditation programs differ statistically significantly in physical stress(t=2.549, p=.014), psychological stress(t=2.352, p=.022), self-control ability(t=-2.219, p=.031) and positive(t=-2.387, p=.021), which are higher factors in resilience than non-participating groups. In other words, brain education meditation program participants scored lower physical and psychological stress scores than nonparticipating groups, with higher self-control ability and positive scores. Therefore, it is thought that brain education meditation programs can be used as nursing intervention to reduce stress and improve self-control ability and positive in middle-aged women.

• Steel and Composite Structures
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• v.17 no.2
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• pp.145-157
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• 2014

This study aimed to investigate the fatigue crack growth behavior of a kind of fiber metal laminates (FML) under four different stress levels. The FML specimen consists of three 2024-T3 aluminum alloy sheets and two layers of glass/epoxy composite lamina. Tensile-tensile cyclic fatigue tests were conducted on centrally notched specimen at four stress levels with various maximum values. A digital camera system was used to take photos of the propagating cracks on both sides of the specimens. Image processing software was adopted to accurately measure the length of the cracks on each photo. The test results show that: (1) a-N and da/dN-a curves of FML specimens can be divided into transient crack growth segment, steady state crack growth segment and accelerated crack growth segment; (2) compared to 2024-T3 aluminum alloy, the fatigue properties of FML are much better; (3) da/dN-${\Delta}K$ curves of FML specimens can be divided into fatigue crack growth rate decrease segment and fatigue crack growth rate increase segment; (3) the maximum stress level has a large influence on a-N, da/dN-a and da/dN-${\Delta}K$ curves of FML specimens; (4) the fatigue crack growth rate da/dN presents a nonlinear accelerated increasing trend to the maximum stress level; (5) the maximum stress level has an almost linear relationship with the stress intensity factor ${\Delta}K$.

• Journal of Oriental Neuropsychiatry
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• v.33 no.1
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• pp.33-48
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• 2022

Objectives: Academic stress poses a significant risk for the mental health of medical students, and a feasible group intervention program for managing academic stress is required. The purpose of this study was to examine the clinical effectiveness of emotional freedom techniques (EFT) on the mental health of Korean medical students. Methods: The class of first-year medical school students (n=36) participated in an after-school EFT group intervention program comprising six sessions (15 minutes/session, three weeks) to analyze its clinical effectiveness as a single-group test-retest clinical study. The changes in the Perceived Stress Scale (PSS), Test Anxiety Inventory (TAI), Positive and Negative Affect Schedule (PANAS), and State-Trait Anxiety Inventory (STAI) scores were examined using a paired t-test and Cohen's D at post-EFT and two-week follow-up. Results: There were significant curtailments at post-EFT and follow-up measures in TAI-Total (t=2.704 and t=3.289), TAI-Worry (t=2.297 and t=2.454), TAI-Emotionality (t=2.763 and t=3.654), PSS-Negative Perspective (t=2.659 and t=3.877), and PANAS-Negative Affect (t=2.885 and t=3.259) subscales, however not in PSS-Positive Perspective (t=-1.279 and t=-1.101) and PANAS-Positive Affect (t=0.194 and t=-0.122) subscales. The trait anxiety (t=2.227) was significantly mitigated in the post-EFT measure and the state anxiety (t=2.30) in the follow-up measure. Conclusions: The EFT group intervention alleviated test stress, negative affect, and anxiety in the Korean medical students. This study contributes to an understanding of academic stress and EFT intervention in the competitive environment of medical education.

• Structural Engineering and Mechanics
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• v.55 no.4
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• pp.857-869
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• 2015

The aluminum 7075-T6 is known as an alloy widely used in aircraft structural applications, which does not exhibit strain rate sensitivity during dynamic compressive tests. Despite mechanical importance of the material, there is not enough attention to determine appropriate sample dimensions such as a sample diameter relative to the device bar diameter and sample length to diameter (L/D) ratio for dynamic tests and how these two parameters can change mechanical behaviors of the sample under dynamic loading condition. In this study, various samples which have different diameters of 31.8, 25.4, 15.9, and 9.5 mm and sample L/D ratios of 2.0, 1.5, 1.0, 0.5, and 0.25 were tested using Split Hopkinson Pressure Bar (SHPB), as this testing device is proper to characterize mechanical behaviors of solid materials at high strain rates. The mechanical behavior of this alloy was examined under ${\sim}200-5,500s^{-1}$ dynamic strain rate. Aluminum samples of 2.0, 1.5 and 1.0 of L/D ratios were well fitted into the stress-strain curve, Madison and Green's diagram, regardless of the sample diameters. Also, the 0.5 and 0.25 L/D ratio samples having the diameter of 31.8 and 25.4 mm followed the stress-strain curve. As results, larger samples (31.8 and 25.4 mm) in diameters followed the stress-strain curve regardless of the L/D ratios, whereas the 0.5 and 0.25 L/D ratios of small diameter sample (15.9 and 9.5 mm) did not follow the stress-strain diagram but significantly deviate from the diagram. Our results indicate that the L/D ratio is important determinant in stress-strain responses under the SHPB test when the sample diameter is small relative to the test bar diameter (31.8 mm), but when sample diameter is close to the bar diameter, L/D ratio does not significantly affect the stress-strain responses. This suggests that the areal mismatch (non-contact area of the testing bar) between the sample and the bar can misrepresent mechanical behaviors of the aluminum 7075-T6 at the dynamic loading condition.

• Journal of the Korean Society of Propulsion Engineers
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• v.1 no.1
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• pp.104-110
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• 1997

To predict the effect of ring expansion and ring compression on residual stress relief of Al 7175 ring rot]s, 2-D axisymmetric thermal analysis and elastoplastic analysis were performed. The residual stress distributions along the thickness of T73, T7351 and T7352 treated rings were measured using three step sectioning method. The measured results were compared to numerical ones for quenched and stress relieved rings. After quenching, calculated hoop and axial residual stresses were similar to measured ones for T73 treated rings. The residual stresses of T7351 and T7352 treated rings were decreased remarkably compared to T73 treated rings. The effect of axial residual stress relief was superior to that of hoop one, and also ring compression to ring expansion. It was concluded that ring compression is advantageous over ring expansion in view of stress relief effect and practicality, and vice versa in view of dimensional control and press power.

• JSTS:Journal of Semiconductor Technology and Science
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• v.1 no.3
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• pp.141-157
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• 2001

Highly reliable packaged 64kbit ferroelectric memories with $0.8{\;}\mu\textrm{m}$ CMOS ensuring ten-year retention and imprint at 125^{\circ}C$ have been successfully developed. These superior reliabilities have resulted from steady integration schemes free from the degradation, due to layer stress and attacks of process impurities. The resent results of research and development for ferroelectric memories at Hynix Semiconductor Inc. are summarized in this invited paper.