This study was to investigate casual relation of psychological well-being and quality of life of married couples. For the data set 434 married couples living in Pusan, Korea were chosen. The data were analyzed using M, SD, t-test, Pearson's correlation, multiple regression, and path analysis. The findings of this study are as follows; First, marital satisfaction and the level of quality of life are higher for husbands than wives. Whereas psychological distress is higher for wives than husbands. Second, for husbands, husband's level of education, job satisfaction, husband's housework participation, and job stress have significant effect on marital satisfaction. For wives, wife's level of education, husband's housework participation, and husband's job stress have significant effect on marital satisfaction. Third, for husbands, job satisfaction and job stress have significant effect on psychological distress. For wives, husband's job stress have significant effect on psychological distress. Fourth, for husbands, job stress, marital satisfaction and psychological distress have significant direct effect on quality of life. Besides, husband's age, husband's level of education, job satisfaction, job stress, husband's housework participation, and marital satisfaction are indirectly associated with quality of life. For wives, marital satisfaction and psychological distress have significant direct effect on quality of life. Besides, wife's level of education, husband's job stress, husband's housework participation, and marital satisfaction are indirectly associated with quality of life.