• 대한약침학회지
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• 제18권4호
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• pp.12-19
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• 2015

Objectives: This study was done out to evaluate the effects of Sida rhombifolia methanol extract (SRM) on diabetes in moderately diabetic (MD) and severely diabetic (SD) Sprague-Dawley rats. Methods: SRM was prepared by soaking the powdered plant material in 70% methanol and rota evaporating the methanol from the extract. Effective hypoglycemic doses were established by performing oral glucose tolerance tests (OGTTs) in normal rats. Hourly effects of SRM on glucose were observed in the MD and the SD rats. Rats were grouped, five rats to a group, into normal control 1 (NC1), MD control 1 (MDC1), MD experimental 1 (MDE1), SD control 1 (SDC1), and SD experimental 1 (SDE1) groups. All rats in the control groups were administered 1 mL of distilled water (DW). The rats in the MDE1 and the SDE1 groups were administered SRM orally at 200 and 300 mg/kg body weight (BW), respectively, dissolved in 1 mL of DW. Blood was collected initially and at intervals of 1 hour for 6 hours to measure blood glucose. A similar experimental design was followed for the 30-day long-term trial. Finally, rats were sacrificed, and blood was collected to measure blood glucose, lipid profiles, thiobarbituric acid reactive substances (TBARS) and reduced glutathione (GSH). Results: OGTTs indicated that two doses (200 and 300 mg/kg BW) were effective hypoglycemic doses in normal rats. Both doses reduced glucose levels after 1 hour in the MDE1 and the SDE1 groups. A long-term trial of SRM in the MD group showed a reduced glucose level, a normal lipid profile, and normal GSH and TBARS levels. In SD rats, SRM had no statistically significant effects on these parameters. Normal weight was achieved in the MD rats, but the SD rats showed reduced BW. Conclusion: The study demonstrates that SRM has potential to alleviate the conditions of moderate diabetic, but not severe diabetes.

• 한국한의학연구원논문집
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• 제6권1호
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• pp.89-98
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• 2000

Cerebral ischemia, the most prevalent form of clinical stroke, is a medical problem of the first magnitude. Substantial efforts are being made to develop drugs which will protect the brain from the neurodegeneration followed by an ischemic stroke. A key factor in this process is the development of animal models that mimic the neuropathological consequences of stroke. Recently, there is increasing an evidence that free radical is involved in the mechanisms of ischemic brain damage. We investigated the macro scale gene expression analysis on the global ischemia induced by 4-vessel occlusion in Wister rats. The recent availability of microarrays provides an attractive strategy for elaborating an unbiased molecular profile of large number of genes during ischemic injury. This experimental approach offers the potential to identify molecules or cellular pathways not previously associated with ischemia. Ischemia was induced by 4-vessel occlusion for 10 minutes and reperfused again. RNA from sham control brain and time-dependent ischemed brain were hybridized to microarrays containing 4,000 rat genes. 589 genes were found to be at least 2 fold regulated at one or more time points. These survey data provide the foundation studies that should provide convincing proof for ischemia and oxidative stress on gene expression.

• 보건교육건강증진학회지
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• 제30권3호
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• pp.35-46
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• 2013

Objectives: The aim of this study was to investigate the degree of depression cognition and health promoting behaviors of smoking and non-smoking college students. Methods: The research design was a descriptive survey study, and 379 college students were selected by convenience sampling. Measurements were Fagerstrom test for Nicotine Dependence, Depressive cognition and Health Promotion Lifestyle Profile-II. Descriptive statistics, Pearson's correlation, and logistic regression were used to analyze the data. Results: 1) Smoking students showed lower scores in depressive cognitions than non-smoking students, which means that the smoker's depression was higher than the non-smokers. 2) Depressive cognition and health promoting behaviors were negatively correlated for the smokers (r=-.30, p<.01), while they were positively correlated for the non-smokers (r=.45, p<.001). 3) The variables predicting the smoker's health promoting behavior were physical activity (OR .24), health responsibility (OR .25), spiritual growth (OR 5.10), stress management (OR 4.41), extrovert personality (OR .25), and depressive cognition (OR 1.81). Conclusions: Depression and health promoting behavior should be considered in the smoking cessation programs for college students.

• 지역사회간호학회지
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• 제12권2호
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• pp.491-503
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• 2001

Purpose: The purpose of this study is to identify the health promoting lifestyle of Korean immigrants and to develop the health promotion program for Korean immigrants. Method: The subject of the study were 207 adults chosen from Korean religious organizations located in Chicago area. The instrument used in this study was Health Promoting Lifestyle Profile (HPLP) by Walker. Sechrist & Pender(l995). The data were collected between August 1 and October 20. 2000 by using self-administered questionnaire. Analysis of data was done by using descriptive statistics. Pearson correlation coefficient, t-test, ANOVA. Duncan test and stepwise multiple regression with SPSS program. Result. 1) The average score of performance in the health promoting lifestyle 2.43 scores. In the subscales, the highest degree of performance was 'spiritual growth', following 'nutrition', 'interpersonal relationship', 'stress management' and 'health responsibility' and the lowest degree of performance was 'physical activity'. 2) Health promoting lifestyle was significantly correlated with such demographic variables as age (F=2.659. p=.049), family income(F=4.696. p = .027), subjective health status(F = 3.882. p=.005), the frequency of pray(F=9.442. p = .000), the frequency of reading the bible(F=8.584. p= .000) and years of residence in the US(F=4.273. p= .015). 3) Health promoting lifestyle was significantly predicted by the frequency of pray, subjective health status. current working status, taking medication, level of education and family income. These variables explained 27.4% of variance of health promoting lifestyle. Conclusion The above findings indicate that it is necessary to develop a health promotion program facilitating exercise and enhancing health responsibility for Korean immigrants. It is suggested that the comparative study to identify the differences and similarities between Korean immigrants in the U.S.A. and Korean residents in Korea.

• 지역사회간호학회지
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• 제9권1호
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• pp.30-39
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• 1998

The purpose of this study was to identify the factors influencing health promoting lifestyle of teachers and to provide the data for efficient health management of teachers. The subjects of this study were eight hundred nine teachers, who were chosen in Choong-Buk province. Survey Questionaires for data analysis were collected through visiting or mailing from September 1 to 30, 1997. The instruments used in this study were HPLP(Health Promoting Lifestyle Profile) by Walker (1987), Internal Health Locus of Control by Walston et al. (1978), Self Esteem by Rogenberg(1965), Importance of Health by Muhlenkamp (1985), Self Efficacy by Sherer & Maddux(1982), and Family Function by Olson & Schellenberg (1985). Data were analyzed by descriptive statistics, unpaired t-test, ANOVA, Pearsons correlation coefficient and stepwise multiple regression using SPSS/PC(v. 4.01) program. The results were as follows; 1. The mean of health promoting lifestyle was total 2.53 on the average, self-actualization 2.97, nutrition 2.90, interpers 52, stress management 2.33, exercise 1.91, and health responsibility 1.82 in order. The index of total health promoting lifestyle was significantly influenced by the factors including sex, age, religion, marital status, duration of work, teaching load, education level and number of family members. 2. The health promoting Lifestyle was significantly positive correlated with Self Efficacy, Family Function, Importance of Health, Internal Health Locus of Control and Self Esteem. 3. Self Efficacy was the most influential determinant predicting health promoting lifestyle of teachers. Self efficacy, Family Function, Importance of Health, Internal Health Locus of Control and Age explained 42% of the health promoting lifestyle. Based on the above findings, it is suggested to develop nursing intervention to improve Self Efficacy, Importance of Health, Family Function of teachers enhance health promoting lifestyle. Further studies are needed to confirm these findings and to determine factors which significantly influence health promoting lifestyle of teachers.

• 전기화학회지
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• 제4권2호
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• pp.70-76
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• 2001

본 연구는 Pd박막 전극에서 수소 확산시 발생되는 응력해석에 대한 레이저 빔 디플렉션 방법의 응용에 대해 기술하였다. 우선, 탄성에 의한 확산 (고스키 효과) 및 확산에 의한 탄성 현상에 대해 간략히 설명하였고, 주어진 초기 및 경계 조건하에서 Fick 방정식의 해와 Vegard 및 Hooke의 법칙으로부터 확산에 의한 탄성 현상의 모델을 이론적으로 유도하였다. 다음으로 레이저 빔 디플렉션 방법이 수소 확산으로 인해 발생되는 응력해석에 어떻게 사용될 수 있는지 실험 장치 및 시편에 대해 소개하였다 마지막으로, 수학적으로 계산된 디플렉션 시간 추이 곡선과 실험적으로 얻어진 곡선의 비교로부터, 시간에 따른 인장 디플렉션의 변화를 시간에 따른 전극 내부의 수소 농도 구배의 변화 및 수소 확산계수의 차이로 설명하였다.

• Molecular & Cellular Toxicology
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• 제1권2호
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• pp.73-77
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• 2005

Nickel is the one of potent environmental, the occupational pollutants and the classified human carcinogens. It is a serious hazard to human health, when the metal exposure. To prevent human diseases from the heavy metals, it is seemingly important that understanding of how nickel exerts their toxicity and carcinogenic effect at a molecular and a genomic level. The process of nickel absorption has been demonstrated as phagocytosis, iron channel and diffusion. Uptaked nickel has been suggested to induce carcinogenesis via two pathways, a direct DNA damaging pathway and an indirect DNA damaging pathway. The former was originated from the ability of metal to generate Reactive Oxygen Species (ROS) and the reactive intermediates to interact with DNA directly. Ni-generated ROS or Nickel itself, interacts with DNAs and histones to cause DNA damage and chromosomal abnormality. The latter was originated from an indirect DNA damage via inhibition of DNA repair, or condensation and methylation of DNA. Cells have ability to protect from the genotoxic stresses by changing gene expression. Microarray analysis of the cells treated with nickel or nickel compounds, show the specific altered gene expression profile. For example, HIF-I (Hypoxia-Inducible Factor I) and p53 were well known as transcription factors, which are upregulated in response to stress and activated by both soluble and insoluble nickel compounds. The induction of these important transcription factors exert potent selective pressure and leading to cell transformation. Genes of metallothionein and family of heat shock proteins which have been known to play role in protection and damage control, were also induced by nickel treatment. These gene expressions may give us a clue to understand of the carcinogenesis mechanism of nickel. Further discussions on molecular and genomic, are need in order to understand the specific mechanism of nickel toxicity and carcinogenicity.

• The Plant Pathology Journal
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• 제25권2호
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• pp.193-198
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• 2009

A full-length cDNA of OgGRP gene encoding a glycinerich cell wall protein was isolated from wild rice (Oryza grandiglumis). Deduced amino acid sequences of OgGRP are composed of 148 amino acids (16.3 kDa), and show 85.9% homology with Osgrp-2 (Oryza sativa). RT-PCR analysis showed that RNA expression of OgGRP was regulated by defense-related signaling chemicals, such as cantharidin, endothall, jasmonic acid, wounding, or yeast extract treatment. In relation to pathogen stress, the function of OgGRP was analyzed in OgGRP over-expressing Arabidopsis thaliana. Overexpression of OgGRP in Arabidopsis contributed to moderate resistance against fungal pathogen, Botrytis cinerea, by lowering disease rate and necrosis size. In the analysis of the transgenic Arabidopsis lines to check the change of gene expression profile, induction of PR1, PR5 and PDF1.2 was confirmed. The induction seemed to be caused by the interaction of ectopic expression of OgGRP with SA-and JA-dependent signaling pathways.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1241-1245
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• 2012

Aim: In this study we aimed to investigate the healthy life-style behaviour of Turkish women and establish influencing features. Methods: This descriptive study performed by a questionnaire method was conducted in a primary health care centre, in an urban region in Kayseri, Turkey. Every midwife region belonging to the health care centre was accepted as a cluster, and a sample of 450 women between ages 18-64, was gathered from 9 midwife regions. The Health Promotion Life-style Profile (HPLP) was applied to evaluated the healthy lifestyle behaviour of 421 women that could be reached. T test, Tukey HSD with ANOVA, and chi square tests were used for analysis. Results: The mean total HPLP was $126.8{\pm}19.2$ (interpersonal support subscale, $74.3{\pm}14.1$; nutrition subscale, $73.6{\pm}12.6$; self-actualisation subscale, $70.6{\pm}11.9$; stress management subscale, $63.4{\pm}13.0$; health responsibility subscale, $61.2{\pm}13.2$; and exercise subscale, $47.1{\pm}15.0$). There was no statistically significant variation when evaluated for age, marital state, family type, economic status, and perception of self-health, smoking, and BMI. HPLP was high in people with an education of primary school and lower in university graduates, in people who lived mostly in the city centre and in individuals with chronic diseases. In conclusion, it was established that the health promoting behaviour in Turkish women is, in general, at a medium level, and women should be enlightened in order to develop and increase the habit of health preservation and promotion.

• 터널과지하공간
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• 제17권5호
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• pp.372-380
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• 2007

침하로 인한 지표 손상대는 지하 채굴로 인해 발생되는 결과로서, 오랜 기간 동안 서서히 또는 급작스럽게 발생할 수 있다. 이러한 지표 손상대는 싱크홀 혹은 트러프형 침하에서 대규모 슬라딩에 이르기까지 다양한 형태로 관찰된다. 침하 발행 위험에 대한 평가는 광산 침하의 영향을 받는 지역에 있어서는 매우 중요하다. 이러한 위험도 평가나 침하 예측을 위해 경험적 모델, 프로파일함수, 영향 함수 그리고 수치해석과 같은 다양한 방법들이 적용되어 왔다. 본 연구에서는 다양한 인자들 중 지배적으로 침하 현상을 유발할 수 있는 채굴적과 관련한 정보, 즉 채굴적의 위치 및 규모의 정보를 확산이론과 연계한 비교적 간단한 침하 위험도 평가 기법을 제안하였다. 확산 모델은 지반 침하 기구를 설명할 수 있는 입자 모델과 상사관계를 가진다. 확산 모델을 폐금속광 및 폐석탄광 지역의 침하 위험도 작성에 적용하였다. 침하 위험도 평가를 위한 확산 모델은 매우 간단하지만 효율적인 방법임을 확인할 수 있었다.