• Title/Summary/Keyword: Stress Function

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Korean red ginseng extract alleviates advanced glycation end product-mediated renal injury

  • Quan, Hai Yan;Kim, Do Yeon;Chung, Sung Hyun
    • Journal of Ginseng Research
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    • 제37권2호
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    • pp.187-193
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    • 2013
  • The effect of Korean red ginseng (KRG) on diabetic renal damage was investigated using streptozotocin (STZ)-induced diabetic rats. The diabetic rats showed loss of body weight gain, and increases in kidney weight and urine volume, whereas the oral administration of KRG at a dose of 100 or 250 mg/kg of body weight per day for 28 d prevented these diabetes-induced physiological abnormalities. Among the kidney function parameters, elevated plasma levels of urea nitrogen and creatinine in diabetic control rats tended to be lowered in KRG-treated rats. In addition, administration of KRG at a dose of 100 mg/kg body weight in the diabetic rats showed significant decreases in serum glucose and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), implying that KRG might prevent the pathogenesis of diabetic complications caused by impaired glucose metabolism and oxidative stress. KRG also significantly reduced advanced glycation end product (AGE) formation and secretion from kidney of diabetic rats. Furthermore, KRG decreased the levels of N-(carboxymethyl) lysine and expression of AGE receptor. KRG also reduced the overexpression of cyclooxygenase-2 and inducible nitric oxide synthase in the kidney via deactivation of nuclear factor-kappa B. We also found that KRG prevented STZ-induced destruction of glomerular structure and significantly suppressed high glucose-induced fibronectin production. Taken together, KRG ameliorates abnormalities associated with diabetic nephropathy through suppression of inflammatory pathways activated by TNF-${\alpha}$ and AGEs. These findings indicate that KRG has a beneficial effect on pathological conditions associated with diabetic nephropathy.

Protective effect of ultrasonication-processed ginseng berry extract on the D-galactosamine/lipopolysaccharide-induced liver injury model in rats

  • Nam, Yoonjin;Bae, Jinhyung;Jeong, Ji Hoon;Ko, Sung Kwon;Sohn, Uy Dong
    • Journal of Ginseng Research
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    • 제42권4호
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    • pp.540-548
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    • 2018
  • Background: Acute hepatic failure is a life-threatening critical condition associated with rapid deterioration of liver function and liver transplantation. Several studies have shown that Panax ginseng Mayer has antidiabetic and hepatoprotective effects. However, the hepatoprotective effect of ginseng berry is still unveiled. In this study, we evaluated the hepatoprotective effects of ultrasonication-processed ginseng berry extract (UGBE) on acute hepatic failure model in rats. Methods: Ginseng berry extract (GBE) was ultrasonically processed. The GBE, silymarin, and UGBE were orally administered to male Sprague-Dawley rats for 4 wk. Twenty-four h after the last administration, rats were challenged with D-galactosamine (D-GalN)/lipopolysaccharide (LPS). Results: After ultrasonication, the component ratio of ginsenosides Rg2, Rg3, Rh1, Rh4, Rk1, Rk3, and F4 in GBE had been elevated. Administration of UGBE significantly increased the survival rate of D-GalN/LPS-challenged rats. Pretreatment with UGBE significantly decreased serum alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels in D-GalN/LPS-challenged rats in a dose-dependent manner. The levels of enzymatic markers for oxidative stress (superoxide dismutase, glutathione peroxidase, catalase, and glutathione) were increased by UGBE treatment in a dose-dependent manner. Tumor necrosis factor alphalevel, inducible nitric oxide synthase activities, and nitric oxide productions were reduced by UGBE treatment. In addition, hemeoxygenase-1 levels in liver were also significantly increased in the UGBE-treated group. The protein expression of toll-like receptor 4 was decreased by UGBE administration. Hematoxylin and eosin staining results also supported the results of this study showing normal appearance of liver histopathology in the UGBE-treated group. Conclusion: UGBE showed a great hepatoprotective effect on D-GalN/LPS-challenged rats via the toll-like receptor 4 signaling pathway.

우리나라 간호계 석 . 박사학위 논문분석 -실험연구를 중심으로- (Analysis of Experimental Studies on Master s and Doctoral Theses in Nursing)

  • 김명자;이명선;이미형;이화인
    • 대한간호학회지
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    • 제24권1호
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    • pp.96-114
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    • 1994
  • This study was carried out to describe and analyze experimental studies conducted in graduates nursing degree. Of 170 experimental studies conducted during the past three decades between 1962 and August 1991, 150 studies were available, including 124 master’s and 26 doctoral theses. This study examined their general characteristics and detailed research methods using percentiles. The results were as follows 1. Most of the studies adopted a quasi-experimental design. 2. The subjects of the studies were chosen by convenience sampling except for two studies whose subjects were drawn by randomization. Studies comparing experimental and control groups were in the highest proportion and the most frequent sample sizes of each group were 21 to 30 for both experimental and control groups. 3. As to measurement, physiological measures were most frequent followed by psychsociological measures and active report questionnaires. Each study, on average, adopted two kind of measurement tools. Studies in which the data collection period was of 1~2 months were in the highest pro-portion. 4. All doctoral theses and 67.0% of master’s theses examined specific research hypotheses. Of these studies, the results of 92.5% supported the hypotheses. 5. Parametric statistics were the major analytical methods. In particular, t-test was used most frequently followed by Chi square, F-test, and Pearson Correlation Coefficients. 6. Patients were the most frequent study subjects. Frequent nursing interventions were information and education followed by support, distraction, and nursing treatments. 7. With regards to the dependent variables, “feelings” such as anxiety, pain, and depression were most frequent. In addition “exchanging” such as restoring, metabolism, cardiopulmonary function, infection and vital signs were adopted as the dependent variables in 29.1% of the studies examined, while 12.3% of the studies selected “choosing” such as stress, health behavior, or role performance.

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임플란트 피개의치를 위한 Locator 어태치먼트: 문헌 고찰 (A Literature Review on Locator Attachment for Implant Overdenture)

  • 차민상;김대곤;박찬진;조리라
    • 구강회복응용과학지
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    • 제29권2호
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    • pp.127-140
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    • 2013
  • Locator 어태치먼트는 임플란트 유지형 피개의치에 널리 사용하는 어태치먼트로 단일 임플란트에 연결하여 사용하는 개별유지장치이다. Locator 어태치먼트는 수직적으로 적은 공간을 필요로 하며, 유지력과 경사에 따른 나일론 선택이 가능한 특징을 가진다. 이 문헌고찰에서는 Locator 어태치먼트를 사용했을 때 초기유지력, 기능력을 재현한 상태의 유지력 변화에 관해 고찰하였다. 또한 회전자유도와 응력분포에 대해 연구한 문헌을 살펴보았으며 Locator에 관한 보철적 합병증과 유지관리를 연구한 다양한 문헌을 정리함으로써 Locator 어태치먼트의 한계와 장점에 관해 살펴볼 것이다.

PET 및 PVA섬유를 사용한 변형경화형 시멘트 복합체의 직접인장거동에서 섬유 형상비의 영향 (Effect of Aspect Ratio on Direct Tensile Response of Strain Hardening Cement Composites with PET and PVA Fiber)

  • 전에스더;윤현도;박완신;김용철;김윤수
    • 한국콘크리트학회:학술대회논문집
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    • 한국콘크리트학회 2008년도 춘계 학술발표회 제20권1호
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    • pp.913-916
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    • 2008
  • 변형경화형 시멘트 복합체(SHCC)의 직접인장거동은 주로 물시멘트비, 섬유와 매트릭스 간의 상호작용, 부착강도, 섬유 혼입율 등에 의해 영향을 받는다. 본 논문은 PET 및 PVA섬유를 사용한 SHCC의 직접인장거동에서 섬유의 형상비의 영향을 평가하기 위해 PET섬유의 형상비(Aspect ratio, ${\ell}/d_f$ : 150, 300, 600)를 변수로 선정하였다. 동일한 배합조건에서 PET1.5+PVA0.5-300 및 PET1.5+PVA0.5-600시험체는 PET1.5+PVA0.5-150에 비해 우수한 유사변형경화특성과 미세균열분산 특성을 보였으며, PET1.5+PVA0.5-300 및 PET1.5+PVA0.5-600 시험체는 최대인장응력시 각각 0.5, 2.0%의 변형율을 나타내었다.

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신장이식 환자의 치료지시 이행정도와 교육 요구도에 관한 연구 (A study on the Compliance and Educational Demand of Renal Transplantation Patient)

  • 류정하;김명희;강인순
    • 재활간호학회지
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    • 제6권2호
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    • pp.226-238
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    • 2003
  • This study was started for the purpose of providing the basic data for continous managment of kidney transplantation patients after discharge. This study was conducted on 180 patients who received renal transplants at three hospital( B, M, P) pusan, korea. The data collection was done for june 1, to August 31, 2002. General characteristics, renal transplantaton characteristics, physical characteristics, the level of compliance and the degree of educational demand were done by the number and percentage, the mean, standard deviation. The level of compliance and educational demand followed by the characteristics of general and kidney transplantation were analyzed by t-test and ANOVA. The result were as fallows; 1. Man was higher than woman such as 60.0%, Mean age was 42.5 years old, Average total duration of after operation was 5.5 years. 2. Cases of systolic blood pressure over 140mmHg were 10.0%, cases of diastolic blood pressure over 90mmHg were 22.8% and obesity factor in BMI was 15.6%. The person who daily water intake amount is 5000cc was 0.6%, the case that daily urine output is below 1000cc was 8.9%, and the case that urine output is zero was 0.6%. 3. The mean score of compliance was 77.47 point, The score in medication part was highest such as 4.67 point, that in stress situation was lowest such as 3.50 point. 4. The average score of educational demand was 154.02 point, and physical state part was 4.36 points highest, activation part was 3.48 points lowest. As a role of nurse Confirmation of compliance is very important encourage to make good through regular hospital visitation, point out the noncompliance part and then increase compliance of renal transplantation patient As well there will be maintain the normal kidney function to satisfy educational demand through continous education.

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뜀-좌굴을 고려한 공간 트러스의 최적구조설계에 관한 연구 (Optimum Structural Design of Space truss with consideration in Snap-through buckling)

  • 손수덕;이승재;최재현
    • 한국공간구조학회논문집
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    • 제12권2호
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    • pp.89-98
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    • 2012
  • 본 연구는 공간 트러스의 전체 좌굴을 고려한 최적 구조설계에 대해 연구를 하였으며, 구조물의 최소중량을 구하는 것이 목적이다. 응력제약에 의한 부재 최적화를 위해서 수리 계획법이 사용되었으며, 뜀-좌굴을 고려하기 위해 동적 계획법을 적용하였다. 트러스 부재의 최적설계를 위한 수리 모형은 전체중량 목적함수와 인장 또는 압축 허용응력 및 세장비 제약식으로 구성하였다. 평형경로상의 임계점 즉 좌굴하중을 구하기 위해서 접선 강성행렬의 행렬식 변화를 조사하였으며, 설계하중에 대한 좌굴하중 비율이 동적계획법의 반복계산과정에서 공간 트러스의 강성을 조절하기위해 반영되었다. 제안된 최적설계 프로세서의 검증을 위해서 스타 돔 구조물 예제를 통해 조사하였으며, 수치 결과는 잘 수렴하고 모든 제약을 만족하였다. 제시된 최적설계 프로세스는 전체좌굴을 고려한 최적설계를 수행하기 위한 비교적 간단 방법이고, 실무 구조설계를 반영하는데 가능하다.

골유착 치과 임플란트를 이용한 상악 무치악부 치료의 예후에 관한 임상적 평가 (CLINICAL EVALUATION OF PROGNOSIS OF OSSEOINTEGRATED DENTAL IMPLANT IN TREATMENT OF MAXILLARY EDENTULOUS AREA)

  • 심원보;이동근;최규환
    • Maxillofacial Plastic and Reconstructive Surgery
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    • 제21권2호
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    • pp.189-197
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    • 1999
  • The use of osseointegrated implant has been reported that is an acceptable procedure for the restoration of totally or partially edentulous patient and that offers good predictability of long term success. It is difficult to get high success rate in edentulous maxillae with inadequate bony quality and quantity, and anatomic limitations such as pneumatic maxillary sinus and nasal floor. The various trials such as sinus lifting, bone grafting, guided bone regeneration, trabecular condensation with osteotome, and the use of wide-diameter implant have been introduced to solve these problems. This study was undertaken to assess the evaluation of clinical prognosis of the implant restorations with these various implantation techniques in the maxillary edentulous area. One hundred eight patients were treated with a total of 386 endosseous implants from March 1994 to January 1998 at Dept. of Dentistry, Korea Veterans Hospital in Seoul Korea. The various techniques for implantation in the edentulous maxillae were supplied to overcome the limitations of implant fixation. These techniques consist of sinus lifting, guided bone regeneration, onlay bone grafting, and osteotome trabecular condensation technique. The total success rate of implant restoration of this study was 93% in the maxillae. The success rate of implant restorations with conventional technique was 94.6%, with osteotome trabecular condensation technique was 94.1%, with guided bone regeneration technique was 93.3%, with bone grafting technique was 92.9%, with sinus lifting technique was 83.8%. The success rate on the maxillary anterior area was 95.2% and that on the posterior area was 91.9%. The failures were associated not only with surgical installation techniques but also bony quality and quantity, characteristics of implant, and stress distribution when in function.

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간호직을 선택한 자녀를 둔 간호사 어머니의 경험 (Intergeneration Occupational Mobility Experience of Nurses: Focus on Mother's Experience)

  • 김주현;남은숙;길명숙;윤성자;손은진;박은영
    • 한국간호교육학회지
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    • 제20권4호
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    • pp.523-533
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    • 2014
  • Purpose: The purpose of this study is to analyze how the experiences of nurses influence their role model function when they are mothers of children who in turn have become nurses or nursing students. Method: The subjects of this study were 12 nurses, 8 of their children who became nurses and another 4 children then in training to become one. Data were collected through in-depth personal interviews and subsequently analyzed through a phenomenological approach. Results: Four main themes were identified as follows; 'Persuasion and dissuasion,' 'Proud but still pathetic,' 'As mom and senior nurse' and 'Great to pass it down.' Conclusion: The results of this study show that the nurse as mother could be a positive professional role model for her children. However, they tended to stress the arduous clinical routines and poor work conditions nurses currently experience. Should such routines and conditions improve, mothers who are nurses would be more willing to recommend the nursing profession to their children. Improving the professional environment is thus important because intergeneration nursing mobility provides a reliable resource to recruit qualified and dedicated nursing personnel.

Oxidative Damage of DNA Induced by Ferritin and Hydrogen Peroxide

  • Kang, Jung-Hoon
    • Bulletin of the Korean Chemical Society
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    • 제31권10호
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    • pp.2873-2876
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    • 2010
  • Excess free iron generates oxidative stress that may contribute to the pathogenesis of various causes of neurodegenerative diseases. Previous studies have shown that one of the primary causes of increased brain iron may be the release of excess iron from intracellular iron storage molecules. In this study, we attempted to characterize the oxidative damage of DNA induced by the reaction of ferritin with $H_2O_2$. When DNA was incubated with ferritin and $H_2O_2$, DNA strand breakage increased in a time-dependent manner. Hydroxyl radical scavengers strongly inhibited the ferritin/$H_2O_2$ system-induced DNA cleavage. We investigated the generation of hydroxyl radical in the reaction of ferritin with $H_2O_2$ using a chromogen, 2,2'-azinobis-(2-ethylbenzthiazoline-6-sulfonate) (ABTS), which reacted with ${\cdot}OH$ to form $ABTS^{+\cdot}$. The initial rate of $ABTS^{+\cdot}$ formation increased as a function of incubation time. These results suggest that DNA strand breakage is mediated in the reaction of ferritin with $H_2O_2$ via the generation of hydroxyl radicals. The iron-specific chelator, deferoxamine, also inhibited DNA cleavage. Spectrophotometric study using a color reagent showed that the release of iron from $H_2O_2$-treated ferritin increased in a time-dependent manner. Ferritin enhanced mutation of the lacZ' gene in the presence of $H_2O_2$ when measured as a loss of $\alpha$-complementation. These results indicate that ferritin/$H_2O_2$ system-mediated DNA cleavage and mutation may be attributable to hydroxyl radical generation via a Fenton-like reaction of free iron ions released from oxidatively damaged ferritin.