• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.25 no.2
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• pp.54-65
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• 2021

In this study, a two-dimensional thermoelastic problem under hyperbolic heat conduction theory with an internal heat source is considered. The general solution for the temperature field, stress components and displacement field are obtained using the reduced differential transform method. The stress and displacement components are obtained using the thermal stress function in the reduced differential transform domain. All the solutions are obtained in the form of power series. The special case with a time-dependent laser heat source has been considered. The problem is considered for homogeneous material with finite rectangular cross-section heated with a non-Gaussian temporal profile. The effect of the heat source on all the characteristics of a material is discussed numerically and graphically for magnesium material taking a pulse duration of 0.2 ps. This study provides a powerful tool for finding the solution to the thermoelastic problem with less computational work as compared to other methods. The result obtained in the study may be useful for the investigation of thermal characteristics in engineering and industrial applications.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.30 no.4
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• pp.1-9
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• 2002

There is the high possibility of crack initiation from mechanical joints, which are widely used in aircraft fuselages, due to the development of stress concentration and contact pressure. In this paper, the mixed-mode stress intensity factors at the surface and deepest points of an inclined quarter elliptical corner crack in mechanical joints are analyzed by the weight function method. The coefficients included in the weight function are obtained by finite element analyses for reference loadings. Critical angle at which mode I stress intensity factor becomes maximum is determined by analyzing the variation of stress intensity factors along incline angle of crack and the effects of the amount of clearance and crack depth on the critical angle are investigated.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.32 no.8
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• pp.91-100
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• 2004

A Green's function approach is adopted for analyzing the thermoelastic deformations and stresses of a plate made of functionally graded materials(FGMs). The solution to the 3-dimensional unsteady temperature is obtained by using the laminate theory. The fundamental equations for thermoelastic problems are derived in terms of out-plane deformation and in-plane force, separately. The thermoelastic deformation and the stress distributions due to the bending and in-plane forces are analyzed by using a Green's function based on the Galerkin method. The eigenfunctions of the Galerkin Green's function for the thermoelastic deformation and the stress distributions are approximated in terms of a series of admissible functions that satisfy the homogeneous boundary conditions of the rectangular plate. Numerical analysis for a simply supported plate is carried out and effects of material properties on unsteady thermoclastic behaviors are discussed.

• The Journal of Internal Korean Medicine
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• v.32 no.1
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• pp.43-55
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• 2011

Objectives : Sokmyeung-tang(SMT) has been used for treatment of CVA in traditional oriental medicine, so this study was designed to evaluate the effect of SMT's protection on brain cell damage against the oxidative stress that was affected by CVA, We also investigated the effect of motor function improvement and neurotrophic factor in ischemic cerebral damaged rats. Methods : We measured cell viability after administrating SMT, chemicals(Paraquat, SNP, rotenone, and $H_2O_2$) which cause oxidative stress, and both SMT and chemicals. We carried out neurobehavioral evaluation(Rotarod test, Beam-walking test, postural reflex test) and observed BDNF (brain-derived neurotrophic factor) expression by injecting SMT into ischemic cerebral damaged rat. Results : Through this study, we observed the following three results. First, brain cell death caused by paraquat, rotenone, and $H_2O_2$ significantly decreased with the treatment of SMT. Second, neuronal movement function in ischemic cerebral damaged rats was significantly improved by the treatment of SMT. Third, BDNF in ischemic cerebral damaged rats increased with the treatment of SMT. Conclusions : SMT protects brain cells from damage induced by oxidative stress (Paraquat, rotenone, $H_2O_2$). SMT also improves neuronal movement function and increases BDNF in ischemic cerebral damaged rats.

• Korean Journal of Microbiology
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• v.45 no.1
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• pp.10-16
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• 2009

A diverse range of stresses such as heat, cold, salt, ethanol, oxygen starvation or nutrient starvation induces same stress-responsive proteins. This general stress response enhances bacterial survival significantly. In Bacillus subtilis and closely related Gram-positive bacteria Listeria monocytogenes, the general stress response is controlled by the alternative transcription factor ${\sigma}^B$. The activity of ${\sigma}^B$ is regulated post-translationally by a signal transduction network that has been extensively studied in B. subtilis, and serve as a model for L. monocytogenes. The proposed model of L. monocytogenes signal transduction network is similar to that of B. subtilis, but the energy stress pathway is missing. More than 150 general stress proteins belong to ${\sigma}^B$ regulon of B. subtilis and L. monocytogenes. In both bacteria, ${\sigma}^B$ function is primarily important for resistance to diverse stresses. In addition, ${\sigma}^B$ function contributes to the control of important virulence genes in food-borne pathogen L. monocytogenes. Therefore, understanding of the general stress response is important not only for bacterial physiology, but also for pathogenicity.

• Journal of Biomedical Engineering Research
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• v.19 no.5
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• pp.495-502
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• 1998

A mathematical model of viscoelasticity on the material property of human pharyngeal tissue utilizing Y.C. Fung's Quasi-linear viscoelastic theory is proposed based on cyclic load, stress relaxation, incremental load, and uniaxial tensile load tests. The material properties are characterized and compared with other biological materials' results. The mathematical model is proposed by combining two characteristic functions determined from the stress relaxation and uniaxial tensile load tests. The reduced stress relaxation function G(t) and elastic response function S(t) are obtained from stress relaxation test and uniaxial tensile load test results respectively. Then the model describing stress-time history of the tissue is implemented utilizing two functions. The proposed model is evaluated and validated by comparing the model's cyclic behaviour with experimental results. The model data could be utilized as an important information for constructing 3-dimensional biomechanical model of human pharynx using FEM(Finite Element Method).

• Molecules and Cells
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• v.46 no.4
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• pp.191-199
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• 2023

The Golgi apparatus modifies and transports secretory and membrane proteins. In some instances, the production of secretory and membrane proteins exceeds the capacity of the Golgi apparatus, including vesicle trafficking and the post-translational modification of macromolecules. These proteins are not modified or delivered appropriately due to the insufficiency in the Golgi function. These conditions disturb Golgi homeostasis and induce a cellular condition known as Golgi stress, causing cells to activate the 'Golgi stress response,' which is a homeostatic process to increase the capacity of the Golgi based on cellular requirements. Since the Golgi functions are diverse, several response pathways involving TFE3, HSP47, CREB3, proteoglycan, mucin, MAPK/ETS, and PERK regulate the capacity of each Golgi function separately. Understanding the Golgi stress response is crucial for revealing the mechanisms underlying Golgi dynamics and its effect on human health because many signaling molecules are related to diseases, ranging from viral infections to fatal neurodegenerative diseases. Therefore, it is valuable to summarize and investigate the mechanisms underlying Golgi stress response in disease pathogenesis, as they may contribute to developing novel therapeutic strategies. In this review, we investigate the perturbations and stress signaling of the Golgi, as well as the therapeutic potentials of new strategies for treating Golgi stress-associated diseases.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.22 no.3
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• pp.680-683
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• 1998

In case of the infinite body containing a rigid inclusion with line crack shape, stress intensity factor is determined and the relation between stress intensity factor and stress distribution near a crack tip is developed. Also, the relation between stress intensity factor and Kolosoff stress function is developed. Finally, these results are compared with those that the crack surface is under no traction.

• Journal of Korean Society for Quality Management
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• v.32 no.4
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• pp.208-219
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• 2004

This paper considers a nonparametric estimation of lifetime distribution for ramp stress tests with stress bound under intermittent inspection. The test items are inspected only at specified time points an⊂1 so the collected observations are grouped data. Under the cumulative exposure model, two nonparametric estimation methods of estimating the lifetime distribution at use condition stress are proposed for the situation which the time transformation function relating stress to lifetime is a type of the inverse power law. Each of items is initially put on test under ramp stress and then survivors are put on test under constant stress, where all failures in the Inspection interval are assumed to occur at the midi)oint or the endpoint of that interval. Two proposed estimators of quantile from grouped data consisting of the number of items failed in each inspection interval are numerically compared with the maximum likelihood estimator(MLE) based on Weibull distribution.

• Journal of Welding and Joining
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• v.16 no.5
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• pp.67-75
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• 1998

This study aimed at he experimental and finite element analytic investigation of the effect of preheating on he residual stress of weldment. In this study, an autogenous arc welding was used on type 304 stainless steel and MARC as F.E.M. common code was utilized in analysis The analyses include transient and moving heat source and thermal properties as function of temperature. During welding, the thermal cycles of four locations in the weldment were recorded to investigate of the behavior of thermal stress and residual stress. The experimental and analytic results had good coincidence and show that there are two factors influencing the formation of welding residual stress in preheat process. One is the elevation of welding equilibrium temperature and the other is the increase of amount of heat input. The former decrease welding residual stress and the latter increase welding residual stress. Therefore, the cumulative effects result in the welding residual stress not being improved significantly with preheating in 304 stainless steel.