• Journal of the Korean Society for Precision Engineering
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• v.21 no.8
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• pp.97-105
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• 2004

The vertical roller mill is the important machine grinding and mixing various crude materials in the manufacturing process of portland cement. Table liner is one of grinding elements of vertical roller mill and is subjected to the cyclic bending stress by rollers and the centrifugal force by rotation of table. It demands $4{\times}10^7$ expense of life but has $4{\times}10^6~-8{\times}10^6$ cycle. It fractures at the edge of grinding path of outside roller The repair expense fur it amounts to 30% of total maintenance of vertical roller mill. Therefore, this study shows the fracture mechanism of table liner of vertical roller mill using HDM and fatigue analysis

• Steel and Composite Structures
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• v.19 no.3
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• pp.585-599
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• 2015

This paper presents the experimental work on fatigue life and specific fatigue strength of circular hollow sectioned steel tube and wood filled circular hollow section steel tube. Burning effect was observed in the case of circular hollow sectioned steel tube when it is subjected to Maximum bending moment of 19613.30 N-mm at 4200 rpm, but this did not happen in the case of wood filled hollow section. Statistical analysis was done based on the experimental data and relations have been built to predict the number of cycles for the applied stress or vice versa. The relations built in this paper can safely be applied for design of the fatigue life or fatigue strength of circular hollow sections and wood filled hollow sections. Results were validated by static specific bending strengths determined by ANSYS using a known applied load.

• Journal of Ocean Engineering and Technology
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• v.15 no.2
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• pp.94-98
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• 2001

fatigue life and nondestructive evaluation were examined experimentally using surface crack specimen and compact tension specimen of 5083 aluminium alloy. Acoustic emission signals emanated during failure of aluminum alloys has been the subject of numerous investigations. Possible sources of AE during deformation have been suggested as the dislocations, fracture of brittle particles and debonding of these particles from the alloy matrix. Fatigue life and penetration behavior of long surface crack can be evaluated quantitatively using K values proposed by authors. The influence of stress ratio on the frequency characteristics of AE signals were investigated.

• Proceedings of the KSR Conference
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• 2003.10c
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• pp.606-610
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• 2003

The 200 class insulation system which adopted to traction motor have excellent dielectric strength but weaken to thermal stress therefore deterioration phenomena analysis according to thermal stress is necessary. Accelerated thermal aging tests have been used to determine thermal reliability of stator coils used as traction motor in electric multiple unit. The conventional aging test is carried on according to IEC 60034-18-31 and IEEE Std. 275-1992. Variation in insulation resistance, P.I, capacitance, dielectric loss($tan{\delta}$) and partial discharge are measured during the aging cycle. Sample coils for traction motor were tested by accelerated aging test which composed of heat, vibration and moisture. Reliability and expected life were evaluated on the insulation system for traction motor.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.6 no.2
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• pp.85-91
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• 1986

Fatigue life is an important consideration for the design of offshore structures in deep sea and in hostile environments. In this paper, the effect of the bandwidth of random stresses on the fatigue life estimation of fixed offshore structures is investigated. The dynamic analysis is carried out in the frequency domain by using the equivalent linearization technique. Fatigue damages are calculated by two stress cycle counting methods; i.e., the narrow band method and the wide band method using rainflow counting technique. Example studies are carried out for two different structures. Numerical results indicate that the wide band approach, which is more complex but theoretically more appropriate pridicts smaller values of fatigue damages compared with those by the narrow band approach for all seastate conditions. Such trend becomes more apparent for the cases of severe seastates where the bandwidth of random stresses becomes large.

• Transactions of the Korean Society of Mechanical Engineers
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• v.13 no.2
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• pp.307-315
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• 1989

In recent years, the fatigue design method by analysis for the mechanical components and the welded structures has much increased, instead of the fatigue design method by rule that has been widely used from the past days. When a fatigue design is conducted by that method, the basic informations, fatigue life curves are mainly obtained from the results of the strain controlled low cycle fatigue test. From these point of views, the low cycle fatigue test is coming to be given a much importance lately. In this paper, the strain controlled low cycle fatigue properties at room temperature in air environment were investigated for the low carbon forged steel, SF45A, and the rolled steel for the welded structure, SM 41B. Throughout the test, strain ratio, R, was maintained constant with the fully reversed condition, -1. As the experimental results, the cyclic stress-strain behaviours of the test materials were different each other, but the low cycle fatigue life-time of them appeared to show little difference in the region of this test conditions.

• Journal of Power System Engineering
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• v.13 no.6
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• pp.95-101
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• 2009

The generator for gas turbine power generation consists of the rotor which generates magnetic field, the winding coil which is the path for the field current and the wedge and retaining ring which prevents the radial movement of the coil. Relatively severe deformation was observed at the coil end section during the inspection of the generator for peaking-load operation, and the thermal-electricity and the centrifugal force were evaluated by the simple modeling of the windings to find the cause. But the simulation stress was not sufficient to induce the coil plastic deformation. The analysis result seems to be applicable to the base-load generators which runs continuously without shut down up to a year, but there had been more deformation than simulated for the generator which is started up and shut down frequently. The cause of the coil deformation was the restriction of the expansion and shrinkage. The restriction occurs when the winding coil shrinks, and the stress overwhelms the yield stress and cause the plastic deformation. The deformation is accumulated during the start-ups and shut-downs and the thermal growth occurs. The factors which induce the coil restriction during the expansion and shrinkage should be reduced to prevent the unallowable deformation. The resolutions are cutting off the field current earlier during the generator shut-down, modifying the coil end section to remove the stress concentration and making the insulation plate inserted between the coil end section and the retaining ring have the constant thickness.

• Biomedical Science Letters
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• v.15 no.3
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• pp.261-263
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• 2009

Methylprednisolone is a synthetic glucocorticoid which is usually taken intravenously for many neurosurgical diseases which cause edema including brain tumor, and trauma including spinal cord injury. Methylprednisolone reduces swelling and decreases the body's immune response. It is also used to treat many immune and allergic disorders, such as arthritis, lupus, psoriasis, asthma, ulcerative colitis, and Crohn's disease. To identify genes expressed during methylprednisolone treatment against neurons of rats (PC12 cells), DNA microarray method was used. We have isolated 2 gene groups (up- or down-regulated genes) which are methylprednisolone differentially expressed in neurons. Lipocalin 3 is the gene most significantly increased among 772 up-regulated genes (more than 2 fold over-expression) and Aristaless 3 is the gene most dramatically decreased among 959 down-regulated genes (more than 2 fold down-expression). The gene increased expression of Fgb, Thbd, Cfi, F3, Kngl, Serpinel, C3, Tnfrsf4 and Il8rb are involved stress-response gene, and Nfkbia, Casp7, Pik3rl, I11b, Unc5a, Tgfb2, Kitl and Fgf15 are strongly associated with development. Cell cycle associated genes (Mcm6, Ccnb2, Plk1, Ccnd1, E2f1, Cdc2a, Tgfa, Dusp6, Id3) and cell proliferation associated genes (Ccl2, Tnfsf13, Csf2, Kit, Pim1, Nr3c1, Chrm4, Fosl1, Spp1) are down-regulated more than 2 times by methylprednisolone treatment. Among the genes described above, 4 up-regulated genes are confirmed those expression by RT-PCR. We found that methylprednisolone is related to expression of many genes associated with stress response, development, cell cycle, and cell proliferation by DNA microarray analysis. However, We think further experimental molecular studies will be needed to figure out the exact biological function of various genes described above and the physiological change of neuronal cells by methylprednisolone. The resulting data will give the one of the good clues for understanding of methylprednisolone under molecular level in the neurons.

• Journal of Animal Reproduction and Biotechnology
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• v.39 no.2
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• pp.131-137
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• 2024

Background: Porcine embryonic development is widely utilized in the medical industry. However, the blastocyst development rate in vitro is lower compared to in vivo. To address this issue, various supplements are employed. Extracellular vesicles (EVs) play the role of communicators that carry many bioactive cargoes. Additionally, the contents of EVs can vary on the estrous cycle. Methods: We compared the effects of adding EVs derived from porcine uterine fluid (UF), categorized as non-EV (G1), EVs in estrus (G2) and EVs in diestrus (G3). After in vitro culture (IVC) was performed in three different groups, cleavage rate and blastocyst development rate were examined. In addition, glutathione (GSH) and reactive oxygen species (ROS) levels were measured 2 days after activation to assess oxidative stress. Results: Using NTA and cryo-TEM, we confirmed the presence of EVs with sizes ranging from 30 nm to 200 nm, that the particles were suitable for analysis for analysis. In IVC data, the highest cleavage rate was observed in G2, which was significantly different from G1 but not significantly different from the next highest, G3. Similarly, the highest blastocyst development rate was observed in G2, which was significantly different from G1 but not significantly different from the next highest, G3. Conclusions: These results indicate that estrus derived EVs contain biofactors beneficial for early blastocyst development, including GSH which protects the blastocyst from oxidative stress. Additionally, although diestrus-derived EVs are expected to have some effect on blastocyst development, it appeared to be less effective than estrus-derived EVs.

• Animal Bioscience
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• v.36 no.11
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• pp.1632-1646
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• 2023

Objective: The objective of the present study was to investigate the effect of dietary betaine (BT) supplementation on the hepatic transcriptome profiles in broiler chickens raised under heat stress (HS) conditions. Methods: A total of 180 (21-d-old) Ross 308 male broiler chicks were allotted to 1 of 3 treatment groups with 6 replicated cages in a completely randomized design. One group was kept under thermoneutral conditions at all times and was fed a basal diet (PC). Other 2 groups were exposed to a cyclic heat stress condition. One of the 2 groups under heat stress conditions was fed the basal diet as a negative control (NC), whereas the other group was fed the basal diet supplemented with 0.2% BT. All chickens were provided with diets and water ad libitum for 21 d. Following the experiment, the liver samples were collected for RNA sequencing analysis. Results: Broiler chickens in NC and BT group had decreased (p<0.05) growth performance. In the transcriptome analysis, the number of differentially expressed genes were identified in the liver by HS conditions and dietary BT supplementation. In the comparison between NC and PC treatments, genes related to energy and nucleic acid metabolism, amino acid metabolism, and immune system were altered by HS, which support the reason why heat-stressed poultry had decreased growth performance. In the comparison between NC and BT treatments, genes related to lipid metabolism, carbohydrate metabolism, and immune system were differently expressed under HS conditions. Conclusion: HS negatively impacts various physiological processes, including DNA replication, metabolism of amino acids, lipids, and carbohydrates, and cell cycle progression in broiler chickens. Dietary BT supplementation, however, offers potential counteractive effects by modulating liver function, facilitating gluconeogenesis, and enhancing immune systems. These findings provide a basis for understanding molecular responses by HS and the possible benefits of dietary BT supplementation in broiler chickens exposed to HS.