• Nutrition Research and Practice
• /
• v.13 no.5
• /
• pp.377-383
• /
• 2019

BACKGROUND/OBJECTIVES: Hyperglycemia-induced hepatic damage has been recognized as one of the major cause of complications in diabetes. Hepatic complications are associated with inflammation and oxidative stress in diabetes. In this study, we investigated the hypothesis that gamma-tocopherol (GT) supplementation ameliorates NLRP3 inflammasome associated hepatic inflammation in diabetes. MATERIALS/METHODS: Diabetes was induced by the intraperitoneal injection of alloxan (150 mg/kg. BW) in ICR mice. All mice were fed with a control diet (AIN-76A). After diabetes was induced (fasting glucose level ${\geq}250mg/dL$), the mice were treated with tocopherol-stripped corn oil or GT-supplemented (35 mg/kg) corn oil, respectively, by gavage for 2 weeks. RESULTS: GT supplementation reduced fasting blood glucose levels in diabetic mice relative to non-treated diabetic mice. Moreover, GT supplementation ameliorated hyperglycemia-induced hepatic damage by regulation of NOD-like receptor protein 3 (NLRP3)-inflammasome associated inflammation represented by NLRP3, apoptosis-associated speck-like protein containing a caspase-recruitment domain, caspase-1, nuclear $factor-{\kappa}B$ pathway as well as oxidative stress demonstrated by nuclear factor erythroid 2-related factor 2, NAD(P)H dehydrogenase quinone 1, catalase and glutathione-dependent peroxidase in diabetic mice. CONCLUSION: The findings suggested that GT supplementation ameliorated hepatic damage by attenuating inflammation and oxidative stress in alloxan-induced diabetic mice. Taken together, GT could be a beneficial nutrient that can ameliorate inflammatory responses associated with NLRP3 inflammasome in hyperglycemia-induced hepatic damage.

• Journal of Ginseng Research
• /
• v.43 no.1
• /
• pp.10-19
• /
• 2019

Background: Frequent overdose of paracetamol (APAP) has become the major cause of acute liver injury. The present study was designed to evaluate the potential protective effects of ginsenoside Rk1 on APAP-induced hepatotoxicity and investigate the underlying mechanisms for the first time. Methods: Mice were treated with Rk1 (10 mg/kg or 20 mg/kg) by oral gavage once per d for 7 d. On the 7th d, allmice treated with 250mg/kg APAP exhibited severeliverinjury after 24 h, and hepatotoxicitywas assessed. Results: Our results showed that pretreatment with Rk1 significantly decreased the levels of serum alanine aminotransferase, aspartate aminotransferase, tumor necrosis factor, and interleukin-$1{\beta}$ compared with the APAP group. Meanwhile, hepatic antioxidants, including superoxide dismutase and glutathione, were elevated compared with the APAP group. In contrast, a significant decrease in levels of the lipid peroxidation product malondialdehyde was observed in the ginsenoside Rk1-treated group compared with the APAP group. These effects were associated with a significant increase of cytochrome P450 E1 and 4-hydroxynonenal levels in liver tissues. Moreover, ginsenoside Rk1 supplementation suppressed activation of apoptotic pathways by increasing Bcl-2 and decreasing Bax protein expression levels, which was shown using western blotting analysis. Histopathological observation also revealed that ginsenoside Rk1 pretreatment significantly reversed APAP-induced necrosis and inflammatory infiltration in liver tissues. Biological indicators of nitrative stress, such as 3-nitrotyrosine, were also inhibited after pretreatment with Rk1 compared with the APAP group. Conclusion: The results clearly suggest that the underlying molecular mechanisms in the hepatoprotection of ginsenoside Rk1 in APAP-induced hepatotoxicity may be due to its antioxidation, antiapoptosis, anti-inflammation, and antinitrative effects.

• Tunnel and Underground Space
• /
• v.31 no.4
• /
• pp.221-242
• /
• 2021

A numerical study of the performance assesment of coupled thermo-hydro-mechanical (THM) processes in improved Korean reference disposal system (KRS⁺) for high-level radioactive waste is conducted using TOUGH2-MP/FLAC3D simulator. Decay heat from high-level radioactive waste increases the temperature of the repository, and it decreases as decay heat is reduced. The maximum temperature of the repository is below a maximum temperature criterion of 100℃. Saturation of bentonite buffer adjacent to the canister is initially reduced due to pore water evaporation induced by temperature increase. Bentonite buffer is saturated 250 years after the disposal of high-level radioactive waste by inflow of groundwater from the surrounding rock mass. Initial saturation of rock mass decreases as groundwater in rock mass is moved to bentnonite buffer by suction, but rock mass is saturated after inflow of groundwater from the far-field area. Stress changes at rock mass are compared to the Mohr-Coulomb failure criterion and the spalling strength in order to investigate the potential rock failure by thermal stress and swelling pressure. Additional simulations are conducted with the reduced spacing of deposition holes. The maximum temperature of bentonite buffer exceeds 100℃ as deposition hole spacing is smaller than 5.5 m. However, temperature of about 56.1% volume of bentonite buffer is below 90℃. The methodology of numerical modeling used in this study can be applied to the performance assessment of coupled THM processes for high-level radioactive waste repositories with various input parameters and geological conditions such as site-specific stress models and geothermal gradients.

• Proceedings of the KSME Conference
• /
• 2007.05a
• /
• pp.1063-1068
• /
• 2007

The present study describes the effects of music and vibroacoustic stimuli to the relaxation of human body. We have carried out the experiment on 6 human subjects of which are composed 3men and 3women. We have investigated the electroencephalogram(EEG) of all subjects before and after the stimuli of which are made a strong noise or the meditatiom music and the acoustic vibration. The vibroacoustic device has transmitted meditation music as vibration between 20Hz and 250Hz to the body. From the experimental results, we made sure the effects that the meditation music and vibroacoustic stimuli influenced the stress reduction of human body for good as alpha-wave was increased continuously during the good stimuli and after that.

• Tunnel and Underground Space
• /
• v.15 no.4 s.57
• /
• pp.250-263
• /
• 2005

Progressive and localized brittle failures around an excavated opening by the overstressed condition can act as a serious obstacle to ensure the stability and the economical efficiency of construction work. In this paper, the characteristics of the brittle failure around an circular opening with stress level was studied by the biaxial compressive test using sealed specimen and by the numerical simulation with $PFC^{2D}$, one of the discrete element codes. The occurring pattern and shape of the brittle failure around a circular opening monitored during the biaxial loading were well coincided with those of the stress induced failures around the excavated openings observed in the brittle rock masses. The crack development stages with stress level were evaluated by the detailed analysis on the acoustic emission event properties. The microcrack development process around a circular opening was successfully visualized by the particle flow analysis. It indicated that the scaled test had a good feasibility in understanding the mechanism of the brittle failure around an opening with a high reliability.

• Proceedings of the KSME Conference
• /
• 2001.06c
• /
• pp.525-530
• /
• 2001

As a part of efforts to examine feasibility of warm forging near-net-shape process for non-heat-treated steel to replace quenched and tempered S45C steel, the optimized process condition has been determined to be $820^{\circ}C$ for heating, 10/sec for strain rate of forging and approximately 250MPa for flow stress from observed results such as the $A_{3}$ transformation temperature of about $790^{\circ}C$, the fully dynamic recrystallized behavior between $800^{\circ}C\;and\;850^{\circ}C$ when compressed up to 63% engineering strain at 10/sec strain rate, and the high temperature microsturctural stability. Also, controlled cooling rate of $6.3^{\circ}C/sec$ by water-spraying at a rate of $0.10cc/sec-cm^{2}$ for 60seconds followed by air-cooling right after forging process has been considered in this study as a feasible approach based on examination of the microsturcture of mixed ${\alpha}-ferrite$ and pearlite, the hardness and tensile properties meeting specification, and the reduced total cooling time to room temperature. Successive works would be carried out for the impact strength, machinalility, and forgeability at this process in the near future.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.25 no.6
• /
• pp.169-176
• /
• 2021

In this study, pull-out tests were conducted at room temperature, 150 ℃ and 250 ℃ to evaluate the residual bond strength of carbon fiber reinforcement polymer, CFRP after elevated temperature and deformed steel rebar of D10 and D13 were also evaluated after the high temperature heating for comparison. As a result of the experiment, the bond strength of the CFRP after 150 ℃ and 250 ℃ decreased by 9.94 % and 41 %, respectively. On the other hand, after thermal heating, both the steel rebar of D10 and D13 had a lower rate of reduction in bond strength than that of the CFRP. Also slip at the maximum bond strength also decreased after the heating for both the CFRP and the rebars. Through it, the correlation between the bond strength and the slip reduction due to thermal heating was confirmed and bond slip models were presented. Finally the experimental result was evaluated as relative bond strength to identify the residual bond performance of the CFRP and the rebar after the heating was confirmed by comparing with the existing test result of the bond strength after elevated temperature.

• Asian-Australasian Journal of Animal Sciences
• /
• v.21 no.8
• /
• pp.1164-1170
• /
• 2008

In this study, the effects of propolis and vitamin C (L-ascorbic acid) supplementation in diets were investigated on feed intake (FI), body weight (BW), body weight gain (BWG), feed conversion rate (FCR) and digestibility and on egg production and qualities (weight, mortality, shell thickness) in laying hens exposed to heat stress. A total of 150 Hyline White Leghorn, aged 42 weeks, hens was divided into five groups of 30 hens. Chicks were randomly divided into 1 positive control, 1 control and 3 treatment groups. The chicks were kept in cages in temperature-controlled rooms at $22^{\circ}C$ for 24 h/d (positive control, Thermoneutral, TN group) or $34^{\circ}C$ for 9 h/d from 08.00-17.00 h followed by $22^{\circ}C$ for 15 h (control, heat stress, HS group) and fed a basal diet or basal diet supplemented with vitamin C (250 mg/kg of L- ascorbic acid/kg of diet) or two levels of propolis (2 and 5 g of ethanol extracted propolis/kg of diet). Increased FI (p<0.05) and improvement in FCR (p<0.05), hen day egg (p<0.05) and egg weight (p<0.05) were found in Vitamin C and propolis-supplemented laying hens reared under heat stress conditions. Mortality rate was higher in the control group than TN, vitamin C and propolis groups (p<0.05). Digestibility of dry matter, organic matter, crude protein and ether extract improved with increasing of both dietary vitamin C and propolis (p<0.05). Vitamin C or propolis supplementation did not affect either the percentage shape index, yolk index or haugh unit and albumen index (p>0.05). However, the egg shell thickness and egg shell weight appeared to be increased in Vitamin C and propolis groups in comparison to HS group birds (p<0.05). In conclusion, dietary supplementation of laying hens with anti-oxidants (vitamin C and propolis) can attenuate heat stress-induced oxidative damage. These positive effects were evidenced by increased growth performance and digestibility, improvement of egg shell thickness and egg weight in comparison to non-supplemented birds. Moreover, supplementation with propolis (5 g/kg diet) was the most efficient treatment.

• Proceeding of EDISON Challenge
• /
• 2017.03a
• /
• pp.241-250
• /
• 2017

Auxetic is a structure that behave as negative Poisson's ratio. It is known for high mechanical property like energy absorption and destruction toughness so far. In this paper, we aimed to design auxetic structure which has small internal energy when force is applied and high NPR and over 50N/mm stiffness by using optimization method. We defined length(L), thickness(t), angle(${\theta}_1$, ${\theta}_2$) as design factors and also von-Mises stress, NPR, stiffness as reaction factors. We used Box-Behnken method and conducted 4factors - 3levels experiment design. We also analyzed each models by using CSD_EPLAST, Edison program, and did extra analysis for more accurate results. Finally, we found out the optimal design factors which is satisfied aimed value and increased reliability through factor analysis and validity verification.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.35 no.11
• /
• pp.1399-1406
• /
• 2011

The reducer of the mixer is one of the main parts of the processor used for water and wastewater treatment. In this study, an advanced reducer with a drywell structure was developed in order to prevent oil leakage during operation in the field. During the development of the advanced reducer prototype, a mockup, a metal mold, and a cast were made using CAD and a CNC machine. The structural safety of the reducer prototype's lower housing (drywell structure) was checked using the ALGOR commercial FEM analysis code, which yielded a von Mises stress of about 123 N/mm2, which is below the yield stress of 250 N/$mm^2$, and a natural frequency of about 650-700 Hz. In addition, the torque transmission efficiency for the advanced prototype was 95.87%, which is about 8% more than that found in a previous study, 88.45%, and the sound level was below 75 dB. Furthermore, no oil leakage or abnormal sound or vibration occurred. Therefore, an optimally designed advanced reducer prototype has been successfully developed.