• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.3009-3014
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• 2015

The epidermal growth factor (EGF) may play a pathological role in hepatocellular carcinoma (HCC). However, the conclusions of published reports on the relationship between the EGF $61^*A/G$ polymorphism and HCC risk remain controversial. To derive a more precise estimation we performed a meta-analysis based on 14 studies that together included 2,506 cases and 4,386 controls. PubMed, EMBASE, Web of Knowledge and the Chinese National Knowledge Infrastructure (CNKI) databases were used to retrieve articles up to August 1, 2014. The crude odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated to evaluate the association. Meta-analysis results showed a significant association between the EGF $61^*A/G$ polymorphism and HCC risk in all four genetic models (allele model: OR=1.25, 95%CI=1.12-1.40; dominant model: OR=1.32, 95%CI=1.14-1.54; recessive model: OR=1.33, 95%CI=1.12-1.58; ho-mozygous model: OR=1.59, 95%CI=1.33-1.90). Moreover, significant associations were observed when stratified by ethnicity, source of controls, etiology and genotype methods. Thus, this meta-analysis suggests that the G-allele of the EGF $61^*A/G$ polymorphism is associated with an increased risk of HCC, especially in Asians and Caucasians, without influence from the source of controls or etiological diversity. Further studies with larger population sizes are needed to confirm these results.

• 디지털융복합연구
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• 제15권10호
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• pp.559-570
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• 2017

이 연구는 베블런효과와 밴드왜건효과가 미용실 선택에 영향을 미치는지를 파악하고자 하는데 목적이 있다. 연구목적의 달성을 위하여 20세 이상의 여성 1,000명을 대상으로 구조화된 설문지를 통하여 자료를 수집하였다. 표본추출은 연구결과의 일반화를 위하여 비례층화표본추출방법을 활용하였다. 수집된 자료는 SPSS ver.19.0을 가지고 빈도분석, 요인분석, 신뢰도분석, 회귀분석을 실시하였다. 연구목적의 달성을 위하여 두 개의 가설을 설정하였다. 가설1은 베블런효과는 미용실 선택에 영향을 미칠 것이다. 가설2는 밴드왜건효과는 미용실 선택에 영향을 미칠 것이다. 분석결과 베블런효과와 밴드왜건효과는 미용실을 선택하는데 영향을 미치는 것으로 검증되었다. 베블런효과는 미용실을 선택하는데 영향을 미칠 것이라는 가설과 밴드왜건효과는 미용실을 선택하는데 영향을 미칠 것이라는 가설은 부분적으로 채택될 수 있는 것으로 나타났다. 연구의 결과는 미용실 이용자의 대부분은 그들의 친구, 지인 또는 함께 교류하는 사람과 미용실을 이용하고 있다는 것을 보여준다.

• 융합보안논문지
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• 제16권6_2호
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• pp.73-82
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• 2016

이 연구는 민간경비원의 직업선택동기가 직업선택평가 및 직무태도에 미치는 영향을 검증하고자 수도권에 분포되어 있는 8개의 업체에 직접 방문하여 유층집락무선표집법을 통하여 2015년 5월 1일 부터 10월 10일까지 총 5개월간에 걸쳐 설문조사를 실시하였다. 설문지는 총 240부를 배포하여 회수된 220부의 설문지를 분석에 활용하였다. 수집된 설문지는 SPSS 21.0, AMOS 21.0프로그램을 활용하여 분석하였으며, 통계분석 기법은 신뢰도분석, 요인분석, 상관분석, 구조모형 분석 등이 사용되었으며, 통계적 유의 수준은 .05로 설정하였다. 이와 같은 방법과 절차에 따른 자료 분석을 통하여 본 연구에서 얻은 결과는 다음과 같다. 직업선택동기는 직업선택평가와 직무태도에 유의한 영향을 미치고, 직업선택평가는 직무태도에 유의한 영향을 미친다. 하지만, 직업선택평가는 직업선택동기와 직무태도 간의 관계에서 매개역할을 하지 않은 것으로 조사되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7713-7718
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• 2014

Background: Despite evidence suggesting roles for caspase-8 (CASP8) -652 6N del and D302H polymorphisms in prostate cancer (PCa), the association of these polymorphisms with PCa risk remains inconclusive. Therefore, a meta-analysis was performed to more precisely estimate the association of CASP8 -652 6N del and D302H polymorphisms with PCa susceptibility. Materials and Methods: A comprehensive literature search was conducted to identify all case-control studies of CASP8 D302H and -652 6N del polymorphisms and PCa risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association and the precision of the estimate, respectively. Results: Nine -625 6N del studies and 4 D302H studies were included. CASP8 -652 6N del and D302H polymorphisms were not significantly associated with PCa risk in the overall analyses. However, in the subgroup analysis stratified by ethnicity, -625 6N del was significantly associated with PCa risk in the East Asian and Indian populations under the recessive model. Furthermore, the subgroup analysis strongly suggested that D302H was associated with lower PCa risk in the Non-Indian population under the dominant model. Conclusions: In our meta-analysis, ethnic-specific differences were evident in the association of CASP8-625 6N del and D302H polymorphisms with PCa risk.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5407-5413
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• 2015

Background: Published data regarding associations between the P275A polymorphism in the macrophage scavenger receptor 1 (MSR1) gene and prostate cancer (PCa) risk are inconclusive. The aim of this study was to comprehensively evaluate the genetic risk of P275A polymorphism in MSR1 gene for PCa. Materials and Methods: A systematic literature search was carried out in Pubmed, Medline (Ovid), Embase, CBM, CNKI, Weipu, and Wanfang databases, covering all available publications (last search was performed on Apr 27, 2015). Statistical analysis was performed using Revman 5.2 and STATA 10.1 software. Results: A total of 5,017 cases and 4,869 controls in 12 case-control studies were included in this meta-analysis. When all groups were pooled, there was no evidence that the P275A polymorphism had a significant association with PCa under dominant (OR=0.93, 95%CI=0.81-1.06, and p=0.28), co-dominant (homogeneous OR=0.97, 95%CI=0.56-1.68, and p=0.92; heterogeneous OR=0.93, 95%CI=0.74-1.15, and p=0.49), recessive (OR=1.10, 95%CI=0.65-1.87, and p=0.73), over-dominant (OR=0.93, 95%CI=0.75-1.15, and p=0.50), and allelic (OR=0.95, 95%CI=0.77-1.16, and p=0.61) genetic models. For stratified analyses by ethnicity and study design, no significant associations were found in the white race, the yellow race, the black race and mixed ethnicity, and the population-based case-control (PCC) and hospital-based case-control (HCC) studies under all genetic models. Conclusions: Based on our meta-analysis, the P275A polymorphism in the MSR1 gene is unlikely to be a risk factor for PCa.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3021-3027
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• 2014

Background: The multidrug resistance 1 gene (MDR1) C3435T polymorphism has been demonstrated to influence the P-glycoprotein (P-gp) activity level which is related to inflammation and carcinogenesis. This meta-analysis was performed to estimate the association between the MDR1 C3435T polymorphism and the risk of gastric cancer (GC) and peptic ulcer (PU). Materials and Methods: A literature search was conducted with PubMed, Embase and the Cochrane library up to November 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Data were analyzed using Review Manager (Version 5.2), and Stata package (version 12.0) for estimation of publication bias. Results: Six case-control studies were included, of which five were for GC and two for PU. Overall, no evidence was found for any association between the MDR1 C3435T polymorphism and the susceptibility to GC and PU. In the stratified analysis by H. pylori infection status, stage and histology classification of GC, and PU type, there was still no significant association between them. Conclusions: This meta-analysis suggested that the MDR1 C3435T polymorphism is not associated with susceptibility to GC and PU. Large and well-designed studies are warranted to validate our findings.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.4983-4988
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• 2012

The xeroderma pigmentosum complementation group C gene (XPC) has been identified as important for repairing UV-related DNA damage. Some subtle changes in this gene may impair repair efficiency and influence susceptibility to human cancers, including skin cancer. Two polymorphisms in XPC, 939A>C (rs2228001) and 499C>T (rs2228000), are considered to have possible associations with the risk of skin cancer, but the reported results have been inconsistent. Here we performed a meta-analysis of the available evidence regarding the relationship between these two polymorphisms and the risk of skin cancer. All relevant studies were searched using PubMed, Embase and Web of Science before February 2012. A total of 8 case-control studies were included in this analysis, and no convincing associations between the two polymorphisms and risk of skin cancer were observed in any of the genetic models. Stratified analyses by skin cancer type also did not detect significant associations in any subgroup. This meta-analysis suggested that the XPC 939A>C and 499C>T polymorphisms may have little involvement in susceptibility to skin cancer.

• 디지털융복합연구
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• 제14권7호
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• pp.347-353
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• 2016

이 연구의 목적은 청주 C지역 초등 5-6학년 189명을 유층표집 하여 방과 후 스포츠 활동 참여가 부모자녀 간 의사소통과 문제행동에 긍정적인 영향을 미치는지를 구조적으로 분석하는 것이었다. SPSS 18.0을 이용한 탐색적 및 확인적 요인분석 결과 방과후 스포츠 활동에 참여는 부모자녀 간 의사소통을 개선(성취동기, 자신감, 자긍심 등)시키고, 문제행동(우울, 불안, 반항, 공격성 등)을 감소시켰으며, 부모자녀 간 의사소통은 부정적인 소통(핀잔, 잔소리, 힐책 등)은 줄어든 반면, 문제행동 감소에도 영향을 주었다. 향후 아동의 정서적 인간적으로 제기되는 심리적 탄력성 신장을 위해서는 방과 후 스포츠 활동 참여의 가치를 종목별로 체계적인 프로그램을 마련하고 이에 대한 유효성을 지속적으로 검증할 필요가 있다고 생각된다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.157-163
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• 2012

Objective: Glutathione S-transferases (GSTs) are multifunctional enzymes that play a crucial role in the detoxification of both the endogenous products of oxidative stress and exogenous carcinogens. Recent studies investigating the association between genetic polymorphisms in GSTs and the risk of adult brain tumors have reported conflicting results. The rationale of this pooled analysis was to determine whether the presence of a GST variant increases adult glioma susceptibility by combining data from multiple studies. Methods: In our meta-analysis, 12 studies were identified by a search of the MEDLINE, HIGHWIRE, SCIENCEDIRECT and EMBASE databases. Of those 12, 11 evaluated GSTM1, nine evaluated GSTT1 and seven evaluated GSTP1 Ile105Val. Between-study heterogeneity was assessed using ${\chi}^2$-based Q statistic and the $I^2$ statistic. Crude odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to estimate the association between GSTM1, GSTT1 and GSTP1 polymorphisms and the risk of adult gliomas. Results: The quantitative synthesis showed no significant evidence to indicate an association exists between the presence of a GSTM1, GSTT1 or GSTP1 Ile105Val haplotype polymorphism and the risk of adult gliomas (OR, 1.008, 1.246, 1.061 respectively; 95% CI, 0.901-1.129, 0.963-1.611, 0.653-1.724 respectively). Conclusions: Overall, this study did not suggest any strong relationship between GST variants or related enzyme polymorphisms and an increased risk of adult gliomas. Some caveats include absence of specific raw information on ethnic groups or smoking history on glioma cases in published articles; therefore, well-designed studies with a clear stratified analysis on potential confounding factors are needed to confirm these results.

• BMB Reports
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• 제38권6호
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• pp.650-660
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• 2005

Proteins accumulated in dry, stratified Arabidopsis seeds or young seedlings, totaled 1100 to 1300 depending on the time of sampling, were analyzed by using immobilized pH gradient 2-DE gel electrophoresis. The molecular identities of 437 polypeptides, encoded by 355 independent genes, were determined by MALDI-TOF or TOF-TOF mass spectrometry. In the sum, 293 were present at all stages and 95 were accumulated during the time of radicle protrusion while another 18 appeared in later stages. Further analysis showed that 226 of the identified polypeptides could be located in different metabolic pathways. Proteins involved in carbohydrate, energy and amino acid metabolism constituted to about 1/4, and those involved in metabolism of vitamins and cofactors constituted for about 3% of the total signal intensity in gels prepared from 72 h seedlings. Enzymes related to genetic information processing increased very quickly during early imbibition and reached highest level around 30 h of germination.